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A PD-Type State-Dependent Riccati Equation With Iterative Learning Augmentation for Mechanical Systems

IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1499-1511页

作者： Saeed Rafee Nekoo joséángel acosta Guillermo Heredia Anibal Ollero GRVC Robotics Lab. Depto de Ingeniería de Sistemas y AutomáticaEscuela Técnica Superior de IngenieríaUniversidad de SevillaSeville 41092Spain

This work proposes a novel proportional-derivative(PD)-type state-dependent Riccati equation(SDRE)approach with iterative learning control(ILC)*** the one hand,the PD-type control gains could adopt many useful available criteria and tools of conventional PD *** the other hand,the SDRE adds nonlinear and optimality characteristics to the controller,i.e.,increasing the stability *** advantages with the ILC correction part deliver a precise control law with the capability of error reduction by *** SDRE provides a symmetric-positive-definite distributed nonlinear suboptimal gain K(x)for the control input law u=–R–1(x)BT(x)K(x)*** sub-blocks of the overall gain R–1(x)BT(x)K(x),are not necessarily symmetric positive definite.A new design is proposed to transform the optimal gain into two symmetric-positive-definite gains like PD-type controllers as u=–KSP(x)e–KSD(x)?.The new form allows us to analytically prove the stability of the proposed learning-based controller for mechanical systems;and presents guaranteed uniform boundedness in finite-time between learning *** symmetric PD-type controller is also developed for the state-dependent differential Riccati equation(SDDRE)to manipulate the final *** SDDRE expresses a differential equation with a final boundary condition,which imposes a constraint on time that could be used for finitetime ***,the availability of PD-type finite-time control is an asset for enhancing the conventional classical linear controllers with this *** learning rules benefit from the gradient descent method for both regulation and tracking *** of the advantages of this approach is a guaranteed-stability even from the first loop of learning.A mechanical manipulator,as an illustrative example,was simulated for both regulation and tracking *** experimental validation was done to show the capability of the system in practice by the implementation of the proposed metho

关键词： Closed-loop iterative learning control(ILC) PD-type SDRE SDDRE symmetric

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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Science Letters:Blind spot detection using vision for automotive applications

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1369-1372页

作者： Miguel ngel SOTELO josé BARRIGA Department of Electronics University of Alcalá Alcalá de Henares 28871 Spain

This paper describes a vision-based system for blind spot detection (BSD) in intelligent vehicle applications. A camera is mounted in the lateral mirror of a car with the intention of visually detecting cars that are located in the so-called blind spot and cannot be perceived by the vehicle driver. The detection of cars in the blind spot is carried out using computer vision techniques, based on optical flow and a double-stage data clustering technique for robust vehicle detection.

关键词： Computer vision Optical flow Blind spot detection (BSD) Intelligent vehicles

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Melatonin:a multitasking indoleamine to modulate hippocampal neurogenesis

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Neural Regeneration Research 2023年第3期18卷 503-505页

作者： Alejandro Romero joséÁngel Morales-García Eva Ramos Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense University of Madrid Institute for Biomedical Research“A.Sols”(CSIC-UAM) Spanish Center for Networked Biomedical Research on Neurodegenerative Diseases(CIBERNED Department of Cellular Biology School of MedicineComplutense University of MadridMadridSpain

Neurodegeneration affects a large number of cell types including neurons,astrocytes or oligodendrocytes,and neural stem *** stem cells can generate new neuronal populations through proliferation,migration,and *** neurogenic potential may be a relevant factor to fight neurodegeneration and *** the last years,we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal *** lack of therapeutic strategies targeting neurogenesis led researchers to explore new *** preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in *** made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration,to summarize the current knowledge and highlight the therapeutic potential of melatonin.

关键词： adult hippocampal neurogenesis aging melatonin neural stem cell neurodegeneration neuroprotection signaling pathway therapeutic strategy

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Effect of magnetic field orientation on fluidized beds of magnetic particles:Theory and experiment

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Particuology 2014年第1期12卷 54-63页

作者： Miguel ángel Sánchez Quintanilla Manuel Jesús Espin josé Manuel Valverde Department of Electronics and Electromagnetism University of Seville Department of Applied PhysicsⅡ University of Seville

Geldart-A fluidized beds of fine particles experience a jamming transition between a fluid-like state and a solid-like state at a certain superficial gas velocity, that depends on the relative strength of interparticle attractive forces with respect to particle weight, lnterparticle forces provide the bed with a certain tensile strength in the jammed state. In the work presented here we analyze the behavior of a fluidized bed of magnetic particles subjected to an externally applied magnetic field, which contributes to enhance interparticle forces. The importance of the magnetic contribution to interparticle forces is measured by the changes in the tensile strength and the superficial gas velocity at the jamming transition. The link of the field orientation with the microstructure of the bed is discussed,

关键词： Magneto-fluidization Jamming transition Fluidization Fine powders Cohesion Magnetization

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Parameter Estimation for Hot-spot Thermal Model of Power Transformers Using Unscented Kalman Filters

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 634-642页

作者： MiguelÁngel González-Cagigal joséAntonio Rosendo-Macías Antonio Gómez-Expósito Department of Electrical Engineering University of SevilleSevilleSpain ENGREEN Laboratory of Engineering for Energy and Environmental Sustainability SevilleSpain

This paper presents a parameter estimation technique for the hot-spot thermal model of power *** proposed technique is based on the unscented formulation of the Kalman filter,jointly considering the state variables and parameters of the dynamic thermal model.A two-stage estimation technique that takes advantage of different loading conditions is developed,in order to increase the number of parameters which can be *** results are presented,which show that the observable parameters are estimated with an error of less than 3%.The parameter estimation procedure is mainly intended for factory testing,allowing the manufacturer to enhance the thermal model of power transformers and,therefore,its customers to increase the lifetime of these *** proposed technique could be additionally considered in field applications if the necessary temperature measurements are available.

关键词： Parameter estimation power transformer unscented Kalman filter thermal model

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Classification of subtypes of patients with eating disorders by correspondence analysis

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World Journal of Psychiatry 2021年第7期11卷 375-387页

作者： josune Martín Ane Anton-Ladislao Ángel Padierna Belén Berjano joséMaría Quintana Department of Research Galdakao-Usansolo HospitalGaldakao 48960Spain Kronikgune Institute for Health Services Research Barakaldo 48902Spain Health Services Research on Chronic Diseases Network–REDISSEC Galdakao 48960Spain Department of Psychiatry Galdakao-Usansolo HospitalGaldakao 48960Spain

BACKGROUND Grouping eating disorders(ED)patients into subtypes could help improve the establishment of more effective diagnostic and treatment *** To identify clinically meaningful subgroups among subjects with ED using multiple correspondence analysis(MCA).METHODS A prospective cohort study was conducted of all outpatients diagnosed for an ED at an Eating Disorders Outpatient Clinic to characterize groups of patients with ED into subtypes according to sociodemographic and psychosocial impairment data,and to validate the results using several illustrative *** all,176(72.13%)patients completed five questionnaires(clinical impairment assessment,eating attitudes test-12,ED-short form health-related quality of life,metacognitions questionnaire,Penn State Worry Questionnaire)and sociodemographic *** patient groups were defined using MCA and cluster *** were validated using key outcomes of subtypes of *** Four ED subgroups were identified based on the sociodemographic and psychosocial impairment *** ED patients were differentiated into well-defined outcome groups according to specific clusters of compensating behaviours.

关键词： Multiple correspondence analysis Eating disorders Compensating behaviour Observational descriptive study

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A virtual model of the retina based on histological data as a tool for evaluation of the visual fields

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Annals of Eye Science 2017年第1期2卷 113-126页

作者： Francisco-Javier Carreras Ángel V.Delgado josé.L.García-Serrano Department of Surgery Medical School2Department of Applied PhysicsSchool of SciencesUniversity of GranadaGranadaSpain Hospital Clínico San Cecilio University of GranadaGranadaSpain School of Computer Science Department of Computer Science and Artificial IntelligenceUniversity of GranadaGranadaSpain

Background:To settle the fundamentals of a numerical procedure that relates retinal ganglion-cell density and threshold sensitivity in the visual *** sensitivity of a generated retina and visual pathways to virtual stimuli are simulated,and the conditions required to reproduce glaucoma-type defects both in the optic-nerve head(ONH)and visual fields are ***:A definition of selected structural elements of the optic pathways is a requisite to a translation of clinical knowledge to computer programs for visual field *** program is able to generate a database of normalized visual *** relationship between the number of extant receptive fields and threshold sensitivity is plotted for background sensitivity and corresponding automated perimetry.A solution in two planes to the 3D distribution of axons in the ONH is *** fields with induced damage in the optic disc are comparable in pattern and quantity to glaucomatous ***:The two-level simulation of the ONH facilitates the analysis of optic-cup/retinal *** can generate the virtual optic pathways tailored to the age and morphology of the patient’s eye,and it is possible to reproduce glaucomatous damage by“reverse engineering”*** virtual cortical model renders a quantitative relationship between visual defect and neural ***:A two-level computing of the retina/optic nerve facilitates the analysis of neuroretinal defects and can be incorporated to automatic perimeters to facilitate visual field analysis.

关键词： Computer modeling early optic pathways neuroretinal defects threshold sensitivity visual fields

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Immune challenge of mating effort:steroid hormone profile,dark ventral patch and parasite burden in relation to intrasexual competition in male Iberian red deer

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Integrative Zoology 2020年第4期15卷 262-275页

作者： Eva DE LA PEÑA joséMARTÍN Isabel BARJA Raúl PÉREZ-CABALLERO Isabel acosta Juan CARRANZA Wildlife Research Unit University of CórdobaCórdobaSpain Department of Evolutionary Ecology National Museum of Natural Sciences(Spanish Research CouncilCSIC)MadridSpain Department of Biology Zoology UnitAutonomous University of MadridMadridSpain Biodiversity and Global Change Research Centre Autonomous University of MadridMadridSpain Parasitology and Parasitic Diseases Unit Animal Health DepartmentUniversity of CórdobaCórdobaSpain Laboratory of Malaria Immunology and Vaccinology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMarylandUSA

Testosterone secretion may regulate the reproductive effort and the development of sexual traits,but it may also involve costs at the immunological and metabolic ***,the evidence for this trade-off in wild populations is *** also plays an important role in mediating the reproductive and immune *** this study,we analyzed whether the endoparasite burden relates to hormonal levels(fecal testosterone and cortisol metabolites)and/or morphological sexual traits(size of the dark ventral patch,a trait that indicates reproductive effort in males)in male Iberian red *** this purpose,we sampled male red deer harvested during hunting actions in 2 types of populations in south western Spain that differed in structure,affecting the level of male–male competition for *** used coprological analyses to estimate the parasite burden mainly of gastrointestinal and bronchopulmonary nematodes and of protozoa,and assessed testosterone and cortisol metabolite levels from fecal *** found a positive relationship of host parasitation with both testosterone levels and the size of the dark ventral patch,but these relationships depended on the intensity of male–male competition in the population,being only found under the high-competition *** results are discussed under the hypothesis of the testosterone immunocompetence handicap,suggesting a cost at the immunological level,and,therefore,higher susceptibility to parasite infection in males that make a greater reproductive ***,this effect seems to be modulated by the social environment(male–male competition)that might lead to different optima in testosterone production and sexual trait development.

关键词： dark ventral patch fecal testosterone metabolites intrasexual competition male Iberian red deer parasite burden

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