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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya jose Ramon Munoz-Rodriguez Miguel angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias jose Manuel Perez-Ortiz Mao-Qiang Man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,P<0.01)and in vitro(90%vs.65%reduction in wound area,P<0.01).Moreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HMGCoA,SPT,filaggrin,loricrin and involucrin(P<0.05 ***-treated controls)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),P<0.01).Conclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

Fracture Mechanics on Aluminum Specimens

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World Journal of Mechanics 2021年第12期11卷 237-257页

作者： Juan jose Mejia Briseno Francisco Casanova-del-angel Tecnologico Nacional de Mexico Instituto Tecnol&#243 gico de Pachuca Pachuca Estado de Hidalgo Mexico Seccion de Estudios de Posgrado e Investigació n Escuela Superior de Ingenier&#237 a y Arquitectura Unit. Adolfo Lopez Mateos Instituto Polit&#233 cnico Nacional Ciudad de M&#233 xico Mexico

ASTM standards for A413 aluminum alloy specimen assays were used based on standard E399-05, with a minimum requirement of three specimens. Linear elastic fracture mechanic testing was carried out in plane strain conditions and fracture toughness of the tested aluminum, critical stress intensity factor was determined. Four specimens with the selected geometry were made, since in the pre-cracking process a non-acceptable propagation of crack may be present, i.e., the crack does not propagate in a parabolic manner. In like manner, the Type SE (B) specimen, that is, a beam subject to bending under a monotonic load, was used. Stress efforts were induced in the experiment, the load mode for such experiments is mode I, determining a temporary value of the KQ apparent stress intensity factor. When such value complies with the validity criteria of E-399 Standard, it becomes the stress intensity factor KIC of material.

关键词： Metallography A413 Aluminum Fracture Mechanics Stress Efforts Fractography

Healthy diet,depression and quality of life:A narrative review of biological mechanisms and primary prevention opportunities

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World Journal of Psychiatry 2021年第11期11卷 997-1016页

作者： Octavio Pano Elena H Martínez-Lapiscina Carmen Sayón-Orea Miguel angel Martinez-Gonzalez jose Alfredo Martinez Almudena Sanchez-Villegas Preventive Medicine and Public Health University of NavarrePamplona 31008Spain Department of Neurology Center of Neuroimmunology Hospital Clinic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi SunyerBarcelona 08036Spain Department of Preventive Medicine and Public Health University of NavarraPamplona 31008Spain IdiSNA Navarra Institute for Health ResearchPamplona 31008Spain Department of Public Health Navarra Institute of Public Health and EpidemiologyPamplona 31003Spain CIBER Pathophysiology of Obesity and Nutrition Institute of Health Carlos IIIMadrid 28049Spain Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115United States Department of Food Sciences and Physiology University of NavarrePamplona 31008Spain Precision Nutrition and Cardiometabolic Health Program IMDEA Food InstituteMadrid 28049Spain Department of Clinical Sciences University of Las Palmas Gran CanariaLas Palmas Gran Canaria 35080Spain

Unipolar depressive disorder(UDD)affects more than 264 million people worldwide and was projected well before the severe acute respiratory syndrome coronavirus 2 pandemic to be the leading cause of disability-adjusted life years lost in *** is imperative for leading economies to implement preventive strategies targeted towards UDD,given consistent policies are currently *** established similarities between the aetiological hypotheses of depression and cardiometabolic diseases are shifting paradigms within this *** is believed that dietary practices could potentially reduce the incidence of depression;similar to their effects on ***,the aim of this review was to compile current evidence on healthy dietary patterns as suitable contributors towards primary prevention strategies against *** of the well-known biological mechanisms behind depression have been positively associated with healthful diets and dietary patterns to varying ***,a common factor of UDD is the production and overall effects of inflammatory cytokines,such as interleukin-6,tumor necrosis factor-α,and Creactive *** compounds have been associated with depressive symptoms,disturbances in neuroendocrine function,leaky gut,monoamine activity and brain function,while also being key factors in the development of cardiometabolic *** Mediterranean diet(MD)in particular,is well supported by first-level evidence regarding its preventive qualities against metabolic and cardiovascular diseases and thus considered a model for healthy eating by various *** one of the few clinical trials investigating these associations,the PREDIMED trial,individuals with diabetes assigned to a MD supplemented with mixed tree nuts experienced a 41%relative risk reduction for developing ***,there is a need to include health related quality of life as an indicator of physical and mental well-being,considering its putative associations

关键词： Depression Nutrition Mediterranean Quality of life Primary prevention Epidemiology

Dynamics of the ruminal microbial ecosystem, and inhibition of methanogenesis and propiogenesis in response to nitrate feeding to Holstein calves

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Animal Nutrition 2021年第4期7卷 1205-1218页

作者： Abimael Ortiz-Chura jose Gere Gisela Marcoppido Gustavo Depetris Silvio Cravero Claudia Faverin Cesar Pinares-Patino angel Cataldi d Maria E.Ceron-Cucchi Institute of Pathobiology CICVyA National Institute of Agricultural TechnologyIPVetUEDD INTA-CONICETHurlinghamC1686Argentina Engineering Research and Development Division National Technological University(UTN)National Scientific and Technical Research Council(CONICET)Buenos AiresC1179Argentina Agricultural Experimental Station of Balcarce National Institute of Agricultural Technology(INTA)BalcarceB7620Argentina Institute of Agrobiotechnology and Molecular Biology IABIMONational Institute of Agricultural Technology(INTA)National Scientific and Technical Research Council(CONICET)HurlinghamC1686Argentina The Agribusiness Group Lincoln UniversityPO Box 85016Lincoln7674New Zealand

It is known that nitrate inhibits ruminal methanogenesis,mainly through competition with hydrogenotrophic methanogens for available hydrogen(H2)and also through toxic effects on the ***,there is limited knowledge about its effects on the others members of ruminal microbiota and their *** this study,we investigated the effects of dietary nitrate inclusion on enteric methane(CH4)emission,temporal changes in ruminal microbiota,and fermentation in Holstein *** animals were maintained in individual pens for 45 *** were randomly allocated to either a control(CTR)or nitrate(NIT,containing 15 g of calcium nitrate/kg dry matter)*** emissions were estimated using the sulfur hexafluoride(SF6)tracer *** microbiota changes and ruminal fermentation were evaluated at 0,4,and 8 h *** this study,feed dry matter intake(DMI)did not differ between dietary treatments(P>0.05).Diets containing NIT reduced CH4 emissions by 27%(g/d)and yield by 21%(g/kg DMI)compared to the CTR(P0.05)but differed with time,and post-feeding(P<0.05).Increases in the concentrations of ruminal ammonia nitrogen(NH3-N)and acetate were observed,whereas propionate decreased at 4 h post-feeding with the NIT diet(P<0.05).Feeding the NIT diet reduced the populations of total bacteria,total methanogens,Ruminococcus albus and Ruminococcus flavefaciens,and the abundance of Succiniclasticum,Coprococcus,Treponema,Shuttlewortia,Succinivibrio,Sharpea,Pseudobutyrivibrio,and Selenomona(P<0.05);whereas,the population of total fungi,protozoa,Fibrobacter succinogenes,Atopobium and Erysipelotrichaceae L7 AE11 increased(P<0.05).In conclusion,feeding nitrate reduces enteric CH4 emissions and the methanogens population,whereas it decreases the propionate concentration and the abundance of bacteria involved in the succinate and acrylate pathways.D

关键词： Methane emission Nitrate Microbiota Ruminal fermentation

Characterization of Lay Phase in Three Genetic Types of Heavy Broilers Breeder in Tropical Conditions

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Journal of Agricultural Science and Technology(A) 2013年第10期3卷 766-774页

作者： jose angel Miguel Edilberto Acevedo Jesus Ciria Begona Asenjo Escuela de lngenierias Agrarias de Sofia Campus Universitario s/n Universidad de Valladolid Sofia 42004 Espana Avenida Universidad Universidad Nacional Experimental del Tdtchira San Crist6bal Estado T(tchira 87225 Venezuela

The objective of the present work is characterizing some parameters in the lay phase in the lines of heavy broilers breeder Cobb Avian 48, Arbor Acres Plus and Ross 208, reared under the same commercial conditions in the tropics. Monitored three batches of approximately 18,000 females each （one for each genetic type）, from weeks 24 to 64, according to the conditions of handling and power described by the generic lines distribution companies. Although no differences were found for feed intake, Cobb Avian was presented a lower rate of feed conversion, being also that presented the highest percentage of implementation and production of incubables eggs, which meant that it was in line with the highest cumulative production of chickens by bird and week for tropical conditions studied. To adjust the lay data to a Gorssman model, in order to predict the parameters that characterize the lay modeling, estimated the best behavior for Cobb Avian 48 females, because while it takes more time to reach the level of putting constant （5.30 weeks） and maintain it for less time （2.4 weeks）, they manage to put constant high （79.11%） level, considering that the largest number of eggs per bird （171.19 vs. 164.54 and 160.11 in Arbor Acres and Ross 208, respectively）.

关键词： Arbor acres plus Cobb Avian 48 heavy broilers breeder lay intensity lay modeling Ross 208.

Long-Term Follow-Up of 82 Cavernous Sinus Meningiomas Treated with Radiosurgery

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Journal of Cancer Therapy 2014年第11期5卷 1005-1011页

作者： Mari Pascual Gallego jose Samblas jose Carlos Bustos jose angel Gutierrez Diaz Marisa Gonzalez Kita Sallabanda[1 1Departament of Neurosurgery Hospital Clínico San Carlos Universidad Complutense de Madrid Madrid Espana Departament of Neurosurgery Hospital Clínico San Carlos Universidad Complutense de Madrid Madrid Espana Neuro-Oncology Unit Hospital San Francisco de Asís—Grupo IMO Madrid Espana

The cases of 82 patients with cavernous sinus meningioma (CSM) treated with Stereotactic Radiosurgery (SRS) at our institution from 1992 to 2005 were retrospectively reviewed. The mean follow-up time was 8.38 years. Patients’?age ranged between 16 and 78 years (mean 51). There were 35 patients who had been operated before, and two of them had been treated with fractionated radiotherapy. Twenty-three from 35 patients were surgically intervened?(65.7%)?and?presented post-surgical morbidity. Only in 3 cases the surgery was considered complete. The patients were referred for SRS treatment due to having tumour remains or a tumour growth. The mean volume of the tumour was 17.96 (+/?13.67) cm3.?All the patients had been treated with a Linear Accelerator (LINAC) using a high precision positioning and radiation system (SRS 2000) University of Florida. The clinical progress of the patients was assessed using preand post-SRS radiological imaging, post-surgical and pre-post-SRS morbidity and mortality. Tumour volume decreased significantly with RS in 61 of 82 patients (74.4%). The tumour volume remained stable 12 patients (14.6%) and only in 9 patients (11%) was there tumour growth after SRS. Of these, 5 required surgical intervention, and 7 of the 82 underwent SRS or another fractionated stereotactic radiotherapy after the RS. Morbidity due to the SRS was only seen in 14 out of the 82 patients treated with SRS, five of them recovered completely. SRS is a high precise and effective treatment with low morbidity, becoming more and more the option of choices?in the treatment of cavernous sinus meningioma.

关键词： Cavernous Sinus Meningioma Radiosurgery LINAC

LJItrasensitive H2S gas sensors based on p-type WS2 hybrid materials

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Nano Research 2018年第8期11卷 4215-4224页

作者： Georgies Alene Asrest jose J. Baldovi Aron Dombovari Topias Jarvinen Gabriela Simone Lorite Melinda Mohl Andrey Shchukarev Alejandro Perez Paz Lede Xian Jyri-Pekka Mikkola Anita Lloyd Spetz Heli Jantunen angel Rubio Krisztian Kordas Microelectronics Research Unit Faculty of Information Technology and Electrical Engineering University of Oulu P.O. Box 4S00FI-90014 Oulu Finland Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 149 22761 Hamburg Germany Nano-Bio Spectroscopy Group European Theoretical Spectroscopy Facifity (ETSF) Universidad del Pals Vasco CFM SCIC-UPV/EHU-MPC DIPC A venida Tolosa 72 20018 San Sebastian Spain Technical Chemistry Department of Chemistry Chemical-Biological Centre Umea University SE-90187 Umea Sweden School of Chemical Sciences and Engineering School of Physics and Nanotechnology Yachay Tech University Urcuquf Ecuador Industrial Chemistry & Reaction Engineering Department of Chemical Engineering Johan Gadolin Process Chemistry Centre AboAkademi University FI-20500 Abo-Turku Finland Sensor and Actuator Systems Department of Physics Chemistry and Biology Link~ping University SE-58183 LinkOping Sweden

Owing to their higher intrinsic electrical conductivity and chemical stability with respect to their oxide counterparts, nanostructured metal sulfides are expected to revive materials for resistive chemical sensor applications. Herein, we explore the gas sensing behavior of WS2 nanowire-nanoflake hybrid materials and demonstrate their excellent sensitivity （0.043 ppm-1） as well as high selectivity towards H2S relative to CO, NH~, H2, and NO （with corresponding sensitivities of 0.002, 0.0074, 0.0002, and 0.0046 pprn-1, respectively）. Gas response measurements, complemented with the results of X-ray photoelectron spectroscopy analysis and first-principles calculations based on density functional theory, suggest that the intrinsic electronic properties of pristine WS2 alone are not sufficient to explain the observed high sensitivity towards H2S. A major role in this behavior is also played by O doping in the S sites of the WS2 lattice. The results of the present study open up new avenues for the use of transition metal disulfide nanomaterials as effective alternatives to metal oxides in future applications for industrial process control, security, and health and environmental safety.

关键词： ws nanowire nanoflake gas sensor H2S,O doping

Colorectal cancer prognosis twenty years later

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World Journal of Gastroenterology 2010年第7期16卷 862-867页

作者： Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona angel Cosme Ines Gil jose Luis Elorza jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association Department of Gastroenterology Donostia HospitalUniversity of Basque CountryCentro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas(CIBEREHD)20014 San SebastiánSpain Department of Epidemiology Donostia HospitalCIBERESP20014 San SebastiánSpain Department of Surgery Donostia Hospital20014 San SebastiánSpain Department of Gastroenterology General Hospital Department of Gastroenterology Clinic HospitalCIBEREHDIDIBAPS08036 BarcelonaSpain Digestive Diseases and Nutrition Secion University of IllinoisChicagoIL 60607United States Department of Gastroenterology Del Mar Hospital08003 BarcelonaSpain Department of Gastroenterology General Hospital 03010 AlicanteSpain

AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 ***:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and ***Ⅱincluded 871 patients diagnosed in ***:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor *** surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 *** increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.

关键词： Colon cancer Prognosis Survival Chemotherapy Surgery

Co-occurrence of germline pathogenic variants for different hereditary cancer syndromes in patients with Lynch syndrome

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Cancer Communications 2021年第3期41卷 218-228页

作者： Rosario Ferrer-Avargues Maria Isabel Castillejo Estela Damaso Virginia Diez-Obrero Noemi Garrigos Tatiana Molina Alan Codoner-Alejos angel Segura Ana Beatriz Sanchez-Heras Adela Castillejo jose Luis Soto Foundation for the Promotion of Health and Biomedical Research of Valencia Region(FISABIO) FISABIO-Elche Health DepartmentElche 032303Spain Molecular Genetics Unit.Elche University Hospital Elche 032303Spain Department of Molecular Biopathology Immunological Center of AlicanteSan Juan-Alicante 03550Spain Medical Oncology Department Cancer Genetic Counseling Unit.La Fe University HospitalValencia 46026Spain Medical Oncology Department Cancer Genetic Counseling Unit.Elche University HospitalElche 03203Spain

Background:Lynch syndrome(LS)is a hereditary condition characterized by a high risk of colorectal cancer,endometrial cancer,and other neoplasia associated with germline alterations in DNA mismatch repair *** classical genetic diagnostic strategy for LS consists of the Sanger sequencing of genes associated with the suspected ***-generation sequencing(NGS)enables the simultaneous sequencing of a large number of hereditary cancer ***,we aimed to study whether other germline pathogenic variants of hereditary cancer genes are present in patients with ***:A cohort of 84 probands with a previous genetic diagnosis of LS by Sanger sequencing was reanalyzed using NGS via a commercial panel of 94 hereditary cancer genes by hybrid *** American College of Medical Genetics and Genomics criteria were used to classify the clinical significance of the *** findings of NGS were confirmed by Sanger *** possible,genetic analyses of the new findings in the proband’s relativeswere also performed by Sanger ***:We identified five families(6%),out of 84,with at least two germline pathogenic variants conferring to high or moderate risk in different dominant cancer-predisposing genes:[MLH1-BRCA2-NBN],[MLH1-BRCA1],[MSH2-ATM],[MSH6-NF1],and[MLH1-FANCA].Interestingly,only one out of these five families exhibited a clinical phenotype associated with the new pathogenic *** family with three pathogenic variants of the[MLH1-BRCA2-NBN]genes showed a high aggregation of tumors associated with LS and breast and ovarian cancer ***:Our results showed that the co-occurrence of more than one pathogenic variant in cancer-predisposing genes was remarkable among cases of *** cases,no clinicial manifestations were associated with the secondary pathogenic *** studies are needed to confirm these findings and elucidate their clinical *** of LS families should be considered only in fa

关键词： cancer panel hereditary cancer lynch syndrome moderate penetrance genes multilocus inherited neoplasia alleles syndrome next-generation sequencing secondary findings