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Cadaveric liver transplantation for non-acetaminophen fulminant hepatic failure:A 20-year experience

World Journal of Gastroenterology 2007年第9期13卷 1427-1430页

作者： Olivier Detry Arnaud De Roover Carla Coimbra Jean Delwaide Marie-France Hans Marie Hélène Delbouille Joseé Monard Jean joris pierre Damas Jacques Belache Michel Meurisse pierre Honoré Department of Liver Surgery and Transplantation University of Liège CHU Sart Tilman B35Liège B4000 Belgium Department of Hepato- gastroenterology University of Liège CHU Sart Tilman B35 Liège B4000 Belgium Department of Anaesthesia and Intensive Care University of Liège CHU Sart Tilman B35Liège B4000Belgium

AIM: To investigate the long-term results of liver transplantation (LT) for non-acetaminophen fulminant hepatic failure (FHF). METHODS: Over a 20-year period, 29 FHF patients underwent cadaveric whole LT. Most frequent causes of FHF were hepatitis B virus and drug-related (not acetaminophen) liver failure. All surviving patients were regularly controlled at the out-patient clinic and none was lost to follow-up. Mean follow-up was 101 mo. RESULTS: One month, one-, five- and ten-year patient survival was 79%, 72%, 68% and 68%, respectively. One month, one-, five- and ten-year graft survival was 69%, 65%, 51% and 38%, respectively. Six patients needed early (plantation, four for primary non-function, one for early acute refractory rejection because of ABO blood group incompatibility, and one for a malignant tumor found in the donor. Two patients with hepatitis B FHF developed cerebral lesions peri-transplantion: One developed irreversible and extensive brain damage leading to death, and one suffered from deep deficits leading to continuous medical care in a specialized institution. CONCLUSION: Long-term outcome of patients transplanted for non-acetaminophen FHF may be excellent. As the quality of life of these patients is also particularly good, LT for FHF is clearly justified, despite lower graft survival compared with LT for other liver diseases.

关键词： Liver transplantation Liver failure Surgery Hepatitis B Liver support

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Complement activation and long-term graft function in ABO-incompatible kidney transplantation

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World Journal of Nephrology 2019年第6期8卷 95-108页

作者： Marit S van Sandwijk Astrid Klooster Ineke JM ten Berge Arjan Diepstra Sandrine Florquin joris J Hoelbeek Frederike J Bemelman Jan-Stephan Sanders Department of Nephrology Amsterdam University Medical CentersAmsterdam NL-1105 AZNetherlands Dianet Dialysis Center Amsterdam NL-1105 AZNetherlands Department of pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen NL-9700 RBNetherlands Department of pathology Pathology FrieslandLeeuwarden NL-8917 ENNetherlands Department of pathology Amsterdam University Medical CentersAmsterdam NL-1105 AZNetherlands Department of Internal Medicine Division of NephrologyUniversity Medical Center GroningenUniversity of GroningenGroningen NL-9700 RBNetherlands

BACKGROUND ABO-incompatible and ABO-compatible kidney transplantation are equivalent in terms of short-term graft and patient survival. This is thought to be the result of ABO-incompatible graft accommodation, which occurs when anti-blood group antibodies re-occur after transplantation but somehow do not yield their detrimental effect. The underlying mechanism is unclear, but one of the hypotheses is that this is the result of complement inhibition. Since virtually all ABO-incompatible graft biopsies are C4d positive, this complement inhibition must occur somewhere in the complement cascade after the formation of C4d has already taken place, but where exactly is unclear. It is also unclear whether complement inhibition is complete. Incomplete accommodation could explain why recent studies have shown that long-term graft function in ABOincompatible transplantation is somewhat inferior to ABO-compatible kidney *** To unravel the relationship between pre-transplant anti-ABO antibodies,complement activation, and long-term graft *** We included all 27 ABO-incompatible transplantations that were performed between 2008 and 2013 at the Academic Medical Center Amsterdam and the University Medical Center Groningen. For each ABO-incompatible transplantation, we included four ABO-compatible controls matched by age, sex,and transplantation *** Graft and patient survival were not significantly different. The slope of kidney function during five-year follow-up was also not significantly different, but ABOincompatible recipients did have a lower kidney function at three months(creatinine clearance 58 vs 69 mL/min, p = 0.02, Modification of Diet in Renal Disease 46 vs 52 mL/min/1.73 m^2, p = 0.08), due to a high rate of early rejection(33% vs 15%, p = 0.03), mostly T-cell mediated. pre-transplant anti-ABO Ig G titers were positively correlated with C5b-9 staining, which itself was positively correlated with the occurrence of T-cell mediated reje

关键词： ABO-incompatible Kidney transplantation Complement Graft function Rejection

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柏林观察

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建筑学报 2012年第8期 6-12页

作者： Ingrid Schrder joris Fach 戴叶子李华东剑桥大学建筑学院苏州大学金螳螂建筑与城市环境学院苏州215123 北京工业大学建筑与城规学院北京100124

通过设计课程介绍尝试为柏林的市民空间提供一种非纪念性的设计方法。设计工作集中在对复杂和脱节的自发城市空间与纪念性空间进行观察及分析,并试图寻找这座异质城市中隐藏的功能计划,经观察发现的现象提供了一种新的框架来理解(既是... 详细信息

通过设计课程介绍尝试为柏林的市民空间提供一种非纪念性的设计方法。设计工作集中在对复杂和脱节的自发城市空间与纪念性空间进行观察及分析,并试图寻找这座异质城市中隐藏的功能计划,经观察发现的现象提供了一种新的框架来理解(既是提炼、也是重定位)设计的条件。

关键词：城市观察自发城市建筑纪念性空间

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青海湖盆地史前狩猎采集人群的石料利用策略研究

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第四纪研究 2020年第2期40卷 525-537页

作者：申旭科王建姚娟婷夏欢王倩倩任晓燕 Olaf joris 张东菊兰州大学资源环境学院西部环境教育部重点实验室甘肃兰州730000 青海省文物考古研究所青海西宁810007 MONREpOS Archaeological Research Centre and Museum for Human Behavioral Evolution Romisch-Germanisches ZentralmuseumSchloss Monrepos56567 NeuwiedGermany

史前人类向青藏高原扩散的过程和适应高海拔缺氧环境的机制是多学科关注的热点科学问题.青海湖盆地是青藏高原旧石器-中石器时代遗址分布最为丰富的区域,对这些遗址出土的石制品原料的分析有助于深入理解青藏高原史前狩猎采集人群的石... 详细信息

史前人类向青藏高原扩散的过程和适应高海拔缺氧环境的机制是多学科关注的热点科学问题.青海湖盆地是青藏高原旧石器-中石器时代遗址分布最为丰富的区域,对这些遗址出土的石制品原料的分析有助于深入理解青藏高原史前狩猎采集人群的石料开发策略、人群迁徙和交流联系.青海湖盆地151遗址出土的928件石制品的石料研究分析显示,处于末次冰消期的下文化层的石制品以近源的石英和石英岩为主要原料,而处于全新世早中期的上文化层在同类型近源石料仍占主体地位的情况下,开始出现较高比例和多样化的优质硅质石料,并且主要用于生产细石器.野外调查和查阅地质资料均未发现青海湖盆地内有151遗址中出现的同类型优质硅质石料产出,推测其来自远距离搬运.青海湖盆地内其他8个末次冰消期至全新世中期遗址的3269件石制品石料分析结果显示,与151遗址同类型的远源优质硅质石料在全新世早期开始在盆地内的遗址中出现.这一结果表明青海湖盆地末次冰消期古人类活动强度和范围有限,全新世早中期古人类受到全新世大暖期气候变好和周边地区农业人群兴起挤压活动空间的双重影响,在高原上的活动范围和强度大大增加,伴随着开始有意识地开发优质石料,较频繁地进行远距离迁移和人群交流.远源优质硅质石料的产地可能位于北祁连山区和青藏高原上的陆相火山岩区,需要未来更深入的研究揭示.该研究为深入理解青藏高原古人类的高海拔环境适应策略和移动模式提供了重要材料,为理解史前人类向高原扩散的机制提供了重要信息.

关键词：青海湖盆地 151遗址石料利用策略狩猎采集人群

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基于不同压电材料作动机制的压电层厚度研究

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材料导报 2010年第4期24卷 1-3页

作者：韩国华靳晓雄 joris Degrieck Wim Van paepegem 侯艳芳同济大学汽车学院上海201804 根特大学材料科学工程学院同济大学电信学院上海201804

研究了压电材料复合板的3种作动机制,弯曲作动机制、剪切作动机制、混合作动机制,针对粘贴在纤维板上不同厚度的压电作动层,具体分析了复合板的端部位移,研究结果对噪声和振动的主动控制中的模态控制和智能结构静态形状控制提供了一定... 详细信息

研究了压电材料复合板的3种作动机制,弯曲作动机制、剪切作动机制、混合作动机制,针对粘贴在纤维板上不同厚度的压电作动层,具体分析了复合板的端部位移,研究结果对噪声和振动的主动控制中的模态控制和智能结构静态形状控制提供了一定的参考。

关键词：作动机制主动控制压电作动端部位移

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pulsed Lavage in Cementless Total Hip Arthroplasty Reduces the Incidence ofBrooker Grade 3 and 4 Heterotopic Ossifications

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Open Journal of Orthopedics 2011年第2期1卷 9-13页

作者： joris Mellema Wierd Zijlstra Tom van Raaij Bas ten Have Jos van Raay 不详

Heterotopic ossification (HO) may cause pain, and can lead to loss of hip motion after total hip arthroplasty (THA). There is evidence that pulsed lavage may lower the incidence of HO formation. We assessed the effect of pulsed lavage on the incidence of HO in 87 male patients after THA. All patients received an uncemented THA through a posterolateral approach. 39 patients were treated with pulsed lavage (index group) and 48 males were treated without pulsed lavage (historical control group, matched on aetiology, gender, surgical approach and type of prosthesis). Both groups followed the same postoperative treatment regimen. HO severity was scored in both groups according to the Brooker classification by three blinded orthopaedic surgeons one year postoperatively. Good inter-observer agreement (Kappa 0.7) for scoring HO was found. The incidence of HO (51%) in the index group did not differ significantly (p = 0.53) from the control group (58%). However, the incidence of clinically relevant HO (Brooker grades 3 and 4) was significantly lower (p = 0.04) in the index group (3%) as compared to the control group (17%). These results suggest a beneficial effect of pulsed lavage on the incidence of severe heterotopic ossification after cementless THA in male patients.

关键词： Heterotopic Ossification pulsed Lavage Total Hip Arthroplasty Uncemented

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Short-and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma:does left or right side matter?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 154-162,I0001,I0002页

作者： Lotte C.Franken pim B.Olthof joris I.Erdmann Otto M.van Delden Joanne Verheij Marc G.Besselink Olivier R.Busch Thomas M.van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of Surgery Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands Department of Radiology and Nuclear Medicine Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Department of pathology Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background:The only potentially curative option for patients with perihilar cholangiocarcinoma(pHC)is resection,typically an extrahepatic bile duct resection in combination with(extended)liver *** such as bile leakage and liver failure have been suggested to be more common after right-sided resections compared to left-sided resections,whilst superior oncological outcomes have been reported after right-sided ***,data on outcomes after right-sided or left-sided liver resections in pHC are ***,we aimed to investigate short-and long-term outcomes after left and right hemihepatectomy in patients with ***:In this retrospective study,patients undergoing major liver resection for suspected pHC in a tertiary center between 2000-2018 were *** who had undergone left-sided resections were compared to patients with right-sided resections in terms of complications(90-day mortality,overall and severe morbidity and specific complications).For long-term outcomes,only patients with pathologically proven pHC were included in the survival ***:A total of 178 patients undergoing hemihepatectomy for suspected pHC were analysed,including 76 left-sided and 102 right-sided *** 90-day mortality was 14%(24 out of 178),with no significant difference after left-sided resection(11%;8 out of 76)versus right-sided resection(16%;16 out of 102)(p=0.319).Severe morbidity(Clavein Dindo≥3)was also comparable in both groups:54%versus 61%(p=0.361).No differences in specific complications including bile leakage were observed,although liver failure appeared to occur more frequently after right hemihepatectomy(22%versus 11%,p=0.052).Five-year overall survival for pathologically proven pHC,excluding in-hospital mortality,did not differ;43.7%after left-sided resection *** 38.2%after right-sided resection(p=0.553).Conclusions:Both short-and long-term outcomes between patients undergoing left and right hemihepate

关键词： perihilar cholangiocarcinoma(pHC) hepatectomy outcomes mortality survival

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Widely tunable 2.3μm III-V-on-silicon Vernier lasers for broadband spectroscopic sensing

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photonics Research 2018年第9期6卷 858-866页

作者： RUIJUN WANG STEpHAN SpRENGEL ANTON VASILIEV GERHARD BOEHM joris VAN CAMpENHOUT GuY LEpAGE pETER VERHEYEN ROEL BAETS MARKUS-CHRISTIAN AMANN GUNTHER ROELKENS photonics Research Group Ghent University-IMECTechnologiepark-Zwijnaarde 15B-9052 GhentBelgium Center for Nano-and Biophotonics(NB-photonics) Ghent UniversityB-9052 GhentBelgium Walter Schottky Institut Technische Universitat MunchenAm Coulombwall 485748 GarchingGermany IMEC Kapeldreef 75Leuven B-3001Belgium

Heterogeneously integrating III-V materials on silicon photonic integrated circuits has emerged as a promising approach to make advanced laser sources for optical communication and sensing applications. Tunable semiconductor lasers operating in the 2–2.5 μm range are of great interest for industrial and medical applications since many gases(e.g., CO_2, CO, CH_4) and biomolecules(such as blood glucose) have strong absorption features in this wavelength region. The development of integrated tunable laser sources in this wavelength range enables low-cost and miniature spectroscopic sensors. Here we report heterogeneously integrated widely tunable III-V-on-silicon Vernier lasers using two silicon microring resonators as the wavelength tuning components. The laser has a wavelength tuning range of more than 40 nm near 2.35 μm. By combining two lasers with different distributed Bragg reflectors, a tuning range of more than 70 nm is achieved. Over the whole tuning range, the side-mode suppression ratio is higher than 35 dB. As a proof-of-principle, this III-V-on-silicon Vernier laser is used to measure the absorption lines of CO. The measurement results match very well with the high-resolution transmission molecular absorption(HITRAN) database and indicate that this laser is suitable for broadband spectroscopy.

关键词：硅光子集成电路通讯技术发展现状

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Monolithic GaAs/Si V-groove depletion-type optical phase shifters integrated in a 300 mm Si photonics platform

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photonics Research 2022年第6期10卷 1509-1516页

作者： YOUNGHYUN KIM DIDIT YUDISTIRA BERNARDETTE KUNERT MARINA BARYSHNIKOVA REYNALD ALCOTTE CENK IBRAHIM OZDEMIR SANGHYEON KIM SEBASTIEN LARDENOIS pETER VERHEYEN joris VAN CAMpENHOUT MARIANNA pANTOUVAKI IMEC Heverlee B-3001Belgium Current address:Department of photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang UniversityAnsan 15588Republic of Korea Current address:School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

We demonstrate monolithically integrated n-GaAs/p-Si depletion-type optical phase shifters fabricated on a 300 mm wafer-scale Si photonics *** measured the phase shifter performance using Mach–Zehnder modulators with the GaAs/Si optical phase shifters in both arms.A modulation efficiency of V_(π)L as low as 0.3 V·cm has been achieved,which is much lower compared to a carrier-depletion type Si optical phase shifter with pn *** propagation loss is relatively high at.5 d B∕mm,the modulator length can be reduced by the factor of.2 for the same optical modulation amplitude of a Si reference Mach–Zehnder modulator,owing to the high modulation efficiency of the shifters.

关键词： GaAs/Si modulator optical

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NiCu-based catalysts for the low-temperature hydrodeoxygenation of anisole:Effect of the metal ratio on SiO_(2)andγ-Al_(2)O_(3)supports

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Green Carbon 2023年第2期1卷 170-184页

作者： Tom Vandevyvere Maarten K.Sabbe pedro S.F.Mendes joris W.Thybaut Jeroen Lauwaert Industrial Catalysis and Adsorption Technology Department of Materials Textiles and Chemical EngineeringGhent UniversityValentin Vaerwyckweg 19000 GhentBelgium Laboratory for Chemical Technology Department of Materials Textiles and Chemical EngineeringGhent UniversityTechnologiepark 125B-9052 GhentBelgium

The effects of the metal ratio of NiCu catalysts on the low-temperature hydrodeoxygenation(HDO)of anisole were assessed on a neutral SiO_(2) and an acidicγ-Al_(2)O_(3) *** activity of SiO_(2)-supported catalysts increases with the Ni content in the NiCu phase,related to Ni’s hydrogenation *** contrast,on aγ-Al_(2)O_(3) support,the activity decreases with the Ni ***,Al_(2)O_(3)-supported catalysts,exhibiting a smaller NiCu alloy particle size,are more active than SiO_(2)-supported *** terms of selectivity,SiO_(2)-supported catalysts mainly hydrogenate anisole to methoxycyclohexane,while,particularly at higher conversions,γ-Al_(2)O_(3)-supported catalysts are able to further convert methoxycyclohexane to cyclohexane,demonstrating the importance of acid sites for low-temperature *** Ni/Cu ratio also steers the selectivity,but not the catalyst *** phenomena are only support dependent:while on SiO_(2)-supported catalysts,active site sintering occurs,attributed to weak stabilization of metal particles by the support,acid catalyzed coking is the main cause of deactivation on theγ-Al_(2)O_(3)-supported catalysts.

关键词： Bio-oil pyrolysis-oil Anisole Hydrodeoxygenation Bimetallic catalyst

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