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Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients

World Journal of Gastroenterology 2021年第41期27卷 7014-7024页

作者： Pilar García-Peñarrubia antonio joséruiz-Alcaraz Miriam ruiz-Ballester Tamara Nadira Ramírez-Pávez María Martínez-Esparza Department of Biochemistry and Molecular Biology B and Immunology School of MedicineUniversity of MurciaMurcia 30100Spain

Macrophages are a diverse myeloid cell population involved in innate and adaptive immune responses,embryonic development,wound repair,and regulation of tissue *** cells link the innate and adaptive immunities and are crucial in the development and sustainment of various inflammatory *** are tissue-resident cells in steady-state conditions;however,they are also recruited from blood monocytes after local pathogen invasion or tissue *** macrophages vary based on their cell complexity,phenotype,and functional *** cells regulate inflammation and control bacterial infections in the ascites of decompensated cirrhotic *** recent work reported several phenotypic and functional characteristics of these cells under both healthy and pathological conditions.A direct association between cell size,CD14/CD16 expression,intracellular level of GATA-6,and expression of CD206 and HLA-DR activation/maturation markers,indicate that the large peritoneal macrophage CD14^(high)CD16^(high)subset constitutes the mature phenotype of human resident peritoneal macrophages during ***,elevated expression of CD14/CD16 is related to the phagocytic *** novel large CD14^(high)CD16^(high)peritoneal subpopulation is increased in the ascites of cirrhotic patients and is highly sensitive to lipopolysaccharide(LPS)-induced activation,thereby exhibiting features of inflammatory ***,phosphorylation of ERK1/2,PKB/Akt,and c-Jun is remarkably increased in response to LPS in vitro,whereas that of p38 MAPK is reduced compared with the monocyte-derived macrophages from the blood of healthy ***,in vitro activated monocyte-derived macrophages from ascites of cirrhotic patients secreted significantly higher levels of IL-6,IL-10,and TNF-αand lower amounts of IL-1βand IL-12 than the corresponding cells from healthy donor’s *** on these results,other authors have recently reported that the sur

关键词： Cirrhosis Inflammation Peritoneal macrophages Phenotypic markers Activation routes

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Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto Manuel Borobia joséantonio ruiz Ana María Martínez Julia Martín Manuel Quintana Santos Garcfa antonio jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

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Elastic Smart Contracts in Blockchains

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1901-1912页

作者： Schahram Dustdar Pablo Fernández joséMaría García antonio ruiz-Cortés Distributed Systems Group Vienna University of TechnologyWien 1040Austria Smart Computer Systems Research and Engineering Lab Research Institute of Computer EngineeringUniversity of SevillaSevilla 41012Spain

In this paper,we deal with questions related to blockchains in complex Internet of Things(IoT)-based *** ecosystems are typically composed of IoT devices,edge devices,cloud computing software services,as well as people,who are decision makers in scenarios such as smart *** decisions related to analytics can be based on data coming from IoT sensors,software services,and ***,they are typically based on different levels of abstraction and *** poses a number of challenges when multiple blockchains are used together with smart *** work proposes to apply our concept of elasticity to smart contracts and thereby enabling analytics in and between multiple blockchains in the context of *** propose a reference architecture for Elastic Smart Contracts and evaluate the approach in a smart city scenario,discussing the benefits in terms of performance and self-adaptability of our solution.

关键词： Blockchain elasticity Internet of Things(IoT) smart cities smart contracts virtual chains

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Study of reverse osmosis membranes fouling by inorganic salts and colloidal particles during seawater desalination

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Chinese Journal of Chemical Engineering 2020年第3期28卷 733-742页

作者： Santiago Gutiérrez ruiz Juan antonio López-Ramírez Mohammed Hassani Zerrouk Agata Egea-Corbacho Lopera joséMaría Quiroga Alonso Department of Environmental Technologies Faculty of Marine and Environmental SciencesUniversity of Cadiz11510Puerto RealCadizSpain

Fouling phenomenon is considered among the major reasons that cause significant increase of operating cost of desalination plants equipped with reverse osmosis(RO)*** phenomenon is studied in the present work in the case of RO polyamide aromatic membranes using model seawater containing inorganic salts and colloidal *** solubility conditions of CaCO3 and CaSO4 were applied to study RO performances with and without colloid *** experiments,the membrane permeate fluxes were continuously ***,studies of chemical composition,structure,and morphology of the materials deposited on the membrane surface were conducted using energy dispersive microanalysis(EDS)X-ray diffraction and scanning electronic microscopy(SEM).Results show that in conditions of calcium carbonate oversaturation there is a reduction in the permeate flow of 11.2%due to fouling of the membrane by the precipitation of this *** in the same conditions of calcium sulphate oversaturation the reduction of the flow is 5%,so we can conclude that in conditions of oversaturation of both salts,calcium carbonate produces a greater fouling of the membrane that in its view causes greater decrease in the flow of *** this based on the results of the test with both salts in oversaturated *** in the formation of calcite and gypsum crystals onto the membranes as XRD analyses *** presence of colloidal silica in those conditions intensifies strongly the fouling,leading until to 24.1%of permeate flux decrease.

关键词： Reverse osmosis Desalination Fouling Seawater Scaling

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Coping with drought? The hidden microhabitat selection and underground movements of amphisbaenians under summer drought conditions

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Current Zoology 2024年第5期70卷 647-658页

作者： joséMartín Gonzalo Rodríguez-ruiz joséJavier Cuervo Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain

Habitat selection is a dynamic process that depends on many environmental variables that can vary with weather *** is important because,within a context of global change,extreme weather events,such as severe droughts,are predicted to become more *** examined the patterns of microhabitat selection and underground movements(using PIT-tag telemetry)of a strictly fossorial reptile,the North African checkboard amphisbaenian Trogonophis wiegmanni,during the summer drought *** aimed to test whether changes in strategies of habitat use and movements could allow this amphisbaenian to cope with unfavorable *** found that during the summer drought period,*** did not use the microhabitats in relationship to their availability,but particularly selected sites with high abundance of rocks but also areas under a high cover of bushes,where environmental conditions were more *** also found,using PIT-tag telemetry,that the numbers of *** individuals located under rocks and their activity(number of days with movements)decreased largely in ***,the animals were not entirely inactive,but,especially males were active below the ground under bushes and made some relatively long underground hidden movements between favorable areas.

关键词： arid environments fossoriality habitat selection movement ecology Trogonophis wiegmanni weather conditions

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GenoDrawing:An Autoencoder Framework for Image Prediction from SNP Markers

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Plant Phenomics 2023年第4期5卷 816-824页

作者： Federico Jurado-ruiz David Rousseau Juan A.Botía Maria josé Aranzana Center for Research in Agricultural Genomics(CRAG) 08193 BarcelonaCerdanyolaSpain Universitéd'Angers LARISINRAe UMR IRHS49000 AngersFrance Department of Information and Communication Engineering University of Murcia30071 MurciaSpain IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain

Advancements in genome sequencing have facilitated whole-genome characterization of numerous plant species,providing an abundance of genotypic data for genomic *** selection and neural networks(NNs),particularly deep learning,have been developed to predict complex traits from dense genotypic ***,an NN model to extract features from images in an unsupervised manner,has proven to be useful for plant *** study introduces an autoencoder framework,GenoDrawing,for predicting and retrieving apple images from a low-depth single-nucleotide polymorphism(SNP)array,potentially useful in predicting traits that are difficult to *** demonstrates proficiency in its task using a small dataset of shape-related *** indicate that the use of SNPs associated with visual traits has substantial impact on the generated images,consistent with biological *** using substantial SNPs is crucial,incorporating additional,unrelated SNPs results in performance degradation for simple NN architectures that cannot easily identify the most important *** proposed GenoDrawing method is a practical framework for exploring genomic prediction in fruit tree phenotyping,particularly beneficial for small to medium breeding companies to predict economically substantial heritable *** GenoDrawing has limitations,it sets the groundwork for future research in image prediction from genomic *** studies should focus on using stronger models for image reproduction,SNP information extraction,and dataset balance in terms of phenotypes for more precise outcomes.

关键词： Auto Drawing prediction

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A stable anthraquinone-derivative cathode to develop sodium metal batteries: The role of ammoniates as electrolytes

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Journal of Energy Chemistry 2023年第2期77卷 572-580,I0015页

作者： Débora ruiz-Martínez josé M.Orts Roberto Gómez Departament de Química Física i Institut Universitari d’Electroquímica Universitat d’AlacantApartat 99Alicante E-03080Spain

Rechargeable sodium metal batteries constitute a cost-effective option for energy storage although sodium shows some drawbacks in terms of reactivity with organic solvents and dendritic *** we demonstrate that an organic dye,indanthrone blue,behaves as an efficient cathode material for the development of secondary sodium metal batteries when combined with novel inorganic *** electrolytes are ammonia solvates,known as liquid ammoniates,which can be formulated as NaI·3.3NH_(3) and NaBF_(4)·2.5NH_(3).They impart excellent stability to sodium metal,and they favor sodium non-dendritic growth linked to their exceedingly high sodium ion *** advantage is complemented by a high specific *** battery described here can last hundreds of cycles at 10 C while keeping a Coulombic efficiency of 99%from the first *** of the high capacity of the cathode and the superior physicochemical properties of the electrolytes,the battery can reach a specific energy value as high as 210 W h kgIB^(-1),and a high specific power of 2.2 kW kgIB^(-1),even at below room temperature(4℃).Importantly,the battery is based on abundant and cost-effective materials,bearing promise for its application in large-scale energy storage.

关键词： Sodium metal batteries Anthraquinone-based cathode Vat dye Indanthrone blue Inorganic electrolytes Liquid ammoniates

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Population structure and range expansion:the case of the invasive gastropod Cyclope neritea in northwest Iberian Peninsula

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Integrative Zoology 2012年第3期7卷 286-298页

作者： Lucía COUCEIRO Lúa LÓPEZ joséMiguel ruiz Rodolfo BARREIRO Department of Ecology College of ScienceUniversity of A CoruñaA CoruñaSpain

Biotic invasions have a reputation for unpredictable ***,we report how slight changes in human activity responsible for the introduction and range expansion of a non-native mollusk have led to detectable differences in the genetics of the *** neritea is a non-predatory gastropod introduced to 2 areas of the European Atlantic:the northwest Iberian Peninsula(NWIP)and the French Atlantic coast(FAC).Shellfish seabed farming is intense in both areas but focuses on different commercial *** mitochondrial gene sequences,the lower genetic diversity recorded along the NWIP suggests a more homogeneous range of source populations than in the *** FAC,genetic diversity and haplotype composition in the NWIP correlate with the date of first occurrence of *** at each site rather than with geographical *** this pattern evokes the genetic signature expected under a serial-founder colonization model from a single initial enclave,a comparison with samples from potential source populations suggests that the NWIP probably experienced several independent *** jump dispersal pattern of *** in the NWIP,together with the observation that populations established in the same year are genetically undifferentiated,point to human transport as the most plausible explanation for the current range *** evidence for human-mediated dispersal,*** managed to develop a seemingly non-random genetic pattern in the *** is suggested that caution must be exerted when interpreting genetic patterns in invaders.

关键词： alien species Cyclope neritea cytochrome oxidase I genetic geographic pattern population structure

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Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

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Journal of Geriatric Cardiology 2018年第4期15卷 268-274页

作者： jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando josé ruiz Laiglesia josé antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez Hospital Carlos III Madrid Spain Hospital Infanta Elena Huelva Spain Hospital Clínico Universitario Lozano Blesa Zaragoza Spain Complejo Hospitalario Universitario de Santiago Santiago de Compostela Spain Hospital Virgen del Camino Sanlucar-Cádiz Spain Centro Socio-Sanitario Vallparadís Terrassa Spain Hospital de Basurto Bilbao Spain Hospital Universitario de La Princesa Madrid Spain

Background Available data regarding clinical profile and management of elderly patients with atrial fibrillation （AF） according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods Cross- sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain. Results A total of 837 patients （83.0 ± 5.0 years; CHA2DS2-VASc： 5.0 ± 1.4; HAS-BLED： 2.1 ± 0.9） were included. 44.4% of patients had some degree of dependency, 43.3% were fragile, and 32.3% had cognitive impairment. Patients with any of these conditions were older, had a worse clinical profile, with more comorbidities and higher risks of thromboembolic and bleeding events. All these conditions were independently associated among them. Overall, 70.8% of patients were taking vitamin K antagonists, the remaining 29.2% direct oral anticoagulants and 9.7% oral antiplatelets. This distribution was independent of the presence of dependency or fragility, but there was a trend to a higher prescription of vitamin K antagonists in those patients with cognitive impairment （75.2% vs. 68.8%; P = 0.05）. Conclusions Approximately 32%-44% of elderly anticoagulated AF patients attended have some degree of dependency, fragility and/or cognitive impairment. Patients with any of these conditions are older and have a worse clinical profile. Ap？proximately 71% of patients are taking vitamin K antagonists, regardless dependency or frailty, but with a trend to higher prescription in patients with cognitive impairment.

关键词： Atrial fibrillation Cognitive impairment Dependency Fragility Oral anticoagulants

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Sintering study of Ti6Al4V powders with different particle sizes and their mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1389-1401页

作者： joséLuis Cabezas-Villa joséLemus-ruiz Didier Bouvard Omar Jiménez Héctor Javier Vergara-Hernández Luis Olmos University Michoacana of San Nicolás of Hidalgo IIMMMorelia 58060México University Grenoble Alpes CNRSSIMaPGrenoble 38000France University of Guadalajara Departamento de Ingeniería de ProyectosZapopan 45100México National Technological Institute of Mexico I.T.MoreliaMorelia 58120México University Michoacana of San Nicolás of Hidalgo INICITMorelia 58060México

Ti6Al4V powders with three different particle size distributions(0–20, 20–45, and 45–75 μm) were used to evaluate the effect of the particle size distribution on the solid-state sintering and their mechanical properties. The sintering kinetics was determined by dilatometry at temperatures from 900 to 1260°C. The mechanical properties of the sintered samples were evaluated by microhardness and compression tests. The sintering kinetics indicated that the predominant mechanism depends on the relative density irrespective of the particle size used. The mechanical properties of the sintered samples are adversely affected by increasing pore volume fraction. The elastic Young's modulus and yield stress follow a power law function of the relative density. The fracture behavior after compression is linked to the neck size developed during sintering, exhibiting two different mechanisms of failure: interparticle neck breaking and intergranular cracking in samples with relative densities below and above of 90%, respectively. The main conclusion is that relative density is responsible for the kinetics, mechanical properties, and failure behavior of Ti6 Al4 V powders.

关键词： Ti6Al4V powders dilatometry microhardness sintering kinetics compression failure behavior

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