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Bile duct hamartomas-the von Meyenburg complex

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 108-109页

作者： Valdemir José Alegre Salles Alexandre Marotta jorge Miguel Kather Netto Manlio Basílio Speranzini marcos Roberto Martins University of Taubaté Department of Medicine So Paulo Brazil

: Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma. We report a 42-year-old female patient with symptomatic cholecystitis, whose gross and ultrasonic appearance suggestive of multiple liver metastases. Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition.

关键词： bile duct hamartoma von Meyenburg complex nonparasitic hepatic cyst, surgery

Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第36期24卷 4104-4118页

作者： jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel marcos Department of Internal Medicine University Hospital of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL Spanish Working Group on Alcohol and Alcoholism Spanish Society of Internal Medicine Department of Internal Medicine University Hospital of Santiago de Compostela Department of Internal Medicine HM Rosaleda HospitalSantiago de Compostela Department of Medicine Faculty of MedicineUniversity of Salamanca

MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease.

关键词： Alcohol use disorder Alcoholic liver disease Non-alcoholic fatty liver disease Steatosis Obesity miRNA Biomarkers

Estimation of the impact of biomass burning based on regional transport of PM_(2.5) in the Colombian Caribbean

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Geoscience Frontiers 2022年第1期13卷 430-436页

作者： Jehison Bolaño-Truyol Ismael L.Schneider Heidis Cano Cuadro jorge D.Bolaño-Truyol marcos L.S.Oliveira Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia Department of Productivity and Innovation Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia Faculdade Meridional IMED 304 Passo FundoRS 99070–220Brazil Universidad de Lima Avenida Javier Prado Este 4600Santiago de Surco 1503Peru

Deterioration of air quality due to the increase in atmospheric emissions from biomass burning(BB)is one of the major environmental problems *** this study,we estimated the contributions of BB to PM_(2.5) concentrations in the municipalities of Soledad and Malambo located in the Colombian *** evaluation period ranged from February 24 to March 30,2018,a period with a high number of BB events recorded in the surroundings of the evaluated *** contribution of BB to the two sampling sites was estimated using the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)dispersion model with forwarding trajectories from each of the burning points identified by satellite images(n=1089).The PM_(2.5) emissions were determined using the fire radiative power(FRP),obtained by remote-sensing data,and corresponded to the radiant energy released per time unit by burning *** average PM_(2.5) concentrations during the evaluation period were 19.91μg/m^(3) for Soledad and 22.44μg/m^(3) for *** average contribution of BB to these municipalities was 22.8%and 28.8%,*** methodology used in this study allowed to estimate the contribution of this important source without knowledge of a previous tracer of BB,thereby increasing the use of the proposed procedure *** information would enable the implementation of effective mitigation,thereby diminishing the adverse impact of PM_(2.5) on the health of the population.

关键词： Biomass burning Particulate matter HYSPLIT Dispersion model Remote sensing

Ecological Costs Applied in the Bleaching of Cotton： A Study for an Optimized Process

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Journal of Chemistry and Chemical Engineering 2013年第7期7卷 633-636页

作者： rosa jorge marcos Tambourgi Elias Basile Santana Jose Carlo Curvelo Carmo Renee Simoes Argolo Arafjo Mauricio de Campos College of Chemistry Engineering State University of Campinas Sao Paulo 03008-020 Brazil Post Graduation Department College of Technology Antoine Skaf Sao Paulo 03008-202 Brazil Production Engineering Post Graduation Program Nine o f July University Sao Paulo 5001-100 Brazil Textile and Fashion Post Graduation Program Sao Paulo University S6o Paulo 03828-000 Brazil

The aim of this paper was to study three variables in hydrogen peroxide bleaching of cotton fabrics： the amount of hydrogen peroxide （H2O2）, peroxide stabilizer （Na2SiO3） and the process temperature. The factorial planning of two levels and three factors was done in order to obtain an optimized recipe for subsequent comparison with commons recipes used in industry. Were evaluated the brightness （DL）, energy consumption （dQ）, H2O2 residual （Rox）, processing time and ecological costs.

关键词： Cotton bleaching factorial planning ecological costs.

Assessment of the Total Organic Carbon and Conductivity in Consecutive Dyeings with Reactive Dyestuffs Using Treated Effluent by UV/H202 Photocatalysis

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Journal of Chemistry and Chemical Engineering 2014年第2期8卷 139-144页

作者： Leite Adilson da SilvaI Barco Luiz Trindade Nelson Barros Araujo Mauricio de Campos rosa jorge marcos Tambourgi Elias Basile Santana José Carlos Curvelo Chemical Textile Post Graduation Department College of Technology SENAI Antoine Skaf $6o Paulo 03008-020 Brazil Textile and Fashion Post Graduation Program S6o Paulo University S6o Paulo 03828-000 Brazil College of Chemical Engineering State University of Campinas Campinas 13083-852 Brazil Production Engineering Post Graduation Program Nove de Julho University Sao Paulo 05001-100 Brazil

The paper was monitored the conductivity （g.L＂l of NaCI）, the absorbances values （Abs） and the amount of TOC （total organic carbon）, before and after five consecutive dyeings made with reuse water, obtained from treated effluent by UV/H202 photocatalysis. All rates of decolorization were above 92%, the removal of total organic carbon was above 89% in all treatments and the economy of NaCI was from 3.10 in the first recipe, 3.17 in the second, 3.49 in the third, 3.79 in the fourth and 4.05 in the fifth recipe. The five dyeings compared with same dyeings made with deionized water presented a color deviation （AE＊） below 1. The conventional dyeings would consume 80 L/kg against 40 L/kg used in the dyeing process proposed in this study, representing a great economy of water, with no discharge of effluents.

关键词： Conductivity reactive dyestuffs reuse of water photocatalysis textile effluent.

Impact,economic evaluation,and sustainability of integrated vector management in urban settings to prevent vector-borne diseases:a scoping review

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Infectious Diseases of Poverty 2018年第1期7卷 830-843页

作者： jorge marcos-marcos Antonio Olry de Labry-Lima Silvia Toro-Cardenas Marina Lacasaña Stephanie Degroote Valery Ridde Clara Bermudez-Tamayo Public Health Research Group University of AlicanteAlicanteSpain Andalusian School of Public Health GranadaSpain Biomedical Research Centre Network for Epidemiology and Public Health(CIBERESP) MadridSpain Biomedical Research Centre(ibs.GRANADA) GranadaSpain Public Health Research Institute(IRSPUM) University of MontrealMontrealQuebecCanada IRD(French Institute for Research on Sustainable Development) CEPED(IRD-Universite Paris Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:The control of vector-borne diseases(VBD)is one of the greatest challenges on the global health *** and uncontrolled urbanization has heightened the interest in addressing these challenges through an integrated vector management(IVM)*** aim was to identify components related to impacts,economic evaluation,and sustainability that might contribute to this integrated approach to VBD *** body:We conducted a scoping review of available literature(2000-2016)using PubMed,Web of Science,Cochrane,CINAHL,Econlit,LILACS,Global Health Database,Scopus,and Embase,as well as Tropical Diseases Bulletin,WHOLIS,WHO Pesticide Evaluation Scheme,and Google *** terms and free-text terms were used.A data extraction form was used,including TIDieR and *** and CHEERS were used to evaluate *** the 42 documents reviewed,30 were focused on dengue,eight on malaria,and two on *** than a half of the studies were conducted in the *** used a quantitative descriptive approach(n=21),followed by cluster randomized controlled trials(n=11).Regarding impacts,outcomes were:a)use of measures for vector control;b)vector control;c)health measures;and d)social *** reduced breeding sites,the entomology index,and parasite *** were heterogeneous,with variable magnitudes,but in all cases were favourable to the *** of IVM impacts on health outcomes was very limited but showed reduced *** outcomes were improved abilities and capacities,empowerment,and community *** economic evaluation,only four studies performed an economic analysis,and intervention benefits outweighed *** was dependent on illness *** results provided key elements to analyze sustainability in terms of three dimensions(social,economic,and environmental),emphasizing the implementation of a community-focused eco-bio-social ***:IVM has an impact on redu

关键词： Vector-borne diseases Integrated vector management Urban health Intervention Scoping review

Dynamics of Knowledge in Software Project Development Environments: An Approach Using Affiliation Networks

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Social Networking 2021年第4期10卷 45-69页

作者： jorge Luiz dos Santos Renelson Ribeiro Sampaio Hernane Borges de Barros Pereira marcos Grilo Computer Modelling Program SENAI CIMATEC Salvador Brazil SENAI CIMATEC University Center Salvador Brazil Bahia State University Salvador Brazil State University of Feira de Santana Feira de Santana Brazil

This work presents an approach to study the diffusion of knowledge in software development project teams based on the formation of complex social network structures in a public organization that offers information and communication technology services. We collected historical data on the allocation and records of hours worked by people in projects to build an affiliation network. We applied the method of reflections to analyze the data obtained. The constructed model enabled the description of the participation of project team members from the perspective of the creation and diffusion of knowledge in affiliation networks that describe the participation of people in projects, mediated by the knowledge and the capabilities developed for the execution of these projects. A contribution of this work is the construction of indicators related to the process of creation and diffusion of knowledge in the context of the execution of software development and maintenance projects, based on the concepts of diversification and ubiquity applied to the process of knowledge diffusion;an additional contribution is the presentation of an application of the method of reflections in an organizational context applied to the creation and diffusion of knowledge. We found that the application of management models associated with the collaborative method applied to the project development process contributed to the joint growth of diversified and more specialized knowledge alongside the knowledge considered more generic and ubiquitous. Our results show that contrary to previous expectations based on assumptions established at the beginning of the study, we concluded that in six of the seven subnetworks obtained in the period between 2007 and 2013, kno

关键词： Social Network Analysis Affiliation Networks Method of Reflections Organizational Knowledge

Laminated Solid Timber Slab with Transverse Prestressing Using the Strategy of Interleaved Vertical Displacement of Lamellae

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Journal of Civil Engineering and Architecture 2024年第4期18卷 186-198页

作者： Bianca Bispo dos Reis jorge Daniel de Melo Moura marcos Vinício de Camargo Everaldo Pletz Graduate Program in Architecture and Urbanism Londrina State UniversityJardim Portal de Versalhes 1Londrina 86057-970PRBrazil Department of Civil Engineering Federal Technological University of Paraná(UTFPR)Apucarana 86812-460PRBrazil Retired professor Department of Structural Engineering Londrina State UniversityLondrina 86057-970PRBrazil

This article presents a study on the structural behavior of transversely prestressed laminated timber slabs,focusing on an innovative approach:vertically misaligned *** misalignment,achieved by sliding vertically the wooden lamellae rather than aligning them,enhances the slab’s cross-section moment of inertia,thereby improving load-bearing capacity and *** involved two groups of structural size specimens:one with vertically aligned lamellae(control group)and the other with misaligned lamellae(study group).Results showed the study group exhibited 42%superior stiffness and 10%less load capacity compared to the *** typically occurred individually in the lamellae,particularly in those with defects or lower modulus of elasticity,concentrated in the middle third of the slabs’free span where tensile stresses *** a higher number of failed lamellae,the study group demonstrated promising *** of prestressing bar indicated no damage at all in the thread,suggesting potential for reducing bar *** findings offer crucial insights into applying these slabs in timber construction as well as to any kind of construction.

关键词： Transversal prestressed slabs wooden construction plantation wood flexural testing design methodology

Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

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Infectious Disease Modelling 2024年第4期9卷 1027-1044页

作者： Francisco Antonio Bezerra Coutinho marcos Amaku Fernanda Castro Boulos Jose Alfredo de Sousa Moreira Joao Italo DiasFranca Julio Antonio do Amaral Eliana Nogueira Castro de Barros Claudio Jose Struchiner Esper jorge Kallas Eduardo Massad School of Medicine University of Sao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil

In this paper we examine several definitions of vaccine efficacy(VE)that we found in the literature,for diseases that express themselves in outbreaks,that is,when the force of infection grows in time,reaches a maximum and then *** fact that the disease occurs in outbreaks results in several problems that we *** propose a mathematical model that allows the calculation of VE for several *** trials usually needs a large number of volunteers that must be ***,all volunteers should be enrolled in approximately the same time,but this is generally impossible for logistic reasons and they are enrolled in a fashion that can be replaced by a continuous density function(for example,a Gaussian function).The outbreak can also be replaced by a continuous density function,and the use of these density functions simplifies the ***,for example Gaussian functions,one of the problems one can immediately notice is that the peak of the two curves do not occur at the same *** model allows us to conclude:First,the calculated vaccine efficacy decreases when the force of infection increases;Second,the calculated vaccine efficacy decreases when the gap between the peak in the force of infection and the peak in the enrollment rate increases;Third,different trial protocols can be simulated with this model;different vaccine efficacy definitions can be calculated and in our simulations,all result are approximately the *** final,and perhaps most important conclusion of our model,is that vaccine efficacy calculated during outbreaks must be carefully examined and the best way we can suggest to overcome this problem is to stratify the enrolled volunteer's in a cohort-by-cohort basis and do the survival analysis for each cohort,or apply the Cox proportional hazards model for each cohort.

关键词： Vaccine efficacy Clinical trials Mathematical models Simulations Covid-19