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The tip of the iceberg:ROP2 directly interacts with SYP121 to regulate root-hair polarization,elongation,and exocytosis

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molecular Plant 2022年第7期15卷 1084-1086页

作者： martiniano m.Ricardi jose m.Estevez Instituto de Fisiología Biología Molecular y Neurociencias(IFIBYNE-UBA-CONICET)and Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaBuenos Aires C1428EHAArgentina Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiago 8370146Chile ANID-millennium Science Initiative Program-millennium Nucleus for the Development of Super Adaptable Plants(mN-SAP) Santiago 8370146Chile

Root hairs(RHs)grow in a polar manner as cylindrical protrusions from the root *** significantly expand the root volume in the rhizosphere to search for water and nutrients,anchor the plant,and promote interactions with several kinds of microorganisms in the ***,the epidermis cell type responsible for RH development,switch from anisotropic cell elongation to tip growth through polarization of the growth machinery to a predefined RH initiation domain(RHID)at the plasma membrane.

关键词： tip polarization cylindrical

Entropy model to assess sediment resuspension probability and trap efficiency of small dams

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International Journal of Sediment Research 2022年第5期37卷 675-686页

作者： Francisco Jairo Soares Pereira Antonio Viana da Silva Filho josé Wellington Batista Lopes josé Carlos de Araújo Department of Agricultural Engineering Federal University of Ceará Campus Do Pici Rural Federal University of Pernambuco Federal University of Piauí

In the Brazilian drylands, there are tens of thousands of small dams. Despite their paramount importance to the rural population, they are rarely monitored. Water demand increases with time while, simultaneously, siltation reduces reservoir water capacity and availability. Reservoir siltation models are, therefore, mandatory to manage the numerous ungauged small dams in these *** objective of the current study is to improve sediment trap efficiency(TE) modeling by including resuspension as a key probabilistic process. The Shannon entropy was used to estimate the sediment resuspension probability, which was merged with the Camp model and generated the RETSED entropy model. To validate the RETSED model, an experimental check dam(ECD, 300 m3), located in the Gilbu es desertification site, Brazil, was monitored hourly during one hydrological year(July 2018-July 2019). measurements show that the annual volumetric decline of the check dam was 12%; and that the average trap efficiency equaled 86%. Only 9.5% of the hourly sediment concentration outflow exceeded the average plus one standard deviation, showing that the reservoir is well mixed; a fact which highlights the relevance of the resuspension process. Three empirical models failed to mimic the experimental results: Churchill(TE = 99%), Brune(TE = 75%), and maryland(TE = 94%). According to the RETSED entropy model, the resuspension probability during the experiment was 10%and TE = 81%, a value only 6% below the measured one. The Camp model simulated TE = 89%, only 3%higher than the measured value, but confirmed the Camp model’s tendency to overestimate TE due to a disregard of resuspension. The deterministic model showed low sensitivity concerning the hydrodynamic effects, whereas the entropy formulation proved to be more consistent with physical behavior: the resuspension probability clearly increased and trap efficiency decreased with rising reservoir discharge.

关键词： Erosion Check dam Sedimentation Ungauged basins Camp model

Induced and heavy aggregation operators with distance measures

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Journal of Systems Engineering and Electronics 2010年第3期21卷 431-439页

作者： josé m.merigó montserrat Casanovas Department of Business Administration University of Barcelona

This paper introduces a new aggregation model by using induced and heavy aggregation operators in distances measures such as the Hamming *** is called the induced heavy ordered weighted averaging（OWA） distance（IHOWAD） *** paper studies some of its main properties and a wide range of particular cases such as the induced heavy OWA（IHOWA） operator,the induced OWA distance（IOWAD） operator and the heavy OWA distance（HOWAD） *** approach is generalized by using generalized and quasi-arithmetic means obtaining the induced generalized IHOWAD（IGHOWAD） operator and the Quasi-IHOWAD *** application of the new approach in a decision making problem regarding the selection of strategies is developed.

关键词： distance measures aggregation operators decision making OWA operator.

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A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3221-3224页

作者： josémanuel García-Heredia marco Pérez Eva m.Verdugo-Sivianes maría m.martínez-Ballesteros Sara m.Ortega-Campos Amancio Carnero Instituto de Biomedicina de Sevilla(IBIS)/HUVR/Universidad de Sevilla/CSIC SevillaSpain Departamento de Bioquímica Vegetal y Biología molecular Universidad de SevillaSevillaSpain CIBERONC IS Carlos IIIMadridSpain Departamento de Anatomía Patológica HUVRSevillaSpain Departamento de Lenguajes y Sistemas Informáticos Escuela Superior de Ingeniería InformáticaUniversidad de SevillaSevillaSpain

Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20%of *** treatment for sarcomas is surgical resection,and only some patients are treated with ch... 详细信息

关键词： neoplasms chemotherapy treatment

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel manuel méndez-Bailón joséPérez-Silvestre josémaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-Franco Alicia Conde-martel Sara Carrascosa-García marta Sánchez-marteles josémanuel Cerqueiro-González Noel Lorenzo-Villalba manuel montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

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Two titans fin ally meet each other under nitrogen deficiencies:FERONIA-TORC1 activation promotes plant growth

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molecular Plant 2022年第7期15卷 1095-1097页

作者： Javier martinez Pacheco jose m.Estevez Fundación Instituto Leloir and IIBBA-CONICET.Av.Patricias Argentinas 435 Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID-millennium Science Initiative Program-millennium Nucleus for the Development of Super Adaptable Plants(mN-SAP) SantiagoChile

Plant growth is determined by well-defined developmental processes that integrate cell-intrinsic factors and external environmental cues,and it is largely dependent on the assimilation of macro-and micro-nutrients from the *** the macro-nutrients,the inorganic nitrogen(e.g.,nitrate and ammonium)and amino acids are essential for plant survival and *** acting as macro-nutrients and structural components of macro-molecules,these nitrogen-containing molecules could also act as signaling molecules to orchestrate diverse genetic programs(Wang et al.,2018).

关键词： activation inorganic nitrate

mEAT AND mEAT PRODUCTS

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Journal of Integrative Agriculture 2013年第11期12卷 1916-1918页

作者： josé m Lorenzo Centro Tecnológico de la Carne de Galicia

In recent years, meat quality has assumed a greater consumer significance and public attention. There is growing awareness of the link between diet and health and this is reflected in the demand for more information a... 详细信息

关键词： mEAT AND mEAT PRODUCTS

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Alterations in blink and masseter reflex latencies in older adults with neurocognitive disorder and/or diabetes mellitus

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World Journal of Clinical Cases 2022年第1期10卷 177-188页

作者： Jaime Alberto Bricio-Barrios Eder Ríos-Bracamontes mónica Ríos-Silva miguel Huerta Walter Serrano-moreno joséEnrique Barrios-Navarro Genaro Gabriel Ortiz miguel Huerta-Trujillo joséGuzmán-Esquivel Xóchitl Trujillo Faculty of medicine University of ColimaColima 28040ColimaMexico General Hospital Zone#1 Mexican Social Security InstituteVilla de Alvarez 28983ColimaMexico University Biomedical Research Center University of ColimaColima 28045ColimaMexico University Biomedical Research Center CONACYTColima 28045ColimaMexico Department of Philosophical and methodological Disciplines University Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico

BACKGROUND Blink and masseter reflexes provide reliable,quantifiable data on the function of the central nervous system:Delayed latencies have been found in patients with neurocognitive disorder(ND)and type 2 diabetes mellitus(T2Dm),but this has not been studied in patients with both *** To investigate if older adults with ND plus T2Dm have prolonged latencies of blink and masseter-reflex and if they were associated with disease *** This cross-sectional study included 227 older adults(>60 years)from Colima,*** disorder was identified by a neuropsychological battery test,and T2Dm identified by medical history,fasting glucose,and glycosylated *** in the early reflex(R1),ipsilateral late(R2),and contralateral late(R2c)components of the blink reflex were analyzed for all subjects,and 183 subjects were analyzed for latency of the masseter *** In 20.7%of participants,ND was *** 37%,T2Dm was *** in R1,R2,and R2c were significantly prolonged for groups with ND plus T2Dm,ND,and T2Dm,compared with the control group(Pmasseter reflex was only prolonged in older adults(regardless of T2Dm status)with ND vs controls(P=0.030).In older adults with ND and without T2Dm,the more the cognitive impairment progressed,the more prolonged latencies in R2 and R2c presented(Pmasseter reflexes could be used to evaluate possible changes in brainstem circuits in older adults with ND and T2Dm.

关键词： Blink reflex masseter reflex Brainstem reflexes Neurocognitive disorder Type 2 diabetes mellitus Older adults

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 46-69页

作者： Sarah Lépine maria josé Castellanos-montiel Thomas martin Durcan The Neuro’s Early Drug Discovery Unit(EDDU) Department of Neurology and NeurosurgeryMontreal Neurological Institute-HospitalMcGill University3801 University StreetMontrealQC H3A 2B4Canada Faculty of medicine and Health Sciences McGill University3605 De La MontagneMontrealQC H3G 2M1Canada

Amyotrophic lateral sclerosis(ALS)is a disease characterized by upper and lower motor neuron(mN)loss with a signature feature of cytoplasmic aggregates containing TDP-43,which are detected in nearly all *** in the gene that encodes TDP-43(TARBDP)are known to result in both familial and sporadic *** ALS,disruption of neuro-muscular junctions(NmJs)constitutes a critical event in disease pathogenesis,leading to denervation atrophy,motor impairments and *** defects and impaired synaptic transmission at NmJs have been reported in several TDP-43 animal models and in vitro,linking TDP-43 dysregulation to the loss of NmJ integrity in *** the lens of the dying-back and dying-forward hypotheses of ALS,this review discusses the roles of TDP-43 related to synaptic function,with a focus on the potential molecular mechanisms occurring within mNs,skeletal muscles and glial cells that may contribute to NmJ disruption in ALS.

关键词： Amyotrophic lateral sclerosis Denervation Neuromuscular junction TDP-43 Dying-back Dying-forward