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INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)

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环境与职业医学 2016年第9期33卷 919-921页

作者： Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura jordi sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiología y Salud Pública(CIBERESP) Department of Analytical Chemistry University of Cordoba ISGlobal Barcelona Centre for International Health Research(CRESIB)Hospital Clínic-Universitat de Barcelona Instituto de Investigación Biosanitaria de Granada(Granada.ibs) University of Granada Foundation for the Promotion of Health and Biomedical Research in the Valencian Region FISABIO/CSISP Universidad de Valencia Hospital del Mar Medical Research Institute(IMIM) 不详

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性（-4．88％；95％CI：-8．36，-1．36），且与EFW增长减低也有... 详细信息

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性（-4．88％；95％CI：-8．36，-1．36），且与EFW增长减低也有显著相关性（-4．32％；95％CI：-8．33，-0．27）（图3及补充材料表S8）。

关键词：胎儿发育邻苯二甲酸酯超声测量双酚A 中孕期队列相关性出生结局

生命早期室外空气污染暴露与婴幼儿呼吸系统健康、耳部感染和湿疹:INMA研究

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环境与职业医学 2013年第6期30卷 440-440页

作者： Inmaculada Aguilera Marie Pedersen Raquel Garcia-Esteban Ferran Ballester Mikel Basterrechea Ana Esplugues Ana Fernández-Somoano Aitana Lertxundi Adonina Tardón jordi sunyer

[背景]产前和生命早期可能是空气污染对婴幼儿健康造成有害影响的重要窗口期。[目的]选择西班牙出生队列中2199名婴儿,研究他们在孕期和出生第1年空气污染暴露与年龄为12~18个月时的呼吸系统疾病、耳部感染和湿疹之间的关联。[方法]父... 详细信息

[背景]产前和生命早期可能是空气污染对婴幼儿健康造成有害影响的重要窗口期。[目的]选择西班牙出生队列中2199名婴儿,研究他们在孕期和出生第1年空气污染暴露与年龄为12~18个月时的呼吸系统疾病、耳部感染和湿疹之间的关联。[方法]父母提供医生诊断的呼吸道感染（LRTI）、喘息、湿疹和耳部感染等信息。使用经时间调整的土地利用回归模型,估计个体二氧化氮（NO2）和苯的暴露情况。采用对数二项式回归模型和联合随机效应meta分析,评估4个研究地点空气污染暴露对健康结果的影响。[结果]在孕期,NO2均值每增加10μg/m3与LRT[I相对危险度（RR）=1.05,95%CI：0.98~1.12]和耳部感染（RR=1.18,95%CI：0.98~1.41）相关联。NO2每增加1个四分位距（IQR）,LRTI的RR为1.08（95%CI：0.97~1.21）,耳部感染的RR为1.31（95%CI：0.97~1.76）。与NO2相比,苯暴露均值每增加1个IQR,其与LRTI具有类似的关联性（RR=1.06,95%CI：0.94~1.19）,与耳部感染的关联性稍弱（RR=1.17,95%CI：0.93~1.46）。母亲孕期大多数时间在家里的婴幼儿,其关联性稍强。由于出生第1年的空气污染暴露与产前暴露高度相关,所以无法分辨各个暴露时期的相对重要性。[结论]研究结果表明生命早期环境空气污染暴露可能增加婴幼儿上、下呼吸道感染的风险。

关键词：空气污染儿童健康耳部感染湿疹子宫内暴露呼吸系统感染

人类生命早期暴露组(HELIX)：项目理念与设计(待续)

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环境与职业医学 2015年第1期32卷 90-95页

作者： Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux jordi sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiología y Salud Pública(CIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of Crete(UOC) Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT) Sensing & Control Systems S.L(.S&C) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.R.L(.HYLO) Centre for Genomic Regulation(CRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de Compostela Center of Excellence in Genomic Medicine Research King Abdulaziz University Vytauto Didziojo Universitetas(VDU)

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项... 详细信息

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画"生命早期暴露组"。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。

关键词：人类生命早期暴露设计出生队列研究儿童健康生物标志效应评估生命早期

人类生命早期暴露组(HELIX)：项目理念与设计(续完)

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环境与职业医学 2015年第2期32卷 186-190页

作者： Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux jordi sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiologíay Salud Pública(CIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of Crete(UOC) HeraklionCreteGreece Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Sensing & Control Systems S.L.(S&C) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.R.L.(HYLO) RomeItaly Centre for Genomic Regulation(CRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddahKingdom of Saudi Arabia Vytauto Didziojo Universitetas(VDU) KaunusLithuania Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT)

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的... 详细信息

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统（GIS）（Beelen等，2013;Eeflens等，2012）、遥感（Dadvand等，2012）和智能手机技术（deNazelle等，2013）使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。

关键词：早期暴露人类生命地理信息系统设计空气污染测量误差体力活动建筑环境

Hankel operators on exponential Bergman spaces

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Science China Mathematics 2022年第2期65卷 421-442页

作者： Zhangjian Hu jordi Pau Department of Mathematics Huzhou UniversityHuzhou 313000China Departament de Matematiques i Informatica Universitat de BarcelonaBarcelona 08007Spain

We completely describe the boundedness and compactness of Hankel operators with general symbols acting on Bergman spaces with exponential type weights.

关键词： weighted Bergman space Hankel operator ?-equation

Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy

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Neural Regeneration Research 2018年第5期13卷 775-778页

作者： jordi Bruna Roser Velasco Neuro-Oncology Unit Hospital Universitari de Bellvitge-ICO L'Hospitalet IDIBELL (Institut d'Investigació Biomèdica de Bellvitge) Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Autonoma de Barcelona and Centro de Investigación Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)

Chemotherapy-induced peripheral neuropathy is a very frequent neurological complication in cancer. Oxaliplatin（OXA） is a platinum analogue used as a first-line agent in the treatment of colorectal cancer. OXA induced peripheral neuropathy（OIN） is the main toxicity both during and after the completion of chemotherapy that presents as two distinct syndromes： acute and chronic neuropathy. None of the neuroprotective agents previously tested had prevented or limited the acute and/or chronic OIN. MR309（previously developed as E-52862） is a novel selective sigma-1 receptor（S1R） antagonist with preclinical analgesic activity in OXA-induced neuropathic pain in animal models. This review analyzes the results of the recently published phase Ⅱ, randomized, double-blind, placebo-controlled clinical trial including 124 patients with colorectal cancer（CRC） treated with MR309. This study shows encouraging findings in the setting of neuroprotection against OIN with an acceptable safety profile. The study demonstrated MR309 usefulness in decreasing acute OIN, by reducing cold hypersensitivity experienced by patients, and pointed to the amelioration of chronic OIN by lowering the proportion of patients who developed severe chronic OIN. In addition, we provide a summary and discussion on the pathways that can be modulated by the S1R to explain the observed clinical benefits in the OIN.

关键词： oxaliplatin chemotherapy-induced peripheral neuropathy sigma-1 receptor neurotoxicity MR309 E-52862

Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease:The search for alternative causative factors

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World Journal of Gastroenterology 2015年第10期21卷 2875-2882页

作者： jordi Camps Jorge Joven Unitat de Recerca Biomèdica Hospital Universitari de Sant Joan Institut d’Investigació Sanitària Pere Virgili Universitat Rovira i Virgili

The incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is constantly *** this is apparently associated with the growing increase in obesity,insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fatin the ***,NAFLD is a predictor of other metabolic *** is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and endstage liver ***,the search for alternative molecular mechanisms with therapeutic implications in NAFLD and associated disorders deserves a careful *** are possible targets as these organelles generate energy from nutrient *** findings,generated in patients with extreme obesity and in murine models,support the notion that NAFLD could be a mitochondrial *** is plausible because mitochondrial dysfunction affects the accumulation of lipids in hepatocytes and promotes lipid peroxidation,the production of reactive oxygen species,the release of cytokines causing inflammation and cell *** we discuss basic research and mechanistic studies targeting the role of chemokine ligand 2 in liver inflammation and that of the paraoxonases in the oxidative *** combination and association with mitochondrial dysfunction may uncover mechanisms underlying the progression of NAFLD and may help to identify novel therapeutic targets.

关键词： Biomarkers Cytokines Inflammation Metabolism Mitoc

Machine learning applications on lunar meteorite minerals:From classification to mechanical properties prediction

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International Journal of Mining Science and Technology 2024年第9期34卷 1283-1292页

作者： Eloy Peña-Asensio Josep M.Trigo-Rodríguez jordi Sort jordi Ibáñez-Insa Albert Rimola Department of Aerospace Science and Technology Politecnico di MilanoMilano 20156Italy Institut de Ciències de l’Espai(ICE-CSIC) Campus UAB08193 Cerdanyola del VallèsSpain Institut d’Estudis Espacials de Catalunya(IEEC) Barcelona 08034Spain Departament de Física Universitat Autònoma de BarcelonaCerdanyola del Vallès E-08193Spain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Barcelona E-08010Spain Geosciences Barcelona(GEO3BCN-CSIC) E-08028 BarcelonaSpain Departament de Química Universitat Autònoma de BarcelonaBellaterra 08193Spain

Amid the scarcity of lunar meteorites and the imperative to preserve their scientific value,nondestructive testing methods are *** translates into the application of microscale rock mechanics experiments and scanning electron microscopy for surface composition *** study explores the application of Machine Learning algorithms in predicting the mineralogical and mechanical properties of DHOFAR 1084,JAH 838,and NWA 11444 lunar meteorites based solely on their atomic percentage *** a prior-data fitted network model,we achieved near-perfect classification scores for meteorites,mineral groups,and individual *** regressor models,notably the KNeighbor model,provided an outstanding estimate of the mechanical properties—previously measured by nanoindentation tests—such as hardness,reduced Young’s modulus,and elastic *** considerations on the nature and physical properties of the minerals forming these meteorites,including porosity,crystal orientation,or shock degree,are essential for refining *** findings underscore the potential of Machine Learning in enhancing mineral identification and mechanical property estimation in lunar exploration,which pave the way for new advancements and quick assessments in extraterrestrial mineral mining,processing,and research.

关键词： Meteorites Moon Mineralogy Machine learning Mechanical properties

A model for the control of DNA integrity by the sperm nuclear matrix

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Asian Journal of Andrology 2015年第4期17卷 610-615页

作者： Joanna E Gawecka jordi Ribas-Maynou jordi Benet W Steven Ward Clinical and Translational Research Program Universityof Hawaii Cancer Center Honolulu HI USA Cell BiologyUnit Cell Biology Phisiology and Immunology DepartmentMedicine Faculty Universitat Autonoma de Barcelona08193 Bellaterra Spain Center of Male Infertility andAnalysis de Barcelona Edifici Eureka PBM5 Parc deRecerca de la UAB Campus de la UAB 08193 BellaterraSpain Institute for Biogenesis Research Departmentof Anatomy Biochemistry and Physiology Honolulu HIUSA Department of Obstetrics Gynecology and Women'sHealth John A. Burns School of Medicine University ofHawaii at Manoa. Honolulu. HI 96822. USA.

The highly condensed chromatin of mammalian spermatozoa is usually considered to be biologically inert before fertilization. However, we have demonstrated that even in this compacted state, sperm chromatin is subject to degradation at open configurations associated with the nuclear matrix through a process we have termed sperm chromatin fragmentation （SCF）. ＂[his suggests that a mechanism exists to monitor the health of spermatozoa during transit through the male reproductive tract and to destroy the genome of defective sperm cells. The site of DNA damage in SCF, the matrix attachment sites, are the same that we hypothesize initiate DNA synthesis in the zygote. When sperm that have damaged DNA are injected into the oocyte, the newly created zygote responds by delaying DNA synthesis in the male pronudeus and, if the damage is severe enough, arresting the embryo＇s development. Here we present a model for paternal DNA regulation by the nuclear matrix that begins during sperm maturation and continues through early embryonic development.

关键词： DNA mammalian spermatozoa