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Detection of Progesterone Receptor as a Method of Diagnosing Mammary Cancer in Female Dogs

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Open Journal of Veterinary Medicine 2024年第8期14卷 217-227页

作者： José de Jesús Vázquez Pérez Angel Ramses Figueroa Hernandez jorge Peregrina Sandoval guillermo Nolasco Rodríguez Manuel Rosales Cortés Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico Department of Cellular and Molecular Biology University Center for Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico

Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (PR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of PR was performed by immunohistochemical labeling, using murine anti-PR (anti-PR Biocare brand). A descriptive analysis was carried out with the results using the SPSS program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of PR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of PR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.

关键词： Cancer Mammary Gland Progesterone Immunohistochemistry Progesterone Membrane Receptor Component 1 (PGRMC 1)

Design and optimization of supersonic turbines for detonation combustors

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Chinese Journal of Aeronautics 2022年第11期35卷 33-44页

作者： jorge SOUSA Elena COLLADO-MORATA guillermo PANIAGUA Flemish InstituteforTechnological Research Mol 2400Belgium Commissariat à lénergie atomique et aux énergies alternatives Le Barp 33114France Mechanical Engineering Purdue UniversityWest-Lafayette IN 47906USA

Detonation-based engines offer a potential surge in efficiency for compact thermal power systems. However, these cycles require ad-hoc components adapted to the high outlet velocity from the detonation combustors. This paper presents the design methodology of turbine stages suitable for supersonic inlet conditions and provides a detailed analysis of optimized turbine geometries. A reduced-order solver examines the supersonic blade rows’ functional design space, quantifies the turbine’s non-isentropic performance, and budgets the turbine loss for different optimized leading-edge designs and chord to pitch ratios. The shock-wave interactions were identified as the predominant contributor to turbine losses, and optimal pitch-chord ratios were determined for various inlet Mach numbers. Finally, with this tool, the specific-power output for a wide range of design configurations was computed;and the metal angle that ensures flow starting and maximizes power extraction was calculated. The detailed numerical study describes the flow interactions in a supersonic turbine and offers new correlations to guide the design of future supersonic turbines.

关键词： Rotating detonation Shock waves Supersonic flow Turbines Unstarting

Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian Lindner Raúl Riquelme Rodrigo San Martín Frank Quezada jorge valenzuela Juan P Maureira Martín Einersen Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile Neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： Liver transplantation Postoperative complications Hepatic artery Thrombosis Radiology Artificial intelligence

Properties of nuclear pastas

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Frontiers of physics 2021年第2期16卷 119-173页

作者： jorge A.Lopez Claudio O.Dorso guillermo Frank Department of Physics University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisica FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigacion y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuclear pastas as they are expected to be formed in neutron star *** start with a study of the pastas formed in nuclear matter(composed of protons and neutrons),we follow with the role of the electron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuclear matter embedded in an electron gas).Nuclear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton content ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the critical points,and the symmetry energy was calculated and compared to experimental data and other *** low temperatures(T≤1 MeV)NM produces crystal-like structures around satura-tion densities,and pasta-like structures at sub-saturation *** of the pasta structures were studied with cluster-recognition algorithms,caloric curve,the radial distribution function,the Lindemann coefficient,Kolmogorov statistics,Minkowski functionals;the symmetry energy of the pasta showed a connection with its *** star matter(NSM)is nuclear matter embedded in an electron *** electron gas is included in the calculation by the inclusion of an screened Coulomb *** connect the NM pastas with those in neutron star matter(NSM),the role the strength and screening length of the Coulomb interaction have on the formation of the pastas in NM was *** was found to exist even without the presence of the electron gas,but the effect of the Coulomb interaction is to form more defined pasta structures,among other ***,it was determined that there is a minimal screening length for the developed structures to be independent of the cell *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,structure function and thermal *** in NM,pasta f

关键词： nuclear pasta neutron star matter nuclear symmetry energy molecular dynamics nuclear phase transitions

Sexual dimorphism in immune response： Testing the hypothesis in an insect species with two male morphs

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Insect Science 2013年第5期20卷 620-628页

作者： Gloria Ruiz-Guzman jorge Canales-Lazcano Jesus guillermo Jimenez-Cortes jorge Contreras-Garduno Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud Publica Av. Universidad No. 655 C. P. 62100 Cuernavaca Morelos Departamento de Biologia Divisi6n de Ciencias Naturales y Exactas Universidad de Guanajuato Guanajuato Departamento de Ecologia Evolufiva Instituto de Ecologia Universidad Nacional Autonoma de Mexico Apdo. Postal 70-275 04510 Mexico D. F. Mexico

It has been proposed that given that males should invest in sexual traits at the expense of their investment in immune response, females are better immunocompetent than males. Typically, this idea has been tested in monomorphic species, but rarely has been evaluated in polymorphic male species. We used Paraphlebia zoe, a damselfly with two male morphs： the black-winged morph （Black-W） develop black spots as sexual traits and the hyaline-winged morph （Hyaline-W） resembles a female in size and wings color. We predicted that Black-W should have a lower immune response than Hyaline-W, but that the latter males should not differ from females in this respect. Nitric oxide （NO） and phenoloxidase （PO） production, as well as hemolymph protein content, were used as immune markers. Body size （wing length） was used as an indicator of the male condition. The results show that, as we predicted, females and Hyaline-W had higher values of NO than Black-W, corresponding to differences in size. However, the opposite was found in relation to PO production. Females had the highest levels of hemolymph protein content, whereas no differences were found between Black-W and Hyaline-W. These results partially support the sexual selection hypothesis and are discussed in the context of the life history of this species. Black-W, Hyaline-W, and females could express the immune markers that are prioritized by their particular condition, and probably neither of them could express all immune markers in an elevated manner, as this would result in an excessive accumulation of free radicals.

关键词： immune response male morphs Paraphlebia zoe polymorphic species,territoriality trade-off

Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

Imaging-based prediction of hepatocellular carcinoma recurrence after microwave ablation as bridge therapy: A glimpse into the future

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World Journal of Transplantation 2024年第4期14卷 1-5页

作者： Cristian Lindner Rodrigo San Martín Andrés Concha David Clemo jorge valenzuela Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Liver transplantation(LT)remains the treatment of choice for early-stage hepato-cellular carcinoma(HCC)and offers the best long-term oncological ***,the increasing waiting list for LT has led to a significant dropout rate as patients experience tumor progression beyond the Milan ***,locoregional therapies,such as microwave ablation(MWA),have emerged as promising bridge treatments for patients awaiting *** therapies have shown promising results in preventing tumor progression,thus reducing the dropout rate of LT *** the efficacy of MWA in treating HCC,tumoral recurrence after ablation remains a major challenge and significantly impacts the prognosis of HCC ***,accurately diagnosing tumoral recurrence post-ablation is *** studies have developed novel imaging features based on magnetic resonance imaging of HCC,which could provide essential information for predicting early tumoral recurrence after *** advancements could address this unresolved challenge,improving the clinical outcomes of patients on the LT waiting *** article explored the current landscape of MWA as a bridge therapy for HCC within the Milan criteria,high-lighting the emerging role of novel imaging-based features aimed at improving the prediction of tumor recurrence after MWA.

关键词： Liver transplantation Hepatocellular carcinoma Ablation techniques Multiparametric magnetic resonance imaging Interventional oncology Liver disease Microwaves

Site index for teak in Colombia

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Journal of Forestry Research 2012年第3期23卷 405-411页

作者： Danny A.Torres jorge I.del valle guillermo Restrepo Office National de Forêts International 2av.de Saint-Mandé75570 Paris Cedex 12France Universidad Nacional de Colombia sede Medellín Apartado Aéreo 568MedellínColombia Independent consultant

Determination of site quality is a basic tool for proper selection of locations and species, in management of forest plantations. Throughout the Caribbean studies of site quality are few and are hampered by statistical limitations, inappropriate growth models, and limited data. We fitted growth curves for dominant height to evaluate and clas- sify site quality ofteak （Tectona grandis） plantations by using data from 44 permanent sample plots established since 1990 in 3--22 years old teak plantations in the Colombian Caribbean region. We used Korf＇s and yon Bertalanffy＇s models to fit curves as non-linear effects models. Both models, with a single random parameter, were considered as adequate for dominant height growth modelling, but Korf＇s model was superior. The resulting curves were anamorphic and closely reflected high variability in site quality. Five site classes were clarified： at a base age of 12 years old, teak reached a mean dominant height of 24.8 m on the best sites, 9.8 m in the worst sites, and in the averages sites, 15.8-18.8 m. Using this model, we identified the best and the worst sites for teak plantations in the Caribbean region. This model proved a useful tool, not only for site quality evaluation, but also for improved teak plantation planning and management.

关键词： Tectona grandis site index growth modelling permanentsample plots Colombia

Natural variability of essential oil and antioxidants in the medicinal plant Turnera diffusa

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 114-119页

作者： Ana Lucía Urbizu-González Octelina Castillo-Ruiz guillermo Cristian Guadalupe Martínez-Ávila jorge Ariel Torres-Castillo Universidad Autónoma de Tamaulipas Instituto de Ecología AplicadaDivisión del Golfo 356Col.Libertad87019Ciudad VictoriaTamaulipasMéxico Universidad Autónoma de Tamaulipas Unidad Académica Multidisciplinaria Reynosa AztlánCalle 16 y Lago de Chápala s/n Col.AztlánC.P.88740ReynosaTamaulipasMéxico Universidad Autónoma de Nuevo León Facultad de AgronomíaFrancisco Villa s/n.Col.Ex Hacienda El Canadá66050General EscobedoNuevo LeónMéxico

Objective:To evaluate differences in yield and composition of the essential oil and antioxidant contents in *** plants from localities in central region of ***:Samples were collected in Tamaulipas,Mexico in the arid *** oil was obtained through steam distillation and analyzed using *** contents,antioxidant activities using ABTS and ferric reducing antioxidant power(FRAP) methods also were ***:A total of 21 compunds were identified in the essential oils;nevertheless,only Eucalyptol,1,4-Methanocycloocta[d]pyridazine,1,4,4a,5,6,9,10,10a-octahydro-11,11-dimethyl-,(1à,4à,4aà,10aà) y Ethanone,1-(1,3-dimethyl-3-cyclohexen-1-yl) were detected in the three *** contents were registered in the sample from Padrón y Juárez with phenolic content of 33.85 mg GAE/g of dry material and antioxidant activities with ABTS 72.32% and with FRAP 21.33 mg GAE/g of dry *** differences were observed in essential oil,phenolics and antioxidants contents between ***:Results suggest that climatic differences and origin influence the phytochemicals in the medicinal plant ***,and thus,it is worth to consider such effects for industrial and medicinal purposes.

关键词： Essential oil Antioxidants Phytochemicals Chemical variation