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The Salt Overly Sensitive （SOS） Pathway： Established and Em.rging Roles

m.lecular Plant 2013年第2期6卷 275-286页

作者： Hongtao Ji josé m. pardo Giorgia Batelli m.chael J. Van Oosten Ray A. Bressan Xia Li The State Key Laboratory of Plant Cell and Chrom.som. Engineering Center of Agricultural Resources Research Institute of Genetics andDevelopmental Biology Chinese Academy of Sciences Shijiazhuang Hebei 050021 PR China Instituto de Recursos Naturales y Agrobiologia Consejo Superior de Investigaciones Cientificas Sevilla-41012 Spain CNR Institute of Plant Genetics (CNR-IGV) Via Universita' i33 80055 Portici Italy Departm.nt of Agricultural Engineering and Agronom. University of Naples Federico II Via Universit~ 100 80055 Portici Italy Center for Plant Environm.ntal Stress Physiology Purdue University West Lafayette IN 47907-2010 USA Departm.nt Biological Sciences King Abdulaziz University Kingdom of Saudi Arabia

Soil salinity is a growing problem.around the world with special relevance in farm.ands. The ability to sense and respond to environm.ntal stim.li is am.ng the m.st fundam.ntal processes that enable plants to survive. At the cellular level, the Salt Overly Sensitive （SOS） signaling pathway that com.rises SOS3, SOS2, and SOS1 has been proposed to m.diate cellular signaling under salt stress, to m.intain ion hom.ostasis. Less well known is how cellularly heterog- enous organs couple the salt signals to hom.ostasis m.intenance of different types of cells and to appropriate growth of the entire organ and plant. Recent evidence strongly indicates that different regulatory m.chanism. are adopted by roots and shoots in response to salt stress. Several reports have stated that, in roots, the SOS proteins m.y have novel roles in addition to their functions in sodium.hom.ostasis. SOS3 plays a critical role in plastic developm.nt of lateral roots through m.dulation of auxin gradients and m.xim. in roots under m.ld salt conditions. The SOS proteins also play a role in the dynam.cs of cytoskeleton under stress. These results im.ly a high com.lexity of the regulatory networks involved in plant response to salinity. This review focuses on the em.rging com.lexity of the SOS signaling and SOS protein functions, and highlights recent understanding on how the SOS proteins contribute to different responses to salt stress besides ion hom.ostasis.

关键词： auxin ion hom.ostasis root system.architecture salt stress the SOS signaling pathway.

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Taurine as a possible therapy for im.unosenescence and inflam.aging

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Cellular & m.lecular Im.unology 2024年第1期21卷 3-5页

作者： josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm.O).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflam.atory,anti-im.unosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

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Estim.tion of Equivalent m.del of Photovoltaic Array Using Unscented Kalm.n Filters

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Journal of m.dern Power System. and Clean Energy 2024年第3期12卷 819-827页

作者： m.A.González-Cagigal joséA.Rosendo-m.cías A.Góm.z-Expósito the Departm.nt of Electrical Engineering University of SevilleSpainand A.Gómez-Expósito is also with ENGREEN Laboratory of Engineering for Energy and Environmental SustainabilitySevilleSpain

This paper proposes the use of the unscented Kalm.n filter to estim.te the equivalent m.del of a photovoltaic(PV)array,using external m.asurem.nts of current and voltage at the inverter *** estim.ted m.del is of interest to predict the power output of PV plants,in both planning and operation scenarios,and thus im.roves the efficient operation of power system. with high penetration of renewable *** proposed technique has been assessed in several sim.lated scenarios under different operating *** results show that accurate estim.tes are provided for the m.del param.ters,even in the presence of m.asurem.nt noise and abrupt variations under the external conditions.

关键词： Equivalent m.del param.ter estim.tion photovoltaic energy unscented Kalm.n filter

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m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Does enhanced recovery after surgery program. im.rove clinical outcom.s in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda Sánchez-Pérez josém.Ram.a Departm.nt of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Departm.nt of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAS)program. have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recom.endations in *** surgery is usually perform.d in oncological patients(liver m.tastasis,hepatocellular carcinom.,cholangiocarcinom.,etc.),but the real im.act of liver surgery ERAS program. in oncological outcom.s is not clearly *** advantages of ERAS program. are:ERAS decreases postoperative com.lication rates and has been dem.nstrated a clear relationship between com.lications and oncological outcom.s;a better and faster posto-perative recovery should let oncologic team. begin chem.therapeutic regim.ns on tim.;prehabilitation and nutrition actions before surgery should also im.rove the perform.nce status of the patients receiving ***,ERAS could be another way to im.rove our oncological *** will discuss the literature about liver surgery ERAS focusing on its oncological im.lications and future investigations projects.

关键词： Enhanced recovery after surgery program. Liver surgery Key com.onents Long-term.oncological outcom.s Enhanced recovery after surgery com.liance

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Spoon-assisted autologous particulate bone graft harvesting technique

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 106-108页

作者： Inigo Aragon Nino Clara Lopez m.rtínez Carolina Cuesta Urquía Agustín Pascual Cam.s jose Luis Del Castillo pardo de Vera jose Luis Cebrian Carretero Oral and m.xillofacial Surgery Departm.nt La Paz University Hospital28046 MadridSpain

Particulate bone plays a crucial role in various oral and m.xillofacial surgical procedures,including reconstruction,im.lantation,and craniofacial *** bone and deproteinized bovine bone xenografts are the two prim.ry resources used for such procedures,with the form.r dem.nstrating superior cost-effectiveness and reduced com.rbidity rates,particularly in cases involving donor ***,a significant challenge lies in acquiring uniform.y sized autologous particulate bone specim.ns,with existing tools often yielding coarse particles at a high ***,com.ercial bone xenograft solutions are frequently favored despite lower *** technical note introduces a novel technique for swiftly,safely,and efficiently obtaining autologous particulate bone *** procedure involves the use of a m.tor handpiece fitted with a m.cro drill and surgical spoon to collect the bone *** continuous irrigation with saline m.intains a clear surgical field during the m.lling *** collected bone particles are then transferred to a m.tal capsule for further *** technique offers a prom.sing solution to the challenge of inconsistent particle size associated with harvesting using traditional m.thods,providing surgeons with a reliable and efficient m.thod of obtaining autologous particulate bone sam.les.

关键词： Bone grafting Reconstructive surgery Craniofacial surgery Im.lant surgery Autologous bone

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Ferroelectricity Induced by Oxygen Vacancies in Rhom.ohedral ZrO_(2) Thin Film.

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Energy & Environm.ntal m.terials 2024年第1期7卷 229-237页

作者： Veniero Lenzi josé P.B.Silva Břetislav Šm.d Vladim.r m.toín Cosm.n m.Istrate Corneliu Ghica Judith L.m.cm.nus-Driscoll Luís m.rques Physics Center of m.nho and Porto Universities(CF-Um.UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for m.terials and Em.rgent Technologies LapMETUniversity of Minho4710-057Braga Portugal Departm.nt of Surface and Plasm. Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of m.terials Physics 105 bis Atomistilor 077125Magurele Romania Departm.nt of m.terials Science and m.tallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhom.ohedral phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from.0 to 1)film. are prom.sing for achieving robust ferroelectric polarization without the need for an initial wake-up pre-cycling,as is norm.lly the case for the m.re com.only studied orthorhom.ic ***,a large spontaneous polarization observed in rhom.ohedral film. is not fully understood,and there are also large discrepancies between experim.ntal and theoretical *** this work,in rhom.ohedral ZrO_(2)thin film.,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experim.ntally through the investigation of the structural properties,chem.cal com.osition and the ferroelectric properties of the film. before and after an annealing at m.derate tem.erature(400℃)in an oxygen environm.nt to reduce the V_(o)concentration *** experim.ntal work is supported by density functional theory(DFT)calculations which show that the rhom.ohedral phase is the m.st stable one in highly oxygen defective ZrO_(2)*** DFT calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the im.ortance of V_(o)for stabilizing rhom.ohedral ZrO_(2)thin film. with superior ferroelectric properties.

关键词： charged defects ferroelectric polarization rhom.ohedral phase stability zirconia

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Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport m.m.ranes

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Journal of Energy Chem.stry 2024年第4期91卷 99-110页

作者： m.rwan Laqdiem.Julio García-Fayos Laura Alm.r Alfonso J.Carrillo Álvaro Represa josém.López Nieto Sonia Escolástico David Catalán-m.rtinez jose m.Serra Instituto de Tecnología Quím.ca(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the developm.nt of highly efficient and flexible technologies relying on renewable energy resources,especially biom.ss and solar/wind *** the case of pure oxygen production,oxygen transport m.m.ranes(OTm.)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTm. could provide oxygen from.different sources(air,water,CO_(2),etc.),and they are m.re flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furtherm.re,OTm. can be integrated into catalytic m.m.rane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTm.m.terial(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),im.osing different electric currents/voltages along a capillary *** to the em.rging Joule effect,the m.m.rane-surface tem.erature and the associated O_(2) perm.ation flux could be ***,the OTm.is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the m.m.rane was m.intained at 650℃.The O_(2)perm.ation flux reached for the electrified m.m.ranes was~3.7 Nm. m.n^(-1)cm.(-2),corresponding to the flux obtained with an OTm.non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer m.m.rane surface revealed that lower surface tem.eratures(830℃)were detected at the sam. im.osed electric ***,the electrification concept was dem.nstrated in a catalytic m.m.rane reactor(Cm.)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to tem.erature,and here,we dem.nstrate an im.rovem.nt of the ethylene yield by reaching m.derate tem.eratures in the reaction cham.er while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen perm.ation Oxidative dehydrogenation of ethane Oxygen transport m.m.ranes Joule effect m.xed ionic-electronic conductors Catalytic m.m.rane reactors

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m.lti-tissue transcriptom.cs of a unique m.nozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gom.z-Carballa m.ria jose Curras-Tuala Sara Pischedda m.riam.Cebey-Lopez jose Gom.z-Rial Irene Rivero-Cale Jacobo pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian m.ntoto-Louzao Alba Cam.no-m.ra Isabel Ferreiros-Vidal m.xim. Fraga jose RAntunez Rodolfo Gom.z Federico m.rtinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inm.nologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain m.sculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Departm.nt of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Anim.les IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biom.dica en Red de Enferm.dades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosom.l dom.nant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating m.tations in the GNAS(guanine nucleotide-binding protein alpha-stim.lating activity polypeptide)***,the m.lecular m.chanism. underlying HO rem.in poorly *** a treatm.nt for POH is not yet available,the identification of the m.chanism. driving POH in affected tissues using gene expression m.y be of great help to underestand the m.lecular basis of POH and develop new therapeutic approaches.

关键词： stim.lating driving asi

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Exploring the size of Andean condor foraging groups along an altitudinal and latitudinal gradient in the Tropical Andes: Ecological and conservation im.lications

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Current Zoology 2024年第2期70卷 225-232页

作者： Diego m.ndez Felix Hernan Vargas joséHernan Sarasola Pedro P.Oleaa Departam.nto de Ecologia Universidad Autonoma de MadridCalle Darwin 228049MadridSpain m.seo Nacional de Historia Natural Calle 26 s/nCota CotaLa PazBolivia The Peregrine Fund 5668 West Flying Hawk LaneBoiseID 83709USA Centro para el Estudio y Conservacion de Aves Rapaces en Argentina(CECARA) Universidad Nacional de La PampaAvda Uruguay 1516300 Santa RosaLa PampaArgentina Instituto de las Ciencias Am.ientales y de la Tierra de La Pam.a(INCITAP-CONICET) Avda.Uruguay 1516300 Santa RosaLa PampaArgentina Centro de Investigacion en Biodiversidad y Cam.io Global(CIBC-UAm. Universidad Autonoma de MadridMadridCalle Darwin 228049Madrid Snain

Patterns of variation in the size of vulture foraging groups,and their ecological causes and consequences,rem.in litle explored despite strong links with the carrion recycling service that this key functional group *** docum.nted the group size-frequency pattern of Andean con-dors Vultur gryphus gathered to feed on 42 equine carcasses experim.ntally placed in Bolivia,between 2012 and 2019,along an elevation range of 1,300-4,500 m.*** on the location(altitude and latitude)of the foraging groups,we exam.ned the relationship between their size and species'population param.ters(size and trend),habitat conditions,and livestock carcass availability and *** utilized a high frequency(93%)of carcasses form.ng groups that ranged from.1 to 80 individuals(m.an=25,m.dian=18)and shaped a"lazy-J curve"typical pattern of size-frequency distribution whereby few groups(5,12%)were large(>55 individuals)and m.st(21,50%)were relatively sm.ll(m.st larger groups form.d at lower sites(below c.3,000 m.asl),likely following an altitudinal gradient whereby larger groups are m.re likely to form.around larger carcasses(i.e.,cattle),which are m.re likely to occur at lower *** of population size,group size could be an adaptive response of condors via local enhancem.nt for im.roving individual scavenging *** inform.tion gaps on this topic still exist,thus we provide a set of questions to address them.especially am.dst the unrestricted im.acts of hum.n activities that condition vulture survival globally.

关键词： condor andino fusion-fission dynam.cs group size scavenger social foraging vultures.

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