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Effects of Resistant Starch on Symptoms,Fecal Markers,and Gut Microbiota in Parkinson’s disease—The RESISTA-Pd Trial

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 274-287页

作者： Anouck Becker Georges Pierre Schmartz Laura Groger Nadja Grammes Valentina Galata Hannah Philippeit Jacqueline Weiland Nicole Ludwig Eckart Meese Sascha Tierling Jorn Walter Andreas Schwiertz jorg Spiegel Gudrun Wagenpfeil Klaus Faßbender Andreas keller Marcus M.Unger department of Neurology Saarland UniversityD-66421 HomburgGermany Chair for Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany department of Human Genetics Saarland UniversityD-66421 HomburgGermany department of Genetics/Epigenetics Saarland UniversityD-66123 SaarbruckenGermany Institute of Microecology D-35745 HerbornGermany Institute of Medical Biometry Epidemiology and Medical InformaticsSaarland UniversityD-66421 HomburgGermany department of Neurology Stanford UniversityPalo AltoCA 94305USA

The composition of the gut microbiota is linked to multiple diseases,including Parkinson’s disease(Pd).Abundance of bacteria producing short-chain fatty acids(SCFAs)and fecal SCFA concentrations are reduced in *** exert various beneficial functions in *** the interventional,monocentric,open-label clinical trial “Effects of Resistant Starch on Bowel Habits,Short Chain Fatty Acids and Gut Microbiota in Parkinson’s disease”(RESISTA-Pd;Id:NCT02784145),we aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch(RS).We enrolled 87 subjects in three study-arms:32 Pd patients received RS(Pd+RS),30 control subjects received RS,and 25 Pd patients received solely dietary *** performed paired-end 100 bp length metagenomic sequencing of fecal samples using the BGISEQ platform at an average of 9.9 *** was *** the Pd+RS group,fecal butyrate concentrations increased significantly,and fecal calprotectin concentrations dropped significantly after 8 weeks of RS ***,we observed a reduction in non-motor symptom load in the Pd+RS *** reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups,including bacteria producing ***-free analysis suggested punctual,yet pronounced differences in the metagenomic signature in the Pd+RS ***-Pd highlights that a prebiotic treatment with RS is safe and well-tolerated in *** stable alpha-diversity and beta-diversity alongside altered fecal butyrate and calprotectin concentrations call for long-term studies,also investigating whether RS is able to modify the clinical course of Pd.

关键词： Parkinson’s disease Short-chain fatty acid Microbiota Metagenomics Intestinal inflammation

文本与图像的对话——检视夏钦·仁钦米久坚赞(1717-1780年)生平传记唐卡的历史宗教语境

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藏学学刊 2020年第1期 275-298,348,349页

作者：约克·韩贝勒尔德国汉堡大学

丰富多彩的生平传记和历史传记类藏文文献是研究西藏艺术史的重要文献资料,它们为我们提供了关于神圣艺术品委托制作的珍贵参考(即外部证据)。同样重要的是艺术品中包含的信息,如图像、风格和铭文(即内部证据)。这两类证据之间的对话可... 详细信息

丰富多彩的生平传记和历史传记类藏文文献是研究西藏艺术史的重要文献资料,它们为我们提供了关于神圣艺术品委托制作的珍贵参考(即外部证据)。同样重要的是艺术品中包含的信息,如图像、风格和铭文(即内部证据)。这两类证据之间的对话可以极大地帮助我们发现重要的信息,不仅有助于单个艺术品的年代判断,而且有助于澄清它们所产生的历史宗教背景。运用这种方法,本文讨论了夏钦·仁钦米久坚赞(■)1717-1780年,俄尔寺第37任堪布,(1746-1751在任)的生平传记叙事绘画。这幅画描绘了他一生中的六个片段,并伴有金色乌坚字体撰写的偈颂题记。相关的文献材料,包括他的长篇传记中,都有这些生平片段的介绍并且被置于他一生更为广阔的语境中。此外,如果我们考虑到许钦•楚臣任钦(■1697-1774年)为神圣艺术品的委托制作而撰写的偈颂文作为题记,那么就可以清楚地知道这幅绘画是一大套唐卡中的一部分,这套唐卡不仅描绘了夏钦•米久坚赞的今生,还描述了他的前世,这些在他的传记中都有记载。不仅如此,我们还可以证明这整套唐卡的委托绘制时间是1760年代或1770年代左右。为了进一步阐明该项委托的历史背景,本文探讨了夏钦·米久坚赞作为俄尔上师在德格王室的作用,并且介绍了他与王室成员的关系,包括国王洛卓嘉措(■1723-1774年),他的妻子扎西旺姆(■卒于1768年),他的侄子却迥贡布(■卒于1767/68年)和他的姐姐央金卓玛(■1727-1786年)。

关键词：文献材料贡布唐卡仁钦重要文献资料宗教背景王室成员

基于微缩雷达应用的硅基毫米波片上天线（英文）

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现代雷达 2019年第11期41卷 42-50页

作者：张我弓 SCHULZE J?rg KASPER Erich 南京楚航科技有限公司斯图加特大学半导体工程研究所斯图加特大学第五系

为研究小型化、微型化天线在现代无线应用中的集成趋势,对当前工艺水平下的毫米波段片上天线(AoC)设计进行了总结。从集成角度,对单片集成和混合集成的概念分别进行了优劣比较和讨论。作为一个单片集成技术方案的可靠候选,对硅基单片毫... 详细信息

为研究小型化、微型化天线在现代无线应用中的集成趋势,对当前工艺水平下的毫米波段片上天线(AoC)设计进行了总结。从集成角度,对单片集成和混合集成的概念分别进行了优劣比较和讨论。作为一个单片集成技术方案的可靠候选,对硅基单片毫米波集成电路(SIMMWIC)技术进行了介绍,并给出了利用该技术实现的整流天线例子。通过单片集成的雪崩二极管发射机展示了如何利用三维电磁仿真工具设计及证明片上天线的性能,利用仿真和实际验证探讨了硅基毫米波片上天线的挑战和方法,为小型化雷达系统方案提供了一个稳固的基础。

关键词：汽车雷达毫米波片上天线硅基单片毫米波集成电路整流天线雪崩二极管发射机三维电磁

Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVId-19 convalescent patients revealed by two different detection methods

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Cellular & Molecular Immunology 2021年第4期18卷 936-944页

作者： Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster Institute of Immunology Hannover Medical SchoolHannoverGermany lnstitute of Virology Hannover Medical SchoolHannoverGermany department of Hematology HemostasisOncology and Stem Cell TransplantationHannover Medical SchoolHannoverGermany Institute of Transfusion Medicine and Transplant Engineering Hannover Medical SchoolHannoverGermany German Primate Center-Leibniz Institute for Primate Research GottingenGermany Faculty of Biology and Psychology University GottingenGottingenGermany department of Rheum atology and Immunology Hannover Medical SchoolHannoverGermany Public Health department HannoverGermany department of Pneumology and German Centre of Lung Research(dZL) Hannover Medical SchoolHannoverGermany German Center for Infection Research(dZIF) partner site Hannover-BraunschweigHannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

Neutralizing antibodies targeting the receptor-binding domain(RBd)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVId-19)convalescent patients interfere with the binding of SARS-CoV-2 S to *** tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVId-19 convalescent ***,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA ***,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient *** to pVNT,sVNT is less sophisticated and does not require any biosafety *** this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy.

关键词： COVId-19 SARS-CoV-2 Neutralizing antibody Serum ELISA

When Lotus Leaves Prevent Metal from Melting一Biomimetic Surfaces for High Temperature Applications

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Journal of Bionic Engineering 2019年第2期16卷 281-290页

作者： Wilfried Konrad jorg Adam Siegfried Konietzko Christoph Neinhuis Technical University of dresden Institute of BotanyZellescher Weg 20bD-01062 Dresden Germany VdEh-Betriebsforschungsinstitut GmbH Sohnstrafie 6540237 DusseldorfGermany Lebronze Alloys Germany-Hundt&Weber GmbH、Birlenbacher Strafie 1 57078 SiegenGermany CON-RE A Consulting&RealizationGrafschafter Strafie 1347199 DuisburgGermany

Functional properties of biological surfaces have gained increasing interest in the last two decades,especially with regard to wetting and ***,biological surfaces of arthropods(Collembola)and plants(sacred Lotus)served as models for the principle design of high temperature resistant surfaces used in blast furnaces to prevent tuyeres from *** are double-walled,watercooled pipes supplying the blast furnace with hot air to keep the reduction and melting process *** failure is mainly caused by melting of the wall after direct contact with liquid iron,resulting in the partial shut down of the blast furnace and huge energy *** a new approach to avoid tuyere failure we developed a new type of tuyere surface with(i)defined cone shaped indentations and(ii)a heat resistant zirconium/corundum coating with"ferrophobic”properties *** forms with liquid iron of 1500°C a contact angle exceeding 130°.Theoretical considerations indicate that liquid iron infiltrates these indentations only partially if this contact angle and the aperture angle of the cone satisfy an inequality *** heat conductivity of the remaining gas trapped inside the cones is by five orders of magnitude lower than in copper,the overall heat flow into the tuyere is substantially reduced and the outer walls are much less prone to melting.

关键词： tuyere blast furnace biomimetics liquid iron heat flow

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3d真振幅有限炮检距偏移

油气藏评价与开发 1994年第3期 83-83页

作者： jorg Schleicher

非零偏一次反射纵波能被成像到经3d时间偏移或深度偏移后的反射波剖面之中,因此偏移后的波场振幅反映了反射波系数随入射角的变化,包括最近提出的加权绕射叠加法在内的各种偏移/反演算法都是以Born近似或克希霍夫近似法为基础的。本文... 详细信息

非零偏一次反射纵波能被成像到经3d时间偏移或深度偏移后的反射波剖面之中,因此偏移后的波场振幅反映了反射波系数随入射角的变化,包括最近提出的加权绕射叠加法在内的各种偏移/反演算法都是以Born近似或克希霍夫近似法为基础的。本文提出了一种3d克希霍夫型叠前偏移法,这种方法预先以零级绕射线近似来描述被成像波场的一次反射波。这样,试图恢复与入射角有关的反射系数这一主要问

关键词：几何扩散因子震源反射波波场

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核废料储罐表面化学环境长期演变预测

装备环境工程 2018年第10期15卷 103-108页

作者：黄彦良郑珉张琦超路东柱王秀通 KUNTE Hans-jorg SANd Wolfgang 中国科学院海洋研究所山东青岛 266071 中国科学院海洋大科学研究中心山东青岛 266071 中国科学院大学北京 100049 Federal Institute for Materials Research and Testing Berlin D-12205 东华大学环境科学与工程学院上海 201620 Technical University and Mining Academy Freiberg Freiberg D-09596 University duisburg-Essen Essen D-47057

通过对国内外的核废料处置库环境试验监测及预测模型的调研,总结了核废料储罐在直接填埋、缓冲/回填和加混凝土缓冲层等埋藏方式下的表面环境变化,主要包括氧含量、缓冲材料的孔隙液成分及pH值,为我国核废料储库环境下储罐表面重要的腐... 详细信息

通过对国内外的核废料处置库环境试验监测及预测模型的调研,总结了核废料储罐在直接填埋、缓冲/回填和加混凝土缓冲层等埋藏方式下的表面环境变化,主要包括氧含量、缓冲材料的孔隙液成分及pH值,为我国核废料储库环境下储罐表面重要的腐蚀演变研究提供了参考。

关键词：核废料处置库腐蚀环境腐蚀演变

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核废料储罐近域环境中温湿度长期演变预测

装备环境工程 2018年第10期15卷 109-113页

为获得核废料储罐与周围环境界面的温湿度信息,以便模拟不同地质处置时期储罐表面的腐蚀环境,通过对一些典型核能利用国家在高放核废料安全处置研究中对储罐表面温度的长期演变计算进行调研,结合不同埋藏模式推测出适于我国的核废料储... 详细信息

为获得核废料储罐与周围环境界面的温湿度信息,以便模拟不同地质处置时期储罐表面的腐蚀环境,通过对一些典型核能利用国家在高放核废料安全处置研究中对储罐表面温度的长期演变计算进行调研,结合不同埋藏模式推测出适于我国的核废料储罐表面温度演变规律。同时根据国内外对核废料储库中缓冲/回填材料饱和度的变化情况推测我国核废料储罐表面环境中膨润土含水量的时间演变趋势。研究表明,储罐表面初始时温度快速升高,至温度峰值后逐渐下降,为安全起见,最高温应设计低于100℃。膨润土的饱和度受到核废料衰变释热及地下水入渗的双重影响,早期以核废料衰变主导,后来受地下水入渗影响显著。一般认为储罐表面膨润土在3年左右含水量明显增加,约10年左右达到饱和。温湿度长期演变预测将为我国核废料储罐表面腐蚀演变研究奠定基础。

关键词：核废料处置库温湿度腐蚀演变

Superior biocompatibility and comparable osteoinductive properties: Sodium-reduced fluoride-containing bioactive glass belonging to the CaO–MgO–SiO2 system as a promising alternative to 45S5 bioactive glass

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Bioactive Materials 2020年第1期5卷 55-65页

作者： S.I.Schmitz B.Widholz C.Essers M.Becker d.U.Tulyaganov A.Moghaddam I.Gonzalo de Juan F.Westhauser Center of Orthopedics Traumatology and Spinal Cord InjuryHeidelberg University HospitalSchlierbacher Landstraße 200a69118HeidelbergGermany disperse Solid Materials Technical University DarmstadtOtto-Berndt-Straße 364287DarmstadtGermany department of Natural-Mathematical Sciences Turin Polytechnic University in Tashkent17 Small Ring Street100095TashkentUzbekistan ATORG-Aschaffenburg Trauma and Orthopedic Research Group Center for Trauma SurgeryOrthopedicsand Sports MedicineKlinikum Aschaffenburg-AlzenauAm Hasenkopf 163739AschaffenburgGermany

Bioactive glasses(BGs)are promising bone substitute ***,under certain circumstances BGs such as the well-known 45S5 Bioglass®(composition in wt%:45.0 SiO2,24.5 Na2O,24.5 CaO,6.0 P2O5)act cytotoxic due to a strong increase in pH caused by a burst release of sodium ions.A potential alternative is a sodiumreduced fluoride-containing BG belonging to the CaO–MgO–SiO2 system,namely BG1d-BG(composition in wt%:46.1 SiO2,28.7 CaO,8.8 MgO,6.2 P2O5,5.7 CaF2,4.5 Na2O),that has already been evaluated in-vitro,in-vivo and in preliminary clinical *** further application,however,BG1d-BG should be compared to the benchmark amongst BGs,the 45S5 Bioglass®composition,to classify its effect on cell viability,proliferation and osteogenic differentiation of human mesenchymal stem cells(MSCs).Therefore,in this study,the biocompatibility and osteogenic potential of both BGs were investigated in an indirect and direct culture setting to assess the effect of the ionic dissolution products and the BGs’physical presence on the *** results indicated an advantage of BG1d-BG over 45S5 Bioglass®regarding cell viability and *** BGs induced an earlier onset of osteogenic differentiation and accelerated the expression of late osteoblast marker genes compared to the control *** conclusion,BG1d-BG is an attractive candidate for further experimental *** basic mechanisms behind the different impact on cell behavior should be assessed in further detail,*** further alteration of the BG compositions.

关键词： 45S5 Bioglass® Sodium-reduced bioactive glass Fluoride-containing bioactive glass Bone tissue engineering Human mesenchymal stromal cells