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In vitro intracellular IFnγ, IL-17 and IL-10 producing T cells correlates with the occurrence of post-transplant opportunistic infection in liver and kidney recipients

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World Journal of Transplantation 2018年第1期8卷 23-37页

作者： Francisco Boix Santiago Llorente Jorge Eguía Gema Gonzalez-Martinez Rafael Alfaro jose a galián jose A Campillo María Rosa Moya-Quiles Alfredo Minguela jose A Pons Manuel Muro Department of Immunology Clinical University Hospital Virgen de la Arrixaca-IMIBClinical University Hospital‘Virgen Arrixaca’ Department of nephrology Clinical University Hospital‘Virgen de la Arrixaca-IMIB’Clinical University Hospital‘Virgen Arrixaca’ Digestive Medicine Service Clinical University Hospital‘Virgen de la Arrixaca-IMIB’Clinical University Hospital‘Virgen Arrixaca’

AIM To validate intracellular cytokine production functional assay as means of cell-mediated immunity monitoring of post-transplant patients with opportunistic infection(OI).METHODS Intracellular cytokine-producing CD4^+ and CD8^+ T-cell monitoring was carried out in 30 liver transplant(LTr) and 31 kidney transplant(KTr) recipients from 2010 to 2012. Patients were assessed in our Department of Immunology at the Clinical University ‘Hospital Virgen de la Arrixaca-IMIB' in Murcia, Spain for one year following transplantation. FACS Canto Ⅱ flow cytometer was employed to quantify the intracellular production of IL-17, IFnγ and IL-10 cytokines on stimulated CD4^+CD69^+ and CD8^+CD69^+ T cells and BD FACS DIVA v.6 software was used to analysed the data. Statistical analysis was carried out using SPSS *** LTr with OI had significantly lower % of CD8^+CD69^+IFnγ^+T cells at 60(7.95 ± 0.77 vs 26.25 ± 2.09, P nd 180(15.31 ± 3.24 vs 24.59 ± 3.28, P = 0.01) d posttransplantation. Higher % of CD4^+CD69^+IL-10^+ as well as CD4^+CD69^+IL-17^+ T cells were yet reported at 30(14.06 ± 1.65 vs 6.09 ± 0.53, P = 0.0007 and 4.23 ± 0.56 vs 0.81 ± 0.14, P = 0.005; respectively), 60(11.46 ± 1.42 vs 4.54 ± 0.91, P = 0.001 and 4.21 ± 0.59 vs 1.43 ± 0.42, P = 0.03; respectively) and 90 d(16.85 ± 1.60 vs 4.07 ± 0.63, P nd 3.97 ± 0.43 vs 0.96 ± 0.17, P = 0.001). Yet, KTr with OI had significantly lower percentage of CD4^+CD69^+IFnγ^+ at 30(11.80 ± 1.59 vs 20.64 ± 3.26, P = 0.035), 60(11.19 ± 1.35 vs 15.85 ± 1.58, P = 0.02), 90(11.37 ± 1.42 vs 22.99 ± 4.12, P = 0.028) and 180(13.63 ± 2.21 vs 21.93 ± 3.88, P = 0.008) d post-transplantation as opposed to CD4^+CD69^+IL-10^+ and CD8^+CD69^+IL-10^+ T cells which percentages were higher at 30(25.21 ± 2.74 vs 8.54 ± 1.64, P nd 22.37 ± 1.35 vs 17.18 ± 3.54, P = 0.032; respectively), 90(16.85 ± 1.60 vs 4.07 ± 0.63, P nd 23.06 ± 2.89 vs 10.19 ± 1.98, P = 0.002) and 18

关键词： Intracellular cytokine Liver transplantation Kidney transplantation Opportunistic infection

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium nucleus of neuroepigenetics and Plasticity(Epineuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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Perceptions and emotions in postoperative recovery of patients with perianal diseases

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World Journal of Psychiatry 2025年第1期15卷 179-184页

作者： Bryan Adrian Priego-Parra jose Maria Remes-Troche Digestive Physiology and Gastrointestinal Motility Lab Instituto de Investigaciones Médico-BiológicasUniversidad VeracruzanaVeracruz 91700Mexico

This article examines the complex relationship between disease perception,negative emotions,and their impact on postoperative recovery in patients with perianal *** conditions not only cause physical discomfort,but also carry a significant emotional burden,often exacerbated by social ***-logical factors,including stress,anxiety,and depression,activate neuroendocrine pathways,such as the hypothalamic–pituitary–adrenal axis,disrupting the gut microbiota and leading to *** disruption can delay wound healing,prolong hospital stay,and intensify *** on the findings of Hou et al,our article highlights the critical role of illness perception and negative emotions in shaping recovery *** advocates for a holistic approach that integrates psychological support and gut microbiota modulation,to enhance healing and improve overall patient outcomes.

关键词： Perianal disease Illness perception Gut microbiota Post-surgical outcomes Microbiota

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： jose Enrique MARTÍn-ALFOnSO María jose MARTÍn-ALFOnSO Concepción VALEnCIA María Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remarkable lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

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Visual grading criteria for Japanese larch ( Larix kaempferi ) structural timber from Spain

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Journal of Forestry Research 2020年第6期31卷 2605-2614页

作者： Mari-jose Barriola José-Ramón Aira Edgar Lafuente Tknika LHri Aplikatutako Ikerketa eta Berrikuntzako EAEko zentroaZamalbide Auzoa z/g20100 ErrenteriaGipuzkoaSpain Escuela de Ingeniería de la Industria Forestal Agronómica y de la BioenergíaUniversidad de ValladolidUVa-Campus Duques de Sorias/n42005 SoriaSpain Cesefor Centro de Servicios y Promoción Forestal y de su Industria de Castilla y LeónCalle C42005 SoriaSpain

Larch wood is structurally classifi ed in many countries as one of conifers with the highest load-bearing capacity(strength class of C30).The Spanish visual classifi cation regulation only assigns a strength class to 4 pine woods:Laricio pine(Pinus nigra ***),Silvestre pine(Pinus sylvestris L.),Radiata pine(Pinus radiata ***),and Pinaster pine(Pinus pinaster Ait.).This work adds to the number of structurally characterised species by creating a visual classifi cation table for Japanese larch wood(Larix kaempferi(Lamb.)Carr.)which diff erentiates between 2 visual classes,MEG-1 and *** strength values were calculated for each class(fk,MEG-1=31.80 MPa,f k,MEG-2=24.55 MPa),mean module of elasticity(E 0,mean,MEG-1=13,082 MPA,E 0,mean,MEG-2=12,320 MPA)and density(ρk,MEG-1=456.6 kg m−3,ρk,MEG-2=469.1 kg m−3),before fi nally assigning a strength class of C30 to visual class MEG-1,and a strength class of C24 to visual class MEG-2.

关键词： Japanese larch wood Visual grading Strength class Mechanical properties Density

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Effects of small-scale disturbances and elevation on the morphology,phenology and reproduction of a successful geophyte

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Journal of Plant Ecology 2009年第1期2卷 13-20页

作者： Daniel Gomez-Garcıa jose´Azorın AJavier Aguirre Instituto Pirenaico de Ecologı´a-CSIC Apartado.64E-22700 JacaHuescaSpain A´rea de Ingenierı´a Agroforestal.EPSH Universidad de Zaragoza.Ctra Cuarte s/n.E-22071 HuescaSpain

Aims We aimed to find out how a geophyte,Merendera montana,occupies a wide ecological,elevational and climatic *** occurrence in that environmental array is outstanding not only among geophytes but also in the whole flora of the Iberian Peninsula,where only a very few plants show such an apparent ***,we compared morphological and reproductive traits,and frequency of different types of reproduction in disturbed and undisturbed ***,we have analyzed the phenology of this plant by trying to understand how it manages to spread in an exceptional elevational gradient of 2000 m,with contrasting climatic regimes between the mediterranean and the alpine *** We measured the plant density of *** populations in different types of Pyrenean grasslands either with or without small-scale disturbances at seven sites from the basal to the alpine belt(400–2300 m a.s.l.).In each one of these populations,100 individuals—1200 in total—were uprooted to measure their morphological features as well as type and occurrence of ***(flowering and fruiting dates and leaf lifespan)was estimated using 5 years of records in the studied areas and>200 herbarium sheets from the whole altitudinal rank and collected in the last 30 *** in plant densities were analyzed with non-parametric Mann–Whitney U-test;differences in morphological traits,fruit and seed production associated with disturbance,with one-way analysis of covariance test(general linear model).Finally,linear regression analyses were used to determine the relationships between clonal reproduction and elevation and those between flowering,fruiting and senescence and date and *** Findings In all cases,plant density in disturbed grasslands was significantly higher than in undisturbed *** height and weight,bulb depth,leaf width and bulb and root weight were higher in disturbed *** and undisturbed plots were similar

关键词： Spanish Pyrenees Merendera montana functional traits disturbed grasslands

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Brent *** Texas Intermediate in the US petro derivatives price formation

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Petroleum Science 2024年第1期21卷 729-739页

作者： Alejandro Almeida Antonio A.Golpe Juan Manuel Martín-Alvarez jose Carlos Vides Universidad Internacional de La Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over *** the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the refined ***,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate ***,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined *** results possess important considerations to policymakers and the market participants and the price formation.

关键词： Crude oil prices Spatial panel model Refined products Price formation

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Spatial variability of soil organic carbon stock in an olive orchard at catchment scale in Southern Spain

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International Soil and Water Conservation Research 2023年第2期11卷 311-326页

作者： jose A.Gòmez Gema Guzmán Tom Vanwalleghem Karl Vanderlinden Institute for Sustainable Agriculture.Spanish national Research Council(IAS-CSIC) Alameda del Obispo S/N14004CordobaSpain Department of Agronomy University of CordobaCampus de Rabanales14071CordobaSpain Centro IFAPA Alameda del Obispo 14004CordobaSpain

Orchards have a high potential for carbon ***,little research is available on the spatial variability at catchment scale and on the difference between the tree area and the *** analyzed theik spatial variability of soil organic carbon stock,SOCstock at 90 cm depth in an 8-ha catchment in Southern Spain with olives on a vertic *** showed higher soil organic carbon concentration,SOC,in the tree area as compared to the lane up to 60 cm depth,but its impact on SOCstock was negligible since it was compensated by the higher soil bulk density in the *** at different depths was correlated with that in the top 0-5 *** overall SOCstock of the orchard was 4.14 kg m^(-2),ranging between 1.8 and 6.0 kg m^(-2).This SOCstock is in the mid-lower range of values reported for olive orchards,measured at smaller scale,and similar to those other intensive field crops and agroforestry under comparable rainfall *** spatial variability in SOCstock was correlated to several geomorphological variables:elevation,cumulative upstream area,topographic wetness index,sediment transport index,and tillage *** in SOC and SOCstock are driven by the sediment redis-tribution downslope,mainly by tillage erosion,and higher soil water availability in lower areas allowing higher biomass *** topographic indexes and the correlation between SOC in the topsoil and SOCstock up to 90 cm should be further explored in other typology of olive orchards for facilitating the mapping of SOC_(stock).

关键词： Carbon sequestration Mediterraneancrops Catchment Spatial variability Vertic soils

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An atomistic approach for the structural and electronic properties of twisted bilayer graphene-boron nitride heterostructures

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npj Computational Materials 2022年第1期8卷 687-696页

作者： Min Long Pierre A.Pantaleón Zhen Zhan Francisco Guinea joseÁngel Silva-Guillén Shengjun Yuan Key Laboratory of Artificial Micro-and nano-structures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan430072China Imdea nanoscience C/Faraday 928015MadridSpain Donostia International Physics Center Paseo Manuel de Lardizábal 420018San SebastiánSpain Ikerbasque Basque Foundation for Science48009BilbaoSpain Wuhan Institute of Quantum Technology Wuhan430206China

Twisted bilayer graphene(TBG)has taken the spotlight in the condensed matter community since the discovery of correlated *** this work,we study heterostructures of TBG and hexagonal boron nitride(hBn)using an atomistic tight-binding model together with semi-classical molecular dynamics to consider relaxation *** hBn substrate has significant effects on the band structure of TBG even in the case where TBG and hBn are not ***,the substrate induces a large mass gap and strong pseudo-magnetic fields that break the layer ***,such degeneracy can be recovered with a second hBn ***,we develop a continuum model that describes the tight-binding band *** results show that a real-space tight-binding model in combination with semi-classical molecular dynamics is a powerful tool to study the electronic properties of moiréheterostructures,and to explain experimental results in which the effect of the substrate plays an important role.

关键词： boron electronic twisted

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