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Cambrian Reefs in the Western North China Platform,Wuhai,Inner Mongolia

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 1946-1954页

作者： LEE Jeong-hyun KIM Byeong-Jun LIANG Kun PARK Tae-Yoon S. CHOH Suk-joo LEE Dong-Jin WOO Jusun Department of Geology and Earth Environmental Sciences Chungnam National University Department of Geoenvironmental Sciences Kongju National University Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Division of Polar Earth-System Sciences Korea Polar Research Institute Department of Earth and Environmental Sciences Korea University Department of Earth and Environmental Sciences Andong National University

Mid to late Cambrian thrombolites and maze-like maceriate reefs from the western North China Platform, Wuhai, Inner Mongolia, northwestern China, occur in the middle of a succession dominated by thin-bedded lime mudstone-shale/marlstone alternations, and are laterally surrounded by limestone conglomerate and/or grainstone. Thrombolite, characterized by meter-scale lenticular mounds composed of millimeter- to centimeter-scale mesoclots and wackestone matrix, occurs in the lower middle part of the sequence. Thrombolite mesoclots are composed of microstromatolites with alternating dark gray and light gray micritic laminae. The maze-like maceriate reefs occur in the middle to the upper part of the sequence, commonly forming lenticular mounds up to 1 m thick. They are characterized by centimeter- to decimeter-scale branched maze-like structures, whose biogenic portions （maceria） are selectively dolomitized. The maceriae are composed of poorly preserved microstromatolites and siliceous sponges. Inter-macerial sediments consist of lime mud and scattered bioclasts. These Wuhai reefs are generally similar to but older than various other Cambrian reefs previously reported from the Shandong region, northeastern China.

关键词： organosedimentary petrology reefal carbonate microbialite siliceous sponge Cambrian Series 3: Guzhangian North China Platform

Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

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World Journal of Gastroenterology 2014年第33期20卷 11753-11761页

作者： Ho hyun nam Dae Won Jun Hye joon Jeon Jai Sun Lee Waqar Khalid Saeed Eun Kyung Kim Department of Translational Medicine Hanyang University Graduate School of Biomedical Science and Engineering Seoul 133-791 South Korea Department of Internal Medicine Hanyang University School of Medicine Seoul 133-791 South Korea Department of Pathology Eulji University College of Medicine Seoul 139-872 South Korea

AIM: To evaluate the effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.

关键词： Osthol Non-alcoholic fatty liver disease Ste-rol regulatory element binding protein

Effects of tissue-cultured mountain ginseng （Panax ginseng CA Meyer） extract on male patients with erectile dysfunction

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Asian Journal of Andrology 2009年第3期11卷 356-361页

作者： Tae-Hwan Kim Seung hyun Jeon Eun-joo Hahn Kee-Yoeup Paek Jong Kwan Park Nae Young Youn hyung-Lae Lee Department of Urology School of Medicine Kyung Hee University Seoul 134-727 Korea Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-711 Korea Department of Urology Chonbuk National University Medical School Jeonju 561-712 Korea Infertility Clinic Sanbornjeil Women＇s Hospital Kunpo 435-042 Korea

Korean ginseng and mountain ginseng （Panax ginseng CA Meyer） are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract （TMGE） on male patients with erectile dysfunction （ED）. A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1 000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function （IIEF） questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE （P 〈 0.05）, whereas no significant improvement was observed in the placebo group （P 〉 0.05）. Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group （P 〈 0.05）. Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients.

关键词： erectile dysfunction Panax ginseng tissue-cultured mountain ginseng extract

Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

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World Journal of Gastroenterology 2012年第40期18卷 5771-5778页

作者： hyun Jung Lee Youn nam Kim Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo nam Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April *** also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with *** endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was *** determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were ***:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the *** endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ***,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD *** with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the ***:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD ***,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词： Intestinal Behcet's disease Disease activityindex Colonoscopy Ulcer Endoscopic severity

Preliminary Results of the Ground-Based Orographic Snow Enhancement Experiment for the Easterly Cold Fog (Cloud) at Daegwallyeong during the 2006 Winter

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Advances in Atmospheric Sciences 2009年第2期26卷 222-228页

作者： Myoung-joo LEE Ki-Ho CHANG Gyun-Myoung PARK Jin-Yim JEONG Ha-Young YANG Ki-Deok JEONG joo-Wan CHA Sung-Soo YUM Jae-Cheol nam Kyungsik KIM Byung-Chul CHOI National Institute of Meteorological Research Korea Meteorological Administration Department of Atmospheric Sciences Yonsei University Department of Physics Pukyong National University

The snow enhancement experiments, carried out by injecting AgI and water vapor into orographically enhanced clouds （fog）, have been conducted to confirm Li and Pitter＇s forced condensation process in a natural situation. Nine ground-based experiments have been conducted at Daegwallyeong in the Taebaek Mountains for the easterly foggy days from January-February 2006. We then obtained the optimized conditions for the Daegwallyeong region as follows： the small seeding rate （1.04 g min-1） of AgI for the easterly cold fog with the high humidity of Gangneung. Additional experiments are needed to statistically estimate the snowfall increment caused by the small AgI seeding into the orographical fog （cloud） over the Taeback Mountains.

关键词： snow enhancement experiment cold cloud modification forced condensation AgI seeding orographical supersaturation

Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

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Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： Chi B.Ahn Ji-hyun Lee joo H.Kim Tae H.Kim Hee-Sook Jun Kuk H.Son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of Health Sciences and Technology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Pharmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Thoracic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of *** severe cases,islet transplantation into the portal vein is ***,due to the loss of transplanted islets and the failure of islet function,the 5-year insulin independence rate of these patients is<50%.In this study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with the aim of preventing islet *** bioprinted construct was fabricated by the multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed that the bioprinted constructs proliferated and released insulin normally during the 4-week in vitro *** MIN-6 generated clusters with a diameter of 100-200μm,similar to the original pancreatic islets in the *** an in vivo study using type 1 diabetes mice,animals implanted with bioprinted constructs showed three times higher insulin secretion and controlled glucose levels at 8 weeks after *** the implanted,bioprinted constructs had a positive effect on insulin secretion in the experimental animals,the survival rate of the implanted group(75%)was three times higher than that of the non-implanted group(25%).The results suggest that the proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 493-499页

作者： Jin Ho Choi Kyong joo Lee Woo hyun Paik namyoung Park Jung Won Chun Sang Hyub Lee Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University Wonju College of MedicineWonjuKorea

Background:Endoscopic biliary drainage is the treatment of choice for patients with malignant distal common bile duct ***-expandable metal stents have clinical advantages including an increased duration of patency that may be prolonged by acetylsalicylic acid(ASA)*** aim of this study was to investigate whether ASA had a positive effect on the patency of self-expandable metal stents compared with ***:This prospective,multicenter,double-blinded,and randomized placebo-controlled trial was conducted from October 2017 to May 2020 in *** who underwent palliative endoscopic biliary drainage with self-expandable metal stents for malignant distal bile duct obstruction were enrolled,and allocated to ASA treatment or *** study outcomes were the rate of stent dysfunction at 6 months,duration of stent patency,risk factors for stent dysfunction,and any adverse ***:Interim analysis included 24 and 28 patients in the ASA and placebo groups,*** was no significant difference between the ASA and placebo groups in stent dysfunction(25.0%vs.20.7%,P=0.761)or the duration of stent patency(150.97±10.55 vs.158.07±8.70 days,P=0.497).Six patients experienced suspected ASA-related adverse events,and there was one lethal ***:ASA did not prolong stent *** study was terminated early because of the possibility of serious adverse events related to ASA treatment of these patients receiving palliative care.

关键词： Endoscopic retrograde cholangiopancreatography Self expandable metallic stents Randomized controlled trial Acetylsalicylic acid

Functionally Graded Ti-50.5Ni Alloy

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材料科学与工程学报 2007年第6期25卷 917-921页

作者： hyun-Gon Kim Ju-Young Choi Jung-Moo Lee Cha-Yong Lim Suk-Bong Kang Yinong Liu Tae-hyun nam Division of Advanced Materials Engineering i-cube center and ERIGyeongsang National University900 Gajwa-dongJinjuGyeongnam 660-701Korea Advanced Materials Research Division Korean Institute of Machinery and Materials66 Sangnam-dongChangwon 641-831Korea Department of Mechanical Engineering University of Western AustraliaCrawleyWA 6009Australia

Transformation behavior and shape memory characteristics of a temperature gradient annealing(TGA)treated Ti-50.5Ni(at%)alloy have been investigated by means of differential scanning calorimetry(DSC)and thermal cycling tests under constant *** annealing the specimen under the temperature gradient from 823 K to 658 K after solution treatment,the B19' martensitic transformation start temperature changed by 60 K along the length of sample(150mm).Temperature dependence of transformation elongation(dε/dT)of the TGA treated wire was found to be 0.16 %/*** annealing the specimen under the temperature gradient from 823 K to 658 K after 47 % cold working without solution treatment,the B19' martensitic transformation start temperature changed by 61K along the length of sample(150mm).Temperature dependence of transformation elongation(dε/dT)of the TGA treated wire was found to be 0.04 %/*** large decrease in dε/dT by cold working effect suggested that an introduction of dislocation was more effective than precipitates for lowering dε/dT.

关键词：钛镍合金位错温度延长性能温度梯度退火处理

Ampullary adenomyoma presenting as acute recurrent pancreatitis

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World Journal of Gastroenterology 2007年第20期13卷 2892-2894页

作者： Tae-Hee Kwon Do hyun Park Kwang Yeon Shim hyun-Deuk Cho Jeong Hoon Park Suck-Ho Lee Il-Kwun Chung Hong-Soo Kim Sang-Heum Park Sun-joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University Cheonan HospitalCheonanChoongnam 330-721Korea Division of Gastroenterology Department of PathologySoon Chun Hyang University Cheonan HospitalCheonanChoongnam 330-721Korea

Adenomyoma is a term generally applied to nodular lesions showing proliferation of both epithelial and smooth muscle components. Despite its benign nature,ampullary adenomyoma is usually presented as biliary obstruction. Most cases are misdiagnosed as carcinoma or adenoma by preoperative endoscopic or radiologic procedure. Therefore,it is frequently treated with extensive surgery. To our knowledge,this is the first reported case in English literature of adenomyoma located in the peripancreatic orifice resulting in intermittent pancreatic duct obstruction and recurrent pancreatitis diagnosed by the endoscopic piecemeal resection.

关键词： Ampulla Adenomyoma Acute recurrent pancreatitis Endoscopic resection