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A procedure to assess the spatial variability in the importance of abiotic factors affecting distributions： the case of world freshwater fishes

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Current Zoology 2018年第5期64卷 549-557页

作者： Ana M. MANJARRES-HERNANDEZ Castor GUISANDE Emilio GARCiA-ROSELLO Patricia PELAYO-VILLAMIL Jacinto gonzalez-DAcOSTA Juirgen HEINE Luis gonzalez VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE jorge M. LOBO alnstituto Amazonico de Investigaciones-IMANI Universidad Nacional de Colombia Leticia A.A. 215 Colombia 910001 Facultad de Ciencias del Mar Universidad de Vigo Vigo 36310 Spain Departamento de Informatica Edificio Fundicien Universidad de Vigo Vigo 36310 Spain Grupo de Iciologia Universidad de Antioquia Medellin Colombia 050010 eDepartamento de Biologia Vegetal y Ecologia Facultad de Biologia Universidad de Sevilla Sevilla 41080 Spain Departamento de Biogeografia y Cambio Global Museo Nacional de Ciencias Naturales (CSIC) Calle de Jose Gutierrez Abascal 2 Madrid 28006 Spain

Understanding the factors shaping species＇ distributions is a key longstanding topic in ecology with unresolved issues. The aims were to test whether the relative contribution of abiotic factors that set the geographical range of freshwater fish species may vary spatially and/or may depend on the geographical extent that is being considered. The relative contribution of factors, to discriminate between the conditions prevailing in the area where the species is present and those existing in the considered extent, was estimated with the instability index included in the R pack- age SPEDInstabR. We used 3 different extent sizes： 1） each river basin where the species is present （local）; 2） all river basins where the species is present （regional）; and 3） the whole Earth （global）. We used a data set of 16,543 freshwater fish species with a total of 845,764 geographical records, together with bioclimatic and topographic variables. Factors associated with tempera- ture and altitude show the highest relative contribution to explain the distribution of freshwater fishes at the smaller considered extent. Altitude and a mix of factors associated with temperature and precipitation were more important when using the regional extent. Factors associated with precipitation show the highest contribution when using the global extent. There was also spatial variability in the importance of factors, both between species and within species and from region to region. Factors associated with precipitation show a clear latitudinal trend of decreasing in importance toward the equator.

关键词： anisotropic predictors environmental data selection geographical background non-stationary predictors

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Hierarchy: enhancing performances beyond limits

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National Science Review 2020年第11期7卷 1624-1625页

作者： Clément sanchez Chimie de la Matière Condensée de Paris UMR 7574 Collège de France CNRS UMPC Université Paris 06 Sorbonne University PSL Research University Chemistry of Ultra-Divided Matter at USIAS University of Strasbourg Institute for Advanced Study

Living organisms, for their survival and reproduction, have evolved to produce complex hierarchical three-dimensional structures ranging from nanometers to meters with extraordinary and unusual sets of properties. Over the last 20 years,hierarchically porous materials that replicate complex living structures have attracted intense attention from both the academic and industrial worlds.

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Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5129-5131页

作者： ruben A.Ferrer Marta Torregrossa Sandra Franz Department of Dermatology Allergology and VenerologyUniversity LeipzigLeipzigGermany

Skin injury releases damage-associated molecular patterns(DAMPs)represented by tissue-components and intracellular contents as well as changes in the levels of certain molecules and metabolites that signal the“non-homeostatic”state of the *** addition,microorganisms entering a wound release molecules,which are sensed as“non-self”(pathogen-associated molecular patterns,PAMPs).Together,DAMPs and PAMPs initiate a complex and coordinated repair process aimed at restoring *** exciting work from Liu et *** of an additional novel mechanism by which a“non-homeostatic”state in murine cutaneous wounds elicits a response through IL-24 to mediate repair(Fig.1).

关键词： wound homeostasis release

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MEC-based architecture for interoperable and trustworthy internet of moving things

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Digital Communications and Networks 2023年第1期9卷 270-279页

作者： Jesus sanchez-Gomez Rafael Marin-Perez Ramon sanchez-Iborra Miguel Angel Zamora Department of Information and Communications Engineering University of MurciaMurciaSpain Odin Solutions S.L. MurciaSpain University Center of Defense San Javier Air Force BaseMurciaSpain

The expansion of the Internet of Moving Things(IoMT)leads to limitless and continuous working playgrounds exploited by highly dynamic end *** requires the adoption of multi-Radio Access Technologies(RATs)-based strategies to provide IoMT units with ubiquitous *** this end,the development of secure bootstrapping and authentication mechanisms is necessary to permit the secure operation of end *** the transmission and power limitations of these elements,current cryptographic solutions do not address these stringent *** that reason,in the study we present a Multi-Access Edge Computing(MEC)-based endto-end architecture that enables an efficient and secure authentication and key agreement between end devices and network servers over heterogeneous resource-limited networks such as the Low Power Wide Area Networks(LPWANs).Our proposal is based on the Authentication,Authorization,and Accounting(AAA)architecture and the recent Internet Engineering Task Force initiatives Static Context Header Compression and Low-Overhead *** results obtained from experimental tests reveal the validity of the proposal as it enables constrained IoMT devices to gain IPv6 connectivity as well as performs end-to-end secure authentication with notable reliability and controlled latency.

关键词： Internet of moving things LPWAN Authentication LO-CoAP-EAP SCHC

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cell2mol:encoding chemistry to interpret crystallographic data

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npj Computational Materials 2022年第1期8卷 1787-1794页

作者： Sergi Vela ruben Laplaza Yuri Cho Clémence Corminboeuf Laboratory for Computational Molecular Design(LCMD) Institute of Chemical Sciences and Engineering(ISIC)École Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland National Centre for Computational Design and Discovery of Novel Materials(NCCR MARVEL) Ecole Polytechnique Fédérale de Lausanne1015LausanneSwitzerland National Centre for Competence in Research“Sustainable chemical processes through catalysis(NCCR Catalysis)” École Polytechnique Fédérale de Lausanne1015LausanneSwitzerland

The creation and maintenance of crystallographic data repositories is one of the greatest data-related achievements in *** such as the Cambridge Structural Database host what is likely the most diverse collection of synthesizable *** properly mined,they could be the basis for the large-scale exploration of new regions of the chemical space using quantum chemistry(QC).Yet,it is currently challenging to retrieve all the necessary information for QC codes based exclusively on the available structural data,especially for transition metal *** overcome this limitation,we present cell2mol,a software that interprets crystallographic data and retrieves the connectivity and total charge of molecules,including the oxidation state(OS)of metal *** demonstrate that cell2mol outperforms other popular methods at assigning the metal OS,while offering a comprehensive interpretation of the unit *** code is made available,as well as reliable QC-ready databases totaling 31k transition metal complexes and 13k ligands that contain incomparable chemical diversity.

关键词： offering overcome properly

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In <i>Silico</i>Analysis of Cross Reactivity between Lipocalin of Domestic Animals

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Open Journal of Immunology 2018年第4期8卷 97-106页

作者： Múnera Marlon sanchez Andres sanchez jorge Emiliani Yuliana Medical Research Group (GINUMED) Universitary Corporation Rafael Nu&ntilde ez Cartagena Colombia Group of Clinical and Experimental Allergy (GACE) IPS Universitaria University of Antioquia Medellín Colombia

Lipocalins are one of the groups of allergens derived from domestic animals with clinical importance for the development of allergic responses. They have been characterized in different animals. With allergenic capacity characterized, little is known about the epitopes involved in allergic responses. Here, potential antigenic regions involved in cross-reactivity among lipocalins were explored through bioinformatics tools. The amino acid sequences of several lipocalins from different domestic animals (mouse, dog, cat, bull, hamster, horse and pig) were used to determine the degree of kinship by phylogenetic studies. Groups with highest phylogenetic relation were obtained by using MEGA software. 3D models of lipocalins not reported in the protein data bank were modeled by homology to identify potential antigenic regions compromised in the cross-reactivity of this group of allergens. The alignment of the entire database of allergenic lipocalins and the inferred maximum likelihood tree segregate lipocalins into five monophyletic clades (referenced here as A, B, C, D and E). According to the multiple pairing analyzes, group C (Fel d 4, Rat n 1 and Equ c 1) showed the highest degree of identity among their amino acid sequences (58%). The analysis of conserved and exposed residues showed that group C shares three antigenic regions that could potentially contribute to its cross-reactivity. Potential antigenic sites were identified for the generation of cross-reactivity between the different lipocalins analyzed in this study. These studies support the need to carry out directed mutagenesis tests to confirm their relevance in the allergenic capacity of lipocalins.

关键词： Bioinformatics Immunology Prediction Epitope Allergen Antigen

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The History of Pharmacokinetics in Cuba： Role of Universities

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Journal of Pharmacy and Pharmacology 2014年第8期2卷 453-469页

作者： Eduardo Manuel Femandez-sanchez jorge Duconge Department of Pharmacology and Toxicology Institute of Pharmacy and Foods Havana 17100 Cuba Pharmaceutical Sciences Department School of Pharmacy University of Puerto Rico Medical Sciences Campus Puerto Rico009365067 United States

A university is a higher academic institution with a mission to educate individuals in order to help nations reach their developmental goals. It implies teaching innovative disciplines through the most advanced scientific and pedagogical methods, in harmony with recent international standards and national needs. Some of these innovative disciplines turn out to be a valuable driving-force of the transformation in a country. An example of such transforming disciplines is the PK （pharmacokinetics） in Cuba, considered by many as exclusive of developed countries, it shows significant contributions to the current success of the local biopharmaceutical industry, and particularly to the scientific achievements of several biotechnological centers. Noteworthily, the academic activities and scientific work performed at the UH （University of Havana） and other colleges across the Island are closely related to this success. While passing through the different stages of transformation at academic institutions in the country, we discuss herein the most significant milestones in the history of the Pharmacokinetics in Cuba.

关键词： University pharmacokinetics biopharmaceutics teaching biotechnology.

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Core promoter: A critical region where the hepatitis B virus makes decisions

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World Journal of Gastroenterology 2014年第2期20卷 425-435页

作者： jorge Quarleri Instituto de Investigaciones Biomédicas en Retrovirus y Sida Universidad de Buenos AiresBuenos Aires C1121ABGArgentina

The core promoter(CP) of the viral genome plays an important role for hepatitis B virus(HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic(pg) RNAs. The CP consists of the upper regulatory region and the basa core promoter(BCP). The CP overlaps with the 3'-end of the X open reading frames and the 5'-end of the precore region,and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation,when variations appear,they may contribute to the persistence of HBV within the host,leading to chronic infection and cirrhosis,and eventually,hepatocellular carcinoma. Among CP sequence variations,those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen,and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated.

关键词： Hepatitis B virus Core promoter Variants Basal core promoter Transcription regulation

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Inflammatory effect on the gastrointestinal system associated with COVID-19

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World Journal of Gastroenterology 2021年第26期27卷 4160-4171页

作者： Paulina Delgado-gonzalez Carlos A gonzalez-Villarreal jorge A Roacho-Perez Adriana G Quiroz-Reyes Jose Francisco Islas Juan Luis Delgado-Gallegos Daniel Arellanos-Soto Kame A Galan-Huerta Elsa N Garza-Treviño Departamento de Bioquimica y Medicina Molecular UANLMonterrey 64610Nuevo LeónMexico Universidad de Monterrey UDEM Vicerrectoria de Ciencias de la SaludMonterrey 66238Nuevo LeonMexico

The severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)that causes coronavirus disease-2019(COVID-19)has provoked a global pandemic,mainly affecting the respiratory tract;however,a percentage of infected individuals can develop gastrointestinal(GI)*** studies describe the development of GI symptoms and how they affect the progression of *** this review,we summarize the main mechanisms associated with gut damage during infection by SARS-CoV-2 as well as other organs such as the liver and *** only are host factors associated with severe COVID-19 but intestinal microbiota dysbiosis is also observed in patients with severe disease.

关键词： SARS-CoV-2 Gastrointestinal symptoms COVID-19 Gastrointestinal system

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Reactive oxygen species and antioxidant properties from mushrooms

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Synthetic and Systems Biotechnology 2017年第1期2卷 13-22页

作者： Carmen sanchez Laboratory of Biotechnology Research Centre for Biological SciencesUniversidad Autonoma de TlaxcalaIxtacuixtlaTlaxcalaCP.90062Mexico

Preventive medicine and food industry have shown an increased interest in the development of natural antioxidants,since those most commonly used synthetic antioxidants may have restricted use in *** could explain why there is currently much research on the antioxidant properties from natural products such as *** mushrooms have been reported to possess antioxidant properties,which enable them to neutralize free *** oxygen molecule is a free radical,which lead to the generation of the reactive oxygen species and can damage the *** damage caused by free radicals appears to be a major contributor to aging and degenerative *** antioxidant components are found in fruit bodies,mycelium and culture both,which include polysaccharides,tocopherols,phenolics,carotenoids,ergosterol and ascorbic acid among *** bodies or mycelium can be manipulated to produce active compounds in a relatively short period of time,which represent a significant advantage in antioxidant compounds extraction from *** compounds may be extracted to be used as functional additives or mushrooms can be incorporated into our food regime,representing an alternative source of food to prevent damage caused by oxidation in the human body.

关键词： Antioxidant Fruit body Mushroom Mycelium Reactive oxygen species

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