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Measurement of serum paraoxonase-1 activity in the evaluation of liver function

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World Journal of Gastroenterology 2009年第16期15卷 1929-1933页

作者： jordi Camps Judit Marsillach Jorge Joven Centre of Biomedical Research University Hospital Sant JoanInstitute of Health Research Pere VirgiliUniversity Rovira i Virgili

Paraoxonase-1 (PON1) is an esterase and lactonase synthesized by the liver and found in the circulation associated with high-density lipoproteins. The physiological function of PON1 seems to be to degrade specific oxidized cholesteryl esters and oxidized phospholipids in lipoproteins and cell membranes. PON1 is, therefore, an antioxidant enzyme. Alterations in circulating PON1 levels have been reported in a variety of diseases involving oxidative stress including chronic liver diseases. Measurement of serum PON1 activity has been proposed as a potential test for the evaluation of liver function. However, this measurement is still restricted to research and has not been extensively applied in routine clinical chemistry laboratories. The reason for this restriction is due to the problem that the substrate commonly used for PON1 measurement, paraoxon, is toxic and unstable. The recent development of new assays with non-toxic substrates makes this proposal closer to a practical development. The present editorial summarizes PON1 biochemistry and function, its involvement with chronic liver impairment, and some aspects related to the measurement of PON1 activity in circulation.

关键词： Lipoproteins Liver cirrhosis Liver function tests Oxidative stress Paraoxonase-1

Potential of sea buckthorn-based ingredients for the food and feed industry-a review

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Food Production, Processing and Nutrition 2020年第1期2卷 162-178页

作者： Arnau Vilas-Franquesa jordi Saldo Bibiana Juan Centre d’Innovació Recerca i Transferència en Tecnologia dels Aliments(CIRTTA)XaRTATECNIOMALTA-ConsoliderDepartament de Ciència Animal i dels AlimentsFacultat de VeterinàriaUniversitat Autònoma de Barcelona(Cerdanyola del Vallès)BarcelonaSpain Instituto Politécnico Nacional(IPN) Centro de Desarrollo de Productos Bióticos(CEPROBI)YautepecMorelosMexico

Food industries seek to incorporate nutritious ingredients as they could bring added value to the final food *** of the most interesting options is that sea buckthorn contains high concentrations of vitamin C,carotenoids,tocopherols,and other bioactive compounds,in addition to the unique lipid profile in the berry pulp,seed,and *** review summarizes the state-of-the-art of potential applications of sea buckthorn within the food and feed industry based on previously described *** such as cheese,yoghurt or beverages already benefit from its ***,using sea buckthorn in feed products also derives into higher quality final products(*** quality,egg quality).Poultry,pig,and fish farming have been studied for that *** all the accumulated articles depicted in the present review,the use of this fruit in food product formulation is nowadays *** options for food product development with sea buckthorn are herein discussed.

关键词： Food science Feed additive Product development Health Bioactive compounds Added value Sea buckthorn

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation

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Neural Regeneration Research 2020年第12期15卷 2260-2261页

作者： Samuel Pena-Díaz jordi Pujols Salvador Ventura Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

Parkinson’s disease (PD) is a neurodegenerative disorder belonging to a group of human pathologies known as synucleinopathies,which includes multiple system atrophy or dementia with Lewy bodies (Spillantini et al.,1998).These diseases share a common neuropathological feature,the presence ofα-synuclein (α-Syn) deposits,although they differ in the cellular and anatomical compartment in whichα-Syn inclusions *** affects more than 1% of people over 60 years of age,thus being the second most prevalent neurodegenerative disease in the world and the most common synucleinopathy.

关键词： al. diseases atrophy

Developing kNN forest data imputation for Catalonia

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Journal of Forestry Research 2024年第4期35卷 142-155页

作者： Timo Pukkala Núria Aquilué Ariadna Just jordi Corbera Antoni Trasobares Forest Science and Technology Centre of Catalonia(CTFC) Crta.de St.Llorençde MorunysKm 225280 SolsonaSpain Cartographic and Geological Institute of Catalonia(ICGC) 08038 BarcelonaSpain

The combined use of LiDAR(Light Detection And Ranging)scanning and field inventories can provide spatially continuous wall-to-wall information on forest *** information can be used in many ways in forest mapping,scenario analyses,and forest manage-ment *** study aimed to find the optimal way to obtain continuous forest data for Catalonia when using kNN imputation(kNN stands for“k nearest neighbors”).In this method,data are imputed to a certain location from k field-measured sample plots,which are the most similar to the location in terms of LiDAR metrics and topographic *** multidimensional Euclidean distance was used as the similarity *** study tested two different methods to optimize the distance *** first method optimized,in the first step,the set of LiDAR and topographic variables used in the measure,as well as the transformations of these *** weights of the selected variables were optimized in the second *** other method optimized the variable set as well as their transformations and weights in one single *** two-step method that first finds the variables and their transfor-mations and subsequently optimizes their weights resulted in the best imputation *** the study area,the use of three to five nearest neighbors was *** and latitude turned out to be the most important variables when assessing the similarity of two locations of Catalan forests in the context of kNN data *** optimal distance measure always included both LiDAR metrics and topographic *** study showed that the optimal similarity measure may be different for different ***,it was suggested that kNN data imputation should always be started with the optimization of the measure that is used to select the k nearest neighbors.

关键词： Forest inventory Differential evolution Simulated annealing LiDAR

Diffusion-free valve for preprogrammed immunoassay with capillary microfluidics

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Microsystems & Nanoengineering 2023年第4期9卷 197-209页

作者： Pooya Azizian Jasmina Casals-Terré jordi Ricart Joan M.Cabot Energy and Engineering Department Leitat Technological CenterTerrassaBarcelonaSpain Mechanical Engineering Department Technical University of CataloniaTerrassaBarcelonaSpain

By manipulating the geometry and surface chemistry of microfluidic channels,capillary-driven microfluidics can move and stop fluids spontaneously without external ***,complex microfluidic circuits can be preprogrammed by synchronizing the capillary pressures and encoding the surface tensions of microfluidic chips.A key component of these systems is the capillary ***,the main concern for these valves is the presence of unwanted diffusion during the valve loading and activation steps that can cause *** this study,we design and validate a novel diffusion-free capillary valve:theπ-*** valve consists of a 3D structure and a void *** void acts as a spacer between two fluids to avoid direct *** the valve is triggered,the air trapped within the void is displaced by pneumatic suction induced from the capillary flow downstream without introducing a gas bubble into the *** proposed design eliminates diffusive mixing before valve *** simulation is used to study the function and optimize the dimensions of theπ-valve,and 3D printing is used to fabricate either the mould or the microfluidic chip.A comparison with a conventional valve(based on a constrictionexpansion valve)demonstrates that theπ-valve eliminates possible backflow into the valve and reduces the mixing and diffusion during the loading and trigger *** a proof-of-concept,this valve is successfully implemented in a capillary-driven circuit for the determination of benzodiazepine,achieving the successive release of 3 solutions in a 3Dprinted microfluidic chip without external *** results show a 40%increase in the fluorescence intensity using theπ-valve relative to the conventional ***,theπ-valve prevents cross-contamination,minimizes sample use,and facilitates a sophisticated preprogrammed release of fluids,offering a promising tool for conducting automated immunoassays applicable at point-of-

关键词： capillary steps eliminate

Regeneration patterns in Mexican pine-oak forests

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Forest Ecosystems 2019年第4期6卷 384-395页

作者： Teresa Alfaro Reyna jordi Martínez-Vilalta Javier Retana CREAF E-08193 Cerdanyola del VallèsBarcelonaSpain Universitat Autònoma de Barcelona E-08193 Cerdanyola del VallèsBarcelonaSpain

Background: Global change is causing an increase in the incidence of natural and anthropogenic disturbances on forests, which frequently interact synergistically and promote changes in forest structure, composition and functioning. In this study we evaluate the regeneration of Pinaceae and Fagaceae species in pure and mixed stands in Mexico to determine if current regeneration patterns are indicative of changes in the relative dominance of these two tree families, as observed in other temperate regions. We also identify the environmental factors that determine the regeneration patterns of Pinaceae and Fagaceae species in these ***: We use data from two consecutive surveys of the National Inventory of Forests and Soils of Mexico(INFyS),obtained in 2004–2009 and 2009–2014. Our results show that the spatial patterns of regeneration are affected by forest structure, by climate, by the type and intensity of disturbances and by land tenure. Importantly, the presence and abundance of Fagaceae regeneration is generally higher than that of Pinaceae, and tends to be favoured(relative to Pinaceae) under warmer climates and by the presence of ***: The higher regeneration of Fagaceae relative to Pinaceae under warmer and fire-prone conditions could have important impacts on the composition and functioning of Mexican temperate forests under ongoing climate change, as well as affect their resilience to future disturbances.

关键词： Fagaceae Forest dynamics Forest inventory Mexico Pinaceae Regeneration Temperate forests

Metabolomic fingerprinting of pig seminal plasma identifies in vivo fertility biomarkers

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Journal of Animal Science and Biotechnology 2022年第2期13卷 473-487页

作者： Yentel Mateo-Otero Pol Fernández-López Ariadna Delgado-Bermúdez Pau Nolis jordi Roca jordi Miró Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaES-17003 GironaSpain Department of Biology Unit of Cell BiologyFaculty of SciencesUniversity of GironaES-17003 GironaSpain Centre d’Estudis Avançats de Blanes(CEAB) Spanish Research Council(CSIC)ES-17300 GironaSpain Magnetic Nuclear Resonance Facility Autonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Animal Medicine and Surgery Faculty of Veterinary MedicineUniversity of MurciaES-30100 MurciaSpain Equine Reproduction Service Department of Animal Medicine and SurgeryFaculty of Veterinary MedicineAutonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Veterinary Medical Sciences University of BolognaIT-40064 Ozzano dell’EmiliaBolognaItaly

Background:Metabolomic approaches,which include the study of low molecular weight molecules,are an emerging-omics technology useful for identification of *** this field,nuclear magnetic resonance(NMR)spectroscopy has already been used to uncover(in)fertility biomarkers in the seminal plasma(SP)of several mammalian ***,NMR studies profiling the porcine SP metabolome to uncover in vivo fertility biomarkers are yet to be carried ***,this study aimed to evaluate the putative relationship between SPmetabolites and in vivo fertility *** this end,24 entire ejaculates(three ejaculates per boar)were collected from artificial insemination(AI)-boars throughout a year(one ejaculate every 4 months).Immediately after collection,ejaculates were centrifuged to obtain SP-samples,which were stored for subsequent metabolomic analysis by NMR *** outcomes from 1525 inseminations were recorded over a year,including farrowing rate,litter size,stillbirths per litter and the duration of ***:A total of 24 metabolites were identified and quantified in all *** operating characteristic(ROC)curve analysis showed that lactate levels in SP had discriminative capacity for farrowing rate(area under the curve[AUC]=0.764)while carnitine(AUC=0.847),hypotaurine(AUC=0.819),sn-glycero-3-phosphocholine(AUC=0.833),glutamate(AUC=0.799)and glucose(AUC=0.750)showed it for litter ***,citrate(AUC=0.743),creatine(AUC=0.812),phenylalanine(AUC=0.750),tyrosine(AUC=0.753)and malonate(AUC=0.868)levels had discriminative capacity for stillbirths per litter;and malonate(AUC=0.767)and fumarate(AUC=0.868)levels for gestation ***:The assessment of selected SP-metabolites in ejaculates through NMR spectroscopy could be considered as a promising non-invasive tool to predict in vivo fertility outcomes in ***,supplementing AI-doses with specific metabolites should also be envisaged as a way to improve their f

关键词： Artificial insemination in vivo fertility Metabolomics NMR Pregnancy outcomes Seminal plasma

I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life

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World Journal of Gastroenterology 2014年第26期20卷 8709-8716页

作者： Vicente Lorenzo-Zú?iga Elba Llop Cristina Suárez Beatriz álvarez Luis Abreu jordi Espadaler jordi Serra Gastroenterology Motility and Functional Gut Disorders UnitHospital Universitari Germans Trias i Pujol/CIBERehd Gstroenterology Hospital Puerta de Hierro AB-Biotics

AIM: To determine the dose-related effects of a novel probiotic combination, I.31, on irritable bowel syndrome (IBS)-related quality of life (IBS-QoL).

关键词： Irritable bowel syndrome Probiotic combination Irritable bowel syndrome Quality-of-life

Human-driven global nutrient imbalances increase risks to health

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Eco-Environment & Health 2023年第4期2卷 246-251页

作者： Josep Penuelas jordi Sardans CSIC Global Ecology Unit CREAF-CSIC-UAB08193 BellaterraBarcelonaCataloniaSpain CREAF 08193 Cerdanyola del VallèsBarcelonaCataloniaSpain

Human-induced inputs of nitrogen(N)and phosphorus(P)into the biosphere have reached unprecedented levels,particularly N,leading to an escalating global anthropogenic N:P *** ratio has emerged as a significant driver of environmental change,impacting organisms,ecosystems,and global food ***,the implications of this ratio for human health have been largely overlooked and remain *** article aims to fill this knowledge gap by exploring the potential effects of N:P ratios on both non-infectious and infectious *** data emphasize the importance of investigating the influence of N:P ratios on human health,suggesting a potential role in the rise of non-infectious diseases,such as cancer,as well as the proliferation of infectious diseases,including Zika and *** findings highlight the urgent need for increased attention from the scientific community and policymakers regarding the complex impacts of the human-induced biospheric N:P *** is crucial to investigate and understand the underlying mechanisms and drivers behind these ***,there is significant potential for improving human health through the manipulation of N:P ratios and the availability of N and *** applies not only to medical treatments but also to innovative fertilizer management *** avenues present promising opportunities to address the challenges associated with human health in an ever-changing world.

关键词： Nitrogen Phosphorus N:P ratio Non-infectious diseases Infectious diseases Medical treatments