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基于智能手机的人类活动识别

国外科技新书评介 2015年第6期 24-24页

作者： jorge Luis Reyes Ortiz 李亚宁不详中国科学院自动化研究所

人体行为识别是模式识别技术的一种，目前处在动作识别阶段，而动作识别可以看成是特征提取和分类器设计相结合的过程。特征提取过程受到遮挡，动态背景，移动摄像头，视角和光照变化等因素的影响而具有很大的挑战性。其应用背景很广泛... 详细信息

人体行为识别是模式识别技术的一种，目前处在动作识别阶段，而动作识别可以看成是特征提取和分类器设计相结合的过程。特征提取过程受到遮挡，动态背景，移动摄像头，视角和光照变化等因素的影响而具有很大的挑战性。其应用背景很广泛，主要集中在智能视频监控，

关键词：模式识别技术人类活动智能手机智能视频监控动作识别特征提取分类器设计行为识别

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提供低损耗大功率的MOSFET

电子设计技术 EDN CHINA 2011年第8期18卷 57-57页

作者： Camilo Quintáns Graa jorge Marcos Acevedo 西班牙维戈市维戈大学

硅功率二极管的PN结通常有大约1.2V的压降。这个压降使得功率二极管上消耗了相当的能量,从而造成电源效率的损失。对于一个有120W电源和24V标称电压的太阳能板,一个防止回流的二极管可能产生6W功率损失,或相当于受控能量的5%。此外,为... 详细信息

硅功率二极管的PN结通常有大约1.2V的压降。这个压降使得功率二极管上消耗了相当的能量,从而造成电源效率的损失。对于一个有120W电源和24V标称电压的太阳能板,一个防止回流的二极管可能产生6W功率损失,或相当于受控能量的5%。此外,为二极管散热而开发一个冷却系统的成本也可能产生问题。

关键词： MOSFET 大功率低损耗功率二极管电源效率功率损失太阳能板标称电压

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成为优秀的审核员良好审核秘诀

中国认证认可 2021年第8期 23-25页

作者：伊丽莎白·泰勒乔治·布拉沃李文远(译) 不详标智达(北京)管理咨询有限公司

一个优秀的审核员可以为组织带来价值,而一个糟糕的审核员却会使组织戴上官僚主义的枷锁。两者之间的区别通常取决于审核员在审核之前、审核期间和审核之后所做出的不同表现。关于管理体系审核,丨SO 19011提供了相关指南,并规定了审核... 详细信息

一个优秀的审核员可以为组织带来价值,而一个糟糕的审核员却会使组织戴上官僚主义的枷锁。两者之间的区别通常取决于审核员在审核之前、审核期间和审核之后所做出的不同表现。关于管理体系审核,丨SO 19011提供了相关指南,并规定了审核员所具备的能力要求。

关键词：审核员官僚主义管理体系审核优秀组织

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伊西德罗·帕罗迪的六个谜题

伊西德罗·帕罗迪的六个谜题

作者： (阿根廷)豪尔赫·路易斯·博尔赫斯(jorge Luis Borges)，阿道夫·比奥伊·卡萨雷斯(Adolfo Bioy Borges)

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市郊人·信徒天堂

市郊人·信徒天堂

Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

作者： (阿根廷)豪尔赫·路易斯·博尔赫斯(jorge Luis Borges)，阿道夫·比奥伊·卡萨雷斯(Adolfo Bioy Casares)

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

*** hypertension promotes early mitochondrial fragmentation in retinal endothelial cells in a mouse model of glaucoma

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Annals of Eye Science 2018年第1期 424-424页

作者： jorge L.Cueva Vargas Yoko Ito Khalil Miloudi Ariel M.Wilson Christine Vande Velde Przemyslaw Sapieha Adriana Di Polo Department of Neuroscience University of Montreal Hospital Research Center(CR-CHUM)MontrealQuebecCanada Department of Biochemistry Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Neuroscience McGill UniversityMontrealQuebecCanada

Background:Retinal endothelial cells are very active and contribute to the integrity of the neurovascular *** dysfunction has been proposed to contribute to the pathogenesis of ***,we evaluated the hypothesis that ocular hypertension triggers mitochondrial alterations in endothelial cells impairing the integrity of the blood retinal barrier(BRB).Methods:Ocular hypertension was induced by injection of magnetic microbeads into the anterior chamber of EndoMito-EGFP mice,a strain expressing green fluorescent protein selectively in the mitochondria of endothelial *** density,mitochondrial volume,and the number of mitochondrial components were quantified in 3D-reconstructed images from whole-mounted retinas using Imaris ***-related protein(DRP-1),mitofusin-2(MFN-2)and optic atrophy-1(OPA-1)expression were assessed by western blot analysis of enriched endothelial *** structure was evaluated by transmission electron microscopy(TEM)and oxygen consumption rate was monitored by Seahorse *** integrity of the BRB was evaluated by quantifying Evans blue ***:Our data demonstrate that two and three weeks after ocular hypertension induction,the total mitochondria volume in endothelial cells decreased from 0.140±0.002µm3 from non-injured retinas to 0.108±0.005 and 0.093±0.007µm3,respectively in glaucomatous eyes(mean±S.E.M,ANOVA,P<0.001;N=6/group).Frequency distribution showed a substantial increase of smaller mitochondria complexes(<0.5µm3)in endothelial cells from glaucomatous *** upregulation of DRP-1 was found in vessels isolated from glaucomatous retinas compared to the intact retinas,while MFN-2 and OPA-1 expression was not *** alteration in endothelial cell mitochondria was confirmed by TEM,which were accompanied by a 1.93-fold reduction in the oxygen consumption rate as well as 2.6-fold increase in vasculature leakage in glaucomatous retinas(n=3-6/group).In additi

关键词： Glaucoma endothelial cells mitochondria vascular leakage

有效管理合规义务--有效应用ISO 37301:2021降低不合规风险

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中国认证认可 2022年第4期 17-18页

作者：伊丽莎白•塔勒乔治•布拉沃李文远(译) 不详

ISO 373012021为组织管理合规风险提供了一个国际化、专业化和系统化的管理框架;合规管理体系对于组织的可持续发展至关重要,必将得到组织的广泛应用,因此而具有良好的发展前景;认证机构可将合规管理体系作为一个全新的管理体系认证项目... 详细信息

ISO 373012021为组织管理合规风险提供了一个国际化、专业化和系统化的管理框架;合规管理体系对于组织的可持续发展至关重要,必将得到组织的广泛应用,因此而具有良好的发展前景;认证机构可将合规管理体系作为一个全新的管理体系认证项目,从而也有助于认证机构的可持续发展。

关键词：认证机构合规风险可持续发展管理框架管理体系认证有效应用 ISO 发展前景