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International Journal of Oral Science 2014年第2期6卷 87-93页

作者： Jae Min Song Sang Hun Shin yong Deok Kim Jae Yeol Lee Young Jae Baek Sang yong yoon Hong Sung Kim Department of Oral and Maxillofacial Surgery School of Dentistry Pusan National University Yangsan Korea Department of Biomaterial Science Pusan National University Miryang Korea

This study aimed to utilize micro-computed tomography （micro-CT） analysis to compare new bone formation in rat calvarial defects using chitosan/fibroin-hydroxyapatite （CFB-HAP） or collagen （Bio-Gide） membranes. Fifty-four （54） rats were studied. A circular bony defect （8 mm diameter） was formed in the centre of the calvaria using a trephine bur. The CFB-HAP membrane was prepared by thermally induced phase separation. In the experimental group （n= 18）, the CFB-HAP membrane was used to cover the bony defect, and in the control group （n= 18）, a resorbable collagen membrane （Bio-Gide） was used. In the negative control group （n= 18）, no membrane was used. In each group, six animals were euthanized at 2, 4 and 8 weeks after surgery. The specimens were then analysed using micro-CT. There were significant differences in bone volume （BV） and bone mineral density （BMD）（P〈O.05） between the negative control group and the membrane groups. However, there were no significant differences between the CFB-HAP group and the collagen group. We concluded that the CFB-HAP membrane has significant potential as a guided bone regeneration （GBR） membrane.

关键词： chitosan/fibroin-hydroxyapatite collagen membrane guided bone regeneration micro-computed tomography rat calva rial defect

Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

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World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana Park Jin Young yoon Kyeong Hye Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae yoon Chon Jun yong Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:The median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognosis

Non-surgical treatment of post-surgical bile duct injury: Clinical implications and outcomes

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World Journal of Gastroenterology 2014年第22期20卷 6924-6931页

作者： Young Ook Eum Joo Kyung Park Jaeyoung Chun Sang-Hyub Lee Ji Kon Ryu yong-Tae Kim yong-Bum yoon Chang Jin yoon Ho-Seong Han Jin-Hyeok Hwang Department of Internal medicine Cheongju St. Mary's HospitalChungcheongbuk-do 360-568South Korea Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeonggi-do 463-707South Korea Department of Radiology Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea Department of Surgery Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea

AIM: To investigate the prognostic factors determining the success rate of non-surgical treatment in the management of post-operative bile duct injuries (BDIs).

关键词： Endoscopic retrograde cholangiography Percutaneous transhepatic cholangiography Percutaneous transhepatic biliary drainage Bile duct Biliary stricture.

Effect of intra-arterial infusion with triolein emulsion on rabbit liver

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World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： yong-Woo Kim Young Mi Park Sik yoon Hak Jin Kim Do yoon Park Byung Mann Cho Seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver.

关键词： Triolein Emulsions Hepatology Liver dysfunction Histopathology

Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study

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World Journal of Gastroenterology 2022年第36期28卷 5351-5363页

作者： Jae Hyun yoon Sung Kyu Choi Sung Bum Cho Hee joon Kim Yang Seok Ko Chung Hwan Jun Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Gastroenterology and Hepatology Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Surgery Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Surgery Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor ***,data regarding risk factors and survival outcomes of early EHR after surgical resection remain *** To investigate the clinical features and risk factors of early EHR and elucidate its association with survival *** From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic *** excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 *** resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected *** Cox regression analysis was performed to identify the variables associated with *** Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 *** recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early *** 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical *** multivariate analysis,serum albumin100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early *** sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early ***,multivariate analysis revealed that early E

关键词： Early extrahepatic recurrence Hepatocellular carcinoma Prognosis Surgery Survival

Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

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World Journal of Gastroenterology 2018年第27期24卷 3013-3020页

作者： Hyun Joo Shin Haesung yoon Myung-joon Kim Seok Joo Han Hong Koh Seung Kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

AIM To evaluate the correlation between intravoxel incoherent motion(IVIM) diffusion-weighted imaging(DWI) parameters and the degree of hepatic steatosis and fibrosis in *** This retrospective study was approved by the institutional review board. The children(≤ 18 years) who underwent liver IVIM DWI with 8 b-values under the suspicion of hepatic steatosis or fibrosis from February 2013 to November 2016 were included. Subjects were divided into normal, fatty liver(FAT), and fibrotic liver(FIB) groups. The slow diffusion coefficient(D), fast diffusion coefficient(D*), perfusion fraction(f), and apparent diffusion coefficient(ADC) were measured. MR proton density fat fraction(PDFF), MR elastography(MRE), and IVIM values were *** A total of 123 children(median age of 12 years old, range: 6-18 years) were included, with 8 in the normal group, 93 in the FAT group, and 22 in the FIB group. The D* values were lower in the FIB group compared with those of the normal(P = 0.015) and FAT(P = 0.003) groups. The f values were lower in the FIB group compared with the FAT group(P = 0.001). In multivariate analyses, PDFF value was positively correlated with f value(β = 3.194, P < 0.001), and MRE value was negatively correlated with D* value(β =-7.031, P = 0.032). The D and ADC values were not influenced by PDFF or MRE *** In liver IVIM DWI with multiple b-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

关键词： Intravoxel incoherent motion Diffusionweighted imaging Fibrosis Fatty liver Pediatrics

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer

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World Journal of Gastroenterology 2015年第12期21卷 3547-3553页

作者： yong Sik yoon yong Beom Cho Kyu Joo Park Seung Hyuk Baik Sang Nam yoon Seung-Bum Ryoo Kil Yeon Lee Hungdai Kim Ryung-Ah Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center epartment of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Seoul National University College of Medicine Department of Surgery Yonsei University College of Medicine Severance Hospital Department of Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Surgery Kyung Hee University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Surgery Ewha Womans University School of Medicine

AIM: To determine the clinicopathologic characteristics of surgically treated ulcerative colitis(UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer(CAC) to those without CAC. METHODS: Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without ***: Among 415 UC patients, 383(92.2%) underwent total proctocolectomy, and of these, 342(89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients(11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy(P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-yearoverall survival rate was 82.2%.CONCLUSION: Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.

关键词： Ulcerative colitis Colorectal neoplasms Colorectal

Two- and Three-Dimensional Simulations of Beetle Hind Wing Flapping during Free Forward Flight

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Journal of Bionic Engineering 2013年第3期10卷 316-328页

作者： Tuyen Quang Le Tien Van Truong Hieu Trung Tran Soo Hyung Park Jin Hwan Ko Hoon Cheol Park Kwang joon yoon Doyoung Byun Korea Institute of Ocean Science and Technology PO Box 29 Ansan 425-600 Republic of Korea Department of Aerospace and Information Engineering Konkuk University Seoul Republic of Korea Department of Advanced Technology Fusion Konkuk University Seoul Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon440-746 Republic of Korea

Aerodynamic characteristic of the beetle, Trypoxylus dichotornus, which has a pair of elytra （forewings） and hind wings, is numerically investigated. Based on the experimental results of wing kinematics, two-dimensional （2D） and three-dimensional （3D） computational fluid dynamic simulations were carried out to reveal aerodynamic performance of the hind wing. The roles of the spiral Leading Edge Vortex （LEV） and the spanwise flow were clarified by comparing 2D and 3D simulations. Mainly due to pitching down of chord line during downstroke in highly inclined stroke plane, relatively high averaged thrust was produced in the free forward flight of the beetle. The effects of the local corrugation and the camber variation were also investigated for the beetle＇s hind wings. Our results show that the camber variation plays a significant role in improving both lift and thrust in the flapping. On the other hand, the local corrugation pattern has no significant effect on the aerodynamic force due to large angle of attack during flapping.

关键词： beetle flight forward flight three-dimensional simulation corrugation effect time-camber variation

Anesthetics management of a renal angiomyolipoma using pulse pressure variation and non-invasive cardiac output monitoring: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8656-8661页

作者： Woo Jae Jeon Woo Jong Shin Young joon yoon Chan Woo Park Jae Hang Shim Sang Yun Cho Department of Anesthesiolgy and Pain Medicine Hanyang University Guri HospitalGuri-si 471-701Gyeonggi-doSouth Korea

BACKGROUND Hypovolemic shock can lead to life-threatening organ dysfunction,and adequate fluid administration is a fundamental ***,parameters such as vital signs,central venous pressure,and urine output have been used to estimate intravascular ***,pulse pressure variation(PPV)and non-invasive cardiac monitoring devices have been *** this case report,we introduce a patient with massive active bleeding from giant renal angiomyolipoma(AML).During emergent nephrectomy,we used non-invasive cardiac monitoring with CSN-1901(Nihon Kohden,Tokyo,Japan)and PPV to evaluate the patient's intravascular volume status to achieve optimal fluid *** SUMMARY A 30-year-old male patient with giant AML with active bleeding was referred to the emergency room complaining of severe abdominal pain and spontaneous abdominal *** was diagnosed by computed tomography,and emergent nephrectomy was *** bleeding was expected so we decided to use non-invasive cardiac monitoring and PPV to assist fluid therapy because they are relatively easy and fast compared to invasive cardiac *** the surgery,6000 mL of estimated blood loss *** with the patient's vital signs and laboratory results,we monitored cardiac output,cardiac output,stroke volume,stroke volume index with a non-invasive cardiac monitoring device,and PPV using an intra-arterial catheter to evaluate intravascular volume status of the patient to compensate for massive *** In addition to traditional parameters,non-invasive cardiac monitoring and PPV are useful methods to evaluate patient's intravascular volume status and provideguidance for intraoperative management of hypovolemic shock patients.

关键词： Renal angiomyolipoma Pulse pressure variation Cardiac output Case report

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis

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World Journal of Gastroenterology 2019年第3期25卷 367-377页

作者： Haesung yoon Hyun Joo Shin Myung-joon Kim Seok Joo Han Hong Koh Seung Kim Mi-Jung Lee Department of Radiology Severance Hospital Severance Pediatric Liver Disease Research Group Research Institute of Radiological Science Yonsei University College of Medicine Department of Surgery Severance Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Severance Children's Hospital Severance Pediatric Liver Disease Research Group Yonsei University College of Medicine

BACKGROUND A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography(MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been *** To assess the utility of splenic stiffness measurements by MRE to predict gastroesophageal varices in *** We retrospectively reviewed abdominal MRE images taken on a 3 T system in pediatric patients. Patients who had undergone Kasai operations for biliary atresia were selected for the Kasai group, and patients with normal livers and spleens were selected for the control group. Two-dimensional spin-echo echoplanar MRE acquisition centered on the liver, with a pneumatic driver at 60 Hz and a low amplitude, was performed to obtain hepatic and splenic stiffness values. Laboratory results for aspartate aminotransferase to platelet ratio index(APRI) were evaluated within six months of MRE, and the normalized spleen size ratio was determined with the upper normal size limit. All Kasai group patients underwent gastroesophageal endoscopy during routine follow-up. The MannWhitney U test, Kendall's tau b correlation and diagnostic performance analysis using the area under the curve(AUC) were performed for statistical *** The median spleen MRE value was 5.5 kPa in the control group(n = 9, age 9-18 years, range 4.7-6.4 kPa) and 8.6 kPa in the Kasai group(n = 22, age 4-18 years,range 5.0-17.8 kPa). In the Kasai group, the APRI, spleen size ratio and spleen MRE values were higher in patients with portal hypertension(n = 11) than in patients without(n =

关键词： Biliary atresia Magnetic resonance elastography Kasai operation Splenic stiffness Portal hypertension