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Expression of Toll-Like Receptor-2 and -4 in Amniochorion Membranes of Preterm Delivery in the Presence of Histologic Chorioamnionitis

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Open Journal of Obstetrics and Gynecology 2014年第14期4卷 857-863页

作者： Natália Prearo Moco Laura Fernandes Martin jossimara Polettini Ana Carolina pereira josé Carlos Peracoli Márcia Guimaraes da Silva Department of Pathology Botucatu Medical School (FMB) Sao Paulo State University (UNESP) Botucatu Brazil Department of Gynecology and Obstetrics Botucatu Medical School (FMB) Sao Paulo State University (UNESP) Botucatu Brazil

Expression of Toll-like receptors at the maternal-fetal interface during normal and complicated pregnancies has aroused interest in the last few years. However, despite the importance of TLR-2 and TLR-4, which recognizes most microorganisms presenting in the amniotic cavity infections associated with prematurity, comparison of the expressions of these receptors is rare in the literature. Thus, the purpose of this study was to compare the gene expression between TLR-2 and TLR-4 in amniochorion membranes of pregnant women with preterm delivery in the presence of histologic chorioamnionitis (HCA). Amniochorion membranes were collected from 40 pregnant women with preterm delivery;20 presented HCA and 20 did not. Fragments of the membranes were submitted to total RNA extraction, followed by cDNA production by reverse transcription. Real time quantitative PCR was used to quantify the gene expression of the TLRs. mRNA concentrations between TLR-2 and TLR-4 were compared using the nonparametric Mann-Whitney test. TLR-2 expression was higher than TLR-4 expression in the presence of HCA. No difference was observed between TLR-2 and TLR-4 expression in membranes in the absence of inflammatory infiltrate. In conclusion, amniochorion membranes express TLR-2 and TLR-4 and higher TLR-2 expression in the presence of histologic chorioamnionitis suggests that microorganisms recognizable by TLR-2 play an important role in the physiopathology of preterm labor.

关键词： Preterm Labor Pregnancy Complications Innate Immunology TLR-2 TLR-4

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： josé Carlos Rodrigues Nascimento Lianna C pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and Surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of Surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical School Royal Free CampusLondon NW32PFUnited Kingdom Department of Specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

Plant Composition of Skuas Nests at Hennequin Point, King George Island, Antarctica

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American Journal of Plant Sciences 2012年第5期3卷 688-692页

作者： Margéli pereira de Albuquerque Filipe de Carvalho Victoria Adriano Luís Schünemann Jair Putzke Ricardo josé Gunski Suzana Seibert Maria Virginia Petry Antonio Batista pereira Federal University of Pampa Campus Sao GabrielRio Grande do SulBrazil National Institute of Science and Technology Ant-arctic for Environmental Research Sao GabrielBrazil University of Santa Cruz do Sul Santa Cruz do SulBrazi University of Vale do Rio dos Sinos Sao LeopoldoBrazil

We investigate the plant composition in the Skuas nest at Hennequin Point, located in the Admiralty Bay Area, King George Island, Antarctica. Sample of 61 activity nests were analyzed. 21 plant and lichenized fungi species were found in the nest composition, being the mosses Sanioniauncinata (Hedw.) Loeske and Polytrichastrumalpinum (Hedw) G. S. Smith the most frequent species found in the Skuas nests. Usneaantarctica Du Rietz was the most frequent lichen and the grass Deschampsiaantarctica Desv was the most frequent flowering plant found in the nests. These results contribute for the environmental menagement of the Admiralty Bay area research activities.

关键词： Plant Communities Sea Bird Nests Mosses Lichen

Enhancing Nutrient Use Efficiency Using Zeolites Minerals—A Review

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Advances in Chemical Engineering and Science 2016年第4期6卷 295-204页

作者： Alberto Carlos de Campos Bernardi josé Carlos Polidoro Marisa Bezerra de Melo Monte Elaine Inácio pereira Cauê Ribeiro de Oliveira Kulasekaran Ramesh Embrapa Pecuaria Sudeste Sao Carlos Brazil Embrapa Solos Rio de Janeiro Brazil Centro de Tecnologias Minerais (CETEM) Rio de Janeiro Brazil Embrapa Instrumentacao Sao Carlos Brazil ICAR-Indian Institute of Soil Science Bhopal India

On tropical soils, liming and balanced nutrient supply are essential to ensure high crop yield and quality. An adequate agronomic nutrient management should be a balanced nutrition and fertilizers are the key factor on supplying nutrients. Urea is the most commonly used fertilizer-N source, despite potential losses by NH3 volatilization. Thus, new fertilizers technologies are needed to support the increasing demand and avoid the low N use efficiency (NUE). The reduction of NH3-N volatilization can be achieved by the use of natural aluminosilicates with nitrogenous fertilizer materials. This review consolidates the current status on the subject and the experience with the application of aluminosilicates as a slow release plant-nutrient fertilizer. Volatilization losses of nitrogenous fertilizers on the soil surface could be reduced with addition of natural aluminosilicates. Clay minerals (zeolites) are widely used in many countries to reduce NH3 volatilization from amide N fertilizers, such as urea, besides several organic forms of nitrogenous sources. The reduction in ammonia losses by volatilization and the increased efficiency of N utilization and slow release nature of urea-zeolite mixtures when urea is used together with aluminosilicates was demonstrated in laboratory, greenhouse and field experiments with different crops and environments. These results indicate that aluminosilicates minerals used with urea mineral fertilizer can enhance the efficiency of this source by improving the nitrogen use through the control of retention of ammonium ion, contributing to increasd N uptake and crop yields.

关键词： Zeolite Stilbite Slow-Release N-Losses Volatalization

Autoimmune hepatitis in a patient infected by HIV-1 and under highly active antiretroviral treatment:Case report and literature review

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World Journal of Immunology 2014年第3期4卷 194-198页

作者： Marta Casal Moura Edite pereira Vítor Braz Catarina Eloy Joanne Lopes Fátima Carneiro josé Paulo Araújo Faculdade de Medicina da Universidade do Porto 4200-319 PortoPortugal Servico de Medicina Interna Centro Hospitalar de Sao Joao4200-319 PortoPortugal Serviao de Anatomia Patológica Centro Hospitalar de Sao Joao4200-319 PortoPortugal

Liver disease has recently been described as an im-portant cause of morbidity and mortality in patientsinfected with human immunodeficiency virus （HIV）.Liver test changes are useful surrogates of the burdenof liver disease. Previous studies have shown that trans-aminase elevations are frequent among these *** cause of those changes is harder to establish inHIV-patients. We present a 61-year-old caucasian male,diagnosed with HIV type 1 infection since 1998, underhighly active antiretroviral treatment （HAART）, withvirological suppression and immunological *** presented in a follow-up laboratory workup highvalues of transaminases, arthralgia at the hip joints and hepatomegaly. Liver function tests were normal. Theantibodies to hepatitis viruses were negative. However,autoimmune study and liver biopsy were compatible with autoimmune hepatitis （AIH）. The AIH is a rare di-agnosis in HIV-infected patients perhaps because the elevation of transaminases and changes in liver function tests are often associated to HAART or to other possible liver diseases, namely viral hepatitis and non-alcoholic steatohepatitis. The diagnosis may be underestimated. There are no specifc recommendations available for the treatment of HIV-associated AIH although the immuno-supression with slower tapering seems the most reason-able approach.

关键词： Autoimmune hepatitis Human immunode-fciency virus type 1 Highly active antiretroviral treat-ment Liver tests Liver biopsy

Morphology Characterization and Kinetics Evaluation of Pitting Corrosion of Commercially Pure Aluminium by Digital Image Analysis

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Materials Sciences and Applications 2012年第5期3卷 287-293页

作者： Marinalda C.pereira josé W.J.Silva Heloisa A.Acciari Eduardo N.Codaro Luis R.O.Hein Department of Physics and Chemistry Sao Paulo State UniversitySao PauloBrazil Department of Materials and Technology Sao Paulo State UniversitySao PauloBrazil

The pit morphology and growth kinetics of commercially pure aluminium in naturally aerated NaCl solutions were studied using an image processing method based on reflected light microscopy. In order to distinguish between pits and pre-existing cavities, metallographic examination and statistical analysis were carried out before and after corrosion testing. The results show that the pit shapes and sizes are more dependent on the immersion time than the chloride concentration. Pits are predominantly hemispherical, but they undergo reasonable geometric transitions associated with increased immersion time and occur without significant depth variation. The role of chloride ions is more closely associated with the pit nucleation phenomenon.

关键词： Aluminium Alloys Pitting Corrosion Morphology Characterization NaCl Solution Image Processing

Cultivation of “Roxo de Valinhos” Fig Tree in Different Plant Densities for Production of Green Figs for Industry in the Region of Campo Das Vertentes-MG

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Agricultural Sciences 2018年第9期9卷 1097-1106页

作者： Paulo Márcio Norberto Angelo Albérico Alvarenga joséClelio de Andrade Filipe Almendagna Rodrigues Lair Victor pereira Emerson Dias Goncalves Company of Farming Research of Minas Gerais—EPAMIG LavrasBrazil Federal University of Lavras—UFLA LavrasBrazil

The objective of this work was to study the effect of different planting densities on the development and production of “Roxo de Valinhos” green figs for industry, in the Campo das Vertentes-MG region. The experiment was installed at the Risoleta Neves Experimental Field—CERN/EPAMIG. The plants used were three years old and were arranged in three randomized blocks, subject to three different planting densities, with spacings ranging from 1 m (4000 plants·ha-1), 1.5 m (2666 plants·ha-1), and 2 m (2000 plants·ha-1) between plants in the planting line and 2.5 m between row for all planting densities. The average length of the branches (m), average number of fruits per branch, average number of fruits per plant, average weight of fruits, average yield per plant and the average yield per hectare (kg) were evaluated. It was verified that, there were no significant differences in the length of branch and in the average weight of fruit, in the three densities of fig tree planting. (4000 plants·ha-1), the average number of fruits per branch (7.5), per plant (55.87) and yield per plant (878.93 kg) were lower, however. The average yield per hectare (3515.73 kg) was higher than in other growing densities. It is concluded that, the higher density of plants (4000 plants·ha-1), provides the highest productivity per area, without damages to the quality of the fruits.

关键词： Planting Densities Agroindustry Ficus carica L.

Effect of Zn Sputtering Rate on the Morphological and Optical Properties of ZnO Films

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Materials Sciences and Applications 2013年第12期4卷 802-807页

作者： Michel Chaves Erica pereira da Silva Steven Frederick Durrant Nilson Cristino da Cruz Paulo Noronha Lisboa-Filho josé Roberto Ribeiro Bortoleto Technological Plasmas Laboratory Sao Paulo State University-UNESPSorocabaBrazil Group of Advanced Materials Sao Paulo State University-UNESPBauruBrazil

Zinc oxide (ZnO) thin films were deposited onto glass substrates by reactive radiofrequency (RF) magnetron sputtering using a metallic zinc target. Optical emission spectroscopy (OES) was used to monitor and control the Zn sputtering rate for the deposition of the ZnO films. Film thicknesses ranged from 350 to 750 nm. Optical transmittances greater than 80% were observed in the wavelength interval from 450 nm to 650 nm. The energy gap of the films remained constant at (3.28 ± 0.01) eV. The surface morphology was found to be homogeneous with well-distributed structures. Surface roughness was dependent on the Zn sputtering rate, indicating that greater densities of Zn atoms increase the surface diffusion. X-ray diffraction (XRD) analysis showed that the ZnO films were polycrystalline with a hexagonal wurtzite structure and preferential growth along the (002) plane.

关键词： ZnO Thin Films Surface Morphology Optical Properties OES

Multicentric Cervical Paraganglioma. Rare Case of Five Locations in One Patient. Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 82-88页

作者： josé Francisco de Sales Chagas Maria Beatriz Nogueira Pascoal josé Luis Braga de Aquino Luis Antonio Brandi Filho Fernanda Fruet Douglas Alexandre Rizzanti pereira Amilcar de Castro Matos Thalita Ruba Fernanda Callegari Department of Pathology School of Medicine Catholic Uni-versity of Campinas Campinas Brazil Head and Neck Service School of Medicine Catholic University of Campinas Campinas Brazil School of Medicine Catholic University of Campinas Cam-pinas Brazil

Objective: To report a case of a multiple paraganglioma with 5 concurrent locations and also describe a complication not found in the literature, spontaneous tumor bleeding. Introduction: The paragangliomas are mostly benign and more frequent in women. Can be multiple, and these are considered as the most likely source of familial origin (30%-35%). The multicentric lesions can occur at different life stages not being necessarily simultaneous, a fact that prevents image exam research to be conclusive for tumor presence or absence. In this way the examination of the family members of patients, specially young ones, diagnosed with multicentric tumors may lead to negative results which doesn’t meant that the disease can be developed at a later time period. Therefore routine examination is not justifiable when symptoms relative to tumor presence are not present. Case report: A female patient of 32 years old complaining of tinnitus and diagnosed with five paragangliomas (jugulo-timpanic, bilateral carotid body and bilateral brachiocephalic trunk) through imaging studies. She reported suffering relatives of paragangliomas. Conclusion: The paper reports a rare case and perhaps unique in the literature, multiple paraganglioma with five locations and discusses difficult choice of treatment and complications.

关键词： Glomus Tumor Paraganglioma Glomus Jugulare Carotid Body Tumor Postoperative Complications