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Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal

World Journal of Gastroenterology 2013年第14期19卷 2249-2255页

作者： Min Woo Hwang Jung Nam Kim Ho Jun Song Bora Lim young Kyu kwon Byung joo Kim Department of Sasang Constitutional Medicine College of Korean MedicineKyung-hee University School of Korean Medicine Pusan National University

AIM:To investigate the effects of Lizhong Tang,an herbal product used in traditional Chinese medicine,on mouse small intestine interstitial cells of Cajal(ICCs).METHODS:Enzymatic digestions were used to dissociate ICCs from mouse small intestine *** ICCs were morphologically distinct from other cell types in culture and were identified using phase contrast microscopy after verification with anti c-kit antibody.A whole-cell patch-clamp configuration was used to record potentials(current clamp) from cultured *** of the experiments were performed at 30-32 ℃.RESULTS:ICCs generated pacemaker potentials,and Lizhong Tang produced membrane depolarization in current-clamp *** application of flufenamic acid(a nonselective cation channel blocker) abolished the generation of pacemaker potentials by Lizhong *** with thapsigargin(a Ca 2+-ATPase inhibi-tor in the endoplasmic reticulum) also abolished the generation of pacemaker potentials by Lizhong ***,pacemaker potentials were completely abolished in the presence of an external Ca 2+-free solution,and under this condition,Lizhong Tang induced membrane ***,When GDPβ-S(1 mmol/L) was in the pipette solution,Lizhong Tang still induced membrane *** addition,membrane depolarizations were not inhibited by chelerythrine or calphostin C,which are protein kinase C inhibitors,but were inhibited by U-73122,an active phospholipase C ***:These results suggest that Lizhong Tang might affect gastrointestinal motility by modulating pacemaker activity in interstitial cells of Cajal.

关键词： Interstitial cells of Cajal Lizhong Tang Motility Gastrointestinal tract Whole-cell patch clamp configuration

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Neuroimaging characterization of recovery of impaired consciousness in patients with disorders of consciousness

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Neural Regeneration Research 2019年第7期14卷 1202-1207页

作者： Sung Ho Jang young Hyeon kwon Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

Elucidation of critical brain areas or structures that are responsible for recovery of impaired consciousness in patients with disorders of consciousness is important because it can provide information that is useful when developing therapeutic strategies for neurorehabilitation or neurointervention in patients with disorders of *** this review,studies that have demonstrated brain changes during recovery of impaired consciousness were *** studies used positron emission tomography,electroencephalography/transcranial magnetic stimulation,diffusion tensor tractography,and diffusion tensor tractography/*** majority of these studies reported on the importance of supratentorial areas or structures in the recovery of impaired *** important brain areas or structures that were identified were the prefrontal cortex,basal forebrain,anterior cingulate cortex,and parietal *** results have a clinically important implication that these brain areas or structures can be target areas for neurorehabilitation or neurointervention in patients with disorders of ***,most of studies were case reports;therefore,further original studies involving larger numbers of patients with disorders of consciousness are *** addition,more detailed information on the brain areas or structures that are relevant to the recovery of impaired consciousness is needed.

关键词： consciousness vegetative state minimally conscious state ascending reticular activating system diffusion tensor imaging neuroimaging neural regeneration review

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Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease

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World Journal of Gastroenterology 2010年第20期16卷 2496-2503页

作者： joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee young Han young Chae Chu Kye Sook kwon Eun joo Kim Department of Pathology College of Medicine Inha University7-206 Shin-heung-Dong 3 GaJoong-GuIncheon 400-711South Korea Gastroenterology College of Medicine Inha University7-206 Shinheung-Dong 3 GaJoong-GuIncheon 400-711South Korea Department of Nano and Bio Research Daegu Gyeongbuk Institute of Science and TechnologyDeocksan-dong 110Daegu 700-742South Korea

AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and ***: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic *** features of ITB and CD were reviewed,and eight pathologic parameters were *** cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,*** assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy ***: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with *** sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,*** PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy *** the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combi

关键词： Intestine Tuberculosis Crohn’s disease Histopathology Polymerase chain reaction Kit IS6110 MPB64

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Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： Ju-Hee Oh joo Hyun Lee young-joo Lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

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Diagnostic evaluation of endoscopic ultrasonography with submucosal saline injection for differentiating between T1a and T1b early gastric cancer

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World Journal of Gastroenterology 2022年第46期28卷 6564-6572页

作者： Ji young Park Tae joo Jeon Department of Internal Medicine Inje University College of MedicineSanggye Paik HospitalSeoul 01757South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Endoscopic ultrasonography(EUS)has become a reliable method for predicting the invasion depth of early gastric cancer(EGC).However,diagnostic accuracy of EUS is affected by several *** particular,it is difficult to differentiate between T1a and T1b EGC through *** To confirm whether submucosal saline injection(SSI)could improve the accuracy of EUS in distinguishing T1a and T1b lesions in *** Twenty-four patients with EGC were examined by EUS and subsequently by SSI combined EUS to compare the degree of tumor ***,they underwent endoscopic or surgical resection within 7 *** diagnostic accuracy of EUS and SSI combined EUS was evaluated based on the final pathological findings *** injected into the submucosa acted as an echoic contrast enhancing agent and had the effect of distinguishing the mucosal and submucosal layers *** Of total 24 patients,23 were diagnosed with EGC(T1 cancer:13 as T1a,and 10 as T1b).Standard EUS identified 6 of 13 T1a cancer patients and 3 of 10 T1b cancer ***,EUS-SSI identified 12 of 13 T1a cancer patients and 6 of 10 T1b cancer *** this study,SSI combined EUS was more accurate than EUS alone in diagnosing T1a and T1b lesions of EGC(75.0%and 37.5%,respectively).CONCLUSION SSI improved the diagnostic accuracy of EUS in distinguishing between the T1a and T1b stages in EGC.

关键词： Endoscopic ultrasonography Gastric cancer Endoscopy Surgery

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Application of artificial intelligence in gastroenterology

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World Journal of Gastroenterology 2019年第14期25卷 1666-1683页

作者： young joo Yang Chang Seok Bang Department of Internal Medicine Hallym University College of Medicine

Artificial intelligence(AI) using deep-learning(DL) has emerged as a breakthrough computer technology. By the era of big data, the accumulation of an enormous number of digital images and medical records drove the need for the utilization of AI to efficiently deal with these data, which have become fundamental resources for a machine to learn by itself. Among several DL models, the convolutional neural network showed outstanding performance in image analysis. In the field of gastroenterology, physicians handle large amounts of clinical data and various kinds of image devices such as endoscopy and ultrasound. AI has been applied in gastroenterology in terms of diagnosis,prognosis, and image analysis. However, potential inherent selection bias cannot be excluded in the form of retrospective study. Because overfitting and spectrum bias(class imbalance) have the possibility of overestimating the accuracy,external validation using unused datasets for model development, collected in a way that minimizes the spectrum bias, is mandatory. For robust verification,prospective studies with adequate inclusion/exclusion criteria, which represent the target populations, are needed. DL has its own lack of *** interpretability is important in that it can provide safety measures, help to detect bias, and create social acceptance, further investigations should be performed.

关键词： Artificial intelligence Convolutional neural network Deep-learning Computer-assisted Gastroenterology Endoscopy

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Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis

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World Journal of Gastroenterology 2017年第21期23卷 3883-3889页

作者： Tae joo Jeon Ji young Park Division of Gastroenterology Department of Internal Medicine Inje University College of Medicine Sanggye Paik Hospital

AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these *** We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups. RESULTS Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d(median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d(median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88in predicting organ failure in acute pancreatitis. CONCLUSION Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.

关键词： Acute pancreatitis Neutrophil-lymphocyte ratio Organ failure Severe acute pancreatitis

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Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow

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World Journal of Gastroenterology 2014年第37期20卷 13273-13283页

作者： Mi-young Kim Jun-Hyung Cho joo young Cho Digestive Disease Center Soonchunhyang University Hospital

Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced.

关键词： Endoscopic resection Early gastric cancer Confocal laser endomicroscopy Sentinel node navigation Hybrid natural orifice transluminal endoscopic surgery

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Multiple flexor tendon ruptures due to osteochondroma of the hamate:A case report

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World Journal of Clinical Cases 2023年第13期11卷 3038-3044页

作者： Tae young kwon young-Keun Lee Department of Orthopedics Jeonbuk National University HospitalJeonju-si 54907South Korea Department of Orthopedic Surgery Research Institute of Clinical Medicine of Jeonbuk National University–Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54896South Korea

BACKGROUND Closed rupture of the little and ring finger flexor tendons caused by the hamate is mostly associated with a fracture or nonunion of the hamate *** one case of a closed rupture of the finger flexor tendon caused by osteochondroma in the hamate has been ***,we present a case study to highlight the possibility of hamate osteochondroma as a rare cause of finger closed flexor tendon rupture based on our clinical experience and literature *** SUMMARY A 48-year-old man who had been a rice-field farmer for 7–8 h a day for the past 30 years visited our clinic due to the loss of right little finger and ring finger flexion involving both the proximal and distal interphalangeal *** patient was diagnosed with a complete rupture of the ring and little finger flexors because of the hamate and was pathologically diagnosed with an *** surgery was performed,and a complete rupture of the ring and little finger flexors due to an osteophyte-like lesion of the hamate was observed,which was pathologically diagnosed as an *** One should consider that osteochondroma in the hamate may be the cause of closed tendon ruptures.

关键词： Flexor tendon Finger Closed tendon rupture Hamate Osteochondroma Case report

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Effectiveness and safety of auriculotherapy for breastfeeding: a systematic review

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Journal of Traditional Chinese Medicine 2020年第5期40卷 721-737页

作者： Boram Lee Chan-young kwon Sun Haeng Lee Department of Clinical Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 02453Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Pediatrics of Korean Medicine Kyung Hee University Korean Medicine HospitalKyung Hee University Medical CenterSeoul 02447Republic of Korea

OBJECTIVE:To summarize and critically evaluate the evidence pertaining to the effectiveness and safety of auriculotherapy for ***:We performed a systematic search of10 databases from their inception dates to May 15,*** controlled trials evaluating the effectiveness and safety of auriculotherapy for breastfeeding were *** of bias was assessed using the Cochrane risk of bias ***:This review included 31 randomized controlled trials with 5389 *** to the obvious clinical or statistical heterogeneity,a Meta-analysis was not ***-nine studies compared auriculotherapy plus routine care with routine care *** consistent adjunctive effect of auriculotherapy was observed in increasing the volume of milk production(9 studies showed significant results in favor of auriculotherapy and 5 did not)and serum prolactin level(7 studies showed significant results in favor of auriculotherapy and 2 did not),and in facilitating the initiation of milk secretion(10 studies showed significant results in favor of auriculotherapy and 7 did not).Two studies compared auriculotherapy with no *** as a monotherapy showed significant effects in increasing serum prolactin level and facilitating the onset of milk secretion;however,it was limited and inconclusive because only two studies were included in this *** subgroup analysis of women who underwent cesarean delivery showed inconsistent results with respect to all *** serious adverse events were reported with the use of *** methodological quality of the included studies was generally ***:Although some studies showed positive results,no definite conclusion about the effectiveness and safety of auriculotherapy for breastfeeding could be drawn,owing to the low methodological quality of the included studies and the heterogeneity among ***-scale,well-designed studies are warranted on this topic.

关键词： Breastfeeding Auriculotherapy Systematic review

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