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Monolithic GaAs/Si V-groove depletion-type optical phase shifters integrated in a 300 mm Si photonics platform

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Photonics Research 2022年第6期10卷 1509-1516页

作者： YOUNGHYUN KIM DIDIT YUDISTIRA BERNARDETTE KUNERT MARINA BARYSHNIKOVA REYNALD ALCOTTE CENK IBRAHIM OZDEMIR SANGHYEON KIM SEBASTIEN LARDENOIS PETER VERHEYEN joris van campenhout MARIANNA PANTOUVAKI IMEC Heverlee B-3001Belgium Current address:Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang UniversityAnsan 15588Republic of Korea Current address:School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

We demonstrate monolithically integrated n-GaAs/p-Si depletion-type optical phase shifters fabricated on a 300 mm wafer-scale Si photonics *** measured the phase shifter performance using Mach–Zehnder modulators with the GaAs/Si optical phase shifters in both arms.A modulation efficiency of V_(π)L as low as 0.3 V·cm has been achieved,which is much lower compared to a carrier-depletion type Si optical phase shifter with pn *** propagation loss is relatively high at.5 d B∕mm,the modulator length can be reduced by the factor of.2 for the same optical modulation amplitude of a Si reference Mach–Zehnder modulator,owing to the high modulation efficiency of the shifters.

关键词： GaAs/Si modulator optical

Capacitive actuation and switching of add–drop graphene-silicon micro-ring filters

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Photonics Research 2017年第6期5卷 274-278页

作者： TOMMASO CASSESE MARCO ANGELO GIAMBRA VITO SORIANELLO GABRIELE DE ANGELIS MICHELE MIDRIO MARIANNA PANTOUVAKI joris van campenhout INGE ASSELBERGHS CEDRIC HUYGHEBAERT ANTONIO D'ERRICO MARCO ROMAGNOLI Scuola Superiore Sant'Anna-Te CIP Institute CNIT-Consorzio Nazionale Interuniversitario per le Telecomunicazioni CNIT-Consorzio Nazionale Interuniversitario per le Telecomunicazioni Università degli Studi di Udine Imec Ericsson Research

We propose and experimentally demonstrate capacitive actuation of a graphene–silicon micro-ring add/drop filter. The mechanism is based on a silicon–SiO_2–graphene capacitor on top of the ring waveguide. We show the capacitive actuation of the add/drop functionality by a voltage-driven change of the graphene optical absorption. The proposed capacitive solution overcomes the need for continuous heating to keep tuned the filter's in/out resonance and therefore eliminates "in operation" energy consumption.

关键词： MRR drop graphene-silicon micro-ring filters Capacitive actuation and switching of add

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将激光集成到硅上的4种方法

科技纵览 2023年第5期 32-37,4页

作者： Roel Baets joris van campenhout Bernardette Kunert Gunther Roelkens 不详

在日常生活中,将一系列光电子功能集合在一块芯片上的光子集成电路越来越常见,它们被用于连接数据中心服务器机架的高速光收发器(包括用于提供本刊网站的光收发器)、保持自动驾驶汽车正常行驶的激光雷达、发现大气中化学物质的光谱仪,... 详细信息

在日常生活中,将一系列光电子功能集合在一块芯片上的光子集成电路越来越常见,它们被用于连接数据中心服务器机架的高速光收发器(包括用于提供本刊网站的光收发器)、保持自动驾驶汽车正常行驶的激光雷达、发现大气中化学物质的光谱仪,以及许多其他应用。所有这些系统都变得越来越便宜,并且在某些情况下,使用硅制造技术生产大部分集成电路也是经济可行的。

关键词：化学物质集成电路激光雷达自动驾驶汽车数据中心服务器光谱仪光电子硅

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三五族激光器的硅基单片集成

三五族激光器的硅基单片集成

Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]

第十一届全国硅基光电子材料及器件研讨会

作者：王喆超 joris van campenhout Dries van Thourhout Gunther Roelkens Photonics Research Group Ghent University/IMEC Technologiepark-Zwijnaarde 15 9052 Gent Belgium imec 3001 Leuven Belgium

＜正＞经过十多年的发展,硅基光子学已经成为一个非常有吸引力的集成光学平台。通过利用成熟的300 mm CMOS pilot line,硅基光子集成芯片能够实现大规模的低成本制造[1]。同时,光子器件与电子器件的混合集成,能够极大的提高系统的集成...

＜正＞经过十多年的发展,硅基光子学已经成为一个非常有吸引力的集成光学平台。通过利用成熟的300 mm CMOS pilot line,硅基光子集成芯片能够实现大规模的低成本制造[1]。同时,光子器件与电子器件的混合集成,能够极大的提高系统的集成度和功能的多样性[2]。硅基光子学最近几年的发展重点是硅基有源器件的集成,虽然超高速的调制器和探测器已经被广泛实现,但由于硅材料本身特性的限制

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Photonics Research 2015年第5期3卷 47-59页

作者： Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol van Dorpe joris van campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries van Thourhout Zeger Hens Gunther Roelkens Roel Baets Photonics Research Group INTEC Department Ghent University-imec Centre for Nano and Biophotonics Ghent University University of California Department of Molecular Biotechnology Ghent University imec Kapeldreef 75 Physics and Chemistry of Nanostructures Ghent University

There is a rapidly growing demand to use silicon and silicon nitride（Si3N4） integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip.

关键词： Invited SOI mode

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function

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Journal of Animal Science and Biotechnology 2020年第4期11卷 993-1008页

作者： Jeroen Degroote Hans Vergauwen Wei Wang Chris van Ginneken Stefaan De Smet joris Michiels Laboratory for Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyFaculty of Bioscience EngineeringGhent UniversityBlock FCampus CoupureCoupure Links 6539000 GhentBelgium Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of BiomedicalPharmaceutical and Veterinary SciencesUniversity of AntwerpUniversiteitsplein 1WilrijkBelgium.

Background: Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is hypothesized to correlate with changes in the glutathione(GSH)redox system. Therefore, these parameters were simultaneously measured throughout the weaning phase, in piglets differing in birth weight category and weaning age, as these pre-weaning factors are important determinants for the weaning transition. Low birth weight(LBW) and normal birth weight(NBW) littermates were assigned to one of three weaning treatments;i.e. weaning at 3 weeks of age(3 w), weaning at 4 weeks of age(4 w) and removal from the sow at 3 d of age and fed a milk replacer until weaning at 3 weeks of age(3 d3 w). For each of these treatments, six LBW and six NBW piglets were euthanized at 0, 2, 5, 12 or 28 d post-weaning piglets, adding up 180 ***: Weaning increased the glutathione peroxidase activity on d 5 post-weaning in plasma, and duodenal and jejunal mucosa. Small intestinal glutathione-S-transferase activity gradually increased until d 12 post-weaning, and this was combined with a progressive rise of mucosal GSH up till d 12 post-weaning. Oxidation of the GSH redox status(GSH/GSSG Eh) was only observed in the small intestinal mucosa of 3 d3 w weaned piglets at d 5 postweaning. These piglets also demonstrated increased fluorescein isothiocyanate dextran(FD4) and horseradish peroxidase fluxes in the duodenum and distal jejunum during the experiment, and specifically demonstrated increased FD4 fluxes at d 2 to d 5 post-weaning. On the other hand, profound villus atrophy was observed during the weaning transition for all weaning treatments. Finally, LBW and NBW piglets did not demonstrate notable differences in GSH redox status, small intestinal barrier function and histo-morphology throughout the ***: Although moderate changes in the GSH redox system were observed upon weaning, the GSH redox status remai

关键词： Barrier function Glutathione Oxidative stress Redox status Small intestine Weaned piglet

Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 622-629页

作者： Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt joris J Roelofs Otto M van Delden Thomas M van Gulik Department of RadiologyAcademic Medical Center University of Amsterdam Department of Surgery (Surgical Laboratory)Academic Medical Center University of Amsterdam Department of PathologyAcademic Medical Center University of Amsterdam

BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor *** latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver *** study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor ***:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 *** weeks after implantation,18 rabbits were used for TAE experiments,5were for sham *** response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating ***:All super-selective arterial tumor embolization procedures were performed *** embolization,the tumor volume increased after an initial steady *** tumor volume after embolization was smaller than that of the sham group,but this difference was not *** necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver *** was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal *** regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained ***:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT *** of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma.

关键词： hypertrophy liver regeneration animal model transarterial embolization hepatic artery

Artificial rearing influences the morphology,permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets

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Journal of Animal Science and Biotechnology 2017年第3期8卷 707-720页

作者： Hans Vergauwen Jeroen Degroote Sara Prims Wei Wang Erik Fransen Stefaan De Smet Christophe Casteleyn Steven van Cruchten joris Michiels Chris van Ginneken Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of BiomedicalPharmaceutical and Veterinary SciencesUniversity of AntwerpCampus Drie EikenUniversiteitsplein 1D.U0152610 WilrijkBelgium Department of Applied Biosciences Faculty of Bioscience EngineeringGhent UniversityGhentBelgium Laboratory for Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal ProductionFaculty of Bioscience EngineeringGhent UniversityMelleBelgium StatUa Center for Statistics University of AntwerpAntwerpBelgium

Background： In this study the physiological implications of artificial rearing were investigated. Low（LBW） and normal birth weight（NBW） piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW piglets from 16 litters suckled the sow until d19 of age or were artificially reared starting at d3 until d19 of age. Blood and tissue samples that were collected after euthanasia at 0, 3, 5, 8 and 19 d of age. Histology, ELISA, and Ussing chamber analysis were used to study proximal and distal small intestine histomorphology, proliferation, apoptosis, tight junction protein expression, and permeability. Furthermore, small intestine,liver and systemic redox parameters（GSH, GSSG, GSH-Px and MDA） were investigated using ***： LBW and NBW artificially reared piglets weighed respectively 40 and 33% more than LBW and NBW sowreared piglets at d19（P 〈 0.01）. Transferring piglets to a nursery at d3 resulted in villus atrophy, increased intestinal FD-4 and HRP permeability and elevated GSSG/GSH ratio in the distal small intestine at d5（P 〈 0.05）. GSH concentrations in the proximal small intestine remained stable, while they decreased in the liver（P 〈 0.05）. From d5 until d19, villus width and crypt depth increased, whereas PCNA, caspase-3, occludin and claudin-3 protein expressions were reduced. GSH,GSSG and permeability recovered in artificially reared piglets（P 〈 0.05）.Conclusion： The results suggest that artificial rearing altered the morphology, permeability and redox state without compromising piglet performance. The observed effects were not depending on birth weight.

关键词： Milk replacer Oxidative stress Small intestine Suckling period Tight junction proteins