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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1549-1554页

作者： Abdo Karim Tourkmani Colm Mcalinden David F.Anderson jorge l.alio del Barrio jorge l.alió Royal Gwent Hospital NewportWales NP202UBUK Ophthalmology Department Universidad Miguel HernándezAlicante 03202Spain Ulster University Northern IrelandBelfast BT151EDUK Southampton General Hospital Southampton SO166YDEnglandUK Cornea Cataract&Refractive Surgery UnitVissum(Miranza Group)Alicante 03106Spain

AIM:To report the outcomes of three cases of corneal perforation managed with simultaneous tectonic Descemet stripping endothelial keratoplasty(t-DSEK)and tectonic Bowman layer transplant(t-BlT)as an alternative to tectonic penetrating keratoplasty(t-PKP).METHODS:Three eyes of three patients receiving simultaneous t-DSEK and t-BlT for corneal perforation were *** technique for DSEK was modified depending on individual *** t-BlT technique was standardised using an 8 mm graft and fixated with a running *** was measured by the ability of this procedure to close a corneal ***:All three cases achieved tectonic eye globe restoration and remained stable during the minimum 3-month observation *** were relatively common:2 cases required amniotic membrane transplant for persistent epithelial *** case required DSEK *** case developed angle closure glaucoma requiring surgical peripheral ***:Simultaneous t-DSEK and t-BlT may be a useful strategy for the management of corneal perforation as an alternative management to t-PKP for selected cases.

关键词： tectonic corneal graft Descemet stripping endothelial keratoplasty Bowman layer transplant penetrating keratoplasty

Accommodative intraocular lenses:where are we and where we are going

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Eye and Vision 2017年第1期4卷 81-92页

作者： jorge l.alió jorge l.aliódel Barrio Alfredo Vega-Estrada Cornea Cataract and Refractive Surgery UnitVissum CorporaciónAvda de Denia s/nEdificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain

Presbyopia still remains the last frontier of refractive *** surgical management is under constant evolution due to the limitations that exist today with respect to its management,which is probably in relation with the multifactorial basis in which presbyopia is clinically developed in the *** currently,virtually all surgical techniques that have been proposed for its correction are based on the induction of pseudoaccommodation in the presbyopic eye,including ***,the real restoration of accommodation is more complex,and it has been tried by the use of different,so called,“accommodative”pseudophakic intraocular lenses(AIOl).Overall,the reported results with these lenses by independent authors have been modest in relation with the restoration of the accommodative power of the eye and these modest benefits are usually lost with time due to the long term changes in the capsular *** fact made these lenses to be almost abandoned in the last few years,but there are currently other AIOl models being used with innovative mechanisms of action and different anatomical support outside the capsular bag that offer encouraging preliminary results that could bring a new potential of application to these types of *** this article,we will update the modern refractive surgeon about the fundamentals and provide updated information about the outcomes of AIOls by reviewing the concept of accommodation,the different attempts that have been accomplished in the past,their demonstrated published results in human clinical trials,and the future alternatives that may arrive in the near future.

关键词： Accommodation Accommodative intraocular lens Presbyopia

Small incision lenticule extraction(SMIlE)in the correction of myopic astigmatism:outcomes and limitations-an update

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Eye and Vision 2017年第1期4卷 151-158页

作者： jorge l.aliódel Barrio Verónica Vargas Olena Al-Shymali jorge l.alió Cornea Cataract and Refractive Surgery UnitVissum CorporaciónAlicanteSpain Division of Ophthalmology School of MedicineUniversidad Miguel HernándezAlicanteSpain

Small Incision lenticule Extraction(SMIlE)is a flap-free intrastromal technique for the correction of myopia and myopic *** date,this technique lacks automated centration and cyclotorsion control,so several concerns have been raised regarding its capability to correct moderate or high levels of *** objective of this paper is to review the reported SMIlE outcomes for the correction of myopic astigmatism associated with a cylinder over 0.75 D,and its comparison with the outcomes reported with the excimer laser-based corneal refractive surgery techniques.A total of five studies clearly reporting SMIlE astigmatic outcomes were *** shows acceptable outcomes for the correction of myopic astigmatism,although a general agreement exists about the superiority of the excimer laser-based techniques for low to moderate levels of *** correction of the static cyclotorsion should be adopted for any SMIlE astigmatic correction over 0.75 D.

关键词： Small incision lenticule extraction SMIlE Astigmatism Refractive surgery

Corneal compensation of presbyopia:PresbylASIK:an updated review

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Eye and Vision 2017年第1期4卷 48-55页

作者： Veronica Vargas-Fragoso jorge l.alió Vissum Corporation Edificio VissumCalle Cabañal 1AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezCarretera Alicante-Valencia km 8.7AlicanteSpain.

The main purpose of this review is to compare and analyze the results of the main PresbylASIK approaches;central and ***:A comprehensive research was conducted in PUBMED using keywords like“presbyopia correction”,“PresbylASIK”,“Corneal multifocality”,“laser blended vision”.We reviewed the PresbylASIK technique,uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),uncorrected near visual acuity(UNVA),and corrected near visual acuity(CNVA),and compared the differences between the techniques.

关键词： Central and peripheral PresbylASIK Corneal multifocality Presbyopia

Clinical outcomes with a new design in multifocal intraocular lens:a pilot study

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Eye and Vision 2020年第1期7卷 366-374页

作者： jorge l.alió Pilar Yébana Mario Cantó Ana B.Plaza Alfredo Vega jorge l.aliódel Barrio Francisco lugo Vissum Corporation Avda de Denia s/nEdificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain

Purpose:To evaluate the clinical and visual outcomes,quality of near vision and the influence of photic phenomena in patients bilaterally implanted with a new Precizon Presbyopic multifocal intraocular lens(IOl).Methods:In this prospective consecutive case series,20 eyes of 10 patients were included(mean age 63.80±12.55 years).Uncorrected and corrected visual acuity(far,intermediate and near),subjective refraction,binocular defocus curve,contrast sensitivity(CSV-1000)and quality of vision and satisfaction questionnaires were *** follow-up was 12 months after ***:At 12 months after surgery,uncorrected distance visual acuity(UDVA)improved with surgery(p=0.001)with a value of 0.08±0.08 *** near visual acuity(UNVA)was 0.22±0.12 logMAR and distance corrected near visual acuity(DCNVA)was 0.16±0.13 *** distance visual acuity(UIVA)was 0.22±0.10 *** sensitivity outcomes were similar to normal population in photopic conditions and slightly reduced in mesopic conditions of *** curve showed that this multifocal IOl was able to provide a visual acuity(VA)equal or better to 0.16 logMAR between defocus levels of+1.00 to−2.50 *** patient satisfaction was obtained in quality of vision and satisfaction questionnaires ***:The Precizon Presbyopic NVA IOl(OPHTEC BV)provides good visual *** multifocal IOl provides a high percentage of spectacle independence due to good VA at far,intermediate and near distances and satisfactory contrast *** patient satisfaction was observed in quality of vision and satisfaction questionnaires with a low percentage of patients manifesting photic phenomena.

关键词： Multifocal intraocular lens Near vision Photic phenomena Continuous transitional focus optic

Pharmacological treatments of presbyopia:a review of modern perspectives

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Eye and Vision 2017年第1期4卷 14-17页

作者： Antonio Renna jorge l.alió luis Felipe Vejarano Vissum alicante AlicanteSpain Studi Medici Renna MelendugnoLecceItaly Universidad Miguel Hernandez Calle Cabañal 103016 AlicanteSpain Vissum Instituto Oftalmologico de alicante AlicanteSpain Fundación Oftalmológica Vejarano PopayanColombia Universidad del Cauca PopayanColombia

Introduction:Presbyopia affects people from the 4^(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life.A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of *** purpose of this review is to analyze the emerging pharmacological solutions proposed to address ***:Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and *** topical treatment deals with drug combinations aimed to modify one or more factors involved in the accommodative process and have been proposed to be instilled either monocularly or *** remains unclear how much each drug in the final combined form is involved in the achievement of the outcome and contributes to ***:Despite the lack of a completely well understood mechanism,pharmacological control of presbyopia seems to be a possible and very attractive alternative for presbyopic *** studies mentioned in this review are to be considered pilot investigations as they involve either a small number of subjects or are single case *** studies are needed to confirm which will be the more effective pharmacological compound for the treatment of presbyopia.

关键词： Presbyopia Ageing Near vision Glasses Multifocality Accommodation Pharmacological therapy Eyedrops

Safety and visual outcomes following posterior chamber phakic intraocular lens bilensectomy

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Eye and Vision 2020年第1期7卷 328-335页

作者： Veronica Vargas jorge l.alió Rafael I.Barraquer Justin Christopher D’Antin Cristina García Francisco Duch Joan Balgos jorge laliódel Barrio Vissum Instituto Oftalmológico de alicante AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Institut Universitari Barraquer Universitat Autònoma de BarcelonaBarcelonaSpain Centro de Oftalmología Barraquer BarcelonaSpain Universitat Internacional de Catalunya BarcelonaSpain Clínica Real Vision MadridSpain Instituto Catalán de Retina(ICR)unidad de Cirugía Refractiva BarcelonaSpain

Background:To evaluate the safety,efficacy,refractive outcomes and causes for bilensectomy(phakic intraocular lens–pIOl–explantation with cataract surgery and pseudophakic intraocular lens implantation)in patients previously implanted with posterior chamber ***:This multi-center retrospective study included 87 eyes of 55 patients who underwent bilensectomy for posterior chamber pIOl with a follow up time of 12 *** uncorrected and best corrected distance visual acuities(UDVA,CDVA),endothelial cell density before and after bilensectomy were assessed,as well as the cause of bilensectomy and intra or postoperative ***:There was a statistically significant improvement in uncorrected and best corrected visual acuities after bilensectomy(p=0.00).The main reason for bilensectomy was cataract development(93.1%of the cases),followed by miscalculation of lens size,and corneal *** endothelial cell count remained stable without a statistically significant change after surgery(p=0.67).The refractive efficacy index was 0.8,none of the patients lost lines of CDVA after surgery,73%of the patients were within±1 D(spherical equivalent)of the target *** complications were one posterior capsule rupture with the intraocular lens(IOl)implanted in the sulcus,and 3 eyes required the use of pupil expanders for adequate pupil ***,one eye developed retinal *** three pIOls models explanted were the Implantable Collamer lens(ICl),Implantable Phakic Contact lens(IPCl)and the Phakic Refractive lens(PRl).Conclusions:Good safety and visual outcomes were observed 1 year after bilensectomy for posterior chamber phakic intraocular lenses(PC pIOls).There were few intra and postoperative complications and there was no significant endothelial cell loss after the bilensectomy procedure.

关键词： Bilensectomy Posterior chamber phakic intraocular lenses Cataract Endothelial cell count Visual outcomes Postoperative complications Intraoperative complications

Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies

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Eye and Vision 2018年第1期5卷 250-259页

作者： jorge l.aliódel Barrio jorge l.alió Cornea Cataract and Refractive Surgery UnitVissum CorporaciónAlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain. Vissum Instituto Oftalmologico de AlicanteAvda de Denia s/n03016 AlicanteSpain

Cellular therapy of the corneal stroma,with either ocular or extraocular stem cells,has been gaining a lot of interest over the last *** publications from different research groups are showing its potential benefits in relation to its capacity to improve or alleviate corneal scars,improve corneal transparency in metabolic diseases by enhancing the catabolism of the accumulated molecules,generate new organized collagen within the host stroma,and its immunosuppressive and immunomodulatory *** extraocular stem cells do not require a healthy contralateral eye and they do not involve any ophthalmic procedures for their *** stem cells have been the most widely assayed and have the best potential to differentiate into functional adult keratocytes in vivo and in *** embryonic stem cells have been partially abandoned due to ethical implications,the discovery of the induced pluripotent stem cells(iPSC)has opened a new and very promising field for future research as they are pluripotent cells with the capacity to theoretically differentiate into any cell type,with the special advantage that they are obtained from adult differentiated *** delivery into the corneal stroma has been experimentally assayed in vivo in multiple ways:systemic versus local injections with or without a *** preliminary human clinical data is already available although still very limited,and further research is necessary in order to consolidate the clinical applications of this novel therapeutic line.

关键词： Stem cells Regenerative medicine Corneal transplant Decellularized cornea Cornea Corneal stroma Cellular therapy MSC Mesenchymal stem cells

Patients’dissatisfaction with multifocal intraocular lenses managed by exchange with other multifocal lenses of diferent optical profles

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Eye and Vision 2024年第1期10卷 31-40页

作者： Olena Al‑Shymali Colm Mcalinden jorge l.alio del Barrio Mario Canto‑Cerdan jorge l.alio Research&Development Department VISSUM Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthalmology Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthalmology School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to evaluate the outcomes of dissatisfed patients reporting poor visual quality following implantation of multifocal intraocular lenses(MF-IOls),managed by IOl exchange with another multifocal optical ***:This is a retrospective series of ***-IOl exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual quality for far distance afected by neuroadaptation *** underwent a bilateral exchange of a MF-IOl with another MF-IOl of a diferent optical *** outcomes and complications were *** including Quality of Vision(QoV),Visual Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were also used for outcome ***:The mean elapsed time from implantation to explantation-reimplantation was 11.8 *** QoV scores improved signifcantly across all the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(Pl acuity improved from 0.24 to 0.12 logMAR after exchange(Pl acuity improved from 0.15 to 0.04 logMAR(Pllowing MF-IOl exchange,80%of the patients reported they would have the MF-IOl reimplantation procedure ***:Patient dissatisfaction with neuroadaptation failure following MF-IOl implantation can be managed in 80%of our cases by MF-IOl exchange with a diferent MF-IOl optical profle.

关键词： Multifocal intraocular lenses IOl exchange Visual acuity Neuroadaptation failure

Deep optics preconditioner for modulation-free pyramid wavefront sensing

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Photonics Research 2024年第2期12卷 301-312页

作者： FElIPE GUZMÁN jorge TAPIA CAMIlO WEINBERGER NICOlÁS HERNÁNDEZ jorge BACCA BENOIT NEICHEl ESTEBAN VERA School of Electrical Engineering Pontificia Universidad Católica de Valparaı´soValparaı´soChile Department of Systems Engineering Universidad Industrial de SantanderBucaramangaColombia laboratoire d’Astrophysique de Marseille MarseilleFrance

The pyramid wavefront sensor(PWFS)can provide the sensitivity needed for demanding adaptive optics applications,such as imaging exoplanets using the future extremely large telescopes of over 30 m of diameter(D).However,its exquisite sensitivity has a limited linear range of operation,or dynamic range,although it can be extended through the use of beam modulation—despite sacrificing sensitivity and requiring additional optical *** by artificial intelligence techniques,this work proposes to train an optical layer—comprising a passive diffractive element placed at a conjugated Fourier plane of the pyramid prism—to boost the linear response of the pyramid sensor without the need for cumbersome *** develop an end-2-end simulation to train the diffractive element,which acts as an optical preconditioner to the traditional least-square modal phase estimation *** results with a large range of turbulence conditions show a noticeable improvement in the aberration estimation performance equivalent to over 3λ∕D of modulation when using the optically preconditioned deep PWFS(DPWFS).Experimental results validate the advantages of using the designed optical layer,where the DPWFS can pair the performance of a traditional PWFS with 2λ∕D of *** and adding an optical preconditioner to the PWFS is just the tip of the iceberg,since the proposed deep optics methodology can be used for the design of a completely new generation of wavefront sensors that can better fit the demands of sophisticated adaptive optics applications such as ground-to-space and underwater optical communications and imaging through scattering media.

关键词： process optics pyramid