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Oncology Research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAK JUHYUN LEE EUNJI OH DOHYUN LEE WONSHIK HAN jongmin kim KYONG-TAI kim Department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea R&D Center NovMetaPharma Co.Ltd.Pohang37668Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics Research Center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein *** this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRK2).This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2,which leads to an increase in tumor cell *** we reported that VRK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin D and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VRK2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VRK2 exhibited a greater increase in breast cancer ***,it is concluded that VRK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VRK2 Kinase activity Breast cancer Tumor RNA editing Cell proliferation Cell growth

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Microfluidic dual loops reactor for conducting a multistep reaction

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 239-246页

作者： Si Hyung Jin Jae-Hoon Jung Seong-Geun Jeong jongmin kim Tae Jung Park Chang-Soo Lee Department of Chemical Engineering Chungnam National University Daejeon 34134 Korea Lotte Chemical R&D Center Daejeon 34110 Korea Department of Chemistry Chung-Ang University Seoul 06974 Korea

Precise control of each individual reaction that constitutes a multistep reaction must be performed to obtain the desired reaction product efficiently. In this work, we present a microfluidic dual loops reactor that enables multistep reaction by integrating two identical loop reactors. Specifically, reactants A and B are synthesized in the first loop reactor and transferred to the second loop reactor to synthesize with reactant C to form the final product. These individual reactions have nano-liter volumes and are carded out in a stepwise manner in each reactor without any cross-contamination issue. To pre- cisely control the mixing efficiency in each loop reactor, we investigate the operating pressure and the operating frequency on the mixing valves for rotary mixing. This microfluidic dual loops reactor is integrated with several valves to realize the fully automated unit operation of a multistep reaction, such as metering the reactants, rotary mixing, transportation, and collecting the product. For proof of concept, CdSeZn nanopartieles are successfully synthesized in a microfluidic dual loops reactor through a fully automated mukistep reaction. Taking all of these features together, this microfluidic dual loops reactor is a general microfluidic screening platform that can synthesize various materials through a multistep reaction.

关键词： microfluidics multistep reaction rotary mixing nanoparticle

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Hybridisation of perovskite nanocrystals with organic molecules for highly efficient liquid scintillators

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Light(Science & Applications) 2020年第1期9卷 530-538页

作者： Sangeun Cho Sungwoo kim jongmin kim Yongcheol Jo Ilhwan Ryu Seongsu Hong Jae-Joon Lee SeungNam Cha Eun BiNam Sang Uck Lee Sam Kyu Noh Hyungsang kim Jungwon Kwak Hyunsik Im Division of Physics and Semiconductor Science Dongguk UniversitySeoul 04620Republic of Korea Department of Radiation Oncology Asan Medical CenterSeoul 05505Republic of Korea Department of Energy and Materials Engineering Dongguk UniversitySeoul 04620Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 2066Republic of Korea Department of Bionano Technology and Department of Applied Chemistry Hanyang UniversityAnsan 15588Republic of Korea

Compared with solid scintillators,liquid scintillators have limited capability in dosimetry and radiography due to their relatively low light ***,we report a new generation of highly efficient and low-cost liquid scintillators constructed by surface hybridisation of colloidal metal halide perovskite CsPbA_(3)(A:Cl,Br,I)nanocrystals(NCs)with organic molecules(2,5-diphenyloxazole).The hybrid liquid scintillators,compared to state-of-the-art CsI and Gd_(2)O_(2)S,demonstrate markedly highly competitive radioluminescence quantum yields under X-ray irradiation typically employed in diagnosis and *** and theoretical analyses suggest that the enhanced quantum yield is associated with X-ray photon-induced charge transfer from the organic molecules to the ***-resolution X-ray imaging is demonstrated using a hybrid CsPbBr_(3) NC-based liquid *** novel X-ray scintillation mechanism in our hybrid scintillators could be extended to enhance the quantum yield of various types of scintillators,enabling low-dose radiation detection in various fields,including fundamental science and imaging.

关键词： perovskite liquid typically

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Infrared-harvesting colloidal quantum dot inks for efficient photovoltaics: Impact of surface chemistry and device engineering

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Journal of Materials Science & Technology 2023年第16期147卷 224-240页

作者： Younghoon kim Min-Jae Choi jongmin Choi Department of Chemistry Kookmin UniversitySeoul02707Republic of Korea Department of Chemical and Biochemical Engineering Dongguk UniversitySeoul04620Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu42988Republic of Korea

Colloidal quantum dots(CQDs)are promising semiconducting materials,which can be used as a photoactive layer in various optoelectronic applications,because of their size-tunable bandgap energy,solution processability,and excellent optical and optoelectronic *** particular,these features have generated great interest in the development of CQD solar cells and led to a rapid increase in their power conversion *** improvements were enabled by many innovative approaches in terms of CQD’s surface chemistry and device architecture *** this review,a critical overview of the research progress in CQD solar cells is presented with a focus on the strategies adopted for achieving record efficiency in CQD solar *** strategies include the use of organic/inorganic surface ligands,pre-and post-treatment of CQDs,and solid-state/solution-phase ligand ***,we provide an understanding of the research history to inspire the rational design of next-generation CQD optoelectronic devices,such as solar cells,light-emitting diodes,and *** research on the development of infrared CQD solar cells as complementary platforms to other solar cell technologies is also critically discussed to provide another perspective on CQD technologies.

关键词： Quantum dot Lead sulfide Ligand exchange Colloidal ink Infrared light Solar cell

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Growth of nitrogen-doped p-type ZnO thin films prepared by atomic layer epitaxy

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Rare Metals 2006年第Z1期25卷 110-114页

作者： LEE Chongmu LIM jongmin PARK Suyoung kim Hyounwoo Department of Materials Science & Engineering Inha University 253 Yonghyeon-dong Incheon 402-751 Korea

Nitrogen-doped, p-type ZnO thin films were grown successfully on sapphire (0001) substrates by using atomic layer epitaxy (ALE). Zn(C2H5)2 [Diethylzinc, DEZn], H2O and NH3 were used as a zinc precursor, an oxidant and a doping source gas, respectively. The lowest electrical resistivity of the p-type ZnO films grown by ALE and annealed at 1000 ℃ in an oxygen atmosphere for 1 h was 18.3 Ω·cm with a hole concentration of 3.71×1017 cm-3. Low temperature-photoluminescence analysis and time-dependent Hall measurement results support that the nitrogen-doped ZnO after annealing is a p-type semiconductor.

关键词： p-type ZnO atomic layer deposition electrical resistivity carrier concentration photoluminescence

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Numerical analysis of clamping pressure during carton clamp handling of heavyweight corrugated packages

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International Journal of Agricultural and Biological Engineering 2017年第5期10卷 25-34页

作者： jongmin Park Jongsoon kim Jonghun Park Laszlo Horvath Ghiseok kim Department of Bio-industrial Machinery Engineering Pusan National UniversityMiryang 627-706Republic of Korea Department of Sustainable Biomaterials Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Department of Biosystems and Biomaterials Science and Engineering Seoul National UniversitySeoul 151-921Republic of Korea

In order to determine the theoretical minimum clamping pressure required in carton clamp handling of heavyweight corrugated package(HCP)such as large packages or unitized agricultural product packages,a numerical model of clamping pressure was *** develop the model,the dynamic load factor was measured at the handling test course which was designed on the basis of actual handling environment of the target ***,the static-frictional coefficients between the HCPs and between the HCP and a rubber contact pad of carton clamp arm were *** main factors in the developed numerical model of clamping pressure were the handling load weight and the effective contact area of the carton clamp *** addition,field tests were performed to validate the theoretical minimum clamping pressure calculated from the *** slip distance from the single package and two packages handling was estimated as a 3.2 mm through field test,and it is expected that the 3.2 mm slip distance will be acceptable for a safe operation in the handling *** suggested analytical approach with the numerical model can be a useful means for estimating the clamping pressure of the carton clamps used to handle the HCP.

关键词： corrugated paperboard heavyweight package agricultural product packages carton clamp clamping pressure dynamic load factor

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Indian monsoon variability in the Mahanadi Basin over the last two glacial cycles and its implications on the Indonesian throughflow

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Geoscience Frontiers 2023年第1期14卷 215-229页

作者： jongmin Lee Sunghan kim Minoru Ikehara Keiji Horikawa Yoshihiro Asahara Chan Min Yoo Boo-Keun Khim Department of Oceanography Pusan National UniversityBusan 46241South Korea Deep-sea Mineral Resources Research Center Korea Institute of Ocean Science&TechnologyBusan 49111South Korea Division of Glacial Environment Research Korea Polar Research InstituteIncheon 21990South Korea Center for Advanced Marine Research Kochi UniversityKochi 783-8502Japan Graduate School of Science and Engineering for Research University of ToyamaToyama 930-8555Japan Department of Earth and Planetary Sciences Nagoya UniversityNagoya 464-8601Japan

The orbital-scale variability of the Indian summer monsoon(ISM)has been influenced by multiple factors,such as atmospheric CO_(2)concentration,global ice volume,and *** for weathering activity and paleo-productivity provide potential insights into the driving forces of its *** documented multi-proxy data at IODP Site U1445,located in the Mahanadi Basin of the northwestern Bay of Bengal,to find out ISM variability over the last 200 *** proxy records,such as Nd/Sr isotopes of detrital particles,clay mineral compositions of the fine-grained sediments,biogenic opal and CaCO_(3),organic carbon contents,and carbon isotopes of organic matter,represent sediment sources,weathering patterns,and paleo-productivity related to the ISM *** Nd/Sr isotope data and clay mineral compositions suggest that the sediments at Site U1445 originated mainly from the Ganges,Brahmaputra,and Meghna rivers without dramatic provenance change between the glacial and interglacial *** weathering activity inferred from clay mineral compositions and the paleo-productivity shift reconstructed by biogenic opal and CaCO_(3)contents suggest that the land-sea interactions were closely linked to the ISM precipitation between the glacial and interglacial *** precipitation by the strong ISM resulted in intense chemical weathering and dominant biogenic opal deposition during the interglacial *** contrast,low precipitation by the weak ISM led to reduced chemical weathering and predominant CaCO_(3)deposition during the glacial ***,the ISM variability driving the land-sea interactions in the Mahanadi Basin was modulated by the Indonesian throughflow(ITF).Our study emphasizes the role of low-latitude forcing of climatic changes in the strong relationship between the ISM and ITF over orbital periods,providing a base for future investigations.

关键词： Provenance Weathering activity Paleo-productivity Indian summer monsoon Bay of Bengal Indonesian throughflow

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High-Performance Perovskite Quantum Dot Solar Cells Enabled by Incorporation with Dimensionally Engineered Organic Semiconductor

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Nano-Micro Letters 2022年第12期14卷 272-285页

作者： Seyeong Lim Dae Hwan Lee Hyuntae Choi Yelim Choi Dong Geon Lee Sung Beom Cho Seonkyung Ko jongmin Choi Younghoon kim Taiho Park Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Center of Materials Digitalization Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Chemistry Kookmin UniversitySeoul 02707Republic of Korea

Perovskite quantum dots(PQDs)have been considered promising and effective photovoltaic absorber due to their superior optoelectronic properties and inherent material merits combining perovskites and ***,they exhibit low moisture stability at room humidity(20-30%)owing to many surface defect sites generated by inefficient ligand exchange *** surface traps must be re-passivated to improve both charge transport ability and moisture *** address this issue,PQD-organic semiconductor hybrid solar cells with suitable electrical properties and functional groups might dramatically improve the charge extraction and defect *** organic semiconductors are typically low-dimensional(1D and 2D)and prone to excessive self-aggregation,which limits chemical interaction with *** this work,we designed a new 3D star-shaped semiconducting material(Star-TrCN)to enhance the compatibility with *** robust bonding with Star-TrCN and PQDs is demonstrated by theoretical modeling and experimental *** Star-TrCN-PQD hybrid films show improved cubic-phase stability of CsPbI_(3)-PQDs via reduced surface trap states and suppressed moisture *** a result,the resultant devices not only achieve remarkable device stability over 1000 h at 20-30%relative humidity,but also boost power conversion efficiency up to 16.0%via forming a cascade energy band structure.

关键词： CsPbI3 quantum dots Star-shaped organic semiconductors Hybrid perovskite quantum dots Solar cell stability High-efficiency photovoltaics

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Online Predictive Monitoring and Prediction Model for a Periodic Process Through Multiway Non-Gaussian Modeling

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Chinese Journal of Chemical Engineering 2008年第1期16卷 48-51页

作者： Changkyoo Yoo Minhan kim Sunjin Hwang Yongmin Jo jongmin Oh College of Environmental and Applied Chemistry Green Energy Center Kyung Hee University Gyeonggi-Do 446-701 Korea

A new on-line predictive monitoring and prediction model for periodic biological processes is proposed using the multiway non-Gaussian modeling. The basic idea of this approach is to use multiway non-Gaussian modeling to extract some dominant key components from daily normal operation data in a periodic process, and subsequently combining these components with predictive statistical process monitoring techniques. The proposed predictive monitoring method has been applied to fault detection and diagnosis in the biological wastewater-treatment process, which is based on strong diurnal characteristics. The results show the power and advantages of the proposed predictive monitoring of a continuous process using the multiway predictive monitoring concept, which is thus able to give very useful conceptual results for a daily monitoring process and also enables a more rapid detection of the process fault than other traditional monitoring methods.

关键词： inferential sensing multiway modeling non-Gaussian distribution online predictive monitoring process supervision wastewater treatment process

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Domain-engineered BiFeO3 thin-film photoanodes for highly enhanced ferroelectric solar water splitting

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Nano Research 2018年第2期11卷 642-655页

作者： Song, Jaesun kim, Taemin Ludvic Lee, jongmin Cho, Sam Yeon Cha, Jaeseong Jeong, Sang Yun An, Hyunji kim, Wan Sik Jung, Yen-Sook Park, Jiyoon Jung, Gun Young kim, Dong-Yu Jo, Ji Young Bu, Sang Don Jang, Ho Won Lee, Sanghan School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Department of Materials Science and Engineering Research Institute of Advanced Materials Seoul National University Seoul Republic of Korea Department of Physics Chonbuk National University Jeonju Republic of Korea

In photoelectrochemical （PEC） water splitting, charge separation and collection by the electric field in the photoactive material are the most important factors for improved conversion efficiency. Hence, ferroelectric oxides, in which electrons are the majority carriers, are considered promising photoanode materials because their high built-in potential, provided by their spontaneous polarization, can signifi＇canfly enhance the separation and drift of photogenerated carriers. In this regard, the PEC properties of BiFeO3 thin-film photoanodes with different crystallographic orientations and consequent ferroelectric domain structures are investigated. As the crystallographic orientation changes from （001）pc via （ll0）pc to （lll）p~, the ferroelastic domains in epitaxial BiFeO3 thin films become mono-variant and the spontaneous polarization levels increase to 110 btC/cm2. Consequent136 the photocurrent density at 0 V vs. Ag/AgC1 increases approximately 5.3-fold and the onset potential decreases by 0.180 V in the downward polarization state. It is further demonstrated that ferroelectric switching in the （lll）pc BiFeO3 thin-film photoanode leads to an approximate change of 8,000% in the photocurrent density and a 0.330 V shift in the onset potential. This study strongly suggests that domain-engineered ferroelectric materials can be used as effective charge separation and collection layers for efficient solar water-splitting photoanodes.

关键词： BiFeO3 ferroelectric photoelectrochemical domain orientation pulsed laser deposition

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