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Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis Muñoz de Nova jorge hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María Isabel del Olmo García jorge Barriuso Jaume Capdevila Elena Martín-Pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and Nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Pathology Universidad Autónoma de MadridMadrid 28029Spain Department of Nuclear Medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and Nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy Neoplasm grading Treatment outcome

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Mantle derived crystal-poor rhyolitic ignimbrites:Eruptive mechanism from geochemical and geochronological data of the Piedra Parada caldera,Southern Argentina

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Geoscience Frontiers 2018年第5期9卷 1529-1553页

作者： Eugenio Aragon Antonio Castro Juan Diaz-Alvarado Lucio Pinotti Fernando D'eramo Manuel Demartis jorge Coniglio Irene hernando Carmen Rodriguez Centro de Investigaciones Geológicas(UNLP-CONICET) 1 N^o 644(1900)La PlataBuenos AiresArgentina Departamento de Geología Universidad de Huelva21071 HuelvaSpain Departamento de Geología Universidad de AtacamaCopayapu 485CopiapóChile Departamento de Geología Universidad Nacional de Río Cuarto(UNRC-CONICET)Ruta 36 km 601Río CuartoCórdobaArgentina

Trace elements, isotopic modeling and U-Th-Pb SHRIMP zircon age constraints are used to reconstruct the eruption history and magmatic processes of the Piedra Parada Caldera. In the early Eocene, the crystal-poor Barda Colorada ignimbrite(BCI), having >>15% micro-porphyritic crystals with respect to magmatic components, erupted a volume estimated in more than 300 km^3. The Piedra Parada caldera is located in the Patagonian Andes foreland, at the southern end of the calderas field of the Pilcaniyeu Volcanic Belt(PVB). This belt is related to an extensional tectonic setting as a result of the collision of the Farallon-Aluk ridge with South America, which enabled the development of a transform ocean/continental plate margin followed by the detachment of the Aluk plate and the opening of a slab window. The BCI extra-caldera Plateau is a >100 m thick deposit, having a lower unit with high silica(Si O_2> 76 wt.%),potassium poor rhyolitic composition(trondhjemitic like magma), and an upper unit with normal to high potassium rhyolitic composition(granitic like magma). A trace elements modeling of the BCI units shows that the BCI lower and upper units did not evolve from fractionation or immiscibility in the shallow magma reservoir. The BCI also have a primitive isotopic signature(initial87 Sr/86 Sr =0.7031-0.7049 and ε_(Nd)= +3.4 to +3.65). Thus, tectonic, compositional and isotopic constraints suggest the fast ascent of high silica magmas to a shallow reservoir, and point to an upper mantle origin for these rhyolitic magmas in a transitional(Orogenic-Anorogenic) tectono-magmatic setting. U-Th-Pb SHRIMP zircon crystallization ages of the Syn-caldera stage BCI units(56 -51.5 Ma) show a protracted life of 5 Ma for this caldera reservoir. The age of 52.9 ± 0.3 Ma is considered the best fit for the possible maximum age for the caldera collapse. The Late-caldera magmatism has trachyandesitic and rhyolitic *** trace element modeling suggests that these rhyolites evolv

关键词： Mantle derived rhyolite Crystal-poor ignimbrite Bimodal volcanism Slab window volcanism K poor-rhyolite

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The Farallon-Aluk ridge collision with South America:Implications for the geochemical changes of slab window magmas from fore- to back-arc

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Geoscience Frontiers 2013年第4期4卷 377-388页

作者： Eugenio Aragón Lucio Pinotti Fernando D'Eramo Antonio Castro Osvaldo Rabbia jorge Coniglio Manuel Demartis Irene hernando Claudia E.Cavarozzi Yolanda E.Aguilera Centro de Investigaciones Geologicas(UNLP-CONICET) 1 N°644(1900) La Plata.Buenos Aires.Argentina Facultad de Ciencias Naturales y Museo Universidad Nacional de la Plata122 y 60s/n.(1900).La PlataBuenos AiresArgentina Departamento de Geologia.Universidad Nacional de Rio Cuarto.(UNRC-CONICET).Ruta 36 km 601.Rio Cuarto.Cordoba.Argentina Departamento de Geologia.Universidad de Huelva.21071 Huelva.Spain Instituto de Geologia Economica Aplicada.Universidad de Concepcion.Concepcion.Chile Departamento de Geologia.Universidad Nacional de Rio Cuarto.(UNRC-CONICET) Ruta 36 km 601.Rio Cuarto.CordobaArgentina Centro de Investigaciones Geologicas(UNLP-CONICET).1 N°644.(1900) La Plata.Buenos Aires.Argentina Facultad de Ciencias Naturales y Museo.Universidad Nacional de la Plata.122 y 60 s/n.(1900).La PlataBuenos Aires.Argentina Facultad de Ciencias Naturales y Museo.Universidad National dela Plata.122 y 60 s/n(1900)La Plata.Buenos Aires.Argentina Direccion de Aplicacion de Imagenes Satelitarias(M.O.S.P.).58 e/ 7 y 8.piso 2.1900 La Plata.Buenos Aires.Argentina

The collision of a divergent ocean ridge may evolve into two end cases： in the continuity of ocean-floor subduction, or in the detachment of the subducted plate. The northern Patagonia active plate margin has the unique situation that in Cenozoic time it has been subjected to two divergent ridge collisions, each one representing one of the end members. The Neogene Antarctica-Nazca divergent ridge collision evolved as a continuous ocean-floor subduction system, promoting a magmatic hiatus at the arc axis, the obduction of part of the ridge ocean-floor in the fore-arc, and basaltic volcanism in the back-arc. In contrast, the Paleogene Farallon-Aluk divergent ridge collision evolved into a transform margin, with the detachment and sinking of the Aluk plate and the development of a large slab window. As in the previous case, this collision promoted a magmatic hiatus at the arc axis, but the tectono-magmatic scenario changed to postorogenic synextensional volcanism that spread to the former fore-arc （basalt, andesite, rhyolite） and former back-arc （bimodal ignimbrite flare-up, basalt）. Geochemistry of this slab window synextensional volcanism shows more MORB-like basalts towards the former fore-arc, and MORB-OIB-Iike basalts towards the former back-arc. Instead, an isolated undeformable crustal block in the former back-arc, with an ＂epeirogenic＂ response to the slab window and extensional regime, was covered by OIB-type basalts after uplift. Major elements show that slab window basalts reach TiO2 values up to 3 wt%, as compared with the top value of 1.5 wt% of arc magmas. Besides, the MgO with respect to （FeOt ＋ A1203） ratio helps to distinguish slab window magma changes from the former fore-arc to the former back-arc and also with respect to the ＂epeirogenic＂ block. Higher contents of HFS elements such as Nb and Ta also help to distinguish this slab window from arc magmas and also, to distinguish slab window magma changes from the former fore-arc to the former back-arc

关键词： AndesActive ridge collisionSubduction-transform transitionSlab window volcanismSynextensional calc-alkalineBimodal volcanism

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Biodiesel production from waste frying oil in sub- and supercritical methanol on a zeolite Y solid acid catalyst

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 401-407页

作者： jorge MEDINA-VALTIERRA jorge RAMIREZ-ORTIZ Department of Chemical & Biochemical Engineering Aguascalientes Institute of Technology Aguascalientes Ags. 20256 M6xico Academic Unit of Chemical Sciences Autonomous University of Zacatecas Zac. 98160 Mexico

Waste frying oil （WFO） is a very important feedstock for obtaining biodiesel at low cost and using WFO in transesterification reactions to produce biodiesel helps eliminate local environmental problems. In this study biodiesel was produced from WFO in sub- and super- critical methanol on a zeolite Y solid acid catalyst. The procedure was optimized using a design of experiments by varying the methanol to WFO molar ratio, the reaction temperature, and the amount of catalyst. Typical biodiesel yields varied from 83 to nearly 100% with methyl esters content ranging from 1.41-1.66mol.L-~ and typical dynamic viscosities of 22.1-8.2 cE Gas chromatography was used to determine the molecular composition of the biodiesel. The reaction products contained over 82 wt-% methyl esters, 4.2 wt-% free acids, 13.5 wt-% monoglycer- ides, and 0.3 wt-% diglycerides. The transesterification of WFO with methanol around its critical temperature combined with a zeolite Y as an acid catalyst is an efficient approach for the production of biodiesel with acceptable yields.

关键词： biodiesel methanol critical temperature,waste frying oil zeolite Y

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Core promoter: A critical region where the hepatitis B virus makes decisions

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World Journal of Gastroenterology 2014年第2期20卷 425-435页

作者： jorge Quarleri Instituto de Investigaciones Biomédicas en Retrovirus y Sida Universidad de Buenos AiresBuenos Aires C1121ABGArgentina

The core promoter(CP) of the viral genome plays an important role for hepatitis B virus(HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic(pg) RNAs. The CP consists of the upper regulatory region and the basa core promoter(BCP). The CP overlaps with the 3'-end of the X open reading frames and the 5'-end of the precore region,and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation,when variations appear,they may contribute to the persistence of HBV within the host,leading to chronic infection and cirrhosis,and eventually,hepatocellular carcinoma. Among CP sequence variations,those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen,and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated.

关键词： Hepatitis B virus Core promoter Variants Basal core promoter Transcription regulation

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Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： jorge CARAVANTES Laureano GONZALEZ-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词： Topology computation Real plane curves Sweeping method

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Stable Matchings in the Marriage Model with Indifferences

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Journal of the Operations Research Society of China 2021年第3期9卷 593-617页

作者： Noelia Juarez jorge Oviedo Instituto de Matemática Aplicada San Luis IMASLUniversidad Nacional de San Luis and CONICETEjército de los Andes 950D5700HHW San LuisArgentina

For the marriage model with indifferences,we define an equivalence relation over the stable matching *** identify a sufficient condition,the closing property,under which we can extend results of the classical model(without indifferences)to the equivalence classes of the stable matching *** condition allows us to extend the lattice structure over classes of equivalences and the rural hospital theorem.

关键词： Stability Indifferences Lattice structure

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Asymptomatic male currently not desiring fertility with bilateral subclinical varicocele found on ultrasound evaluation and borderline semen analysis results

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Asian Journal of Andrology 2016年第2期18卷 315-316页

作者： jorge Hallak Androscience High Complexity Andrology and Research Laboratory in MaleReproductive Health Section of Andrology Division of Urology Department of Surgery Hospital das Clinicas University of Sao Paulo Medical School Sao PauloBrazil Reproductive Toxicology Unit Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil.

Varicoceles are a fountain of inspiration for male health providers since times immemorial, and it has haunted men ever since with so many different and multifaceted aspects that even today, basic scientists and andrologists are finding new and exciting discoveries derived from its pathophysiology, clinical outcomes, and consequences. Varicocele is a perfect model to link basic science with technological innovation in diagnostic testing in semen analysis and surgical techniques improving medical practice and improving male reproductive and general health.

关键词： @@

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