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An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros lima Wu Hong Kwong Antonio josé Goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

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COMBINING SINGULAR SPECTRUM ANALYSIS AND PAR(p) STRUCTURES TO MODEL WIND SPEED TIME SERIES

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Journal of Systems Science & Complexity 2014年第1期27卷 29-46页

作者： MENEZES Moises lima de SOUZA Reinaldo Castro PESSANHA jos Francisco Moreira Department of Statistics Fluminense Federal University ( UFI~ Brazil. Email: moisesAima@msn.com.SOUZA Reinaldo Castro Electrical Engineering Department: Pontifical Catholic University of Rio de Janeiro (PUC-Rio) Brazil. Institute of Mathematics and Statistics State University of Rio de Janeiro (UERJ) Brazil.

Singular spectrum analysis （SSA） is a technique that decomposes a time series into a set of components, such as, trend, harmonics, and residuals. Leaving out the residual components and adding up the others, the time series can be smoothed. This procedure has been used to model Brazilian electricity consumption and flow series. The PAR（p）, periodic autoregressive models, has been broadly used in modelling energy series in Brazil. This paper presents an approach of this decomposition method, by fitting the PAR（p）, considering its multivariate version known as multivariate SSA （MSSA）. The method was applied to a vector of two wind speed series recorded at two locations in the Brazilian Northeast region. The obtained results, when compared to the univariate decomposition of each series, were far superior, showing that the spatial correlation between the two series were considered by MSSA decomposition stage.

关键词： MSSA periodic autoregressive model SSA wind speed series.

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Diabetes and obesity:A debate on bariatric interventions and its implications

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World Journal of Diabetes 2024年第11期15卷 2157-2161页

作者： joséC Tatmatsu-Rocha Marcos R lima da Silva College of Medicine Postgraduate Program in Physiotherapy and FunctionalityDepartment of PhysiotherapyFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil

In this editorial,we comment on an article by Tang et al published in the World Journal of *** and diabetes are two pathological situations that are intrinsically *** lifestyle changes nor pharmacological treatments have achieved diabetes *** this perspective,bariatric surgery has been widely used as an approach for weight loss in obese patients and as a strategy to promote metabolic *** main effects of bariatric surgery involve direct action in improving cardiovascular function and endothelial function and reducing insulin resistance,leading to diabetes remission in the short term following *** this context,it has been observed that hormones from the gastrointestinal tract and endothelium play a prominent role in this *** reversing endothelial dysfunction,it is possible to balance pro-inflammatory cytokine production,improving the availability of nitric oxide and inhibiting vascular oxidative ***,it can be considered an efficient anti-inflammatory strategy,alleviating interferon-gamma-mediated adipose tissue *** current challenge must be to unravel the pathophysiological mechanisms and potential targets for treating metabolic diseases.

关键词： Bariatric surgery Diabetes mellitus Oxidative stress Endothelial dysfunction Obesity

Personalized medicine in gastric cancer:Where are we andwhere are we going?

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World Journal of Gastroenterology 2016年第3期22卷 1160-1171页

作者： Alexandre A Jácome Anelisa K Coutinho Enaldo M lima Aline C Andrade joséSebastião dos Santos Department of Medical Oncology Hospital Mater DeiBelo Horizonte 30190-131Minas GeraisBrazil Department of Gastrointestinal Oncology Brazilian Gastrointestinal Tumor GroupClinica AMOSalvador 41950-640BahiaBrazil Department of Surgery and Anatomy University of São Paulo at Ribeirão PretoSchool of MedicineRibeirão Preto14049-900São PauloBrazil

Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer.

关键词： stomach neoplasms biological markers Molecular targeted therapy Individualized medicine Transcriptome

Unpaved rural roads as source areas of sediment in a watershed of the Brazilian semi-arid region

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International Journal of Sediment Research 2019年第5期34卷 475-485页

作者： Teresa Raquel lima Farias Pedro Henrique Augusto Medeiros Joaquín Navarro-Hevia josé Carlos de Araújo Federal Institute of Education Science and Technology of Ceará University of Valladolid Campus La Yutera Federal University of Ceará Department of Agricultural Engineering Campus do Pici

Approximately 80% of the road network in Brazil is unpaved and shows evidences of a high erosion potential. In the semi-arid Caatinga Biome in the northeast of the country, a monitoring programme has been done for two years in order to analyze runoff and sediment production from unpaved rural roadways and from embankments. Sediment production ranged from 0.30 to 0.92 Mg/ha yr, higher than in undisturbed areas, but generally lower than that reported for unpaved roads in other regions. However,this is a semi-arid area with low rainfall and runoff and, hence, with a limited hydrological connectivity and sediment production. Sediment production on an embankment with no vegetation was around ten times higher than on an embankment with vegetation. On the road surface, annual sediment production(normalized for gradient) in a section with traffic was three times higher than for a road surface without traffic. In addition, events that occurred after roadway maintenance activities generated peaks of sediment concentration of over 5000 mg/L. These results suggest that sediment production from roads and embankments with bare surfaces is at least one order of magnitude higher than in undisturbed catchment areas. Maintenance activity and vehicle traffic contribute to an increase in sediment availability and impact on the sediment concentration, but less intensely on sediment loads, which depend on the runoff magnitude of the events occurring after roadway maintenance. It was also found that the natural vegetation of the semi-arid region potentially captures sediment on roadway embankments; thereby playing an important role in breaking connectivity between the sediment flow from unpaved roads and the natural drainage system of the catchment.

关键词： Sediment production Caatinga vegetation Road maintenance Embankment

Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration

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World Journal of Gastroenterology 2007年第22期13卷 3112-3116页

作者： josé Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo josé Luiz Pimenta Módena Echoendoscopy and Pathology Units from 9 de Julho Hospital and Ribeiro Preto Medical School-USP So Paulo Brazil

AIM： To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration （EUS-FNA） for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions.METHODS： From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUSFNA. The final diagnosis was obtained either by surgery （356 cases） or after a mean clinical follow-up of 11.8 mo in the remaining patients.RESULTS： There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 （97.4%） cases. There were 352 （57.6%） malignancies and 259 （42.4%） benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67% of the lesions. Overall, the sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4%, 99.2%, 99.3%, 77.2% and 87.2%. Specifically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8% ys 82.4%, 100% ys 98.4%, 100% vs 99%, 54.8% vs 74.1% and 83.1% vs 87.8%. For cystic lesions, the values were, respectively, 72.2%, 99.3%, 97.5%, 91% and 92.2%.CONCLUsioN： EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions can reveal the best negative predictive value and diagnostic accuracy, both higher than 90%.

关键词： Diagnosis Endoscopic ultrasound Fineneedle-aspiration biopsy Pancreas cancer Pancreatic disease Sampling

Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice

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World Journal of Hepatology 2015年第24期7卷 2551-2558页

作者： Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo josé Aires Pereira josé Pedrazzoli Marcelo lima Ribeiro Alessandra Gambero Clinical Pharmacology and Gastroenterology Unit Sao Francisco University Medical School

AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3

关键词： Pentoxifylline Steatosis Obesity Adipose tissue Adipokine Tumor necrosis factor-α

Failure Evaluation of Reinforced Concrete Beams Using Damage Mechanics and Classical Laminate Theory

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Journal of Architectural Environment & Structural Engineering Research 2022年第4期5卷 1-9页

作者： joséMário Feitosa lima Geraldo joséBelmonte dos Santos Paulo Roberto Lopes lima State University of Feira de Santana Technology DepartmentFeira de SantanaBahia44030-900Brazil

The prediction of the behavior of reinforced concrete beams under bending is essential for the perfect design of these ***,the classical models do not incorporate the physical nonlinear behavior of concrete under tension and compression,which can underestimate the deformations in the structural element under short and long-term *** the present work,a variational formulation based on the Finite Element Method is presented to predict the flexural behavior of reinforced concrete *** physical nonlinearity due cracking of concrete is considered by utilization of damage concept in the definition of constitutive models,and the lamination theory it is used in discretization of section cross of *** the layered approach,the reinforced concrete element is formulated as a laminated composite that consists of thin layers,of concrete or steel that has been modeled as elastic-perfectly plastic *** comparison of numerical load-displacement results with experimental results found in the literature demonstrates a good approximation of the model and validates the application of the damage model in the Classical Laminate Theory to predict mechanical failure of reinforced concrete *** results obtained by the numerical model indicated a variation in the stress-strain behavior of each beam,while for under-reinforced beams,the compressive stresses did not reach the peak stress but the stress-strain behavior was observed in the nonlinear regime at failure,for the other beams,the concrete had reached its ultimate strain,and the beam’s neutral axis was close to the centroid of the cross-section.

关键词： Reinforced concrete Damage mechanics Finite element method Laminate theory

King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria