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Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

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Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： Kyungmin hwang Yeong-Hyeon Seo Daniel Ykim Jinhyo Ahn Soyoung Lee Kyung Hee Han Koun-Hee Lee Sangyong Jon Pilhan kim Kate EYu Hyungsin kim Shin-Hyuk Kang ki-Hun Jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

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Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il kim Sung Kook kim Sang Woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha kim In-kyung Sung Moo In Park joong Goo Kwon Nayoung kim Jae Jun kim Soo Teik Lee Hyun Soo kim ki Bae kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young Yoo ki-Yeon Yoo Joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi kim Goang-Min Choi Seung Myung Moon Dae Won kim Yeo Sung Yoon Moo-Ho Won In Koo hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

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以水性胶粘剂为内层的环保型黄土涂装材料

以水性胶粘剂为内层的环保型黄土涂装材料

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'2007北京国际粘接技术研讨会暨第二届亚洲粘接技术研...

作者： Jae-Yoon An ki-Wook kim Hyun-joong kim Mun-Jae Park Laboratory of Adhesion and Bio-Composites Program in Environmental Materials ScienceSeoul National University Korea Forest Research Institute dongdaemun-guSeoul 130-712S.Korea

现今人们约有90%的时间是在室内度过的。自1960年工业快速发展以来,建筑材料也从原来的自然材料发展到化学材料,并且建筑物的密封性也因节能的需求而得到了提高。这些都导致了不良建筑综合症（SBS）的出现。于是人们希望他们房子中的建...

现今人们约有90%的时间是在室内度过的。自1960年工业快速发展以来,建筑材料也从原来的自然材料发展到化学材料,并且建筑物的密封性也因节能的需求而得到了提高。这些都导致了不良建筑综合症（SBS）的出现。于是人们希望他们房子中的建筑材料是环保型材料。我们设计了一种黄土涂装材料,它是由黄土、水、树脂、硬化剂和填料组成的。本研究目的是制备一种环保型黄土涂装材料,并对其在墙面的使用性能进行评价。另外,可以对墙面的机械性能、挥发性有机化合物、甲醛的释放及红外辐射进行评估。

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Optical Bistability in 2D Photonic Crystal Slab Resonators

Optical Bistability in 2D Photonic Crystal Slab Resonators

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国际纳光电子学研讨会

作者： Myung-ki kim In-Kag hwang Yong-Hee Lee Department of Physics Korea Advanced Institute of Science and Technology（KAIST） Daejeon 305-701Korea Department of physics Chonnam National University Korea Advanced Institute of Science and Technology（KAIST） Korea

＜正＞We report the low-power optical bistability under the continuous wave pumping conditions in photonic crystal linear resonators containing the InGaAsP quantum well active medium. The threshold bistable power is m...

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Experimental Study on the Mechanical Properties of FRP Bars by Hybridizing with Steel Wires

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Engineering（科研） 2014年第7期6卷 365-373页

作者： Ji-Hyun hwang Dong-Woo Seo ki-Tae Park Young-Jun You Structural Engineering Research Division Korea Institute of Construction Technology Goyang Korea

Many studies on fiber reinforced polymer composite bars, as a substitute for reinforcing bars, have been conducted to solve corrosion of steel in reinforced concrete structures since 1960s’. However, FRP Bars have a lower elastic modulus than steel rebar as a structural component of concrete structures. Material properties with brittleness fracture and low elastic modulus can be improved by combining cheaper steel than carbon or aramid fibers. In this study, prototypes of FRP Bars with inserted steel wires (i.e., “FRP Hybrid Bars”) were developed and their tensile performance was compared depending on the proportion and diameter of steel. The FRP Hybrid Bars were made by dividing them into D13 and D16 according to the diameter and proportion of inserted wires: GFRPs were combined with wires having different diameters of 0.5 mm, 1.0 mm, and 2.0 mm in the proportion of 10%, 30%, 50%, and 70%, respectively. As a result of tensile tests, the elastic modulus of FRP Hybrid Bars were improved as 20% - 190% in comparison with the fully GFRP Bars.

关键词： Fiber-Reinforced Polymer (FRP) FRP Hybrid Bar Tensile Test Steel Wire

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Human Body Tracking and Pose Estimation Using Modified Camshift Algorithm

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Journal of Software Engineering and Applications 2013年第5期6卷 37-42页

作者： Seung-Jun hwang Jae-Hong Min In-Gyu kim Seung-Jae Park Gwang-Pyo Ahn joong-Hwan Baek Department of Information and Telecommunication Engineering Korea Aerospace University Go-yang South Korea

In this paper, we propose multiple CAMShift Algorithm based on Kalman filter and weighted search windows that extracts skin color area and tracks several human body parts for real-time human tracking system. The CAMShift Algorithm we propose searches the skin color region by detecting the skin color area from background model. Kalman filter stabilizes the floated search area of CAMShift Algorithm. Each occlusion areas are avoided by using weighted window of non-search areas and main-search area. And shadows are eliminated from background model and intensity of shadow. The proposed modified Camshaft algorithm can estimate human pose in real-time and achieves 96.82% accuracy even in the case of occlusions.

关键词： Body Tracking CAMShift Pose Estimation Kalman Filter Weighted Search Windows

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Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I

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Chinese Medical Journal 2014年第19期127卷 3396-3405页

作者： Joon Ha Park Ok kyu Park Yah Bingchun Ji Hyeon Ahn In Hye kim Jae-Chul Lee Seung-Hae Kwon ki-Yeon Yoo Choong Hyun Lee In Koo hwang Jung Hoon Choi Moo-Ho Won Jong-Dai kim Department of Neurobiology School ot Medicine Kangwon NationalUniversity Chuncheon 200-701 South Korea Division of Analytical Bio-Imaging Chuncheon Center Korea BasicScience Institute Chuneheon 200-701 South Korea Department of Integrative Traditional & Western Medicine MedicalCollege Yangzhou University Yangzhou Jiangsu 225001 China Department of Oral Anatomy College of Dentistry Gangneung-Woniu National University Gangneung 210-702 South Korea Department of Pharmacy College of Pharmacy Dankook UniversityCheonan 330-714 South Korea Department of Anatomy and Cell Biology College of VeterinaryMedicine and Research Institute for Veterinary Science SeoulNational University Seoul 151-742 South Korea Department of Anatomy College of Veterinary Medicine KangwonNational University Chuncheon 200-701 South Korea Division of Food Science and Biotechnology College of Agriculture and Life Sciences Kangwon National University Chuncheon 200- 701 South Korea

Background Danshen （Radix Salvia miltiorrhizae） has been used as a traditional medicine in Asia for treatment of various microcirculatory disturbance related diseases. Tanshinones are mainly hydrophobic active components, which have been isolated from Danshen and show various biological functions. In this study, we observed the neuroprotective effect of tanshinone I （Tsl） against ischemic damage in the gerbil hippocampal CA1 region （CA1） after transient cerebral ischemia and examined its neuroprotective mechanism. Methods The gerbils were divided into vehicle-treated-sham-group, vehicle-treated-ischemia-group, Tsl-treated-sham- group, and Tsl-treated-ischemia-group. Tsl was administrated intraperitoneally three times （once a day for three days） before ischemia-reperfusion. The neuroprotective affect of Tsl was examined using H＆E staining, neuronal nuclei （NeuN） immunohistochemistry and Fluoro-Jade B staining. To investigate the neuroprotective mechanism of Tsl after ischemia- reperfusion, immunohistochemical （IHC） and Western blotting analyses for Cu, Zn-superoxide dismutase （SOD1）, Mn- superoxide dismutase （SOD2）, brain-derived neurotrophic factor （BDNF） and insulin-like growth factor-I （IGF-I） were *** Treatment with Tsl protected pyramidal neurons from ischemia-induced neuronal death in the CA1 after ischemia-reperfusion. In addition, treatment with Tsl maintained the levels of SOD1 and SOD2 as determined by IHC and Western blotting in the CA1 after ischemia- reperfusion compared with the vehicle-ischemia-group. In addition, treatment with Tsl increased the levels of BDNF and IGF-I determined by IHC and Westem blotting in the Tsl-treated-sham-group compared with the vehicle-treated- sham-group, and their levels were maintained in the stratum pyramidale of the ischemic CA1 in the Tsl-treated- ischemia-group. Conclusion Treatment with Tsl protects pyramidal neurons of the CA1 from ischemic damage induced by transient cerebral ischemia via the maintena

关键词： transient cerebral ischemia ischemic damage tanshinone I neuroprotection antioxidants neurotrophic factors

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Control Strategy of 600kW E-BOP for Molten Carbonate Fuel Cell Generation System

Control Strategy of 600kW E-BOP for Molten Carbonate Fuel Ce...

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第11届国际电机与系统学术会议

作者： Tai-Sik hwang Kwang-Seob kim Byung-ki Kwon POSCON Coporation R＆D Center Techno-Complex

＜正＞An electrical balance of plant（E-BOP） of a 600kW molten carbonate fuel cell（MCFC） has to transit from grid-connected（GC） mode to grid-independent（GI） mode when a grid is in a fault conditions.A minimum transition time is limited by four cycle for a 600kW MCFC to ride through a grid *** this paper,we propose a control algorithm of a 600kW E-BOP for a MCFC *** E-BOP has three operation modes,i.e.,GC mode,GI mode,and grid-synchronized（GS） *** E-BOP controls output currents in a GC mode and regulates output voltages in GI or GS *** mode is defined as an interface between GC mode and GI mode to make a mode transition smooth, i.e.,limitation of inrush currents,regulation of output voltages within ANSI *** and experiments carried out to verify the effectiveness of the proposed control algorithm.

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Neuroprotective effects of roasted licorice,not raw form,on neuronal injury in gerbil hippocampus after transient forebrain ischemia

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Acta Pharmacologica Sinica 2006年第8期27卷 959-965页

作者： In-koo hwang Soon-sung LIM Kyu-hyun CHOI ki-yeon YOO Hyun-kyung SHIN Eun-ji kiM Jung-han YOONPARK Tae-cheon KANG Young-sup kiM Dae-young KWON Dong-woo kiM Won-kook MOON Moo-ho WON Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Silver Biotechnology Research Center Korea Silver Biotechnology Research Center Department of Food Science and Nutrition Hallym UniversityChunchon 200-702Korea Medical Science Division Korea Research Institute of Chemical TechnologyYuseong.Daejeon 305-343Korea Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Korea Silver Biotechnology Research Center

Aim:To observe neuroprotective effects of raw and roasted licorice against hy-poxia and ischemic ***:When elucidating the protective effects ofraw and roasted licorice,we analyzed the lactate dehydrogenase (LDH) releaseusing PC12 cells after hypoxia in an in vitro study and after transient forebrainischemia in an in vivo study on Mongolian ***:Raw and roastedlicorice significantly reduced LDH release from PC12 cells exposed to an hypoxicchamber for *** the roasted licorice-treated group,the decrease of LDH releasewas more pronounced compared to that of the raw licorice-treated *** licorice-treated animals,approximately 66%-71% of CA1 pyramidal cellsin the ischemic hippocampus were stained with cresyl violet compared to thecontrol ***,in the raw licorice-treated animals,no significantneuroprotection against ischemic damage was *** addition,ischemic ani-mals in roasted licorice-treated group maintained the Cu,Zn-superoxide dismutase(SOD1) activity and protein levels compared to the control group,while in rawlicorice-treated group SOD1 activity and protein levels were reduced *** pressure liquid chromatography analysis showed that non-polar compoundscontaining glycyrrhizin-degraded products,such as glycyrrhetinic acid (GA) andglycyrrhetinic acid monoglucuronide (GM),were increased in roasted ***:Roasted licorice had neuroprotective effects against ischemic dam-age by maintaining the SOD1 *** addition,the difference in protectiveability between raw and roasted licorice may be associated with non-polarcompounds,such as GA and GM.

关键词： transient ischemic attack roasted licorice raw licorice neurons PC12 cells hippocampus pyramidal cells Gerbillinae superoxide dismutase

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