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New Rotative Radiofrequency Technology: A multicenter Retrospective Study on Efficacy and Safety

Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 69-83页

作者： josé Antonio Ferrández martínez Gregorio Viera mármol Fabrizio Vignoli Joanet Perera Agustin Blanch mara Suárez Alicia Robledo Jorge Reyna Vargas Lamas Sinclair Barcelona Spain Studio Vignoli Bologna Italy Clinica Perla medic Alicante Spain Dr. Agustin Blanch Clinica Barcelona Spain Intek medical Technology S.L.U. Barcelona Spain

Background: Non-ablative radiofrequency (RF) technology is widely used for the treatment of signs of aging, skin laxity, localized fat and cellulite. However, many RF devices suffer from technical limitations that make the results highly dependent on the user’s experience or clinical limitations that compromise safety, efficacy and comfort. Objective: To evaluate the efficacy and safety of a novel semi-automatic non-ablative RF device for skin tightening, body shaping and cellulite reduction. materials and methods: A retrospective multicenter study was performed using a novel rotative RF device with temperature and impedance control (Sculpt&Shape®, Sinclair, Spain). 58 subjects underwent a minimum of 4 treatments every 1-2 weeks. A total of 120 treatments (56.7% body and 43.3% facial) and 1034 sessions were performed. Efficacy was evaluated by 3 researchers using the Global Aesthetic Improvement Scale (GAIS) and anthropometric measurements were collected. Subject and practitioner satisfaction were recorded. Safety was evaluated by analyzing the perception of pain during the treatment and the side and adverse effects immediately after treatment and over the next 48 hours. Results: Between 25% and 50% improvement was achieved according to the GAIS. Statistically significant (p minal fold reduction of 5.1 mm and circumference reduction of 32.0 mm, 16.4 mm and 13.9 mm were recorded for the abdomen, legs and arms, respectively. 77.5% of subjects and 94.9% of practitioners were either satisfied or very satisfied. minor adverse effects were found in 0.97% of the sessions. Conclusion: This novel semi-automatic rotative RF device has been found to provide treatments that are effective, safe and comfortable for both practitioners and subjects. .

关键词： Rotative Radiofrequency RF Cellulite Skin Tightening Body Shaping

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High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： michael Ehret Jakub Cikhardt Philip Wykeham Bradford Iuliana-mariana Vladisavlevici Tomas Burian Diego de Luis jose Luis Henares Rubén Hernández martín Jon Imanol Apiñaniz Roberto Lera joséAntonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

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Use of absorbable meshes in laparoscopic paraesophageal hernia repair

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World Journal of Gastrointestinal Surgery 2019年第10期11卷 388-394页

作者： bernabé m Quesada Adelina E Coturel Department of Surgery Cosme Argerich Hospital

Paraesophageal hernia(PEH)repair is one of the most challenging upper gastrointestinal *** high rate of recurrence is due mostly to the low quality of the crura and size of the hiatal *** an attempt to diminish the recurrence rates,some clinical investigators have begun performing meshreinforced cruroplasty with nonabsorbable meshes like polypropylene or *** main problem with these materials is the occurrence,in some patients,of serious mesh-related morbidities,such as erosions into the stomach and the esophagus,some of which necessitate subsequent esophagectomy or *** meshes can be synthetic or biological and were introduced in recent years for PEH repair with the intent of diminishing the recurrence rates observed after primary repair alone but,theoretically,without the risks of morbidities presented by the nonabsorbable *** current role of absorbable meshes in PEH repair is still under debate,since there are few data regarding their long-term efficacy,particularly in terms of recurrence rates,morbidity,need for revision,and quality of *** this opinion review,we analyze all the presently available evidence of reinforced cruroplasty for PEH repair using nonabsorbable meshes(synthetic or biological),focusing particularly on recurrence rates,mesh-related morbidity,and long-term quality of life.

关键词： Paraesophageal hernia Laparoscopy mesh Absorbable Biological

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Advanced Oxidation Wastewater Treatment of 3 LPS of an Avocado Sauce Company,at morelia,michoacan,mexico

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Journal of Environmental Science and Engineering(A) 2024年第5期13卷 151-155页

作者： Alfonso Espitia-Cabrera Francisco Javier Barrón-Santos joséL.méndez-Antonio Héctor m.Alemán-Vásquez Omar G.Color-Vázquez Saneamiento y Planeación Ambiental Azcapotzalco CDMX 02200México Energy Department Metropolitan Autonomous University Azcapotzalco CampusCDMX 02200Mexico Environmental System Engineering Department Environmental Engineering AcademyNational School of Biological SciencesNational Polytechnic InstituteCiudad de MéxicoCDMX 07738México Planta Congeladora y Empacadora Nacional Morelia 58190MichoacánMéxico

This paper describes the wastewater treatment of 3 liters per second of capacity of discharges of capacity,from the avocado washed,as well as the production of avocado *** were pretreated with a grease and oil trap and contained small amounts of oil and grease,dissolved and total solids,organic matter and trace of organic and inorganic compounds from the vitamins and minerals of *** treatment train is located in an small surface and the train is integrated with coagulation in line with alumina in a static mixer,rapid filtration in two steps,double advanced oxidation with ozone and heterocyclic photocatalysis with a nanofilm of zinc oxide as,photocatalyzer and final adsorption of refractory compounds with activated *** treated wastewater meets the environmental regulation to urban sewerage discharges of the city,according to the results of a mexican Certified Laboratory.

关键词： Wastewater primary treatment rapid filter performance static mixer

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： matheus Truccolo michalczuk Larisse Longo melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari joséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIm07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(mASLD).AIm To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(mmp2),and metalloproteinases-9(mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(map1 Lc3b),and p62/sequestosome-1(p62/SQSTm1)-*** with controls,map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pm1 was lower in HCC compared to RIF(Pmmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pm1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(PmiR-26b was lower in HCC compared to RIF,and the inverse was observed for miR-224(Pmong groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma metabolic dysfunction-associated steatotic liver disease Rifaximin

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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-mendívil maría Pérez-Zabalza Antoni Oliver-Gelabert josémaría Vallejo-Gil Javier Fañanás-mastral manuel Vázquez-Sancho Javier AndréBellido-morales Alexánder Sebastián Vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental medicine and Biology of Cuyo(ImBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

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考古植物遗存中的碳稳定同位素

东方考古

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东方考古 2024年第1期 146-179页

作者： Juan Pedro Ferrio mònica Aguilera Jordi Voltas josé Luis Araus 褚黎明阿拉贡研究与发展机构(ARAID) 阿拉贡农业研究与技术中心(CITA)森林资源部 CTFC-AGROTECNIO联合研究单位莱里达大学农作物与森林科学系巴塞罗那大学生物学院植物生理学部综合作物生理生态学组农业技术研究中心(AGROTECNIO) 山东大学文化遗产研究院

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面... 详细信息

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面的线索。本文全面介绍了分析植物遗存的碳稳定同位素在考古学中的潜在应用。在对决定植物碳稳定同位素特性的广泛生理和环境因素进行解释之后,对最相关的方法问题进行了讨论。其中,本文对样品的前处理方式、与大气变化有关的不确定性以及植物遗存在土壤中沉积前后经历的潜在变化进行了评述。以选定的案例研究为例,为碳稳定同位素在考古学中的应用提供了方法和概念上的线索。同时,也强调了依旧存在的挑战。

关键词：碳稳定同位素植物考古环境农业

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Expanding the Boundaries of the Chemical Space of DNA methyltransferase 1 modulators

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Computational molecular Bioscience 2024年第1期14卷 1-16页

作者： massyel S. martínez-Cortés Diana L. Prado-Romero josé L. medina-Franco DIFACQUIm Research Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltransferase 1 (DNmT1), one of the main epigenetic targets, is involved in the duplication of the DNA methylation pattern during replication, and it is essential for proper mammalian development. Small molecule DNmT1 modulators are attractive for biochemical epigenetic studies and have the potential to become drugs. So far, more than five hundred small molecules have been reported as DNmT1 inhibitors. However, only a limited number of DNmT1 activators have been disclosed because, at least in part, DNmT1 activators are typically regarded as negative data in virtual screening campaigns or optimization projects. This manuscript aims to report the chemical structures and biological activity of small molecules that increase the enzymatic activity of DNmT1. Results of the biochemical experimental assays are discussed. It was found that small molecule activators have a large variety of chemical scaffolds but share pharmacophore features. Visual analysis of the chemical space and multiverse based on molecular fingertips supported that activators are structurally diverse. This is the first report of eight small molecules that increase the enzymatic activity of DNmT1 by more than 400% in an enzymatic-based assay. The outcome warrants further investigation of the epigenetic activity of the compounds in a counter-screen assay, e.g., cell-based and in vivo context.

关键词： Chemical multiverse Chemoinformatics Epigenetics Pharmacophore Hypothesis Small molecules

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High performance novel flexible perovskite solar cell based on a low-cost-processed ZnO:Co electron transport layer

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Nano Research 2020年第9期13卷 2546-2555页

作者： Feriel Bouhjar Lotfi Derbali bernabémari Institut de Disseny i Fabricació(IDF)-Departament de Fisica Aplicada Universitat Politecnica de Valenciciy Cami de Vera s/n46022 ValenciaSpain Photovoltaic Laboratory Research and Technology Centre of Energy(CRTEn)Borj-Cedria Science and Technology Parky BP 952050 Hammam-LifTunisia Laboratory of Semiconductors Nanostructures and Advanced TechnologyResearch and Technology Center of Energy(CRTEn)Borj-Cedria Science and Technology ParkBP 952050 Hammam-LifTunisia Department of Physics College of Sciences and HumanitiesAl QuwayiyahShaqraa UniversityAl QuwayiyahSaudi Arabia

In this work,high quality uniform and dense nanostructured cobalt-doped zinc oxide(ZnO:Co)films were used as electron-transport layers in CH3NH3Pbl3-based planar heterojunction perovskite solar cells(PSCs)on a flexible conductive *** photo catalytically active ZnO:Co films were prepared by a low cost hydrothermal process using the aqueous solution of zinc nitrate hexahydrate,hexamethylenete-tramine and cobalt(II)nitrate ***:Co films were deposited on indium tin oxide(ITO)covered polyethylene terephthalate(PET)flexible *** growth was controlled by maintaining the autoclave temperature at 150℃for 4 *** CH3NH3Pbl3 layer was deposited on the ZnO:Co films by spin ***-OmeTAD was employed as a hole-transporting *** structural,morphology and optical properties of the grown ZnO nanostructures were characterized by X-ray diffraction(XRD),field-emission scanning electron microcopy(FESEm),energy-dispersive X-ray spectrometry(EDX),ultraviolet-visible(UV-Vis)and photoelectrochemical *** spectra showed that both ZnO and ZnO:Co nanorods had a hexagonal wurtzite structure with a strong preferred orientation along the(002)*** surface morphology of films was studied by FESEm and showed that both the pure and Co-doped ZnO films had hexagonal shaped *** the steady state,the ZnO electrode gave a photocurrent density of about 1.5 mA/***,the Co-doped ZnO electrode showed a photocurrent density of about 6 mA/cm^2,which is 4-fold higher than that of the ZnO *** on the above synthesized Co-doped ZnO films,the photovoltaic performance of PSCs was *** Co-doped ZnO layers had a significant impact on the photovoltaic conversion efficiency(PCE)of the *** latter was attributed to an efficient charge separation and transport due to the better coverage of perovskite on the nanostructured Co-doped ZnO *** a result,the measured PCE under standard solar conditions(A m 1.5G,100 mW/cm^2)r

关键词： perovskite solar cell ZnO nanorods hydrotherm al deposition X-ray diffraction(XRD)analysis field-em ission scanning electron m icrocopy(FESEm)analysis photoelectrochem ical properties

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Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

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World Journal of Clinical Cases 2019年第16期7卷 2269-2286页

作者： Sonia Pascual Cayetano miralles Juan m.bernabé Javier Irurzun mariana Planells Liver Unit Hospital General Universitario de AlicanteAlicante 03010Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDAlicante 03010Spain Radiology Department Hospital General Universitario de AlicanteAlicante 03010Spain

BACKGROUND Hepatocellular carcinoma (HCC) appears in most of cases in patients with advanced liver disease and is currently the primary cause of death in this *** of HCC has been proposed and recommended in clinical guidelines to obtain earlier diagnosis,but it is still controversial and is not accepted *** To review the actual evidence to support the surveillance programs in patients with cirrhosis as well as the diagnosis *** Systematic review of recent literature of surveillance (tools,interval,cost-benefit,target population) and the role of imaging diagnosis (radiological non-invasive diagnosis,optimal modality and agents) of *** The benefits of surveillance of HCC,mainly with ultrasonography,have been assessed in several prospective and retrospective analysis,although the percentage of patients diagnosed in surveillance programs is still *** of HCC permits diagnosis in early stages allows better access to curative treatment and increases life expectancy in patients with *** is a tumor with special radiological characteristics in computed tomography and magnetic resonance imaging,which allows highly accurate diagnosis without routine biopsy *** actual recommendation is to perform biopsy only in indeterminate *** The evidence supports the recommendation of performing surveillance of HCC in patients with cirrhosis susceptible of treatment,using ultrasonography every 6 *** diagnosis evaluation of HCC can be established based on noninvasive imaging criteria in patients with cirrhosis.

关键词： Surveillance Hepatocellular carcinoma Ultrasonography Cirrhosis Imaging diagnosis

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