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What Isat Stake in Comparing the Literatures?

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Journal of Foreign Languages and Cultures 2023年第1期7卷 53-64页

作者： jose Luis Jobim Fluminense Federal University

This paper will present and discuss a few questions raised in David Damrosch's Comparing the Literatures:Literary Studies in a Global Age,a book that,divided into chapters based on some selected keywords,develops rele... 详细信息

关键词： comparative literature translation world literature trasnational literary experience linguistic imperialism

Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

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Chinese Journal of Integrative Medicine 2018年第12期24卷 912-919页

作者： Rosa Martha Perez Gutierrez jose Maria Mota Flores Natural Products Research Laboratory Higher School of Chemical Engineering and Extractive IndustriesInstituto Politecnico Nacional (IPN) Professional Unit Adolfo Lopez Mateos Av. Instituto Politécnico NacionalS/N

Objective： To examine the effect of metanol extract of Petiveria alliacea （PM） on airway inflammation in a murine model of chronic asthma. Methods： Two-month-old male BALB/c mice （n=6-8/group） were sensitized on days 0 and 14 by intraperitoneal injection of 20μg ovalbumin （OVA）. On day 25, the mice received an airway challenge with OVA （3%, w/v, in phosphate buffered saline）. PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline （PBS） to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4 （IL-4）, IL-5, IL-13, tumor necrosis factor-alpha （TNF-α） and reactive oxygen species （ROS） in the bronchoalveolar lavage fluid （BALF） were determined and the levels of serum IgE, intercellular cell adhesion molecule 1 （ICAM-1） and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1 （TGF-β1）. Histologic examination was performed to observe inflammatory cellular infiltration. Results： The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophUs and other inflammatory cells （P〈0.01）. Airway resistance （RI） in the OVA-only induced group was significantly higher than that of the PBS control group （P〈0.01） when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-β in the BALF decreased compared to control mice （P〈0.01 or P〈0.05）. PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF （P〈0.01）, which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion： Administration of PM could inhibit airway inflammation, regulate cyt

关键词： Petiveria alliacea allergy antiinflammation asthma

Expression of juvenile hormone acid O-methyltransferase and juvenile hormone synthesis in Blattella germanica

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Insect Science 2018年第5期25卷 787-796页

作者： Claudia V. Dominguez jose L. Maestro Institute of Evolutionary Biology CSIC-Universitat Pompeu Fabra Barcelona Spain

Juvenile hormone （JH）, a sesquiterpenoid synthetized by the insect corpora allata （CA）, plays critical roles in metamorphosis and reproduction. Penultimate or last step of JH synthesis is catalyzed by juvenile hormone acid O-methyltransferase （JHAMT）. Here we report the cloning and expression analysis of the JHAMT orthologue in the cockroach, Blattella germanica （L.）（BgJHAMT）. BgJHAMT is mainly expressed in CA, with only expression traces in ovary. Three different isoforms, differing in the 3＇-UTR sequence, were identified. Isoform A shows between 35 and 65 times higher expression than B and C in CA from penultimate nymphal instar and adult females. RNAi-triggered knock down of BgJHAMT produces a dramatic reduction of JH synthesis, concomitant with a decrease of fat body viteUogenin expression and basal follicle length. BgJHAMT mRNA levels in CA of females along the gonadotrophic cycle parallel, with a slight advancement, JH synthesis profile. BgJHAMT mRNA levels were reduced in starved females and in females in which we reduced nutritional signaling by knocking down insulin receptor and target of rapamycin （TOR）. Results show that conditions that modify JH synthesis in adult B. germanica females show parallel changes of BgJHAMT mRNA levels and that the JH-specifie branch of the JH synthesis pathway is regulated in the same way as the mevalonate branch. Furthermore, we demonstrate that nutrition and its signaling through the insulin receptor and TOR pathways are essential for activating BgJHAMT expression, which suggests that this enzyme can be a checkpoint for the regulation of JH production in relation to nutritional status.

关键词： Blattella germanica corpora allata JHAMT juvenile hormone nutritionalsignaling

An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea(L.)*** Correa

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 543-552页

作者： Anuthara R Sebastian jose Midhun Jyothis Mathew Microbiology Research Lab School of BiosciencesMahatma Gandhi UniversityKottayamKeralaIndia

Objective:To isolate,purify,and characterize gossypol from the fruits of Thespesia populnea(L)*** Correa,test its antidermatophytic activity,identify its targets on the dermatophyte,and confirm the binding of gossypol with the fungal target by molecular docking ***:Gossypol from Thespesia populnea was characterized by high performance liquid chromatography,liquid chromatographmass spectrometry,Fourier transform infrared spectroscopy,and nuclear magnetic *** anti-dermatophytic activity of gossypol was tested against four different dermatophytes,*** mentagrophytes,Trichophyton rubrum,Microsporum canis,and Microsporum *** mentagrophytes was selected for further *** inhibitory mode of action of gossypol on Trichophyton mentagrophytes was determined by analyzing the modulation of gene expression in various pathways of the ***:Gossypol inhibited all the *** minimum inhibitory concentrations were 12.5μg/mL for Trichophyton mentagrophytes and Microsporum canis and 25μg/mL for Trichophyton rubrum and Microsporum *** minimum fungicidal concentrations were 50μg/mL for Trichophyton mentagrophytes,100μg/mL for Microsporum canis and Trichophyton rubrum,and 200μg/mL for Microsporum *** inhibited the mRNA expression of metalloprotease(MEP4)and isocitrate lyase(ICL).The binding of gossypol with the enzymes was confirmed by molecular docking *** best docking poses were found and the low binding energies were recorded with the two target ***:Gossypol is a potential antifungal agent and can be further explored as an anti-dermatophytic drug.

关键词： Thespesia populnea Gossypol Anti-dermatophytic activity Trichophyton mentagrophytes Mechanism of action Gene expression Molecular docking Metalloprotease MEP4 Isocitrate lyase ICL

Acute upper limb compartment syndrome in children: special focus on nerve recovery

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World Journal of Pediatric Surgery 2020年第3期3卷 11-22页

作者： Terrence jose Jerome Orthopedics Hand and Reconstructive MicrosurgeryOlympia Hospital&Research CentreTiruchirappalliIndia

Background Many studies have discussed acute compartment syndrome in children associated with or without fractures and have given their visible *** is known about the nerve involvement and the factors associated with recovery patterns in these *** intend to propose that ischemic nerve and muscles tend to regenerate after surgical decompression but in a different pattern and the given *** Twenty-four children with acute compartment syndrome in the upper limb were analyzed between 2009 and *** included demographic features of these patients,the time interval between the injury and surgery,and the attempt to correlate with motor and sensory *** The average follow-up was 67.3 months(range 59-80).Of the 24,14 patients(58%)had immediate recovery of motor and sensory *** remaining 10 patients had variable recovery patterns with a mean time for the radial nerve,median nerve and ulnar nerve motor recovery of 6.0,7.5 and 8.5 months,respectively,and sensory recovery at 12,12 and 13 months,*** overall study had a mean sensory recovery as per the Medical Research Council(MRC)of S3 in 3(12%)and S4 in 21(88%).The mean 2-point discrimination(2PD)was 6.9 mm(range 5-10).Twenty-one patients(88%)had a full range of movements at their final follow-up with a mean Visual Analog Scale score of 0.6;a quick Disabilities of the Arm,Shoulder and Hand score of 5.9(range 2.3-25.0)and a Mayo wrist score of *** There was a definite motor and sensory recovery in patients who underwent surgical decompression in acute compartment syndrome of the upper limb irrespective of age,gender,delay in presentation and various *** motor and nerve fibers can regenerate after ischemic sequela of compartment syndrome.

关键词： involvement children fibers

Morphodynamics of sandy beaches under the influence of storm sequences:Current research status and future needs

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Water Science and Engineering 2019年第3期12卷 221-234页

作者： Sonja Eichentopf Harshinie Karunarathna jose M.Alsina Department of Civil and Environmental Engineering Imperial College London South Kensington Campus London SW7 2AZ UK College of Engineering Swansea University Bay Campus Swansea SA1 8EN UK Laboratori d'Enginyeria Marítima Universitat Politecnica de Catalunya Barcelona 08034 Spain

This paper reviews and discusses the current research status, trends, and future needs in the field of beach morphodynamics under the influence of storm *** paper reviews how the three main research methods, field investigations, numerical modelling, and physical modelling, have been used to study beach morphodynamics during storm *** quantitative definitions of storm sequences at different sites are presented and *** is shown that the definition of storm sequences is site-specific and requires knowledge of the storm climate, beach characteristics, and the temporal scale of beach ***, the paper brings together currently available approaches aimed at describing the effect of storm sequences on beach erosion in a general *** importance of storm chronology and the effects of an extreme storm within a sequence of storms are *** that, the more poorly studied aspect of beach recovery in between storms within a sequence is *** indicators for defining beach recovery, namely the shoreline location, sediment volumes, and the beach state, are identified and ***, important research needs, including the need for detailed physical modelling, are identified.

关键词： Storm sequences Beach morphodynamics Beach erosion Extreme storms Return period Beach recovery

Are ATXN2 variants modifying our understanding about neural pathogenesis,phenotypes,and diagnostic?

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Neural Regeneration Research 2022年第11期17卷 2445-2447页

作者： jose Miguel Laffita-Mesa Martin Paucar Per Svenningsson Department of Clinical Neuroscience(CNS) Karolinska Universitetssjukhuset

ATXN2 one gene with multiple phenotype effects:ATXN2 gene encodes a cytosolic protein(ataxin-2)with pleiotropic functions(see below).This gene contains a number of exonic Cytosine-Adenine-Guanine(CAG)-repeats which encodes a polyglutamine tract(polyQ)in the N-terminal intrinsically disordered region(IDR)of the ***2CAG repeats are interrupted by CAA codons which is relevant only for DNA and RNA but not for protein since CAA also encodes glutamine(Q).

关键词： pathogenesis neural interrupted

Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio jose Goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,English Series 2017年第11期33卷 1477-1503页

作者： Veronica HERNANDEZ Domingo PESTANA jose M. RODRIGUEZ Universidad CarlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to Erdos, Pach, Pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs