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依那普利和群多普利在治疗慢性心衰中对循环和血管肾素-血管紧张素系统抑制作用的比较研究

世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 53-54页

作者： jorde u.p. Vittorio T.J. Dimayuga C.A. 刘文秀 Dr. Heart Failure program Leon Charney Division of Cardiology NY Univ. School of Medicine 530 First Avenue New York NY 10016 United States

Experimental studies suggest that angiotensin-converting enzyme(ACE) inhibitors with high tissue affinity confer a greater degree of vascular renin-angiotensin system su.p.ession than those with low tissue affinity despite similar su.p.ession of the circulating renin-angiotensin system. To test this hypothesis in a clinical setting, we randomized subjects with chronic heart failure to receive the low tissue affinity ACE inhibitor enalapril or the high tissue affinity ACE inhibitor trandolapril, and assessed the degree of circulating and vascular renin-angiotensin system su.p.ession. Vascular renin-angiotensin system su.p.ession was determined by measuring the pressor response to intravenous injections of angiotensin I. Circulating reninangiotensin system su.p.ession was determined by measuring plasma angiotensin II. Vascular and circulating renin-angiotensin system su.p.ession, endothelial function(flow-mediated vasodilation), and maximal exercise capacity(peak oxygen uptake) were assessed after a 4-week run-in period on open-label enalapril 40 mg/day and after 8 weeks of randomized double-blind treatment with enalapril 40 mg/day or trandolapril 4 mg/day. Twenty-six men and 4 women(mean age 52±11 years; mean left ventricular ejection fraction 25±9%; New York Heart Association class II[n=16] and III[n=14]) were studied. After a 2-month randomized treatment period, vascular renin-angiotensin system su.p.ession, circulating renin-angiotensin system su.p.ession, endothelial function, and exercise capacity did not differ between subjects treated with enalapril and those treated with trandolapril. Despite substantial differences in the tissue affinity of enalapril and trandolapril, the degree of vascular renin-angiotensin system su.p.ession achievedwith these agents did not differ in subjects with chronic heart failure during long-term therapy.

关键词：慢性心衰抑制作用群多普利心脏病协会射血分数肾素抑制程度血流介导随机双盲试验研究

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Evolution of heart transplant donor characteristics in the 21st century: A united States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims Sasha Vukelic Stephen J Forest Jamil F Borgi Daniel J Goldstein ulrich p jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the united *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

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Cardiac risk stratification of the liver transplant candidate:A comprehensive review

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World Journal of Transplantation 2022年第7期12卷 142-156页

作者： Sanjana Nagraj Spyros peppas Maria Gabriela Rubianes Guerrero Damianos G Kokkinidis Felipe I Contreras-Yametti Sandhya Murthy ulrich p jorde Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineNew York CityNY 10461United States Department of Gastroenterology Athens Naval HospitalAthens 11521Greece Section of Cardiovascular Medicine Yale University School of MedicineYale New Haven HospitalNew HavenCT 06510United States Department of Medicine Wellstar Atlanta Medical CenterAtlantaGA 30312United States Division of Cardiology Montefiore Medical CenterAlbert Einstein College of MedicineNew York CityNY 10467United States

Cardiovascular diseases(CVD)form a principal consideration in patients with end-stage liver disease(ESLD)undergoing evaluation for liver transplant(LT)with prognostic implications in the peri-and post-transplant *** the predominant etiology of ESLD continues to evolve,addressing CVD in these patients has become increasingly ***,as the number of LTs increase by the year,the proportion of older adults on the waiting list with competing comorbidities increase,and the demographics of LT candidates evolve with parallel increases in their CVD risk *** primary goal of cardiac risk assessment is to preemptively reduce the risk of cardiovascular morbidity and mortality that may arise from hemodynamic stress in the peri-and post-transplant *** complex hemodynamics shared by ESLD patients in the pre-transplant period with adverse cardiovascular events occurring in only some of these recipients continue to challenge currently available guidelines and their uniform *** review focusses on cardiac assessment of LT candidates in a stepwise manner with special emphasis on preoperative patient *** hope that this will reinforce the importance of cardiovascular optimization prior to LT,prevent futile LT in those with advanced CVD beyond the stage of optimization,and thereby use the finite resources prudently.

关键词： Cardiovascular risk Liver transplantation End stage liver disease Liver cirrhosis Cardiovascular diseases Cardiovascular diagnostic techniques

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欧洲列车控制系统(ETCS)在挪威的应用

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国外铁道机车与动车 2022年第4期 34-36页

作者： [法]Sverre Kjenne [法]Lars jorde 张建平(译) 不详

挪威国家铁路完成了新一代车载设备的耐久性测试,这标志着该国在推进欧洲铁路运输管理系统(Ertms)方面取得了关键性进展。

关键词：挪威国家铁路欧洲铁路运输管理系统(Ertms) ETCS

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BOTTOM SHEAR STRESS pATTERN AND ITS ECOLOGICAL IMpACT

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International Journal of Sediment Research 1997年第3期 369-378页

作者： Klaus jorde Insitute of Hydraulic Engineering. university of Stuttgart, Germany

The interaction between river bed morphology at different scales and the discharge is one of the key factors for running Water ecosystems and their habitats. In a first approach different habitats for fish, benthic species and vegetation communities can be described as combinations of physical parameters, such as bottom shear stress, local depth and local flow velocity, and substratum. Species demands regarding those physical habitat factors are partially known. From an ecological point of view the temporal and spatial variability of those factores must be included. Computer simulation models have been developed for the ecological evaluation of instream flow regulations in diverted streams and for the investigation of general morphological and hydraulic patterns in running waters. In this study these models are used for benthic habitat quality and availability evaluation as functions of river morphology and discharge. Methods and some results of a case study on instream flow regulations are presented in this paper.

关键词： FST In BOTTOM SHEAR STRESS pATTERN AND ITS ECOLOGICAL IMpACT der ITS

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无症状性消化性溃疡病

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国外医学(消化系疾病分册) 1988年第1期 46-47页

作者： jorde R 陆兴隆

不少穿孔或出血的消化性溃疡病患者以往并无消化不良症状,多年来已认识到临床上存在无症状性胃和十二指肠溃疡病。过去10年内,H2拮抗剂长期维持治疗者经内镜常规随访复查时常可发现此类溃疡。以前专题论述本病甚少,本文作一回顾性综述... 详细信息

不少穿孔或出血的消化性溃疡病患者以往并无消化不良症状,多年来已认识到临床上存在无症状性胃和十二指肠溃疡病。过去10年内,H2拮抗剂长期维持治疗者经内镜常规随访复查时常可发现此类溃疡。以前专题论述本病甚少,本文作一回顾性综述。就定义而论,无症状溃疡并不引起消化不

关键词：消化性溃疡病无症状性十二指肠溃疡病消化不良症状专题论述胃溃疡患者治疗者症状性出血拮抗剂随访复查

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继发性甲状旁腺功能亢进患者的乳糜泻

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 60-61页

作者： jorde R. Saleh F. Sundsfjord J. 程欣 Medical Department B University Hospital of North Norway NO-9038 Tromsφ Norway

Objective. Coeliac disease (CD) may present in its clas sical form with diarrhoea and weight loss, but also with atypical symptoms th at are both related and unrelated to malabsorption. Osteomalacia or osteopenia f ollowing malabsorption of calcium and vitamin D is known to occur in patients wi th CD, and in such cases secondary hyperparathyroidism(SHp) caused by low serum calcium levels is frequently found. However, the prevalence of CD in subjects wi th SHp has not been reported. Material and methods. In the Troms study 2001, ser um parathyroid hormone (pTH) and calcium were measured in 7954 subjects of whom 6061 were eligible for follow- up. From this group, 97 subjects with SHp (serum pTH ≥ 6.5 pmol/l and serum calcium ubj ects were re- examined with serological tests for CD (antitissue transglutamina se, anti- gluten IgA and IgG). Results. CD was diagnosed in 4 subjects, all fro m the original SHp group. At the re- examination, only 29 of the 97 subjects wi th SHp still had elevated serum pTH levels. Among these were 3 of the subjects w ith CD. When grouping the serological test results as negative, borderline or po sitive, there was a significant difference between the SHp group and the control s for anti- tissue transglutaminase and anti- gluten IgA (p usio ns. Subjects with SHp, at least when SHp is persistent, should be tested for CD.

关键词：乳糜泻吸收不良骨质缺乏不典型症状骨质软化症甲状旁腺素血清钙谷蛋白患者群血清学

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高原遗传适应(续)

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西藏医药 1997年第2期18卷 1-5页

作者： LORNAG．MOORE STACYZAMuDIOLYNN LYNNB．jorde LINDACuRRANEVERETT RALpHV．SHOHET ANTONIOTORRONI 土登次仁卓嘎云登卓玛科罗拉多大学医学科学中心美国科罗拉多州丹佛市犹他州大学医学院美国犹他州盐湖城科罗拉多大学美国科罗拉多州丹佛市德克萨斯州大学西南医学中心美国德克萨斯州达拉斯市 EMORY大学医学院美国乔治亚州亚特兰大市西藏自治区

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血管紧张素原遗传变异,血浆血管紧张素原及血压的关系:一项应用犹他州遗传相关研究项目中的家系资料的分析研究

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中华高血压杂志 2010年第12期18卷 1198-1198页

作者： Watkins WS Rohrwasser A peiffer A Leppert MF Lalouel JM jorde LB 黄晓斌

犹他州遗传相关项目（the utah genetic reference project，uGRp）中的家系资料为我们提供了新的机会用于研究遗传变异及其内在表现与血压的数量关系。方法：研究人员从41个uGRp家庭的二代人口中抽取424人分析他们血管紧张素原（angiot... 详细信息

犹他州遗传相关项目（the utah genetic reference project，uGRp）中的家系资料为我们提供了新的机会用于研究遗传变异及其内在表现与血压的数量关系。方法：研究人员从41个uGRp家庭的二代人口中抽取424人分析他们血管紧张素原（angiotensinogen，AGT）基因及其启动因子区域常见的单核苷酸多态性（single-nucleotide polymorphisms，SNp）和单体型。

关键词：血管紧张素原遗传变异家系资料犹他州血压单核苷酸多态性应用血浆

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乳制品中钙、维生素D的摄入量和血压的研究

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国外医学(医学地理分册) 2001年第1期22卷 30-30页

作者： jorde R 孙健曹峻岭

目的 :评估乳制品中钙摄入量及维生素 D摄入量与收缩和舒张血压间的关系。设计 :受检者将因高血压或心脏病而在服药的病人 ,服用钙片者 ,确诊为心血管疾病者以及孕妇除外 ,选择年龄在 2 5岁～69岁之间的 7543名男性及 80 53名女性进行... 详细信息

目的 :评估乳制品中钙摄入量及维生素 D摄入量与收缩和舒张血压间的关系。设计 :受检者将因高血压或心脏病而在服药的病人 ,服用钙片者 ,确诊为心血管疾病者以及孕妇除外 ,选择年龄在 2 5岁～69岁之间的 7543名男性及 80 53名女性进行分析。钙和维生素 D的摄入量由饮食频率调查表计算。结果 :排除年龄、身体状况、饮酒和喝咖啡、体育运动、吸烟以及维生素 D摄入量因素后 ,在两性中随着乳钙摄入量的增加 ,收缩压与舒张压呈显著的线性降低 (p

关键词：摄入量血压维生素乳制品奶制品食品

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