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Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer

World Journal of Gastroenterology 2017年第4期23卷 676-686页

作者： Eun-ki Min Jae Uk Chong Ho Kyoung hwang Sang Joon Pae Chang Moo Kang Woo Jung Lee Yonsei University College of Medicine Seoul 03722 Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer CenterSeverance Hospital National Health Insurance Corporation Ilsan Hospital

AIMTo investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma (PDAC).METHODSFrom January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale (NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC were reviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early (POD 1, 2, 3) and late (POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic *** total of 212 patients were dichotomized into good pain control group (n = 162) and poor pain control group (n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival (OS) was observed in the group of patients receiving distal pancreatectomy (DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival (DFS) in the DP group (18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy (PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients’ perceived pain control was revealed as an independent risk factor of both DFS (HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS (HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic *** postoperative pain relief durin

关键词： Pancreatic cancer Pancreatectomy Survival Postoperative pain Recurrence

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Choroidal and skin metastases from colorectal cancer

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World Journal of Gastroenterology 2016年第43期22卷 9650-9653页

作者： Joo Young Ha Edward Hynseung Oh Moon ki Jung Song Ee Park Ji Tak kim In Gyu hwang Department of Internal Medicine Chung-Ang University College of Medicine Department of Internal Medicine Division of Hemato-oncology Chung-Ang University College of Medicine Department of Ophthalmology Chung-Ang University College of Medicine

Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine(1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from rightsided colorectal cancer.

关键词： Colon cancer Choroid cancer Skin cancer Capecitabine

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Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae Hoon Lee Seo Young Park Yejong Park Woohyung Lee ki Byung Song Dae Wook hwang Song Cheol kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

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Simultaneous Paragonimus infection involving the breast and lung:A case report

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World Journal of Clinical Cases 2019年第24期7卷 4292-4298页

作者： Moon Young Oh Ajung Chu Jeong Hwan Park Jong Yoon Lee Eun Youn Roh Young Jun Chai ki-Tae hwang Department of Surgery Seoul National University HospitalSeoul 156707South Korea Department of Radiology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Pathology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Laboratory Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea Department of Surgery Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 156707South Korea

BACKGROUND Paragonimiasis is a food-borne parasitic infection caused by lung flukes of the genus Paragonimus. Although the most common site of infection is the pleuropulmonary area, the parasite can also reach other parts of the body on its journey from the intestines to the lungs, ending up in locations such as the brain,abdomen, skin, and subcutaneous tissues. Ectopic paragonimiasis is difficult to diagnose due to the rarity of this *** SUMMARY Here, we report a rare case of simultaneous breast and pulmonary paragonimiasis in a woman presenting painless breast mass and lung nodule with a history of eating raw trout. To confirm the diagnosis, serologic testing and tissue confirmation of the breast mass were performed. The patient was treated with surgical resection of the mass and praziquantel *** Ectopic paragonimiasis is difficult to diagnose due to the rarity of this ***, thorough history-taking and clinical suspicion of parasitic infection are important.

关键词： Paragonimiasis Paragonimus westermani Parasitic infection Breast mass Lung nodule Case report

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Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

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BIOCELL 2022年第10期46卷 2231-2234页

作者： JU HYUNG LEE IL-KWON kiM SANG WOO kiM SOYEON LIM SEAHYOUNG LEE ki-CHUL hwang BYEONG-WOOK SONG Graduate Program of Biomedical Engineering Yonsei UniversitySeoul03722Korea Institute for Bio-Medical Convergence College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea Department for Medical Science College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative *** pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease.

关键词： Cell therapy Microenvironment Neurodegenerative disease Stem cells

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Verification of Damage Detection Algorithm by Prototype Building Structure Test

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Engineering（科研） 2013年第10期5卷 827-835页

作者： Ji-Hyun hwang ki-Tae Park Structural Engineering Research Division Korea Institute of Construction Technology Goyang South Korea

Safety related accidents of buildings and civil engineering structures have been reported all over the world. With the increasing importance of securing the safety of social infrastructure and optimum performance levels to prevent these accidents, a lot of attention has been concentrated on monitoring performance degradation due to structural defects and deterioration. In this study, the algorithm was developed to evaluate the safety of structures by analyzing signals of time domain and frequency domain, and the developed algorithm was verified through a forced vibration test. From the results of time-domain and frequency-domain data analysis, the damage detection results by each sensor location with a high degree of accuracy were derived in both methods.

关键词： Infrastructure Algorithm Vibration Test Damage Detection

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Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon

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Chinese Journal of Cancer Research 2013年第6期25卷 777-780页

作者： Ok-Jun Lee Seok-joong Yun Wun-Jae kim Song-Yi Choi Ho-Chang Lee Hyung-Geun Song Sung-Nam Lim ki-Hyeong Lee Seung-Taik kim Hye-Suk Han Department of Pathology College of MedicineChungbuk National University Department of Urology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget＇s disease （EMPD） associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin （H＆E） staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.

关键词： Apocrine glands carcinoma colon cancer penis

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Boost Up the Mechanical and Electrical Property of CNT Fibers by Governing Lyotropic Liquid Crystalline Mesophases with Aramid Polymers for Robust Lightweight Wiring Applications

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Advanced Fiber Materials 2023年第2期5卷 514-526页

作者： ki‑Hyun Ryu Jeong‑Gil kim Dongju Lee Seo Gyun kim Bon‑Cheol Ku Jun Yeon hwang Kwang‑Un Jeong Nam Dong kim Dae‑Yoon kim Functional Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Monofilament type of polyaromatic amide(PA)and carbon nanotube(CNT)composite fibers is presented.A concept of a lyotropic liquid crystal(LLC)constructed via a spontaneous self-assembly is introduced to mitigate the extremely low com-patibility between PA and *** approaches provide an effective co-processing route of PA and CNT simultaneously to fabricate the uniform,continuous,and reliable composite fibers through a ***,the addition of a small amount PA into the dope solution of CNT governs the LLC mesophase not only in a spinneret stage but also in a coagulant ***,the developed PA/CNT composite fibers have the high uniaxial orientational order and the close interfacial packing compared to the pure CNT *** PA/CNT composite fibers achieve the outstanding tensile strength,electrical conductivity,and electrochemical response,while maintaining a *** also exhibit the chemical,mechanical,and thermal *** of these advantages can make flexible,sewable,and washable PA/CNT composite fibers ideal nanocomposite materials for use in next-generation information and energy transporting system by replacing conventional metal electrical conductors.

关键词： Carbon nanotube Aramid polymer Liquid crystal Composite fiber Electrical wire

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Pushing the Band Gap Envelope of Quasi-Type II Heterostructured Nanocrystals to Blue:ZnSe/ZnSe_(1-X)Te_(X)/ZnSe Spherical Quantum Wells

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Energy Material Advances 2021年第1期2021卷 285-294页

作者： Jun Hyuk Chang Hak June Lee Seunghyun Rhee Donghyo Hahm Byeong Guk Jeong Gabriel Nagamine Lazaro APadilha Kookheon Char Euyheon hwang Wan ki Bae SKKU Advanced Institute of Nano Technology Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Instituto de Fisica“Gleb Wataghin” Universidade Estadual de CampinasUNICAMPP.O.Box 616513083-859 CampinasSão PauloBrazil

Quasi-type II heterostructured nanocrystals(NCs)have been of particular interest due to their great potential for controlling the interplay of charge ***,the lack of material choices for quasi-type II NCs restricts the accessible emission wavelength from red to near-infrared(NIR),which hinders their use in light-emitting applications that demand a wide range of visible ***,we demonstrate a new class of quasi-type II nanoemitters formulated in ZnSe/ZnSe_(1-X)Te_(X)/ZnSe seed/spherical quantum well/shell heterostructures(SQWs)whose emission wavelength ranges from blue to *** a given geometry,ZnSe_(1-X)Te_(X) emissive layers grown between the ZnSe seed and the shell layer are strained to fit into the surrounding media,and thus,the lattice mismatch between ZnSe_(1-X)Te_(X) and ZnSe is effectively *** addition,composition of the ZnSe_(1-X)Te_(X) emissive layer and the dimension of the ZnSe shell layer are engineered to tailor the distribution and energy of electron and hole wave *** from the capabilities to tune the charge carriers on demand and to form defectfree heterojunctions,ZnSe/ZnSe_(1-X)Te_(X)/ZnSe/ZnS NCs show near-unity photoluminescence quantum yield(PLQY>90%)in a broad range of emission wavelengths(peak PL from 450nm to 600 nm).Finally,we exemplify dichromatic white NC-based light-emitting diodes(NC-LEDs)employing the mixed layer of blue-and yellow-emitting ZnSe/ZnSe_(1-X)TeX/ZnSe/ZnS SQW NCs.

关键词： ZnSe/ZnS quantum Push

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Appendectomy in patient with suspected COVID-19 with negative COVID-19 results: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1944-1949页

作者： Changho kim Jong Kun kim In Hwan Yeo Jae Young Choe Jeong Eun Lee So Jeong Kang Chan Sub Park ki Tae Kwon Soyoon hwang Department of Emergency Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Surgery School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine School of MedicineKyungpook National UniversityDaeguKoreaDepartment of Infection ControlKyungpook National University Chilgok HospitalDaegu 41944South Korea

BACKGROUND Even at present,we are in the middle of the novel coronavirus disease 2019(COVID-19)pandemic and are facing challenges in trial and ***,emergency surgery for patients with suspected COVID-19 is burdensome not only for patients but also for healthcare ***,we established a surveillance system in the emergency room and established principles for managing patients suspected of COVID-19 who require emergency *** SUMMARY A 67-year-old man was diagnosed with appendicitis in March *** wife was diagnosed with COVID-1910 d earlier,and the patient was in close contact with *** patient tested negative twice on an upper respiratory COVID-19 reverse transcription–polymerase chain reaction screening test,but chest X-ray and chest computed tomography revealed patchy ground-glass opacity in both upper lobes of the patient’s *** same emergency surgery procedure for patients with confirmed COVID-19 was applied to this patient suspected of having the disease to ensure that surgery was not delayed while waiting for the reverse transcription–polymerase chain reaction results.A few hours after surgery,the upper respiratory tract specimen taken in the emergency room was negative for COVID-19 but the lower respiratory tract specimen was found to be positive for the *** When COVID-19 is suspected,emergency surgery should be performed as for confirmed COVID-19 without delay.

关键词： COVID-19 Appendicitis Appendectomy Emergency room Infection control Case report

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