检索结果-南通市图书馆

Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer

引用

World Journal of Diabetes 2023年第7期14卷 977-994页

作者： Andrea Garza-Campos josé roberto prieto-correa josé Alfredo Domínguez-Rosales Zamira Helena Hernández-Nazará Programa de Doctorado en Ciencias en Biología Molecular en Medicina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Biología Molecular y Genómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obesity and type 2 diabetes mellitus(T2DM)are chronic pathologies with a high incidence *** share some pathological mechanisms,including hyperinsulinemia,the production and release of hormones,and *** above,over time,affects other systems of the human body by causing tissue hypoxia,low-grade inflammation,and oxidative stress,which lay the pathophysiological groundwork for *** leading causes of death globally are T2DM and *** main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death(i.e.,damage-associated molecular patterns)such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products(RAGE)-a multiligand receptor involved in inflammatory and metabolic and neoplastic *** review analyzes the latest advanced reports on the role of RAGE in the development of obesity,T2DM,and cancer,with an aim to understand the intracellular signaling mechanisms linked with cancer *** review also explores inflammation,oxidative stress,hypoxia,cellular senescence,RAGE ligands,tumor microenvironment changes,and the“cancer hallmarks”of the leading tumors associated with *** assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.

关键词： Type 2 diabetes Cancer Obesity Advanced glycation end product receptor Receptor for advanced glycation end products Glycation end products,advanced

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro

引用

Cellular & Molecular Immunology 2018年第10期15卷 917-933页

作者： Jacobo Lopez-Abente Adrián prieto-Sanchez Maria-Ángeles Muñoz-Fernandez Rafael correa-Rocha Marjorie Pion Laboratorio de Inmuno-Regulación Immunology DepartmentPabellón de Medicina y Cirugía ExperimentalHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Calle Máiquez9Madrid 28009Spain Laboratorio de Inmuno-Biología Molecular Immunology DepartmentHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)C/Dr.Esquerdo 46Madrid 28007Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)C/Monforte de Lemos 3-5Pabellón 11Madrid 28029Spain

Individuals infected with human immunodeficiency virus type-1(HIV-1)usually show a general dysregulation and hyper-activation of the immune system.A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously ***,the consequences of B-cell dysregulation are still poorly *** evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of *** functionality of treated B cells was challenged in co-culture experiments with autologous CD4+and CD8+T *** demonstrated that HIV-1 induces a phenotypic change in B cells towards a regulatory B-cell phenotype,showing a higher level of IL-10,TGF-β1,EBI3 or IL-12(p35)mRNA expression and acquiring an immunosuppressive *** acquisition of a Breg phenotype was confirmed by co-culture experiments where HIVtreated B cells reduced the proliferation and the TNFαproduction of CD4+or CD8+T *** suppressive ability of HIV-treated B cells was dependent on cell-to-cell contact between these B cells and effector *** our knowledge,these data provide the first evidence that HIV-1 can directly induce a regulatory B cell-like immunosuppressive phenotype,which could have the ability to impair specific immune *** dysregulation could constitute one of the mechanisms underlying unsuccessful efforts to develop an efficient vaccine against HIV-1.

关键词： HIV-1 immune hyper-activation regulatory B cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Benzyl Amino Purine and Gibberellic Acid Coupled to Nitrogen-Limited Stress Induce Fatty Acids,Biomass Accumulation,and Gene Expression in Scenedesmus Obliquus

引用

Phyton-International Journal of Experimental Botany 2021年第2期90卷 515-531页

作者： Hans Christian correa-Aguado Gloria Viviana Cerrillo-Rojas Alejandro Rocha-Uribe Ruth Elena Soria-Guerra joséFrancisco Morales-Domínguez Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México Instituto Politécnico Nacional Unidad Profesional Interdisciplinaria de Ingeniería Campus ZacatecasBlvd.del Bote 202Cerro del Gato Ejido La EscondidaCol.Ciudad AdministrativaZacatecasZAC 98160Mexico

The need for renewable energy sources makes microalgae an essential feedstock for biofuels *** molecular aspects and the response to nitrogen(N)-limited conditions with a phytohormone stimulus in microalgae have been slightly *** this work,Scenedesmus obliquus was used as a study model to analyze the effect of benzyl amino purine(BAP)and gibberellic acid(GA)coupled to nitrogen limitation on cell growth,biomass and fatty *** selected 10^(-5)M BAP increased the biomass by 1.44-fold,and 10^(-6)M GA by *** total lipids also increased by 2.8 and 1.11-fold,*** 10^(-5)M BAP and 10^(-6)M GA addition to *** cultures at different initial nitrogen percentages(N-0,N-25,and N-50)showed a significant increase in cell growth and biomass productivity compared to the unstimulated *** N-0 and GA N-0 produced the highest lipid yields with 55%and 50%,*** lipid profile analysis revealed an increase,particularly in C18:1 and C16:0 fatty *** expression analysis showed an over-expression of acyl carrying protein(ACP),stearoyl-ACP desaturase(SAD),fatty acid acyl-ACP thioesterase(FATA),and diacylglycerol acyltransferase(DGAT)genes,which were mainly induced by nitrogen ***,BAP and GA produced a significant over-expression on these genes in the N-replete *** study shows that BAP and GA,coupled to N limitation stress,can be used to increase the biomass and lipid production in *** for sustainable biofuels.

关键词： Biodiesel gene expression lipids microalgae nitrogen deficiency phytohormones

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diversity of Saxicolous Lichens along an Aridity Gradient in Central México

引用

Phyton-International Journal of Experimental Botany 2022年第4期91卷 827-840页

作者： joséCarmen Soto-correa Abraham Saldaña-Vega Víctor Hugo Cambrón-Sandoval Laura Concostrina-Zubiri Mariela Gómez-Romero Facultad de Ciencias Naturales Universidad Autónoma de QuerétaroQuerétaro73230México Departamento de Biología y Geología Física y Química Inorgánica Tulipán s/nUniversidad Rey Juan CarlosMóstolesMadrid28933España Cátedra CONACYT–Facultad de Biología Universidad Michoacana de San Nicolás de HidalgoMoreliaMichoacán58030México

Lichens are symbiotic organisms that comprise a fungus and a photosynthetic partner wich are recognized as a good indicator of climate ***,our understanding of how aridity affects the diversity of saxicolous lichens in drylands is still *** evaluate the relationship between saxicolous lichen diversity and aridity in a central México dryland,a geographical transect was established of 100 km to build an aridity gradient in the semiarid zone of the State of Querétaro,Mexico,comprising ten sampling sites with a 10 km *** richness,abundance and diversity of soil lichen species were recorded using two sampling methods:the quadrat-intercept and the line-intercept method,to compare their performance in assessing soil lichen diversity in *** number of species and Shannon diversity of saxicolous lichens were higher at intermediate values of the aridity index(AI=0.10-0.34).Quadrat intercept and point intercept methods gave quite similar results,which means that the selected method does not influence the results in a significant *** study confirms the role of saxicolous lichens as climate change indicators and reveals the importance of the sampling method selection in the evaluation of different parameters of soil lichen diversity in drylands.

关键词： Climate change drylands ecological indicators environmental stress precipitation temperature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers

引用

International Journal of Clinical Medicine 2015年第7期6卷 458-464页

作者： Jaime Carranza-Madrigal josé Miguel Cervantes-Alfaro Sonia María López-correa Escuela de Enfermería y Salud Pública Universidad Michoacana de San Nicolás de Hidalgo Morelia México División de Estudios de Postgrado Facultad de Ciencias Médicas y Biológicas “Dr. Ignacio Chávez” Universidad Michoacana de San Nicolás de Hidalgo Morelia México

Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.

关键词： Blood Pressure Hypertension Melatonin Norepinephrine Orthostatism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of a preclinical dry eye model in New Zealand white rabbits during and following topical instillation of 1% ophthalmic atropine sulfate

引用

Animal Models and Experimental Medicine 2022年第3期5卷 266-273页

作者： Alejandra Sánchez-Ríos Elba Yadira correa-Gallegos josé Manuel Medina-Espinoza Andrea Anaid Navarro-Sanchez Oscar Olvera-Montaño Leopoldo Baiza-Durán Patricia Muñoz-Villegas Medical Affairs Department Laboratorios SophiaSA de CVZapopanJaliscoMexico

Background : The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate(OAS) in New Zealand white(NZW) *** : OAS(1%) was applied three times per day to 30 eyes of 15 healthy NZW rabbits. Sacrifice, enucleation, and lacrimal gland removal took place on days 15, 21,and 30(OAS group). A second group(n = 5) was used as control. Clinical evaluations took place on days 3, 10, 15, 18, 21, 24 and 30. The primary endpoints were:Schirmer I test, tear break-up time(TBUT), and corneal fluorescein staining. As secondary endpoints, clinical changes including intraocular pressure, and histopathology were *** : While OAS was administered, the Schirmer I test showed a statistically significant reduction for OAS group versus control( p < 0.001), and versus basal production( p < 0.001). TBUT showed statistically significant differences between groups(days 3 and 10;p = 0.001) and versus basal values(day 3;p < 0.001). Fluorescein staining showed a statistically significant difference(day 3;p = 0.001). The most frequent clinical finding was conjunctival hyperemia(76.9% OAS vs. 20% control). For histopathology, all OAS subjects presented some degree of inflammation(86.7% minimal;13.3% mild) whereas the control presented only 30% minimal inflammation. Goblet cell density showed no *** : The effectiveness of the OAS dry eye model in NZW rabbits as reported in previous studies was confirmed, provided that the application of the drug is maintained throughout the intervention;it is not a viable model after OAS administration is suspended.

关键词： atropine sulfate dry eye rabbit model safety Schirmer I test TBUT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel TINF2 gene mutation in dyskeratosis congenita with extremely short telomeres:A case report

引用

World Journal of Clinical Cases 2022年第33期10卷 12440-12446页

作者： Verónica Judith Picos-Cárdenas Saúl Armando Beltrán-Ontiveros joséAlfonso Cruz-Ramos joséAlfredo Contreras-Gutiérrez Eliakym Arámbula-Meraz Carla Angulo-Rojo Alma Marlene Guadrón-Llanos Emir Adolfo Leal-León Dora María Cedano-prieto Juan Pablo Meza-Espinoza Laboratorio de Genética Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Centro de Investigación y Docencia en Ciencias de la Salud Hospital Civil de CuliacánUniversidad Autónoma de SinaloaCuliacán 80030SinaloaMexico Departamento de Clínicas Médicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Facultad de Medicina Universidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Laboratorio de Genética y Biología Molecular Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacán 80010SinaloaMexico Laboratorio de Neurociencias Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Laboratorio de Diabetes y Comorbilidades Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Facultad de Medicina Universidad Autónoma de TamaulipasMatamoros 87349TamaulipasMexico

BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin *** genetics of dyskeratosis congenita include mutations in genes involved in telomere maintenance,including *** SUMMARY Here,we report a female patient who presented thrombocytopenia,anemia,reticulate hyperpigmentation,dystrophy in fingernails and toenails,and leukoplakia on the tongue.A histopathological study of the skin showed dyskeratocytes;however,a bone marrow biopsy revealed normal cell *** patient was diagnosed with dyskeratosis congenita,but her family history did not reveal significant ***-exome sequencing showed a novel heterozygous punctual mutation in exon 6 from the TINF2 gene,namely,NM_001099274.1:-c.854delp.(Val285-Alafs*32).An analysis of telomere length showed short telomeres relative to the patient’s *** The disease in this patient was caused by a germline novel mutation of TINF2 in one of her parents.

关键词： Dyskeratosis congenita TINF2 Germline mutation Novel mutation Short telomeres Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

引用

World Journal of Psychiatry 2017年第2期7卷 106-113页

作者： Felipe josé Nascimento Barreto Frederico Duarte Garcia Paulo Henrique Teixeira Prado Paulo Marcos Brasil Rocha Nádia Souza Las Casas Felipe Barbosa Vallt Humberto correa Maila Castro Lourenco Neves Department of Mental Health Federal University of Minas Gerais Postgraduation Program in Molecular Medicine School of Medicine Federal University of Minas Gerais Molecular Medicine National Institute of Science and Technology Avenida Alfredo Balena Federal University of Minas Gerais Hospital das Clínicas Federal University of Minas Gerais

AIM To identify factors associated with depressive symptoms among inpatients with cardiovascular disease(CVD). METHODS This is a cross-sectional study performed in a subsample of a large cross-sectional research that investigated affective disorders and suicide behaviour among inpatients hospitalized in non-surgical wards of the University Hospital of the Federal University of Minas Gerais from November 2013 to October 2015. Sociodemographic and clinical data were obtained through a structured interview and medical record review. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Scale, with scores ≥ 8 considered as positive screening for depression. We used the Fagestr?m Test for Nicotine Dependence to characterize nicotine dependence. For assessing resilience and early-life trauma, we used the raw scores of the Wagnild and Young Resilience Scale and Childhood Trauma Questionnaire, *** At endpoint, we included 137 subjects. Thirty-eight(27.7%) subjects presented depressive symptoms and nine(23.7%) of those were receiving antidepressant treatment during hospitalization. The female sex; a lower mean educational level; a greater prevalence of previous suicide attempts; a higher level of pain; a higher prevalence of family antecedents of mental disorders; a lower resilience score; and higher childhood trauma score were the factors significantly associated with screening positive for major depression(P < 0.05). Multivariate analysis demonstrated that the factors independently associated with the depressive symptoms were a higher childhood trauma severity(OR = 1.06; P = 0.004); moderate to severe nicotine dependence(OR = 8.58; P = 0.008); and the number of previous hospital admissions(OR = 1.11; P = 0.034). The obtained logistic model was considered valid, indicating that the three factors together distinguished between having or not depressive symptoms, and correctly classified 74.6% of individuals in the ***

关键词： Inpatients Depression Cardiovascular disease Depressive symptoms General hospital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Angina bullosa hemorrhagica an enigmatic oral disease

引用

World Journal of Stomatology 2015年第1期4卷 1-7页

作者： Javier Alberdi-Navarro María Luisa Gainza-Cirauqui María prieto-Elías josé Manuel Aguirre-Urizar Oral Medicine and Oral and Maxillofacial Pathology Units Dental Clinic Service Master in Oral Pathology Department of Stomatology II UFI 11/25 University of the Basque Country/EHU48950 Leioa Spain Department of Dental Surgery Faculty of Dental Surgery University of Malta 2080 Msida Malta

Angina bullosa hemorrhagica(ABH) is an enigmatic oral disorder described for the first time by Badham in 1967 to define blisters with a hematic content in the oralcavity and oropharynx unrelated to any hematological, dermatological or systemic disease. The ABH is an uncommon disease of the oral cavity distinctively affecting adults, with the highest incidence over the 5th decade of life. This process is considered nowadays to have a multifactorial etiopathogenesis, where mild oral traumatisms can trigger the blisters in susceptible individuals. Certain association on the onset of the lesion with the chronic use of inhaled steroids and, more controversially, with triggering systemic disorders, such as, diabetes or hypertension has been described. Characteristically, the ABH blisters are acute and are located on the lining mucosa, more frequently on the soft palate. Usually, the lesions are solitary and rupture easily, resulting in a superficial ulceration that heals quickly without scarring. The histopathological analysis shows a subepithelial blister containing blood and direct immunofluorescence on the epithelium is negative. The differential diagnosis should consider all oral vesiculobullous disorders with hematic content, including mucocutaneos, hematological or cystic pathology. The diagnosis of ABH is clearly clinical, although the biopsy might be helpful on atypical or abnormally recurrent cases. The general prognosis of ABH is good and the treatment is symptomatic.

关键词： Angina Bullosa Hemorrhagica Traumatic Blister

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Species richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil

引用

Journal of Mountain Science 2023年第6期20卷 1526-1539页

作者： Morgana Maria DO CARMO BARBOSA Anderson FERREIRA PINTO MACHADO Andrea Karla ALMEIDA DOS SANTOS Raymundo joséDE Sá-NETO Michele MARTINS CORRêA Graduate Program in Environmental Sciences State University of Southwest BahiaUniversity Campus“Juvino Oliveira”BR 415km 0445700-000ItapetingaBahiaBrazil Secretary of Education of the State of Bahia Military Police College Eraldo TinocoBrasilia Avenue273Kadija45650-120Vitoria da ConquistaBahiaBrazil Mongoyós Herbarium Multidisciplinary Institute in HealthCampus Anísio TeixeiraFederal University of BahiaRua Hormindo Barros58Bairro Candeias45029-094Vitoria da ConquistaBahiaBrazil Department of Natural Sciences State University of Southwest BahiaEstrada do Bem Querers/nBairro Candeias45083-900Vitoria da ConquistaBahiaBrazil

The municipality of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest phytogeographic *** transition phytophysiognomy is seasonal forest and known locally as mata de cipó.In these phytophysiognomies there are lajedos,which are rock outcrops colonized by vegetation welladapted to extreme microclimatic variation and vegetation diversity is affected by the vegetation types of the surrounding *** to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the species richness and compare the similarity of the flora on four rock outcrops in Boa *** flora was surveyed during exploratory walks along lajedos between 2016 and *** total,162 species were identified on the Boa Nova *** flora has a composition and structure similar to semiarid outcrops,as well as endemic species that also occur in surrounding *** the proximity,a similarity index revealed there is floristic dissimilarity between the *** new occurrences were recorded for the region,five species are threatened with extinction(Aosa gilgiana,Ficus cyclophylla,Hippeastrum stigmovittatum,Pleroma caatingae and Trixis pruskii),and 43 species are common in anthropogenic *** reinforces the importance of actions to conserve these areas.

关键词： Ecotone Flora Inselberg Rock outcrops Semiarid Similarity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：