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World Journal of Gastroenterology 2022年第46期28卷 6564-6572页

作者： Ji young Park Tae joo Jeon Department of Internal Medicine Inje University College of MedicineSanggye Paik HospitalSeoul 01757South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Endoscopic ultrasonography(EUS)has become a reliable method for predicting the invasion depth of early gastric cancer(EGC).However,diagnostic accuracy of EUS is affected by several *** particular,it is difficult to differentiate between T1a and T1b EGC through *** To confirm whether submucosal saline injection(SSI)could improve the accuracy of EUS in distinguishing T1a and T1b lesions in *** Twenty-four patients with EGC were examined by EUS and subsequently by SSI combined EUS to compare the degree of tumor ***,they underwent endoscopic or surgical resection within 7 *** diagnostic accuracy of EUS and SSI combined EUS was evaluated based on the final pathological findings *** injected into the submucosa acted as an echoic contrast enhancing agent and had the effect of distinguishing the mucosal and submucosal layers *** Of total 24 patients,23 were diagnosed with EGC(T1 cancer:13 as T1a,and 10 as T1b).Standard EUS identified 6 of 13 T1a cancer patients and 3 of 10 T1b cancer ***,EUS-SSI identified 12 of 13 T1a cancer patients and 6 of 10 T1b cancer *** this study,SSI combined EUS was more accurate than EUS alone in diagnosing T1a and T1b lesions of EGC(75.0%and 37.5%,respectively).CONCLUSION SSI improved the diagnostic accuracy of EUS in distinguishing between the T1a and T1b stages in EGC.

关键词： Endoscopic ultrasonography Gastric cancer Endoscopy Surgery

Efficacy and safety of 0.4 percent sodium hyaluronate for endoscopic submucosal dissection of gastric neoplasms

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World Journal of Gastroenterology 2013年第20期19卷 3069-3076页

作者： young Dae Kim Jun Lee Ju Yeon Cho Seok Won Kim Seong Hwan Kim young Kwan Cho Jin Seok jang Ji Sun Han joo young Cho Division of Gastroenterology and Hepatology Department of Internal MedicineMedical SchoolChosun UniversityGwangju 501-717South Korea Department of Internal Medicine Eulji HospitalEulji UniversitySeoul 139-872South Korea Department of Internal Medicine Dong A University College of MedicineBusan 602-715South Korea Department of Internal Medicine Institute for Digestive ResearchDigestive Disease CenterSoonchunhyang University College of MedicineSeoul 140-743South Korea

AIM:To evaluate the efficacy and safety of sodium hyaluronate solution(SH) in endoscopic submucosal dissection(ESD) of gastric ***:A prospective multicenter randomized,double blind,controlled trial was designed and utilized in this study.A total of 76 patients with 5-20 mm sized gastric neoplasms were enrolled at three academic hospitals in South Korea from June 2011 to October *** were randomly assigned to the 0.4% sodium hyaluronate or control *** lesions underwent endoscopic *** was performed with 0.4%SH and normal saline(NS) solution for submucosal *** was assessed using en bloc resection and the number of additional *** evaluation variables were the volume of injection material,steepness of mucosal elevation,bleeding rate,procedural time and operator ***,the safety was assessed by analyzing adverse events during the ***:The usefulness rate in the 0.4%SH group and the controlled group had statistically significant difference under intention to treat(ITT) analysis(90.91% vs 61.11% P = 0.0041).Under per protocol(PP),the usefulness rate is statistically significant different(93.10% vs 61.76%,P = 0.0036).The difference in volume of the solution injected between 0.4%SH group and the controlled group and NS group was also statistically significant under intention to treat and per protocol analysis(ITT:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0003,PP:0.03 ± 0.02 mL vs 0.06 ± 0.03 mL,P = 0.0004).Satisfaction above the grade good was significantly higher in the SH group under intention to treat and per protocol analysis(ITT:90.91% vs 61.11%,P = 0.0041,PP = 93.11% vs 61.77%,P = 0.0022).Adverse events above grade 3 were not noticed in either *** adverse events were treated and were judged as not associated with the submucosal injection ***:0.4%SH solution is a safe and effective agent that doesn't cause any significant adverse events and is useful for submucos

关键词： Sodium hyaluronate Endoscopic submucosal dissection Gastric neoplasm Endoscopic mucosal resection

Application of artificial intelligence in gastroenterology

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World Journal of Gastroenterology 2019年第14期25卷 1666-1683页

作者： young joo Yang Chang Seok Bang Department of Internal Medicine Hallym University College of Medicine

Artificial intelligence(AI) using deep-learning(DL) has emerged as a breakthrough computer technology. By the era of big data, the accumulation of an enormous number of digital images and medical records drove the need for the utilization of AI to efficiently deal with these data, which have become fundamental resources for a machine to learn by itself. Among several DL models, the convolutional neural network showed outstanding performance in image analysis. In the field of gastroenterology, physicians handle large amounts of clinical data and various kinds of image devices such as endoscopy and ultrasound. AI has been applied in gastroenterology in terms of diagnosis,prognosis, and image analysis. However, potential inherent selection bias cannot be excluded in the form of retrospective study. Because overfitting and spectrum bias(class imbalance) have the possibility of overestimating the accuracy,external validation using unused datasets for model development, collected in a way that minimizes the spectrum bias, is mandatory. For robust verification,prospective studies with adequate inclusion/exclusion criteria, which represent the target populations, are needed. DL has its own lack of *** interpretability is important in that it can provide safety measures, help to detect bias, and create social acceptance, further investigations should be performed.

关键词： Artificial intelligence Convolutional neural network Deep-learning Computer-assisted Gastroenterology Endoscopy

Torsional vibration analysis of lathe spindle system with unbalanced workpiece

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Journal of Central South University 2011年第1期18卷 171-176页

作者：郭瑞 jang Sung-Hyun CHOI young-Hyu School of Mechatronics Changwon National University

For the purpose of analyzing the torsional vibration caused by the gravitational unbalance torque arisen in a spindle system when it is machining heavy work piece,a 10-DOF lumped parameter model was made for the machine tool spindle system with geared *** using the elementary method and Runge-Kutta method in Matlab,the eigenvalue problem was solved and the pure torsional vibration responses were obtained and *** results show that the spindle system cannot operate in the desired constant rotating speed as far as the gravitational unbalance torque is engaged,so it may cause bad effect on machining *** the torsional vibration increases infinitely near the resonant frequencies,so the spindle system cannot operate normally during these spindle speed ranges.

关键词： unbalanced work piece gravitational unbalance torque torsional vibration spindle system geared transmission

Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis

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World Journal of Gastroenterology 2017年第21期23卷 3883-3889页

作者： Tae joo Jeon Ji young Park Division of Gastroenterology Department of Internal Medicine Inje University College of Medicine Sanggye Paik Hospital

AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these *** We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups. RESULTS Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d(median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d(median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88in predicting organ failure in acute pancreatitis. CONCLUSION Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.

关键词： Acute pancreatitis Neutrophil-lymphocyte ratio Organ failure Severe acute pancreatitis

Anti-Proliferative Effects of Ginsenosides Extracted from Mountain Ginseng on Lung Cancer

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Chinese Journal of Integrative Medicine 2016年第5期22卷 344-352页

作者： Dong Gyu Lee Sung-ll jang young-Rang Kim Kyeong Eun Yang So Jung Yoon Zee-Won Lee Hyun joo An Ik-Soon jang Jong-Soon Choi Hwa-Seung Yoo Division of Life Science Korea Basic Science InstituteDaejeon 305-333Korea East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 305-764Korea

Objective： To investigate the effect of three major ginsenosides from mountain ginseng as anti- cancer substance and explore the underlying mechanism involved in lung cancer. Methods： The inhibitory proliferation of lung cancer by major five ginsenosides （Rbl, Rb2, Rgl, Rc, and Re） was examined using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay. Calculated 50% inhibition （IC50） values of five ginsenosides were determined and compared each other. Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy. The alterations of apoptosis-related proteins were evaluated by Western blot analysis. Results： The abundance of ginsenosides in butanol extract of mountain ginseng （BX-MG） was revealed in the order of Rbl, Rgl, Re, Rc and Rb2. Among them, Rbl was the most effective to lung cancer cell, followed by Rb2 and Rgl on the basis of relative IC50 values of IMR90 versus A549 cell. The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rbl, Rb2 and Rgl. The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides, however, the levels of caspase-9 and anti-apoptotic protein Bax were not changed. Conclusion： Major ginsenosides such as Rbl, Rb2 and Rgl comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway.

关键词： Butanol extract of mountain ginseng ginsenoside lung cancer apoptosis

Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： Mi-young Kim Jun-Hyung Cho joo young Cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

Long-term result of endoscopic Histoacryl （N-butyl-2-cyanoacrylate）injection for treatment of gastric varices

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World Journal of Gastroenterology 2011年第11期17卷 1494-1500页

作者： Eun Jung Kang Soung Won Jeong Jae young jang joo young Cho Sae Hwan Lee Hyun Gun Kim Sang Gyune Kim young Seok Kim young Koog Cheon young Deok Cho Hong Soo Kim Boo Sung Kim Institute for Digestive Research Department of Internal MedicineSoonchunhyang University College of MedicineSeoul HospitalSeoul 140-743South Korea

AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl  for treatment of gastric variceal bleeding and ***:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl  injections *** hundred patients underwent endoscopic Histoacryl  injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic ***:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were *** of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl  per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl  injection as a primary prophylactic *** these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of *** hemostasis during episodes of rebleeding was achieved in 73.9%of *** survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other *** of the 27 subjects who were treated prophylactically experienced treatment-related *** survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,*** 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl  injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which

关键词： Gastric varix Prophylaxis Histoacryl  (Nbutyl-2-cyanoacrylate) Histoacryl  injection Treatment of gastric varix

Some remarks on one-sided regularity

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Frontiers of Mathematics in China 2018年第4期13卷 833-847页

作者： Tai Keun KWAK Yang LEE young joo SEO Department of Mathematics Daejin University Pocheon 11159 Korea Institute of Basic Science Daejin University Pocheon 11159 Korea Department of Mathematics Hanyang University Seoul 04763 Korea

A ring is said to be right （resp., left） regular-duo if every right （resp., left） regular element is regular. The structure of one-sided regular elements is studied in various kinds of rings, especially, upper triangular matrix rings over one-sided Ore domains. We study the structure of （one-sided） regular-duo rings, and the relations between one-sided regular-duo rings and related ring theoretic properties.

关键词： right (left) regular element right (left) regular-duo ring uppertriangular matrix ring right (left) Ore domain

Selective catalytic NO_x reduction on Antimony promoted V_2O_5-Sb/TiO_2 catalyst

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Rare Metals 2006年第Z2期25卷 84-88页

作者： HA Heon Phil CHUNG Soon Hyo OH young joo Metal Processing Research Center Korea Institute of Science and Technology Cheongryang Seoul 130-650 Republic of Korea

Quantum chemical calculation was carried out to choose a promoter which can reduce the poisoning of V2O5/TiO2 catalysts by SO2. Several atoms were chosen as candidates and new catalysts were synthesized by impregnation method. The NOx conversion rate was measured at temperatures between 100 and 400 ℃ and poisoning effect was investigated. The most promising candidate promoter, Se, was excluded because of its high vapor pressure. On the other hand, Sb shows best promoting properties. Sb promoted catalyst reaches the maximum NOx conversion rate at 250 ℃. It also shows considerably enhanced resistance to poisoning of V2O5/TiO2 catalysts by SO2.

关键词： De NOx selective catalytic reduction SO2 poisoning low temperature activity