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Dental pulp stem cells and BonelikeVR for bone regeneration in ovine model

Regenerative Biomaterials 2019年第1期6卷 49-59页

作者： J.m.Campos A.C.Sousa A.R.Caseiro S.S.Pedrosa P.O.Pinto m.V.Branquinho I.Amorim J.D.Santos T.Pereira C.m.mendonca A.Afonso L.m.Atayde A.C.maurı´cio Departamento de Clı´nicas Veterina´rias Instituto de Cieˆncias Biome´dicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreirano 2284050-313 PortoPortugal Centro de Estudos de Cieˆncia Animal(CECA) Instituto de CieˆnciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IIApartado 551424051-401 PortoPortugal Escola Universita´ria Vasco da Gama(EUVG) Hospital Veterina´rio Universita´rio de Coimbra(HVUC)Campo Universita´rio–Bloco BLordem~aoCoimbraPortugal REQUImTE/LAQV–U.Porto–Porto/Portugal Departamento de Engenharia Metalu´rgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRuaDr.Roberto Friass/n4200-465 PortoPortugal Faculdade de Engenharia da Universidade do Porto(FEUP) Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Pathology and molecular Immunology of the Institute of Biomedical Sciences Abel Salazar(ICBAS) University of Porto4050-313 PortoPortugal Institute for Research and Innovation in Health (i3S)University of PortoPortoPortugal Institute of molecular Pathology and Immunology of the University of Porto(IPATImUP) 4200-135 PortoPortugal Faculdade de medicina Denta´ria da Universidade do Porto(FmDUP) 4200-393 PortoPortugal

Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone *** an ovine model,the present pre-clinical study presents a synthetic bone graft(BonelikeVR)in combination with a cellular system as an alternative for the regeneration of non-critical *** association of biomaterials and cell-based therapies is a promising strategy for bone tissue *** stem cells(mSCs)from human dental pulp have demonstrated both in vitro and in vivo to interact with diverse biomaterial systems and promote mineral deposition,aiming at the reconstruction of osseous ***,these cells can be found and isolated from many ***-critical bone defects were treated with BonelikeVR with or without mSCs obtained from the human dental *** showed that BonelikeVR and mSCs treated defects showed improved bone regeneration compared with the defects treated with BonelikeVR ***,it was observed that the biomaterial matrix was reabsorbed and gradually replaced by new bone during the healing *** therefore propose this combination as an efficient binomial strategy that promotes bone growth and vascularization in non-critical bone defects.

关键词： biomaterial BonelikeVR bone regeneration,dental pulp human bone hydroxyapatite mesenchymal stem cells ovine model tissue regeneration tricalcium phosphate

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