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World Journal of Gastroenterology 2022年第46期28卷 6564-6572页

作者： Ji young Park Tae joo Jeon Department of Internal Medicine Inje University College of MedicineSanggye Paik HospitalSeoul 01757South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Endoscopic ultrasonography(EUS)has become a reliable method for predicting the invasion depth of early gastric cancer(EGC).However,diagnostic accuracy of EUS is affected by several *** particular,it is difficult to differentiate between T1a and T1b EGC through *** To confirm whether submucosal saline injection(SSI)could improve the accuracy of EUS in distinguishing T1a and T1b lesions in *** Twenty-four patients with EGC were examined by EUS and subsequently by SSI combined EUS to compare the degree of tumor ***,they underwent endoscopic or surgical resection within 7 *** diagnostic accuracy of EUS and SSI combined EUS was evaluated based on the final pathological findings *** injected into the submucosa acted as an echoic contrast enhancing agent and had the effect of distinguishing the mucosal and submucosal layers *** Of total 24 patients,23 were diagnosed with EGC(T1 cancer:13 as T1a,and 10 as T1b).Standard EUS identified 6 of 13 T1a cancer patients and 3 of 10 T1b cancer ***,EUS-SSI identified 12 of 13 T1a cancer patients and 6 of 10 T1b cancer *** this study,SSI combined EUS was more accurate than EUS alone in diagnosing T1a and T1b lesions of EGC(75.0%and 37.5%,respectively).CONCLUSION SSI improved the diagnostic accuracy of EUS in distinguishing between the T1a and T1b stages in EGC.

关键词： Endoscopic ultrasonography Gastric cancer Endoscopy Surgery

Sexual dimorphism and sex-differential migration of Little Buntings(Emberiza pusilla)at an East Asian stopover site

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Avian Research 2022年第1期13卷 87-93页

作者： Sook-young cho Hyun-young Nam Se-young Park Chang-Yong choi Bird Research Center Korea National Park Research InstituteJeonnam58863Republic of Korea Division of Zoology Honam National Institute of Biological ResourcesMokpo58762Republic of Korea School of Biological Sciences College of Natural SciencesSeoul National UniversitySeoul08826Republic of Korea Department of Agriculture Forestry and BioresourcesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul08826Republic of Korea

Sex differences in morphology provide key information for understanding a species'morphological adaptations in relation to the evolution of sexual *** migratory birds,morphological traits have adapted to long-distance travel,and sexual dimorphism is typically related to sex-differential migration *** Buntings(Emberiza pusilla)have one of the longest migrations and are the least dichromatic species among the Emberiza *** this study,we measured sexual size dimorphism and sexual dichromatism of Little Buntings in relation to the spring arrival dates at a stopover site in *** length was the most important predictor for identifying sex;the wings of males were longer than those of *** also had a significantly stronger chestnut color of the head feathers than females,but this color difference was more prominent in the spring than in the *** arrived earlier than females by four *** dates correlated with both size and color,but unlike other bunting species previously studied in the same area,there was no clear sex-differential trend in the relationship between arrival date and morphological *** differences in the degree of sexual dichromatism suggest that chestnut plumage coloration can be used as a social or sexual signal of males in the breeding *** correlation of size and color to early arrival regardless of sex may indicate that a preference for assortative mating exists or that a sex-differential migration strategy is not clearly defined in the early stages of northward *** findings on the sexual dimorphism of Little Buntings provide insight into the evolution of the sex-differential migration of buntings in the East Asian Flyway.

关键词： Digital photography Emberiza pusilla Little Bunting Protandrous migration Sexual dichromatism Sexual dimorphism

Sigmoid-sigmoid colon fistula caused by diverticulitis

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Chinese Medical Journal 2022年第4期135卷 491-492页

作者： Jeonghun Lee young joo Lee youngsun Kim Department of Internal Medicine Ye HospitalAnyangRepublic of Korea Department of Obstetrics and Gynecology Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea

To the Editor:Diverticular disease is common worldwide and the incidence of this disease increases with *** diverticulitis is serious and includes abscess,fistula,obstruction,and ***,surgical treatment is recommended to the patients with symptomatic *** these,colocolic fistula caused by diverticulitis is rare findings and especially,sigmoid-sigmoid fistula is an extremely rare *** present report describes a case of sigmoid-sigmoid colon fistula caused by *** results of this case may help physicians to recognize that multidisciplinary management and surgery are needed for the treatment of complicated diverticulitis with fistula.

关键词： fistula colon obstruction

Current guidelines for Helicobacter pylori treatment in East Asia 2022:Differences among China,Japan,and South Korea

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World Journal of Clinical Cases 2022年第19期10卷 6349-6359页

作者： Jun-Hyung cho So-young Jin Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea

Helicobacter pylori (H. pylori) infection is highly prevalent in East Asia. The overallseroprevalence rate of H. pylori infection is 44.2% in China, 37.6%-43.2% in Japan,and 51.0% in South Korea. H. pylori can cause peptic ulcer disease and gastriccancer. East Asian countries have high rates of gastric cancer (age-standardizedincidence rate: 20-30 per 100000). The Kyoto global consensus report emphasizedthat H. pylori gastritis should be considered the main cause for the development ofgastric cancer. H. pylori treatment guidelines in China, Japan, and South Koreahave recently been revised according to data from each of those ***, emerging antibiotic resistance is an important barrier to H. pylorieradication. The recommended H. pylori treatment regimens differ among thosethree East Asian countries. In this review, recent guidelines and up-to-dateresearch on H. pylori treatment regimens from China, Japan, and South Korea arediscussed.

关键词： Helicobacter pylori Treatment Antibiotic resistance China Japan South Korea

Byte Frequency Based Indicators for Crypto-Ransomware Detection from Empirical Analysis

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Journal of Computer Science & Technology 2022年第2期37卷 423-442页

作者： Geun Yong Kim joon-young Paik Yeongcheol Kim Eun-Sun cho Department of Computer Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Computer Science and Technology Tiangong UniversityTianjin 300387China

File entropy is one of the major indicators of crypto-ransomware because the encryption by ransomware increases the randomness of file ***,entropy-based ransomware detection has certain limitations;for example,when distinguishing ransomware-encrypted files from normal files with inherently high-level entropy,misclassification is very *** addition,the entropy evaluation cost for an entire file renders entropy-based detection impractical for large *** this paper,we propose two indicators based on byte frequency for use in ransomware detection;these are termed EntropySA and DistSA,and both consider the interesting characteristics of certain file subareas termed“sample areas”(SAs).For an encrypted file,both the sampled area and the whole file exhibit high-level randomness,but for a plain file,the sampled area embeds informative structures such as a file header and thus exhibits relatively low-level randomness even though the entire file exhibits high-level *** and DistSA use“byte frequency”and a variation of byte frequency,respectively,derived from sampled *** indicators cause less overhead than other entropy-based detection methods,as experimentally proven using realistic ransomware *** evaluate the effectiveness and feasibility of our indicators,we also employ three expensive but elaborate classification models(neural network,support vector machine and threshold-based approaches).Using these models,our experimental indicators yielded an average Fl-measure of 0.994 and an average detection rate of 99.46%for file encryption attacks by realistic ransomware samples.

关键词： computer security cryptography machine learning ransomware

Nitrile Electrolyte Strategy for 4.9 V-Class Lithium-Metal Batteries Operating in Flame

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Energy & Environmental Materials 2023年第3期6卷 229-237页

作者： Hyunseok Moon Sung-Ju cho Dae-Eun Yu Sang-young Lee Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Korea Molecular Foundry Lawrence Berkeley National LaboratoryBerkeley CA USA Batteries R&D Center LG Energy SolutionDaejeon 34122Korea

Challenges facing high-voltage/high-capacity cathodes,in addition to the longstanding problems pertinent to lithium(Li)-metal anodes,should be addressed to develop high-energy-density Li-metal *** issue mostly stems from interfacial instability between electrodes and *** carbonate-or ether-based liquid electrolytes suffer from not only volatility and flammability but also limited electrochemical stability ***,we report a nitrile electrolyte strategy based on concentrated nitrile electrolytes(CNEs)with *** CNE consists of high-concentration lithium bis(fluorosulfonyl)imide(LiFSI)in a solvent mixture of succinonitrile(SN)/acetonitrile(AN).The SN/AN solvent mixture is designed to ensure high oxidation stability along with thermal stability,which are prerequisites for high-voltage Li-metal *** CNE exhibits interfacial stability with Li metals due to the coordinated solvation *** nitrate(LiNO_(3))and indium fluoride(InF_(3))are incorporated in the CNE as synergistic co-additives to further stabilize solid-electrolyte interphase(SEI)on Li *** resulting electrolyte(CNE+LiNO_(3)/InF_(3))enables stable cycling performance in Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)and 4.9 V-class Li||LiNi_(0.5)Mn_(1.5)O_(4)***,the Li||LiNi_(0.5)Mn_(1.5)O_(4)cell maintains its electrochemical activity at high temperature(100℃)and even in flame without fire or explosion.

关键词： 4.9 V-class cathodes electrolyte-electrode interfaces lithium-metal batteries nitrile electrolytes safety

Improving thermal efficiency and stability of laser welding process for magnesium alloy by combining power modulation and subatmospheric pressure environment

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Journal of Magnesium and Alloys 2022年第10期10卷 2788-2800页

作者： Jie Ning Suck-joo Na Lin-Jie Zhang Xiang Wang Jian Long Won-Ik cho State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China BIAS-Bremer Institut für angewandte Strahltechnik GmbH Klagenfurter Straße 528359 BremenGermany

The laser welding(LW)process of highly reflective materials presents low thermal efficiency and poor *** solve the problem,the effects of subatmospheric environment on LW process,technological parameters in subatmospheric environment on weld formation and welding with sinusoidal modulation of laser power on the stability of LW process in subatmospheric environment were *** AZ31magnesium(Mg)alloy was used as the test *** test result revealed that the weld penetration in subatmospheric environment can increase by more than ten times compared with that under normal *** the keyhole depth greatly rises,significantly periodic local bulge is observed on the backwall surface of the keyhole and the position of the bulge shifts along the direction of the keyhole ***,the hump-shaped surface morphology of the welded seam is formed;moreover,the weld width in local zones in the lower part of the welded seam remarkably *** LW in subatmospheric environment,the weld penetration can be further greatly increased through power ***,power modulation can inhibit the occurrence of bulges in local zones on the backwall of the keyhole during LW in subatmospheric environment,thus further curbing the significant growth of the weld widths of hump-shaped welding beads and local zones in the lower part of welded ***,the mechanism of synchronously improving the thermal efficiency and stability of LW process of highly reflective materials through power modulation in subatmospheric environment was *** was conducted according to theoretical analysis of recoil pressure and observation results of dynamic behaviors of laser induced plasma clouds and keyholes in the molten pool through high speed photography.

关键词： Laser welding Subatmospheric environment Power modulation Highly reflective materials Thermal efficiency Stability

Nationwide Trends in the Prevalence of Cigarette and E-cigarette Smoking among Korean Adults between 2014-2021:A Representative Serial Study of 1.2 Million Individuals

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Biomedical and Environmental Sciences 2023年第10期36卷 996-998页

作者： Minji Kim Wonyoung cho Jinseok Lee Yong Sung choi Seung Geun Yeo young joo Lee Sang Youl Rhee Chanyang Min Dong Keon Yon Center for Digital Health Medical Science Research InstituteKyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Otolaryngology-Head&Neck Surgery Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Obstetrics and Gynecology Kyung Hee University College of MedicineSeoulSouth Korea Department of Endocrinology and Metabolism Kyung Hee University College of MedicineSeoulKorea

Both cigarette and e-cigarette use cause respiratory tract damage and related health outcomes,and potentially increase the risk of coronavirus disease 2019(COVID-19)-related symptoms[1].Since the COVID-19 pandemic,loc... 详细信息

关键词： respiratory damage legal

ASpediaFI:Functional Interaction Analysis of Alternative Splicing Events

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 466-482页

作者： Kyubin Lee Doyeong Yu Daejin Hyung Soo young cho Charny Park Bioinformatics Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea

Alternative splicing(AS)regulates biological processes governing phenotypes and *** AS(DAS)gene test methods have been developed to investigate important exonic expression from high-throughput ***,the DAS events extracted using statistical tests are insufficient to delineate relevant biological *** this study,we developed a novel application,Alternative Splicing Encyclopedia:Functional Interaction(ASpediaFI),to systemically identify DAS events and co-regulated genes and *** establishes a heterogeneous interaction network of genes and their feature nodes(i.e.,AS events and pathways)connected by coexpression or pathway gene set ***,ASpediaFI explores the interaction network using the random walk with restart algorithm and interrogates the proximity from a query gene ***,ASpediaFI extracts significant AS events,genes,and *** evaluate the performance of our method,we simulated RNA sequencing(RNA-seq)datasets to consider various conditions of sequencing depth and sample *** performance was compared with that of other ***,we analyzed three public datasets of cancer patients or cell lines to evaluate how well ASpediaFI detects biologically relevant *** exhibits strong performance in both simulated and public *** integrative approach reveals that DAS events that recognize a global co-expression network and relevant pathways determine the functional importance of spliced genes in the *** is publicly available at https://***/packages/ASpediaFI.

关键词： Alternative splicing RNA-seq Heterogeneous interaction network Random walk with restart Gene set enrichment analysis

Microstructural characteristics and low-cycle fatigue properties of AZ91 and AZ91-Ca-Y alloys extruded at different temperatures

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Journal of Magnesium and Alloys 2023年第3期11卷 892-902页

作者： Ye Jin Kim young Min Kim Jun Ho Bae Soo-Hyun joo Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Dankook UniversityCheonan 31116Republic of Korea

The commercial AZ91 alloy and nonflammable SEN9(AZ91-0.3Ca-0.2Y,wt%)alloy are extruded at 300°C and 400°*** microstructure,tensile and compressive properties,and low-cycle fatigue(LCF)properties are investigated,with particular focus on the influence of the extrusion *** the AZ91 and SEN9 materials extruded at 300°C(300-materials),numerous fine Mg_(17)Al_(12)particles are inhomogeneously distributed owing to localized dynamic precipitation during extrusion,unlike those extruded at 400°C(400-materials).These fine particles suppress the coarsening of recrystallized grains,decreasing the average grain size of *** the four extruded materials have considerably different microstructures,the difference in their tensile yield strengths is insignificant because strong grain-boundary hardening and precipitation hardening effects in 300-materials are offset almost completely by a strong texture hardening effect in ***,owing to their finer grains and weaker texture,300-materials have higher compressive yield strengths *** the LCF tests,{10-12}twinning is activated at lower stresses in 400-materials than in *** the fatigue damage accumulated per cycle is smaller in 400-materials,they have longer fatigue lives than those of 300-materials.A fatigue life prediction model for the investigated materials is established on the basis of the relationship between the total strain energy density(ΔW_(t))and the number of cycles to fatigue failure(N_(f)),and it is expressed through a simple equation(ΔW_(t)=10·N_(f)-0.59).This model enables fatigue life prediction of both the investigated alloys regardless of the extrusion temperature and strain amplitude.

关键词： AZ91-Ca-Y Extrusion temperature Microstructure Low-cycle fatigue Fatigue life prediction model