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Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan joséPérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

Fast synthesis of gold nanoparticles by cold atmospheric pressure plasma jet in the presence of Au^(+) ions and a capping agent

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Plasma Science and Technology 2024年第7期26卷 108-115页

作者： Tatiana HABIB josé Mauricio A.CAIUT Bruno CAILLIER Laboratoire Diagnostics des Plasmas Hors Equilibre(DPHE) Universitéde ToulouseINU ChampollionAlbi 81000France Department of Chemistry The Nanomaterials and Luminescent Systems GroupFaculty of PhilosophyScience and Letters at Ribeirão PretoUniversity of São PauloRibeirão Preto-SP 14040-901Brazil

Homogeneous gold nanoparticles were synthesized under atmospheric pressure using a nonthermal helium plasma jet in a single-step process.A current power supply was used to generate the plasma discharge rich in diverse reactive *** species induce rapid chemical reactions responsible for the reduction of the gold salts upon contact with the liquid *** this study,spherical and monodispersed gold nanoparticles were obtained within 5 min of plasma exposure using a solution containing gold(Ⅲ)chloride hydrate(HAuCl_(4))as a precursor and polyvinylpyrrolidone(PVP)as a capping agent to inhibit *** formation of these metal nanoparticles was initially perceptible through a visible change in the sample's color,transitioning from light yellow to a red/pink *** was subsequently corroborated by UVvis spectroscopy,which revealed an optical absorption in the 520-550 nm range for Au NPs,corresponding to the surface plasmon resonance(SPR)*** investigation into the impact of various parameters,including plasma discharge duration,precursor and capping agent concentrations,was carried out to optimize conditions for the formation of well-separated,spherical gold *** light scattering(DLS)was used to measure the size of these nanoparticles,transmission electron microscopy(TEM)was used to observe their morphology and X-ray diffraction(XRD)was also employed to determine their crystallographic *** results confirm that homogeneous spherical gold nanoparticles with an average diameter of 13 nm can be easily synthesized through a rapid,straightforward,and environmentally friendly approach utilizing a helium atmospheric pressure plasma.

关键词： gold nanoparticles non-thermal plasma jet helium DBD

Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

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World Journal of Gastroenterology 2024年第10期30卷 1270-1279页

作者： Bruno Rosa joséCotter Department of Gastroenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the small bowel capsule revolutionized the management of patients with small bowel ***,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive *** technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic *** use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic *** recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

关键词： Non-invasive endoscopy Panendoscopy Magnetically controlled capsule endoscopy Crohn’s disease Digestive bleeding

Taurine as a possible therapy for immunosenescence and inflammaging

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Cellular & Molecular Immunology 2024年第1期21卷 3-5页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBMSO).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

Luminous fishes:Endocrine and neuronal regulation of bioluminescence

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Aquaculture and Fisheries 2024年第3期9卷 486-500页

作者： josé Paitio Yuichi Oba Department of Environmental Biology Chubu UniversityKasugai487-8501Japan

Bioluminescence is the ability of organisms to emit their own light which can be self-produced in light organs by photogenic cells(photocytes)or symbiotically by bearing cultures of luminous *** animals are mainly comprised in the ocean,nocturnal coastal shallow-water species or,as the majority of species,inhabiting deep-sea where dim light conditions are optimal for communication by luminous *** to difficult access to species,fisheries of bioluminescent fishes worldwide are rare,mostly for traditional cuisine and fishing *** are the only bioluminescent vertebrates and thus their light organs present an astonishing level of complexity for light modulation to adequate light signals for specific ecological *** control the output of light intensity using different mechanisms which can be categorized as being under control of hormonal or neuronal ***,neural control allows fast and direct response to the photocytes while endocrinal systems allow to control the light produced by bacteria,via manipulation of individual *** some species,mechanical movement of melanophore-filled tissues by muscular action is under neuronal or hormonal *** dimorphism of light organs,driven by hormonal regulation during ontogeny,takes a crucial role in communication and reproductive success of these species.

关键词： Bioluminescence Fish Hormonal Neural Endocrinological Control

粗犷与精致的对话巴塞罗那ALOHAS旗舰店

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室内设计与装修 2024年第8期 16-19页

作者： [西班牙]Clap Studio joséhevia(摄影) 沙漏(编译) Clap Studio

鞋履时尚品牌ALOHAS委托设计工作室Clap Studio为其设计在巴塞罗那的首家旗舰店,店铺位于城市中心标志性的Rambla de Catalunya大街。这家100 m2的旗舰店忠实反映了ALOHAS全新的视觉识别系统,展现出更强烈、更大胆的美学风格。通过这家... 详细信息

鞋履时尚品牌ALOHAS委托设计工作室Clap Studio为其设计在巴塞罗那的首家旗舰店,店铺位于城市中心标志性的Rambla de Catalunya大街。这家100 m2的旗舰店忠实反映了ALOHAS全新的视觉识别系统,展现出更强烈、更大胆的美学风格。通过这家旗舰店,ALOHAS在征服线上渠道之后,迈出了向线下商业进军的重要一步。

关键词：视觉识别系统设计工作室巴塞罗那 ALOHA 线下时尚品牌线上渠道旗舰店

市民之家Els Masovers之家公共空间和市民中心

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室内设计与装修 2024年第9期 106-109页

作者： [西班牙]David Closes 小麦(编译) joséhevia(摄影) David Cosesl建筑师事务所曼雷萨市政府城市项目部

本案建筑原为马尔克斯庄园的佃农住宅ElsMasovers之家,它属于农庄的一部分,位于西班牙加泰罗尼亚的埃尔马斯诺。设计任务的初衷是通过拆除老旧房屋的一部分,开辟一条通往城市足球场的新路径。

关键词：马尔克斯加泰罗尼亚公共空间足球场西班牙新路径

Tracking the change in Spanish greenhouse gas emissions through an LMDI decomposition model:A global and sectoral approach

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Journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula Fernández González María josé Presno Manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this *** this paper we pursue two ***,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining ***,we propose several actions specifically oriented to more tightly controlling the level of *** results showed a remarkable reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita *** detected somewhat different patterns among the various sectors *** the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of *** carbonization effect was revealed as crucial in the commerce *** above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in *** efforts in areas like innovation,R&D,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMDI Decomposition Spain GHG emissions

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窥见历史加泰罗尼亚巴洛克博物馆新入口

室内设计与装修 2024年第9期 98-105页

作者： [西班牙]David Closes 麦子(编译) joséhevia(摄影) AdriàGoula(摄影) David Cosesl建筑师事务所曼雷萨市政府城市项目部

世事常有令人惊讶的巧合!2003年至2011年间,建筑师DavidCloses接受委托,将波多尔的圣弗朗西斯科修道院改造成一座礼堂。该项目是在一座18世纪的修道院遗址上进行的,当时只剩下教堂,修道院的侧翼和回廊已经消失。5年后,建筑师又在加泰罗... 详细信息

世事常有令人惊讶的巧合!2003年至2011年间,建筑师DavidCloses接受委托,将波多尔的圣弗朗西斯科修道院改造成一座礼堂。该项目是在一座18世纪的修道院遗址上进行的,当时只剩下教堂,修道院的侧翼和回廊已经消失。5年后,建筑师又在加泰罗尼亚的曼雷萨市接到了一项相反的设计任务:改造旧圣依纳爵学院。

关键词：修道院加泰罗尼亚巴洛克博物馆建筑师教堂礼堂