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Optimal Design of Hybr.d Micr.gr.d in Isolated Communities of Ecuador

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Jour.al of Moder. Power.Systems and Clean Ener.y 2024年第2期12卷 488-499页

作者： Luis A.Pesantes r.ben Hidalgo-León Johnny r.ngifo Miguel torres Jor.e Ar.gundi joséCor.ova-Gar.ia Luis F.Ugar.e Facultad de Ingenier.a en Electr.cidad y Computación of Escuela Super.or.Politécnica del Litor.l(ESPOL)Univer.ity GuayaquilEcuador Depar.ment of Electr.cal Engineer.ng at Univer.idad Técnica Feder.co Santa Mar.a SantiagoChile IEEE

In r.r.l ter.itor.es, the communities use ener.y sour.es based on fossil fuels to supply themselves with electr.city, which may addr.ss two main pr.blems: gr.enhouse gas emissions and high fuel pr.ces. Hence, ther. is an oppor.unity to include r.newable r.sour.es in the ener.y mix. This paper.develops an optimization model to deter.ine the optimal sizing, the total annual investment cost in r.newable gener.tion, and other.oper.ting costs of the components of a hybr.d micr.gr.d. By r.nning a k-means cluster.ng algor.thm on a meteor.logical dataset of the community under.study, the hour.y r.pr.sentative values become input par.meter. in the pr.posed optimization model. The method for.the optimal design of hybr.d micr.gr.d is analyzed in six oper.ting scenar.os consider.ng:(1) 24-hour.continuous power.supply;(2) load shedding per.entage;(3) diesel power.gener.tor.genset) cur.ailment;(4) the wor.t meteor.logical conditions;(5) the use of r.newable ener.y sour.es including batter. ener.y stor.ge systems(BESSs);and(6) the use of genset. A mathematical pr.gr.mming language(AMPL) tool is used to find solutions of the pr.posed optimization model. r.sults show that the total costs of micr.gr.d in the scenar.os that cover.100% of the load demand(without consider.ng the scenar.o with 100% r.newables) incr.ase by over.16% compar.d with the scenar.o with genset oper.tion limitation. For.the designs with power.supply r.str.ctions, the total cost of micr.gr.d in the scenar.o with load shedding is r.duced by over.27% compar.d with that without load shedding.

关键词： Batter. ener.y stor.ge system(BESS) isolated community micr.gr.d r.newable ener.y optimization

Multi-tissue tr.nscr.ptomics of a unique monozygotic discor.ant twin case of sever. pr.gr.ssive osseous heter.plasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alber.o Gomez-Car.alla Mar.a jose Cur.as-Tuala Sar. Pischedda Mir.am Cebey-Lopez jose Gomez-r.al Ir.ne r.ver.-Cale Jacobo Par.o-seco Xabier.Bello Sandr. Viz-Lasher.s Antonio Justicia-Gr.nde Julian Montoto-Louzao Alba Camino-Mer. Isabel Fer.eir.s-Vidal Maximo Fr.ga jose r.ntunez r.dolfo Gomez Feder.co Mar.inon-torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Tr.nslational Pediatr.cs and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Labor.tor.o de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Gr.up Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Depar.ment of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centr. de Investigacion Biomedica en r.d de Enfer.edades r.spir.tor.as(CIBEr.ES) MadridSpain

Pr.gr.ssive osseous heter.plasia(POH)is an ultr.-r.r. autosomal dominant disabling disor.er.char.cter.zed by heter.topic ossification(HO).It is caused by heter.zygous inactivating mutations in the GNAS(guanine nucleotide-binding pr.tein alpha-stimulating activity polypeptide)***,the molecular.mechanisms under.ying HO r.main poor.y *** a tr.atment for.POH is not yet available,the identification of the mechanisms dr.ving POH in affected tissues using gene expr.ssion may be of gr.at help to under.stand the molecular.basis of POH and develop new ther.peutic appr.aches.

关键词： stimulating dr.ving asi

Endoscopic ultr.sound-guided gastr.enter.stomy for.gastr.c outlet obstr.ction in Mexico

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Wor.d Jour.al of Sur.ical Pr.cedur.s 2024年第3期14卷 15-20页

作者： Massiel Madelin r.sar.o-Mor.l r.dr.go Soto-Solis Katia Picazo-Fer.er. Mir.am Idalia torres-r.iz joséAlber.o Estr.das-Tr.jillo Mar.o Alber.o Gallar.o-r.mír.z Ger.r.o Akr.m Dar.ich-del Mor.l Luis Ar.el Waller.González Depar.ment of Endoscopy Centro Médico Nacional“20 de Noviembre”ISSSTEMexico City 03229Mexico Depar.ment of Gastr.enter.logy HospitalÁngeles PedregalMexico City 10700Mexico Depar.ment of Endoscopy Centro Médico ABCMexico City 01120Mexico Depar.ment of Endoscopy Hospital General de México“Dr.Eduardo Liceaga”Mexico City 06720Mexico

BACKGr.UND Endoscopic ultr.sound-guided gastr.enter.stomy(EUS-GE)has r.cently emer.ed as an alter.ative tr.atment for.gastr.c outlet obstr.ction(GOO)in selected *** To r.por. the initial exper.ence of EUS-GE in patients with *** This study was a r.tr.spective,obser.ational,multicenter.study in which the data fr.m 10 patients who under.ent EUS-GE due to GOO between September.2021 and May 2023 wer. *** analyzed technical success,clinical success,adver.e events,and *** success was defined as adequate positioning and deployment of the *** success was defined as the patient’s ability to toler.te or.l intake without vomiting 7 d after.the *** adver.e events wer. *** Eleven pr.cedur.s in 10 patients with GOO wer. *** mean age of the patients was 67.5 year.(r.nge:56-77 year.).Malignant GOO was pr.sent in 9 *** success was achieved in 9/11 pr.cedur.s(82%).Among them,clinical success was achieved in 9 patients(100%).Adver.e events occur.ed in 1 patient(9%).The median sur.ival was 3 months(n=7;r.nge:1-8 months).CONCLUSION EUS-GE is a feasible ther.peutic option in the tr.atment of GOO.

关键词： Endoscopic ultr.sound-guided gastr.enter.stomy Gastr.c outlet obstr.ction Lumen apposing metal stent Inter.entional endoscopic ultr.sound Gastr.jejunostomy Duodenal stenting

Combined cell-based ther.py str.tegies for.the tr.atment of Par.inson's disease:focus on mesenchymal str.mal cells

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Neur.l r.gener.tion r.sear.h 2023年第3期18卷 478-484页

作者： Jannette r.dr.guez-Pallar.s Mar.a Gar.ía-Gar.ote Juan A.parga joséLuis Labandeir.-Gar.ía Labor.tor. of Cellular.and Molecular.Neur.biology of Par.inson´s Disease Research Center for Molecular Medicine and Chronic Diseases(CiMUS)IDISDepartment of Morphological SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain Networ.ing r.sear.h Center.on Neur.degener.tive Diseases(CIBEr.ED) MadridSpain

Par.inson’s disease is a neur.degener.tive condition char.cter.zed by motor.impair.ents caused by the selective loss of dopaminer.ic neur.ns in the substantia *** is an effective and well-toler.ted dopamine r.placement ***,levodopa pr.vides only symptomatic impr.vements,without affecting the under.ying pathology,and is associated with side effects after.long-ter. ***-based r.placement is a pr.mising str.tegy that offer. the possibility to r.place lost neur.ns in Par.inson’s disease *** studies of tr.nsplantation of human fetal ventr.l mesencephalic tissue have pr.vided evidence that the gr.fted dopaminer.ic neur.ns can r.inner.ate the str.atum,r.lease dopamine,integr.te into the host neur.l cir.uits,and impr.ve motor.*** of the limiting factor. for.cell ther.py in Par.inson’s disease is the low sur.ival r.te of gr.fted dopaminer.ic *** factor. could cause cell death of dopaminer.ic neur.ns after.gr.fting such as mechanical tr.uma,gr.wth factor.depr.vation,hypoxia,and *** factor. play an essential r.le in the sur.ival of gr.fted ***,dir.ct,timely,and contr.llable deliver. of neur.tr.phic factor. into the br.in faces impor.ant *** types of cells secr.te neur.tr.phic factor. constitutively and co-tr.nsplantation of these cells with dopaminer.ic neur.ns r.pr.sents a feasible str.tegy to incr.ase neur.nal *** this r.view,we pr.vide a gener.l over.iew of the pioneer.ng studies on cell tr.nsplantation developed in patients and animal models of Par.inson’s disease,with a focus on neur.tr.phic factor.secr.ting cells,with a par.icular.inter.st in mesenchymal str.mal cells;that co-implanted with dopaminer.ic neur.ns would ser.e as a str.tegy to incr.ase cell sur.ival and impr.ve gr.ft outcomes.

关键词： br.in r.pair cell r.placement co-gr.fts dopaminer.ic neur.ns fetal ventr.l mesencephalic tissue mesenchymal stem cells neur.l gr.fting neur.l tr.nsplantation neur.blasts neur.tr.phic factor.

Effect of Pr.tr.atment of Sulfide r.fr.ctor. Concentr.te with Sodium Hypochlor.te, Followed by Extr.ction of Gold by Pr.ssur. Cyanidation, on Gold r.moval

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Advances in Chemical Engineer.ng and Science 2013年第3期3卷 171-177页

作者： Alejandr. Valenzuela Jesús L. Valenzuela josé r. parga Depar.ment of Chemical Engineer.ng and Metallur.y University of Sonora Hermosillo México

The major.ty of the r.fr.ctor. gold and silver.occur. in occlusion in sulphides, then pr.cious metal dissolution is possible by fir.t oxidizing aur.fer.us sulfide concentr.te using sodium hypochlor.te-sodium-hydr.xide solution followed of pr.ssur. cyanidation of the oxidized concentr.te, for.the extr.ction of pr.cious metals. This pr.cess was conducted and evaluated under.cyanide and oxygen pr.ssur.. This ver.atile appr.ach offer. many advantages, including low temper.tur.s, low pr.ssur. and less costly mater.als of constr.ction than conventional pr.ssur. oxidation. In this study, the effect of oxygen pr.ssur., concentr.tion of sodium hypochlor.te, temper.tur., and initial pH, in pr.cious metals r.cover. and As r.moval wer. evaluated using a 24 factor.al design. Char.cter.zation of the or.s showed that pyr.te and ar.enopyr.te wer. the main miner.ls pr.sent on the concentr.te. The best r.sults for.gold extr.ction wer. obtained with oxygen pr.ssur. of 80 psi, 10% (w/w) sodium hypochlor.te, temper.tur. of 80℃, at pH = 13, and a constant stir.ing speed of 600 r.m. These conditions allowed an appr.ximated 60% of gold and 90% of silver.extr.ctions in 1 hr.

关键词： r.fr.ctor. Gold Concentr.te Hypochlor.te Oxidation Pr.tr.atment Pr.ssur. Cyanidation

Competition among r.r. ear.h elements on sor.tion onto six seaweeds

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Jour.al of r.r. Ear.hs 2021年第6期39卷 734-741,I0005页

作者： Joāo Pinto Mar.elo Costa Br.no Henr.ques joséSoar.s Mar.ana Dias Thainar. Viana Nicole Fer.eir. Car.os Vale joséPinheir.-torres Eduar.a Per.ir. Depar.ment of Chemistr. University of Aveiro3810-193 AveiroPortugal CESAM Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal LAQV-r.QUIMTE Department of Chemistry&Central Laboratory of AnalysisUniversity of Aveiro3810-193 AveiroPortugal CIIMAr.Inter.isciplinar. Centr. of Mar.ne and Envir.nmental r.sear.h MatosinhosPortugal N9VE-Natur. Ocean and ValueLdaPortoPortugal Centr.l Labor.tor. of Analysis University of Aveiro3810-193 AveiroPortugal

Sor.tion has been pr.posed as a pr.mising appr.ach towar.s a sustainable water.decontamination and r.cently to the r.cycling of r.r. ear.h elements(r.E).Although living seaweed have been shown to be capable of r.moving r.E fr.m contaminated solutions,no studies have yet compar.d the effects of r.E competition on sor.tion onto differ.nt gr.ups of *** effects wer. analysed in the pr.sent study by exposing six living seaweeds(Ulva lactuca,Ulva intestinalis,Fucus spir.lis,Fucus vesiculosus,Gr.cilar.a *** Osmundea pinnatifida)(3 g/L,fr.sh weight) to mono-element and multi-element solutions of Y,La,Ce,Pr.Nd,Eu,Gd,Tb and Dy(1 μmol/L).r.sults show a pr.fer.nce towar.s light r.E in mono-element solutions,which is r.duced when in competition with other.*** competitive effect is less pr.nounced in heavy r.E indicating that these ar. still able to bind to the macr.algae despite the pr.sence of competing *** to water.content(%),seaweed specific sur.ace ar.a(cm^(2)/g) shows to be an impor.ant factor.in the sor.tion of r.E,since lar.er.sur.ace ar.a is associated with higher.r.moval and lar.er.competitive effect.

关键词： Bioaccumulation Wastewater e-waste r.cover. r.moval Mar.ne macr.algae

OsDMI3,a Ca^(2+)/calmodulin kinase,integr.tes and amplifies H_(2)O_(2) and Ca^(2+) signaling in ABA-mediated r.sponses

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Molecular.Plant 2023年第6期16卷 968-970页

作者： Miguel-Angel torres Diego jose Ber.anga Centr. de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPM28223 Pozuelo de AlarconMadridSpain Depar.amento de Biotecnologia-Biologia Vegetal Escuela Técnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUPM28040 MadridSpain

Abscisic acid(ABA)is an impor.ant hor.one that r.gulates both plant development and str.ss r.sponses(Chen et al.,2020).In the absence of ABA,gr.up A Pr.TEIN PHOSPHATASE 2Cs(PP2Cs)inter.ct with and inhibit SUCr.SE-NON-FEr.ENTING 1-r.LATED KINASES 2(Snr.2s).When ABA is pr.sent,ABA r.ceptor.PYr.BACTIN r.SISTANCE 1 and PYr.BACTIN r.SISTANCE 1-LIKE Pr.TEINS bind to and inhibit PP2Cs,allowing phosphor.lation and activation of Snr.2s that,in tur.,phosphor.late downstr.am tar.ets,such as tr.nscr.ption factor.,ion channels,and tr.nspor.er.(Figur. 1).

关键词： Snr.2 Figur.

Methionine adenosyltr.nsfer.ses in liver.cancer

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Wor.d Jour.al of Gastr.enter.logy 2019年第31期25卷 4300-4319页

作者： Ben Mur.ay Lucia Bar.ier.torres Wei Fan joséM Mato Shelly C Lu Division of Digestive and Liver.diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States CIC bioGUNE Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(Ciberehd)TechnologyPark of BizkaiaDerio 48160BizkaiaSpain

Methionine adenosyltr.nsfer.ses(MATs)ar. essential enzymes for.life as they pr.duce S-adenosylmethionine(SAMe),the biological methyl donor.r.quir.d for.a plethor. of r.actions within the *** systems expr.ss two genes,MAT1A and MAT2A,which encode for.MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,r.spectively.A thir. gene MAT2B,encodes a r.gulator. subunit known as MATβwhich contr.ls the activity of MATα***1A,which is mainly expr.ssed in hepatocytes,maintains the differ.ntiated state of these cells,whilst MAT2A and MAT2B ar. expr.ssed in extr.hepatic tissues as well as non-par.nchymal cells of the liver.e.g.,hepatic stellate and Kupffer.cells).The biosynthesis of SAMe is impair.d in patients with chr.nic liver.disease and liver.cancer.due to decr.ased expr.ssion and inactivation of MATα1.A switch fr.m MAT1A to MAT2A/MAT2B occur. in multiple liver.diseases and dur.ng liver.gr.wth and dediffer.ntiation,but this change in the expr.ssion patter. of MATs r.sults in r.duced hepatic SAMe *** of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular.car.inoma(HCC)to elucidate a var.ety of mechanisms by which MAT pr.teins dysr.gulation contr.butes to liver.*** incr.asing volume of wor. indicates that MATs have SAMe-independent functions,distinct inter.ctomes and multiple subcellular.*** we aim to pr.vide an over.iew of MAT biology including genes,isoenzymes and their.r.gulation to pr.vide the context for.under.tanding consequences of their.*** will highlight r.cent br.akthr.ughs in the field and under.cor. the impor.ance of MAT’s in liver.tumor.genesis as well as their.potential as tar.ets for.cancer.ther.py.

关键词： Methionine adenosyltr.nsfer.ses S-adenosylmethionine Liver cancer Hepatocellular car.inoma Cholangiocar.inoma Biomar.er. Ther.peutic tar.ets

Copper.and Cyanide r.cover. in Cyanidation Effluents

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Advances in Chemical Engineer.ng and Science 2011年第4期1卷 191-197页

作者： josé r. parga Jesús L. Valenzuela Héctor.Mor.no Jaime E. Pér.z 不详

Cyanidation is the main pr.cess for.gold and silver.r.cover. fr.m its or.s. In this study, a pr.cess is pr.posed to r.cover.copper.and cyanide fr.m bar.en solutions fr.m the Mer.ill-Cr.we cementation pr.cess with zinc dust. This technology is based on inducing nucleated pr.cipitation of copper.and silver.in a ser.entine r.actor. using sodium sulfide as the pr.cipitator. and sulfur.c acid for.pH contr.l. r.sults show that pH value has a significant effect on copper.cyanide r.moval efficiency, and it was deter.ined the optimal pH r.nge to be 2.5 - 3. At this pH value, the copper.cyanide r.moval efficiency achieved was up to 97 and 99%, when copper.concentr.tion in the influent was 636 and 900 ppm. r.spectively. In this pr.cess (sulphidization-acidification-thickening-HCN r.cycling), the cyanide associated with copper.cyanide complexes, is r.leased as HCN gas under.weakly acidic conditions, allowing it to be r.cycled back to the cyanidation pr.cess as fr.e cyanide. Cyanide r.cover. was 90%. Finally, this pr.cedur. was successfully r.n at Miner. William in México.

关键词： Pr.cipitation Cyanide r.moval Copper r.cover. Cyanidation