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dominance of transposable element‑related satDNAs results in great complexity of“satDNA library”and invokes the extension towards“repetitive DNA library”

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Marine Life Science & Technology 2024年第2期6卷 236-251页

作者： Monika Tunjić‑Cvitanić Daniel garcía‑Souto Juan J.Pasantes EvaŠatović‑Vukšić Division of Molecular Biology Ruđer BoškovićInstitute10000 ZagrebCroatia Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain Department of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Centro de Investigación Mariña Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Research on bivalves is fast-growing,including genome-wide analyses and genome *** characteristics qualify oysters as a valuable model to explore repetitive DNA sequences and their genome *** we char-acterize the satellitomes of five species in the family Ostreidae(Crassostrea angulata,***,***,***,Ostrea edulis),revealing a substantial number of satellite DNAs(satDNAs)per genome(ranging between 33 and 61)and peculiarities in the composition of their *** satDNAs were either associated to or derived from transposable elements,displaying a scarcity of transposable element-unrelated satDNAs in these *** to the non-conventional satellitome constitution and dominance of Helitron-associated satDNAs,comparative satellitomics demanded more in-depth analyses than standardly *** analyses(including ***,the first bivalve species with a defined satellitome)revealed that 13 satDNAs occur in all six oyster genomes,with Cg170/HindIII satDNA being the most abundant in all of *** the“satDNA library model”highlighted the necessity to adjust this term when studying tandem repeat evolution in organisms with such *** repetitive sequences with potential variation in the organizational form and repeat-type affiliation are examined across related species,the introduction of the terms“TE library”and“repetitive DNA library”becomes essential.

关键词： Satellitome Comparative satellitomics Helitron Bivalves “Dark matter of the genome”

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How inflammation influences psychiatric disease

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World Journal of Psychiatry 2024年第3期14卷 342-349页

作者： Eduardo Ferat-Osorio JoséLuis Maldonado-garcía Lenin Pavón División de Investigación Clínica de la Coordinación de Investigación en Salud Instituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico

Recent studies highlight the strong correlation between infectious diseases and the development of neuropsychiatric *** this editorial,we comment on the article“Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients”by Zhang et al,published in the recent issue of the World Journal of Psychiatry 2023;13(11):*** discussion highlighted the potential consequences of anxiety,depression,and psychosis,which are all linked to bacterial,fungal,and viral infections,which are relevant to the impact of inflammation on the sequelae in mental health as those we are observing after the coronavirus disease 2019 *** focus specifically on the immune mechanisms triggered by inflammation,the primary contributor to psychiatric ***,pathophysiological mechanisms such as organ damage,post-injury inflammation,and infectioninduced endocrine alterations,including hypocortisolism or autoantibody formation,significantly contribute to the development of chronic low-grade inflammation,promoting the emergence or development of psychiatric alterations in susceptible *** inflammation can have long-term effects on patients,a multidisciplinary treatment plan can avoid complications and debilitating health issues,and it is crucial to recognize and address the mental health implications.

关键词： Inflammation infection Depression Pelvic inflammatory disease Psychiatric complication

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Are dogs not susceptible to retroviral infections?

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Animal Diseases 2024年第3期4卷 217-223页

作者： jorge Casseb João Henrique Campos Luciano Rodrigo Lopes Laboratory of Investigation in Dermatology and Immunodefciencies Department of DermatologyUniversity of São Paulo Medical SchoolSão PauloSPBrazil Igen-Institute of Immunogenetics São PauloSPBrazil Bioinformatics and Biomedical Data Science Division Health Informatics DepartmentUniversidade Federal de São Paulo–UNIFESP.Rua Botucatu 862Prédio Leal PradotérreoVila ClementinoCEP 04023-062São PauloSPBrazil

Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in ***,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to understand why dogs may have not been infected by retroviruses thus *** potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question,looking at some evolutive *** lineage of canids has shown,throughout its evolutionary history,a smaller accumulation of retroviruses in canid genomes,classifed as endogenous *** this context,the genomes of canids seem to ofer obstacles,which have been evolutionarily conserved,in the face of retroviral infection.

关键词： Retrovirus dogs Endogenous retrovirus

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The immune hunger games:the effects of fasting on monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1098-1100页

作者： jorge domínguez-Andrés Holger Reinecke Yahya Sohrabi Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Nijmegen Medical Centre6500HBNijmegenthe Netherlands Department of Cardiology I-Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzech Republic Department of Medical Genetics Third Faculty of MedicineCharles UniversityPragueCzech Republic

Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic ***,how these practices affect immune function is not well *** a recent study published in Immunity,Janssen et *** into the complex relationship among fasting,refeeding,and the immune *** fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].

关键词： becoming fasting she

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Wear protection assessment of ultralow viscosity lubricants in high-power-density engines:A novel wear prediction algorithm

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Friction 2024年第8期12卷 1785-1800页

作者： Javier BLANCO-RODRÍGUEZ Jacobo PORTEIRO JoséA.LÓPEZ-CAMPOS MartíCORTADA-garcÍA Silvia FERNÁNDEZ-CASTEJÓN CINTECX Universidade de VigoLagoas-Marcosende s/nVigo 36310Spain Repsol SA MadridSpain

Durability and reliability have been studied for decades through intensive trial-error ***,there are numerous fields of application where the costs associated with this approach are not *** lubricated machines with severe dynamic loads,such as high-power-density engines,simulation tools offer clear advantages over intensive *** and multiple scenarios can be cost-effectively simulated to assess different lubricants and engine *** work presented here details the study of wear based on a validated elastohydrodynamic(EHD)simulation model of the connecting rod journal *** model accounts for elastic deformation through a connecting rod finite element model(FEM).In addition,multiple lubricant rheological and tribological dependences,determined by specific experimental tests,are applied in the model through their interaction with the simulation ***,a novel wear algorithm is proposed to predict wear depth over time evolution along a proposed wear cycle based on the typical working ranges of high-performance engines.A final assessment is presented to compare 4 different ultralow-viscosity lubricants in their protective performance under severe *** results show the evolution of the wear load and wear depth over the wear *** evaluation is key to describing a lubricant selection procedure for high-power-density engines.

关键词： wear modelling finite element modelling mixed lubrication elastohydrodynamic(EHD) internal combustion engines bearings

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Review of Networked Microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： jorge de la Cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep M.Guerrero Center for Research on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

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Cost-Effectiveness Analysis of Renalof® versus Extracorporeal Shockwave Lithotripsy (ESWL) for the Treatment of Kidney Stones ≤ 1 cm in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： Mélida M. Aguilar Chamorro Sergio Vargas Collado Leslie Pérez Ruíz David Márquez Soriano jorge Luis Soriano garcía Clínica Senior Managua Nicaragua Centro de Inmunología Molecular Havana Cuba Catalysis S.L. Madrid Spain

Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Methods: A cost-effectiveness economic evaluation was carried out based on the results obtained in the randomised, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the incremental cost-effectiveness ratio (ICER) were calculated. Economic data were obtained from the Economics Department of Clínica Senior in Managua, Nicaragua. The monetary cost was expressed in US dollars (USD). Results: Treatment with Renalof® yielded a CE of $1,323.08/% remission, while ESWL was $9,498.54/% remission. The ICER shows that, in order to achieve a high percentage of kidney stone remission with ESWL, an extra $4,734.70 per patient must be invested. Conclusions: The use of Renalof® is shown to be a more cost-effective option than ESWL. It is recommended for the treatment of kidney stones ≤ 1 cm in size.

关键词： Economic Evaluation Pharmacoeconomics Renalof® Extracorporeal Shockwave Lithotripsy Kidney Stones

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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-Cano Gonzalo Flores jorge Guevara Julio Cesar Morales-Medina Samuel Treviño Alfonso Diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

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Mental health in organizations from a healthcare analytics framework:taxonomic model,trends,and impact of COVID-19

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Journal of Management Analytics 2024年第1期11卷 62-86页

作者： jorge Iván Pérez Rave Carlos Mario Zapata Jaramillo Gloria Patricia Jaramillo Álvarez IDINNOV research group IDINNOV S.A.SMedellínColombia Department of Computing and Decision Sciences Universidad Nacional de ColombiaMedellínColombia

Mental disorders negatively affect employee well-being and organizational *** face a challenge in terms of how to manage mental *** paper clarifies three issues(underlying patterns,trends,and impact of COVID-19)regarding the scientific study of mental health in organizations from a healthcare analytics *** framework comprises eight stages considering a text-driven approach with scientific corpora assisted by linguistic/computational and statistical *** study discovers a new taxonomic model comprising five patterns in the scientific discourse on the *** analyses reveal imbalances and concerns regarding the interests associated with the patterns,which is reinforced by examining patterns“before”and“during”*** paper complements psychological/epidemiological studies on mental health in organizations from a healthcare analytics perspective.

关键词： Healthcare analytics healthcare management analytics mental health scientific discourse text analytics taxonomy COVID-19 management analytics

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Deep optics preconditioner for modulation-free pyramid wavefront sensing

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Photonics Research 2024年第2期12卷 301-312页

作者： FELIPE GUZMÁN jorge TAPIA CAMILO WEINBERGER NICOLÁS HERNÁNDEZ jorge BACCA BENOIT NEICHEL ESTEBAN VERA School of Electrical Engineering Pontificia Universidad Católica de Valparaı´soValparaı´soChile Department of Systems Engineering Universidad Industrial de SantanderBucaramangaColombia Laboratoire d’Astrophysique de Marseille MarseilleFrance

The pyramid wavefront sensor(PWFS)can provide the sensitivity needed for demanding adaptive optics applications,such as imaging exoplanets using the future extremely large telescopes of over 30 m of diameter(D).However,its exquisite sensitivity has a limited linear range of operation,or dynamic range,although it can be extended through the use of beam modulation—despite sacrificing sensitivity and requiring additional optical *** by artificial intelligence techniques,this work proposes to train an optical layer—comprising a passive diffractive element placed at a conjugated Fourier plane of the pyramid prism—to boost the linear response of the pyramid sensor without the need for cumbersome *** develop an end-2-end simulation to train the diffractive element,which acts as an optical preconditioner to the traditional least-square modal phase estimation *** results with a large range of turbulence conditions show a noticeable improvement in the aberration estimation performance equivalent to over 3λ∕D of modulation when using the optically preconditioned deep PWFS(DPWFS).Experimental results validate the advantages of using the designed optical layer,where the DPWFS can pair the performance of a traditional PWFS with 2λ∕D of *** and adding an optical preconditioner to the PWFS is just the tip of the iceberg,since the proposed deep optics methodology can be used for the design of a completely new generation of wavefront sensors that can better fit the demands of sophisticated adaptive optics applications such as ground-to-space and underwater optical communications and imaging through scattering media.

关键词： process optics pyramid

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