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Favorable surgical treatment outcomes for chronic constipation with features of colonic pseudo-obstruction

World Journal of Gastroenterology 2012年第32期18卷 4441-4446页

作者： Eon Chul Han Heung-Kwon oh Heon-Kyun Ha Eun Kyung Choe Sang Hui Moon Seung-Bum Ryoo Kyu joo Park Department of Surgery Seoul National University College of MedicineSeoul 110-744South Korea Seoul National University Hospital Gangnam Center Seoul 110-744South Korea

AIM:To determine long-term outcomes of surgical treatments for patients with constipation and features of colonic ***:Consecutive 42 patients who underwent surgery for chronic constipation within the last 13 years were prospectively *** identified a subgroup with colonic pseudo-obstruction(CPO) features,with dilatation of the colon proximal to the narrowed transitional zone,in contrast to typical slowtransit constipation(STC),without any dilated colonic *** outcomes of surgical treatments for chronic constipation with features of CPO were analyzed and compared with outcomes for ***:Of the 42 patients who underwent surgery for constipation,33 patients had CPO with dilatation of the colon proximal to the narrowed transitional *** were 16 males and 17 females with a mean age of 51.2 ± 16.1 *** had symptoms of chronic intestinal obstruction,including abdominal distension,pain,nausea,or vomiting,and the mean duration of symptoms was 67 mo(range:6-252 mo).Preoperative defecation frequency was 1.5 ± 0.6 times/wk(range:1-2 times/wk).Thirty-two patients underwent total colectomy,and one patient underwent diverting transverse *** was no surgery-related *** histologic examination showed hypoganglionosis or agangliosis in 23 patients and hypoganglionosis combined with visceral neuropathy or myopathy in 10 *** contrast,histology of STC group revealed intestinal neuronal dysplasia type B(n = 6) and visceral myopathy(n = 3).Early postoperative complications developed in six patients with CPO;wound infection(n = 3),paralytic ileus(n = 2),and intraabdominal abscess(n = 1).Defecation frequencies 3 mo after surgery improved to 4.2 ± 3.2 times/d(range:1-15 times/d).Long-term follow-up(median:39.7 mo) was available in 32 patients;all patients had improvements in constipation symptoms,but two patients needed intermittent medication for management of *** 32 patients had distinct

关键词： Constipation Total colectomy Pseudoobstruction Surgical outcome Hypoganglionosis

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Effects of difructose dianhydride (DFA)-Ⅳ on in vitro fertilization in pigs

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The Journal of Biomedical Research 2017年第5期31卷 453-461页

作者： Young-joo Yi S. Kamala-Kannan Jeong-Muk Lim Byung-Taek oh Sang-Myeong Lee Division of Biotechnology College of Environmental and Bioresource Sciences Chonbuk National University Iksan 54596 Korea Safety Environment and Life Science Institute Chonbuk National University Iksan 54596 Korea.

Difructose dianhydride Ⅳ(DFA-Ⅳ) is produced from levan, which is a natural polysaccharide that belongs to the fructan family, through the activity of levan fructotransferase(LF) derived from microorganisms. Recently, DFA-Ⅳ has been expected to have diverse applications in the food and medical industry. Here, we examined the potential application of DFA-Ⅳ for in vitro fertilization(ⅣF) in pigs. In the assessment of acrosomal integrity during incubation, intact acrosomal or viable spermatozoa were highly sustained in 0.1% or 0.25% DFA-Ⅳ(69.8%-70.8%,P<0.05). Reactive oxygen species(ROS) levels during sperm incubation decreased following the addition of DFA-Ⅳ, and 0.1 %-0.5% DFA-Ⅳ in particular significantly decreased ROS production relative to that seen with no addition or 0.75% DFA-Ⅳ. Total fertilization(mono + polyspermic oocyte) rate was significantly higher in the addition of0.1% DFA-Ⅳ(94.2%) than with other concentrations(71.8%-86.7%, P<0.05). When using reduced ⅣF times and lower sperm numbers, we found that addition of 0.1%-0.5% DFA-Ⅳ significantly increased the fertilization rate(P<0.05). Fertilized oocytes treated with 0.1% DFA-Ⅳ exhibited higher embryonic development and blastocyst formation than those treated with other concentrations(P<0.05). Consequently, the addition of DFA-Ⅳ during ⅣF improved fertilization and embryonic development, suggesting the possible use of novel sugars for enhancement of assisted reproductive technology(ART) in mammals.

关键词： difructose dianhydride-Ⅳ spermatozoa in vitro fertilization embryo pig

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Direct Synthesis of Molybdenum Phosphide Nanorods on Silicon Using Graphene at the Heterointerface for Efficient Photoelectrochemical Water Reduction

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Nano-Micro Letters 2021年第5期13卷 135-150页

作者： Sang Eon Jun Seokhoon Choi Shinyoung Choi Tae Hyung Lee Changyeon Kim Jin Wook Yang Woon‑oh Choe In‑Hyuk Im Cheol‑joo Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea

Transition metal phosphides(TMPs)and transition metal dichalcogenides(TMDs)have been widely investigated as photoelectrochemical(PEC)catalysts for hydrogen evolution reaction(HER).Using high-temperature processes to get crystallized compounds with large-area uniformity,it is still challenging to directly synthesize these catalysts on silicon photocathodes due to chemical incompatibility at the ***,a graphene interlayer is applied between p-Si and MoP nanorods to enable fully engineered interfaces without forming a metallic secondary compound that absorbs a parasitic light and provides an inefficient electron path for hydrogen ***,the graphene facilitates the photogenerated electrons to rapidly transfer by creating Mo-O-C covalent bondings and energetically favorable band *** a bridging role of graphene,numerous active sites and anti-reflectance of MoP nanorods lead to significantly improved PEC-HER performance with a high photocurrent density of 21.8 mA cm−2 at 0 V versus RHE and high ***,low dependence on pH and temperature is observed with MoP nanorods incorporated photocathodes,which is desirable for practical use as a part of PEC *** results indicate that the direct synthesis of TMPs and TMDs enabled by graphene interlayer is a new promising way to fabricate Si-based photocathodes with high-quality interfaces and superior HER performance.

关键词： Photoelectrochemical water splitting Silicon Molybdenum phosphide Hydrogen evolution Graphene

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TiO_2薄膜光催化灭菌性能表征

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西安交通大学学报 2001年第10期35卷 1085-1088页

作者：方湘怡程向明武明堂 Peter Hing oh joo Tien 西安交通大学理学院西安710049 新加坡南洋理工大学材料与工程学院

以日用荧光灯和自然光为照射光源 ,研究了TiO2 薄膜的光催化灭菌性能 ,对比了具有不同紫外可见吸收边波长薄膜的灭菌性能 .结果显示 ,在日用荧光灯照射下吸收边波长在 384nm的TiO2 薄膜具有较优的灭菌性能 ,而吸收边波长为 2 96nm的... 详细信息

以日用荧光灯和自然光为照射光源 ,研究了TiO2 薄膜的光催化灭菌性能 ,对比了具有不同紫外可见吸收边波长薄膜的灭菌性能 .结果显示 ,在日用荧光灯照射下吸收边波长在 384nm的TiO2 薄膜具有较优的灭菌性能 ,而吸收边波长为 2 96nm的薄膜未显示明显的灭菌效果 .在室外自然光条件下 ,薄膜显示了灭菌性能 .

关键词：钛氧化物抗菌材料 TiO2薄膜光催化灭菌性能吸收边波长灭菌机理

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SERKs serve as co-receptors for SYR1 to trigger systemin-mediated defense responses in tomato

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Journal of Integrative Plant Biology 2024年第10期66卷 2273-2287页

作者： Hyewon Cho Dain Seo Minsoo Kim Bo Eun Nam Soyoun Ahn Minju Kang Geul Bang Choon-Tak Kwon Youngsung joo Eunkyoo oh Department of Life Sciences Korea UniversitySeoul 02841Korea Research Institute of Basic SciencesSeoul National UniversitySeoul 08826Korea School of Biological Sciences Seoul National UniversitySeoul 08826Korea Digital Omics Research Center Ochang Institute of Biological and Environmental ScienceKorea Basic Science InstituteCheongju 28119Korea Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea

Systemin, the first peptide hormone identified in plants, was initially isolated from tomato(Solanum lycopersicum) leaves. Systemin mediates local and systemic wound-induced defense responses in plants, conferring resistance to necrotrophic fungi and herbivorous insects. Systemin is recognized by the leucine-rich-repeat receptor-like kinase(LRRRLK) receptor SYSTEMIN RECEPTOR1(SYR1), but how the systemin recognition signal is transduced to intracellular signaling pathways to trigger defense responses is poorly understood. Here, we demonstrate that SERK family LRR-RLKs function as coreceptors for SYR1 to mediate systemin signal transduction in tomato. By using chemical genetic approaches coupled with engineered receptors, we revealed that the association of the cytoplasmic kinase domains of SYR1 with SERKs leads to their mutual trans-phosphorylation and the activation of SYR1, which in turn induces a wide range of defense responses. Systemin stimulates the association between SYR1 and all tomato SERKs(SlSERK1,SlSERK3A, and SlSERK3B). The resulting SYR1-SlSERK heteromeric complexes trigger the phosphorylation of TOMATO PROTEIN KINASE 1B(TPK1b), a receptor-like cytoplasmic kinase that positively regulates systemin responses. Additionally,upon association with SYR1, SlSERKs are cleaved by the Pseudomonas syringae effector HopB1, further supporting the finding that SlSERKs are activated by systemin-bound SYR1. Finally, genetic analysis using Slserk mutants showed that SlSERKs are essential for systemin-mediated defense responses. Collectively, these findings demonstrate that the systeminmediated association of SYR1 and SlSERKs activates defense responses against herbivorous insects.

关键词： LRR-RLK peptide SERK SYR1 systemin

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Application of the Largest Movable Mold EMS on a Large Section Size CC Bloom

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Journal of Iron and Steel Research International 2012年第S2期19卷 900-904页

作者： oh Kyung-shik LEE joo-dong KIM Sung-jul SIEBO Kunstreich POSCO Danieli -Rotelec

The largest movable mold EMS developed by POSCO in collaboration with Daineli-Rotelec for improving internal quality of a large CC bloom is being used at a large size bloom caster of POSCO since *** quality of carbon steel CC bloom of 700×700 mm~2 section size with the mold EMS was much improved compared with without the mold *** zone ratio increased from 50%to 100%and the grain of equiaxed structure became globular and *** shrinkage was also much reduced by applying the movable mold EMS.

关键词： the largest movable mold EMS a large section size CC bloom top shrinkage

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Real time shear wave elastography in chronic liver diseases:Accuracy for predicting liver fibrosis,in comparison with serum markers

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World Journal of Gastroenterology 2014年第38期20卷 13920-13929页

作者： Jae Yoon Jeong Tae Yeob Kim joo Hyun Sohn Yongsoo Kim Woo Kyoung Jeong Young-Ha oh Kyo-Sang Yoo Department of Gastroenterology Hanyang University College of Medicine Department of Internal Medicine Hanyang Univesity Guri Hospital Department of Radiology Hanyang University College of Medicine Department of Radiology Samsung Medical CenterSungkyunkwan University School of Medicine Department of Pathology Hanyang University College of Medicine

AIM: To evaluate the correlation between liver stiffness measurement (LSM) by real-time shear wave elastography (SWE) and liver fibrosis stage and the accuracy of LSM for predicting significant and advanced fibrosis, ... 详细信息

关键词： Elastography Liver fibrosis Liver stiffness Liver biopsy Serum markers

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Synthesis of high-performance nickel hydroxide nanosheets/gadolinium doped-α-MnO_(2) composite nanorods as cathode and Fe_(3)O_(4)/GO nanospheres as anode for an all-solid-state asymmetric supercapacitor

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Journal of Energy Chemistry 2022年第1期31卷 475-484,I0013页

作者： Milan Babu Poudel Han joo Kim Department of Convergence Engineering Technology Jeonbuk National UniversityJeonju Jeollabuk-do 54896Republic of Korea

The wide use of manganese dioxide(MnO_(2))as an electrode in all-solid-state asymmetric supercapacitors(ASCs)remains challenging because of its low electrical *** complication can be circumvented by introducing trivalent gadolinium(Gd)ions into the MnO_(2).Herein,we describe the successful hydrothermal synthesis of crystalline Gd-doped MnO_(2) nanorods with Ni(oh)_(2) nanosheets as cathode,which we combined with Fe_(3)O_(4)/GO nanospheres as anode for all-solid-state *** tests dem on strate that Gd dopi ng sign ifica ntly affected the electrochemical activities of the MnO_(2),which was further enhanced by introducing Ni(oh)_(2).The GdMnO_(2)/Ni(oh)_(2) electrode offers sufficient surface electrochemical activity and exhibits excellent specific capacity of 121.8 mA h g^(-1),at 1A g^(-1),appealing rate performance,and ultralong lifetime stability(99.3%retention after 10,000 discharge tests).Furthermore,the GdMnO_(2)/Ni(oh)_(2)//PVA/Koh//Fe_(3)O_(4)/GO solid-state ASC device offers an impressive specific energy density(60.25 W h kg^(-1))at a high power density(2332 W kg^(-1)).This investigation thus shows its large potential in developing novel approaches to energy storage devices.

关键词： Solid-state supercapacitor Manganese dioxide Gadolinium doping Nickel hydroxide nanosheets

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Nanotechnology and vaccine development

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Asian Journal of Pharmaceutical Sciences 2014年第5期9卷 227-235页

作者： Mi-Gyeong Kim joo Yeon Park Yuna Shon Gunwoo Kim Gayong Shim Yu-Kyoung oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 151-742Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence ScienceSeoul National UniversityDaehak-dongGwanank-guSeoulRepublic of Korea

Despite the progress of conventional vaccines,improvements are clearly required due to concerns about the weak immunogenicity of these vaccines,intrinsic instability in vivo,toxicity,and the need for multiple *** overcome such problems,nanotechnology platforms have recently been incorporated into vaccine ***-based delivery systems offer an opportunity to enhance the humoral and cellular immune *** advantage is attributable to the nanoscale particle size,which facilitates uptake by phagocytic cells,the gut-associated lymphoid tissue,and the mucosa-associated lymphoid tissue,leading to efficient antigen recognition and *** the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors,thereby stimulating specific and selective immune *** this review,we introduce recent advances in nanocarrierbased vaccine delivery systems,with a focus on the types of carriers,including liposomes,emulsions,polymer-based particles,and carbon-based *** describe the remaining challenges and possible breakthroughs,including the development of needlefree nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems.

关键词： Nanotechnology Vaccine delivery Liposomes Emulsions Polymeric nanocarriers Carbon nanomaterials

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Complications after ileal pouch-anal anastomosis in Korean patients with ulcerative colitis

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World Journal of Gastroenterology 2014年第23期20卷 7488-7496页

作者： Seung-Bum Ryoo Heung-Kwon oh Eon Chul Han Heon-Kyun Ha Sang Hui Moon Eun Kyung Choe Kyu joo Park Division of Colorectal Surgery Department of SurgerySeoul National University College of MedicineSeoul 110-744South Korea Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM: To investigate the outcomes of treatments for complications after ileal pouch-anal anastomosis (IPAA) in Korean patients with ulcerative colitis.

关键词： Ulcerative colitis Ileal pouch-anal anastomosis Complications Pouch failure Pouch function

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