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Anterior segment imaging using non-invasive high-resolution optical coherence tomography

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Annals of Eye Science 2017年第1期2卷 39-40页

作者： Robert Montés-Micó josé.j.esteve-taboada Department of Optics and Optometry and Vision Sciences University of ValenciaValenciaSpain

One of the most important developments in the ophthalmology and visual sciences field has been the application of new techniques for imaging the anterior and posterior segment of the eye with non-contact devices.These techniques have been developed quickly considering that are non-invasive and provide high-resolution images of the different parts of the human eye.Definitely,the most spread and used technique for non-contact imaging of the human eye is the optical coherence tomography(OCT).OCT technique was first demonstrated in 1991 by Huang et al.(1).

关键词： resolution optical visual

Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

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International journal of Ophthalmology(English edition) 2017年第10期10卷 1614-1616页

作者： Daniel Monsálvez-Romín Antonio Del águila-Carrasco Teresa Ferrer-Blasco josé j.esteve-taboada Robert Montés-Micó Optics and Optometry and Vision Sciences Department University of Valencia

The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography.Thirteen right eyes were included in the study.The device used for the measurement was the Visante？omni system.The stimuli were set up at different vergences（0.0 D,-1.5 D,and-3.0 D）.The angle opening distance 500 and 750,the trabecular iris space area 500 and 750,and the scleral spur angle parameters were assessed at the nasal and temporal regions.The results in the iridotrabecular angle comparing the three accommodative states of the eye did not yield any statistically significant difference at nasal or temporal angle sections.In light of our results and in the conditions of our study,the structures of the iridocorneal angle are not significantly changed with accommodation.

关键词： iridocorneal angle accommodation optical coherence tomography anterior segment

Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

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World journal of Gastroenterology 2024年第10期30卷 1270-1279页

作者： Bruno Rosa joséCotter Department of Gastroenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the small bowel capsule revolutionized the management of patients with small bowel disorders.Currently,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive disorders.This technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic treatment.The use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic procedures.The recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

关键词： Non-invasive endoscopy Panendoscopy Magnetically controlled capsule endoscopy Crohn’s disease Digestive bleeding

Taurine as a possible therapy for immunosenescence and inflammaging

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Cellular & Molecular Immunology 2024年第1期21卷 3-5页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBMSO).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et al.identified taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging molecule.The authors also show that restoring taurine to its“youthful... 详细信息

关键词： Taurine inflam

Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： juan joséPérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower limbs.Pat ients can also experience peripheral neuropathy,cognitive impairment,and other neurological symptoms.To date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

Adaptive optics as a tool for controlling the optical signals reaching the retina

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Annals of Eye Science 2017年第1期 331-333页

作者： joséj.esteve-taboada Teresa Ferrer-Blasco Robert Montés-Micó Department of Optics and Optometry and Vision Sciences University of ValenciaValenciaSpain

The use of adaptive optics systems in ophthalmic research studies has increased in the last years thanks to the development of more accurate devices.Adaptive optics was first introduced in Astronomy for the correction of the effects produced by the turbulences of the Earth’s atmosphere when observing astronomical objects(1,2).Sophisticated deformable mirrors controlled by computers can correct in real time atmospheric disturbances,allowing for much finer details on the images of distance objects.Adaptive optics technology makes it possible to correct many of the aberrations with which the wavefront,i.e.,the geometric envelope of all the rays of light that emerged at the same time of the observed object,arrives.Adaptive optics allows for obtaining sharper images,and thus,with better spatial resolution.

关键词： optics details correction

Tracking the change in Spanish greenhouse gas emissions through an LMDI decomposition model:A global and sectoral approach

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journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula Fernández González María josé Presno Manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this century.In this paper we pursue two objectives.First,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining factors.Second,we propose several actions specifically oriented to more tightly controlling the level of emissions.Our results showed a remarkable reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita effect.We detected somewhat different patterns among the various sectors analyzed.While the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of industry.The carbonization effect was revealed as crucial in the commerce sector.The above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in emissions.Additional efforts in areas like innovation,R&D,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMDI Decomposition Spain GHG emissions

Flexible neural probes:a review of the current advantages,drawbacks,and future demands

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journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 153-167页

作者： Sara PIMENTA joao R.FREITAS joséH.CORREIA CMEMS-UMinho University of MinhoGuimarães4800-058Portugal LABBELS-Associate Laboratory Braga/GuimarãesPortugal

Brain diseases affect millions of people and have a huge social and economic impact.The use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network functioning.Ultimately,neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological disorders.The implementation of neural probes with multifunctionalities(electrical,optical,and fluidic interactions)has been increasing in the last few years,leading to the creation of devices with high temporal and spatial resolution.Increasing the applicability of,and elements integrated into,neural probes has also led to the necessity to create flexible interfaces,reducing neural tissue damage during probe implantation and increasing the quality of neural acquisition data.In this paper,we review the fabrication,characterization,and validation of several types of flexible neural probes,exploring the main advantages and drawbacks of these devices.Finally,future developments and applications are covered.Overall,this review aims to present the currently available flexible devices and future appropriate avenues for development as possible guidance for future engineered devices.

关键词： Brain knowledge Flexible interface Multifunctional probe

Fast synthesis of gold nanoparticles by cold atmospheric pressure plasma jet in the presence of Au+ions and a capping agent

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Plasma Science and Technology 2024年第7期26卷 108-115页

作者： Tatiana HABIB josé Mauricio A.CAIUT Bruno CAILLIER Laboratoire Diagnostics des Plasmas Hors Equilibre(DPHE) Universitéde ToulouseINU ChampollionAlbi 81000France Department of Chemistry The Nanomaterials and Luminescent Systems GroupFaculty of PhilosophyScience and Letters at Ribeirão PretoUniversity of São PauloRibeirão Preto-SP 14040-901Brazil

Homogeneous gold nanoparticles were synthesized under atmospheric pressure using a nonthermal helium plasma jet in a single-step process.A current power supply was used to generate the plasma discharge rich in diverse reactive species.These species induce rapid chemical reactions responsible for the reduction of the gold salts upon contact with the liquid solution.In this study,spherical and monodispersed gold nanoparticles were obtained within 5 min of plasma exposure using a solution containing gold(Ⅲ)chloride hydrate(HAuCl_(4))as a precursor and polyvinylpyrrolidone(PVP)as a capping agent to inhibit agglomerations.The formation of these metal nanoparticles was initially perceptible through a visible change in the sample's color,transitioning from light yellow to a red/pink color.This was subsequently corroborated by UVvis spectroscopy,which revealed an optical absorption in the 520-550 nm range for Au NPs,corresponding to the surface plasmon resonance(SPR)band.An investigation into the impact of various parameters,including plasma discharge duration,precursor and capping agent concentrations,was carried out to optimize conditions for the formation of well-separated,spherical gold nanoparticles.Dynamic light scattering(DLS)was used to measure the size of these nanoparticles,transmission electron microscopy(TEM)was used to observe their morphology and X-ray diffraction(XRD)was also employed to determine their crystallographic structure.The results confirm that homogeneous spherical gold nanoparticles with an average diameter of 13 nm can be easily synthesized through a rapid,straightforward,and environmentally friendly approach utilizing a helium atmospheric pressure plasma.

关键词： gold nanoparticles non-thermal plasma jet helium DBD