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Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto Manuel Borobia joséantonio Ruiz Ana María martínez Julia martín Manuel Quintana Santos Garcfa antonio jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

There is life after coking for Ir nanocatalyst superlattices

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Nano Research 2022年第8期15卷 6969-6976页

作者： antonio J.martínez-Galera Haojie Guo Mariano D.Jiménez-Sánchez Stefano Franchi Kevin C.Prince josé M.Gómez-Rodríguez Departamento de Física de la Materia Condensada Universidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Elettra-Sincrotrone Trieste S.C.p.A. in Area Science ParkBasovizza(Trieste)34149Italy Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid E-28049Spain

Achieving superior performance of nanoparticle systems is one of the biggest challenges in *** major phenomena,occurring during the reactions,hinder the development of the full potential of nanoparticle catalysts:sintering and contamination with carbon containing species,sometimes called ***,we demonstrate that Ir nanocrystals,arranged into periodic networks on hexagonal boron nitride(h-BN)supports,can be restored without sintering after contamination by persistent *** restoration yields the complete removal of carbon from the nanocrystals,which keep their crystalline structure,allowing operation without *** findings,together with the possibility of fine tuning the nanocrystals size,confer this nanoparticle system a great potential as a testbed to extract key information about catalysis-mediated oxidation *** the case of the CO oxidation by O2,reaction of interest in environmental science and green energy production,the existence of chemical processes not observed before in other nanoparticle systems is demonstrated.

关键词： catalysis coke nanoparticles scanning tunneling microscopy(STM) X-ray photoemission spectroscopy(XPS)

Phenolic metabolism and molecular mass distribution of polysaccharides in cellulose-deficient maize cells

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Journal of Integrative Plant Biology 2017年第7期59卷 475-495页

作者： María de Castro Romina martínez-Rubio josé L.Acebes antonio Encina Stephen C.Fry Penélope García-Angulo área de Fisiología Vegetal.Dpto.Ingenieríay Ciencias Agrarias.Facultad de Biologíay Ciencias Ambientales.Universidad de León The Edinburgh Cell Wall Group Institute of Molecular Plant Sciences School of Biological Sciences Daniel Rutherford BuildingThe King's Buildings

As a consequence of the habituation to low levels of dichlobenil （DCB）, cultured maize cells presented an altered hemicellulose cell fate with a lower proportion of strongly wall-bound hemicelluloses and an increase in soluble extracellular polymers released into the culture medium. The aim of this study was to investigate the relative molecular mass distributions of polysaccharides as well as phenolic metabolism in cells habituated to low levels of DCB （1.5 μM）. Generally, cell wall bound hemicelluloses and sloughed polymers from habituated cells were more homogeneously sized and had a lower weight-average relative molecular mass. In addition, polysaccharides underwent massive cross-linking after being secreted into the cell wall, but this cross-linking was less pronounced in habituated cells than in non-habituated ones. However, when relativized, ferulic acid and p-coumaric acid contents were higher in this habituated cell line. Feasibly, cells habituated to low levels of DCB synthesized molecules with a lower weight-average relative molecular mass, although cross-linked, as a part of their strategy to compensate for the lack of cellulose.

关键词： Phenolic metabolism and molecular mass distribution of polysaccharides in cellulose-deficient maize cells were for

MMALE—A Methodology for Malware Analysis in Linux Environments

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Computers, Materials & Continua 2021年第5期67卷 1447-1469页

作者： joséJavier de Vicente Mohino Javier Bermejo Higuera Juan Ramón Bermejo Higuera Juan antonio Sicilia Montalvo Manuel Sánchez Rubio joséJavier martínez Herraiz Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogroño26006La RiojaSpain Departamento de Ciencias de la Computación de la Escuela Politécnica Superior Universidad de Alcaláde HenaresAlcaláde HenaresMadridSpain

In a computer environment,an operating system is prone to malware,and even the Linux operating system is not an *** recent years,malware has evolved,and attackers have become more qualified compared to a few years ***,Linux-based systems have become more attractive to cybercriminals because of the increasing use of the Linux operating system in web servers and Internet of Things(IoT)*** is the most employed OS,so most of the research efforts have been focused on its malware protection rather than on other operating *** a result,hundreds of research articles,documents,and methodologies dedicated to malware analysis have been ***,there has not been much literature concerning Linux security and protection from *** address all these new challenges,it is necessary to develop a methodology that can standardize the required steps to perform the malware analysis in depth.A systematic analysis process makes the difference between good and ordinary malware ***,a deep malware comprehension can yield a faster and much more efficient malware *** order to address all mentioned challenges,this article proposed a methodology for malware analysis in the Linux operating system,which is a traditionally overlooked field compared to the other operating *** proposed methodology is tested by a specific Linux malware,and the obtained test results have high effectiveness in malware detection.

关键词： Malware analysis methodology analysis Linux malware IoT malware

Systematic Approach for Web Protection Runtime Tools’Effectiveness Analysis

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 579-599页

作者： Tomás Sureda Riera Juan Ramón Bermejo Higuera Javier Bermejo Higuera Juan antonio Sicilia Montalvo josé Javier martínez Herráiz Computer Science Department University of AlcaláMadrid28801Spain Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogrono26006Spain

Web applications represent one of the principal vehicles by which attackers gain access to an organization’s network or ***,different approaches to protect web applications have been proposed to *** them,the two major approaches are Web Application Firewalls(WAF)and Runtime Application Self Protection(RASP).It is,thus,essential to understand the differences and relative effectiveness of both these approaches for effective decisionmaking regarding the security of web *** we present a comparative study between WAF and RASP simulated settings,with the aim to compare their effectiveness and efficiency against different categories of *** this,we used computation of different metrics and sorted their results using F-Score *** found that RASP tools scored better than WAF *** this study,we also developed a new experimental methodology for the objective evaluation ofweb protection tools since,to the best of our knowledge,nomethod specifically evaluates web protection tools.

关键词： Web Application Firewall(WAF) Runtime Application Self Protection(RASP) F-Score web attacks experimental methodology

Minimally Invasive Surgery for Necrotizing Pancreatitis: A Case Report

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Surgical Science 2024年第9期15卷 514-521页

作者： Néstor Veriel Méndez Huerta Luis Fernando Zorrilla Núñez Noelia Obregón Gaxiola César Jair Treviño Arizmendi Gerardo Iván Muñoz Morales Marco Alejandro Arizmendi Villarreal Pamela Denisse Valdez Navarro Marco antonio Hernández Guedea Gerardo Enrique Muñoz Maldonado Service of General Surgery Hospital Universitario Dr. Jos Eleuterio Gonzlez Universidad Autnoma de Nuevo Len Monterrey Mxico

Introduction: Necrotizing pancreatitis management is complex and varies significantly among clinicians. Minimally invasive approaches like transgastric necrosectomy via laparoscopy are emerging as effective treatment options. This case report underscores the technique’s efficacy, clinical outcomes, and role in reducing complications. Clinical Observation: A 59-year-old male with a history of smoking and alcoholism presented with severe abdominal pain, nausea, and vomiting. Over the following weeks, he developed symptoms including asthenia, weight loss, and melena. Diagnostic workup revealed severe anemia and Balthazar E necrotizing pancreatitis, with significant intra-abdominal fluid collections and signs of infection. After initial conservative management, the patient underwent transgastric necrosectomy via laparoscopy due to deteriorating clinical status. The procedure involved removing necrotic tissue and performing a cystogastroanastomosis and jejunostomy. Postoperative care included fasting, parenteral nutrition, broad-spectrum antibiotics, and enzymatic replacement. The patient recovered well, with reduced necrotic tissue on follow-up imaging, and was discharged twelve days post-surgery [1]. Conclusion: Transgastric necrosectomy by laparoscopy is a valuable first-line surgical option for patients with symptomatic necrotizing pancreatitis, particularly in cases without prior interventions. This minimally invasive technique helps reduce major complications and mortality, offering a less invasive alternative to traditional open necrosectomy. The multidisciplinary approach and careful postoperative management were crucial to the patient’s favorable outcome. The case highlights the potential of transgastric necrosectomy as an effective treatment strategy in managing complex pancreatitis cases, including those with associated duodenal perforation [2].

关键词： Necrotizing Transgastric Pancreatic Necrosectomy Pancreatitis Case Report

T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection

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World Journal of Hepatology 2017年第27期9卷 1115-1124页

作者： María josé martínez-Bravo Berta Sánchez josé Manuel Sousa María josé Acevedo Miguel Angel Gómez-Bravo antonio Núnez-Roldán Isabel Aguilera Immunology Service Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla Digestive Diseases Service Hospital Universitario Virgen del Rocío Liver Transplant Unit Hospital Universitario Virgen del Rocío

AIM To investigate the role of glutathione S-transferase T1 donor-specific T lymphocytes in plasma cell-rich rejection of liver *** The study group included 22 liver transplant patients. Among them, 18 patients were mismatched for the glutathione S-transferase T1(GSTT1) alleles(don+/rec-), and 4 were matched(don+/rec+). Seven of the mismatched patients produced anti-GSTT1 antibodies and developed plasma cell-rich rejection(former de novo immune hepatitis). For the detection of specific Tlymphocytes, peripheral blood mononuclear cells were collected and stored in liquid nitrogen. The memory T cell response was studied by adding to the cell cultures to a mix of 39 custom-made, 15-mer overlapping peptides, which covered the entire GSTT1 amino acid sequence. The specific cellular response to peptides was analyzed by flow cytometry using the markers CD8, CD4, IL-4 and IFNγ.RESULTS Activation of CD8^+ T cells with different peptides was observed exclusively in the group of patients with plasma-cell rich rejection(3 out of 7), with production of IL-4 and/or IFNγ at a rate of 1%-4.92% depending on the peptides. The CD4^+ response was most common and not exclusive for patients with the disease, where 5 out of 7 showed percentages of activated cells from 1.24% to 31.34%. Additionally, two patients without the disease but with the mismatch had cells that became stimulated with some peptides(1.45%-5.18%). Highly unexpected was the finding of a double positive CD4^+CD8^(low) T cell population that showed the highest degree of activation with some of the peptides in 7 patients with the mismatch, in 4 patients with plasma cell-rich rejection and in 3 patients without the disease. Unfortunately, CD4^+CD8^(low) cells represent 1% of the total number of lymphocytes, and stimulation could not be analyzed in 9 patients due to the low number of gated cells. Cells from the 4 patients included as controls did not show activation with any of the peptides. CONCLUSION Patients

关键词： Donor-specific glutathione S-transferase T1 antibodies Indirect presentation Glutathione S-transferase T1-memory T cells De novo immune hepatitis Donor/recipient mismatch

Yield models for predicting aboveground ectomycorrhizal fungal productivity in Pinus sylvestris and Pinus pinaster stands of northern Spain

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Forest Ecosystems 2019年第4期6卷 414-426页

作者： Mariola Sánchez-González Sergio de-Miguel Pablo martin-Pinto Fernando martínez-Pe?a María Pasalodos-Tato Juan Andrés Oria-de-Rueda Juan martínez de Aragón Isabel Ca?ellas josé antonio Bonet Spanish National Institute for Agricultural and Food Research and Technology (INIA)

Background: Predictive models shed light on aboveground fungal yield dynamics and can assist decision-making in forestry by integrating this valuable non-wood forest product into forest management planning. However, the currently existing models are based on rather local data and, thus, there is a lack of predictive tools to monitor mushroom yields on larger ***: This work presents the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms and related ecosystem services in Pinus sylvestris and Pinus pinaster stands in northern Spain, using a long-term dataset suitable to account for the combined effect of meteorological conditions and stand *** were fitted for the following groups of fungi separately: all ectomycorrhizal mushrooms, edible mushrooms and marketed mushrooms. Our results show the influence of the weather variables(mainly precipitation) on mushroom yields as well as the relevance of the basal area of the forest stand that follows a right-skewed unimodal curve with maximum predicted yields at stand basal areas of 30–40 m2·***: These models are the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms in Pinus sylvestris and Pinus pinaster stands in northern Spain, being of the highest resolution developed to date and enable predictions of mushrooms productivity by taking into account weather conditions and forests’ location, composition and structure.

关键词： Mushrooms Fungi Non-wood forest products Mixed models Hurdle models

Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients

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World Journal of Gastroenterology 2021年第41期27卷 7014-7024页

作者： Pilar García-Peñarrubia antonio joséRuiz-Alcaraz Miriam Ruiz-Ballester Tamara Nadira Ramírez-Pávez María martínez-Esparza Department of Biochemistry and Molecular Biology B and Immunology School of MedicineUniversity of MurciaMurcia 30100Spain

Macrophages are a diverse myeloid cell population involved in innate and adaptive immune responses,embryonic development,wound repair,and regulation of tissue *** cells link the innate and adaptive immunities and are crucial in the development and sustainment of various inflammatory *** are tissue-resident cells in steady-state conditions;however,they are also recruited from blood monocytes after local pathogen invasion or tissue *** macrophages vary based on their cell complexity,phenotype,and functional *** cells regulate inflammation and control bacterial infections in the ascites of decompensated cirrhotic *** recent work reported several phenotypic and functional characteristics of these cells under both healthy and pathological conditions.A direct association between cell size,CD14/CD16 expression,intracellular level of GATA-6,and expression of CD206 and HLA-DR activation/maturation markers,indicate that the large peritoneal macrophage CD14^(high)CD16^(high)subset constitutes the mature phenotype of human resident peritoneal macrophages during ***,elevated expression of CD14/CD16 is related to the phagocytic *** novel large CD14^(high)CD16^(high)peritoneal subpopulation is increased in the ascites of cirrhotic patients and is highly sensitive to lipopolysaccharide(LPS)-induced activation,thereby exhibiting features of inflammatory ***,phosphorylation of ERK1/2,PKB/Akt,and c-Jun is remarkably increased in response to LPS in vitro,whereas that of p38 MAPK is reduced compared with the monocyte-derived macrophages from the blood of healthy ***,in vitro activated monocyte-derived macrophages from ascites of cirrhotic patients secreted significantly higher levels of IL-6,IL-10,and TNF-αand lower amounts of IL-1βand IL-12 than the corresponding cells from healthy donor’s *** on these results,other authors have recently reported that the sur

关键词： Cirrhosis Inflammation Peritoneal macrophages Phenotypic markers Activation routes