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Treatment of methicillin-resistant Staphylococcus aureus infections:Importance of high vancomycin minumum inhibitory concentrations

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World Journal of Clinical Infectious Diseases 2015年第2期5卷 14-29页

作者： Alejandra Morales-Cartagena Antonio Lalueza Francisco López-Medrano Rafael San Juan josé maría aguado Infectious Diseases Unit Department of MedicineUniversity Hospital 12 de Octubre

Staphylococcus aureus(SA) infections remain a major cause of morbidity and mortality despite the availability of numerous effective anti-staphylococcal *** organism is responsible for both nosocomial and community-acquired infections ranging from relatively minor skin and soft tissue infections to life-threateningsystemic *** increasing incidence of methicillin-resistant strains has granted an increasing use of vancomycin causing a covert progressive increase of its minimum inhibitory concentration(MIC)(dubbed the MIC "creep").In this way,the emergence of vancomycinintermediate SA(VISA) strains and heteroresistantVISA has raised concern for the scarcity of alternative treatment *** alarming,though fortunately less frequent,is the emergence of vancomycin-resistant *** strains show different mechanisms of resistance but have similar problems in terms of therapeutic ***,various debate issues have arisen regarding the emergence of SA strains with a minimum inhibitory concentration sitting on the superior limit of the sensitivity range(i.e.,MIC = 2 μg/mL).These strains have shown certain resilience to vancomycin and a different clinical behaviour regardless of vancomycin use,both in methicillin-resistant SA and in methicillin-sensitive *** aim of this text is to revise the clinical impact and consequences of the emergence of reduced vancomycin susceptibility SA strains,and the different optimal treatment options known.

关键词： Staphylococcus aureus Minimum inhibitory concentration Methicillin-resistant Staphylococcus aureus Vancomycin-intermediate Staphylococcus aureus Heteroresistant-vancomycin-intermediate Staphylococcus aureus Vancomycin resistant Staphylococcus aureus

Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina aguado Sara Badesso josémartínez-Hernández Alejandro martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-martínez mar Cuadrado-Tejedor Ana García-Osta Rafael Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

Benzyl Amino Purine and Gibberellic Acid Coupled to Nitrogen-Limited Stress Induce Fatty Acids,Biomass Accumulation,and Gene Expression in Scenedesmus Obliquus

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 515-531页

作者： Hans Christian Correa-aguado Gloria Viviana Cerrillo-Rojas Alejandro Rocha-Uribe Ruth Elena Soria-Guerra joséFrancisco Morales-Domínguez Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México Instituto Politécnico Nacional Unidad Profesional Interdisciplinaria de Ingeniería Campus ZacatecasBlvd.del Bote 202Cerro del Gato Ejido La EscondidaCol.Ciudad AdministrativaZacatecasZAC 98160Mexico

The need for renewable energy sources makes microalgae an essential feedstock for biofuels *** molecular aspects and the response to nitrogen(N)-limited conditions with a phytohormone stimulus in microalgae have been slightly *** this work,Scenedesmus obliquus was used as a study model to analyze the effect of benzyl amino purine(BAP)and gibberellic acid(GA)coupled to nitrogen limitation on cell growth,biomass and fatty *** selected 10^(-5)M BAP increased the biomass by 1.44-fold,and 10^(-6)M GA by *** total lipids also increased by 2.8 and 1.11-fold,*** 10^(-5)M BAP and 10^(-6)M GA addition to *** cultures at different initial nitrogen percentages(N-0,N-25,and N-50)showed a significant increase in cell growth and biomass productivity compared to the unstimulated *** N-0 and GA N-0 produced the highest lipid yields with 55%and 50%,*** lipid profile analysis revealed an increase,particularly in C18:1 and C16:0 fatty *** expression analysis showed an over-expression of acyl carrying protein(ACP),stearoyl-ACP desaturase(SAD),fatty acid acyl-ACP thioesterase(FATA),and diacylglycerol acyltransferase(DGAT)genes,which were mainly induced by nitrogen ***,BAP and GA produced a significant over-expression on these genes in the N-replete *** study shows that BAP and GA,coupled to N limitation stress,can be used to increase the biomass and lipid production in *** for sustainable biofuels.

关键词： Biodiesel gene expression lipids microalgae nitrogen deficiency phytohormones

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减缩剂对减少混凝土塑性收缩裂缝的影响

膨胀剂与膨胀混凝土 2009年第4期 7-12页

作者： josé Mora-Ruacho Ravindra Gettu Antonio aguado 贾福杰

暴露在高蒸发速率环境下的新拌混凝土很容易产生塑性收缩裂缝,特别是表面积与体积的比率很大的时候,目前的研究都证明了,减少拌合水的表面张力是减少塑性裂缝的一种很有效的办法。我们将传统混凝土和高强混凝土掺加超塑化剂和减缩剂,在... 详细信息

暴露在高蒸发速率环境下的新拌混凝土很容易产生塑性收缩裂缝,特别是表面积与体积的比率很大的时候,目前的研究都证明了,减少拌合水的表面张力是减少塑性裂缝的一种很有效的办法。我们将传统混凝土和高强混凝土掺加超塑化剂和减缩剂,在塑性阶段暴露干燥,测量毛细孔压、沉降、内部温度和蒸发速率,结果显示减缩剂对减少混凝土甚至是高强混凝土的塑性裂缝都是很有效的,这主要由于蒸发速率减少,原因是孔中弯液面的发展导致毛细管压的峰值出现延迟和较低的沉降率。

关键词：干缩新拌混凝土耐久性收缩外加剂