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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji Hun park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun jong woong park Jae Ho Shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

Towards high-performance and robust anion exchange membranes(AEMs)for water electrolysis:Super-acid-catalyzed synthesis of AEMs

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Journal of Energy Chemistry 2024年第6期93卷 478-510,I0012页

作者： Geun woong Ryoo Sun Hwa park Ki Chang Kwon jong Hun Kang Ho Won Jang Min Sang Kwon Department of Materials Science and Engineering Research Institute of Advanced Materials(RIAM)Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea Department of Chemical and Biological Engineering and Institute of Chemical ProcessSeoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

The increasing demand for hydrogen energy to address environmental issues and achieve carbon neutrality has elevated interest in green hydrogen production,which does not rely on fossil *** various hydrogen production technologies,anion exchange membrane water electrolyzer(AEMWE)has emerged as a next-generation technology known for its high hydrogen production efficiency and its ability to use non-metal ***,this technology faces significant challenges,particularly in terms of the membrane durability and low ionic *** address these challenges,research efforts have focused on developing membranes with a new backbone structure and anion exchange groups to enhance durability and ionic ***,the super-acid-catalyzed condensation(SACC)synthesis method stands out due to its user convenience,the ability to create high molecular weight(MW)polymers,and the use of oxygen-tolerant organic *** the synthesis of anion exchange membranes(AEMs)using the SACC method began in 2015,and despite growing interest in this synthesis approach,there remains a scarcity of review papers focusing on AEMs synthesized using the SACC *** review covers the basics of SACC synthesis,presents various polymers synthesized using this method,and summarizes the development of these polymers,particularly their building blocks including aryl,ketone,and anion exchange *** systematically describe the effects of changes in the molecular structure of each polymer component,conducted by various research groups,on the mechanical properties,conductivity,and operational stability of the *** review will provide insights into the development of AEMs with superior performance and operational stability suitable for water electrolysis applications.

关键词： Green hydrogen production Water electrolysis Anion exchange membrane water electrolyzer(AEMWE) Anion exchange membranes(AEMs) Super-acid-catalyzed condensation(SACC)

In vivo analysis of post-joint-preserving surgery fracture of 3D-printed Ti-6Al-4V implant to treat bone cancer

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Bio-Design and Manufacturing 2021年第4期4卷 879-888页

作者： jong woong park Ye Chan Shin Hyun Guy Kang Sangeun park Eunhyeok Seo Hyokyung Sung Im Doo Jung Division of Convergence Technology National Cancer CenterGoyang 10408Republic of Korea Orthopaedic Oncology Clinic National Cancer CenterGoyang 10408Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National UniversityJin-Ju 52828Republic of Korea Department of Mechanical Engineering Ulsan National Institute of Science and TechnologyUNIST-Gil 50Ulsan 44919Republic of Korea

Cancer growth in the bone due to its random shape disables bone strength and thus changes its capacity to support body weight or muscles,which can crucially affect the quality of human life in terms of normal walking or daily *** successful patient recovery,it is necessary to remove the cancer-affected minimal bone area and quickly replace it with a biocompatible metal implant within less than 2 *** electron beam-melted Ti-6Al-4V implant was designed and applied in a patient to preserve the natural knee joint close to the bone *** developed implant fits the bone defect well,and the independent ambulatory function of the natural knee joint was restored in the patient within six weeks after surgery.A delayed fracture occurred six months after the successful replacement of cancer-affected bone with Ti-6Al-4V implant at the proximal meshed junction of the implant because of a minor downward ***,mechanical,and computational analyses were conducted for the fractured area to find the main reason for the delayed *** findings pertaining to the mechanical and material investigation can help realize the safe implantation of the three-dimensionally printed titanium implant to preserve the natural joints of patients with massive bone defects of the extremities.

关键词： 3D printing Bone cancer Titanium alloy implant Electron beam melting Fracture analysis

Development of temperature-robust damage factor based on sensor fusion for a wind turbine structure

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 42-47页

作者： jong-woong park Sung-Han SIM Jin-Hak YI Hyung-Jo JUNG Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689- 798Republic of Korea Coastal Development & Ocean Engineering Research Division Korea Institute of Ocean Science and Technology Ansan 426-744Republic of Korea Department of Civil and Environmental Engineering KAIST Daejeon 305-701 Republic of Korea

Wind power systems have gained much attention due to the relatively high reliability, maturity in technology and cost competitiveness compared to other renewable alternatives. Advances have been made to increase the power efficiency of the wind turbines while less attention has been focused on structural integrity assessment of the structural systems. Vibration-based damage detection has widely been researched to identify damages on a structure based on change in d^mmic characteristics. Widely spread methods are natural frequency-based, mode shape-based, and curvature mode shape-based methods. The natural frequency-based methods are convenient but vulnerable to environmental temperature variation which degrades damage detection capability; mode shapes are less influenced by temperature variation and able to locate damage but requires extensive sensor instrumentation which is costly and vulnerable to signal noises. This study proposes novelty of damage factor based on sensor fusion to exclude effect of temperature variation. The combined use of an accelerometer and an inclinometer was considered and damage factor was defined as a change in relationship between those two measurements. The advantages of the proposed method are： 1） requirement of small number of sensor, 2） robusmess to change in temperature and signal noise and 3） ability to roughly locate damage. Validation of the proposed method is carried out through numerical simulation on a simplified 5 MW wind turbine model.

关键词： sensor fusion damage detection structural health monitoring

Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong Hyun Cho Minjae Kim Inchan Yang Kyung Tae park Chang Houn Rhee Hai woong park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats

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Neural Regeneration Research 2014年第14期9卷 1351-1357页

作者： Ji Yeong Kim Woo Joo Jeon Dong Hwee Kim Im Joo Rhyu Young Hwan Kim Inchan Youn jong woong park Department of Orthopedic Surgery Seoul Paik HospitalInje UniversitySeoulKorea Department of Orthopedic Surgery Korea UniversitySeoulKorea Department of Physical Medicine & Rehabilitation KoreaUniversitySeoulKorea Department of Anatomy Korea UniversitySeoulKorea Biomedical Research Center Korea Institute of Science and TechnologySeoulKorea

Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with plateletrich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.

关键词： nerve regeneration peripheral nerve injury sciatic nerve platelet-rich plasma in-side-out vein autografi myelinated axons axon diameter myelin sheath thickness histology sciaticnerve index neural regeneration

Dual-light emitting 3D encryption with printable fluorescent-phosphorescent metal-organic frameworks

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Light(Science & Applications) 2023年第10期12卷 2172-2186页

作者： Jin Woo Oh Seokyeong Lee Hyowon Han Omar Allam Ji Il Choi Hyeokjung Lee Wei Jiang Jihye Jang Gwanho Kim Seungsoo Mun Kyuho Lee Yeonji Kim jong woong park Seonju Lee Seung Soon Jang Cheolmin park Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea The George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology801 Ferst DriveAtlantaGA 30332-0405USA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst DriveAtlantaGA 30332-0245USA Om Spin Convergence Research Center Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea

Optical encryption technologies based on room-temperature light-emitting materials are of considerable ***,we present three-dimensional(3D)printable dual-light-emitting materials for high-performance optical pattern *** are based on fluorescent perovskite nanocrystals(NCs)embedded in metal-organic frameworks(MOFs)designed for phosphorescent host-guest ***,perovskite-containing MOFs emit a highly efficient blue phosphorescence,and perovskite NCs embedded in the MOFs emit characteristic green or red fluorescence under ultraviolet(UV)*** dual-light-emitting MOFs with independent fluorescence and phosphorescence emissions are employed in pochoir pattern encryption,wherein actual information with transient phosphorescence is efficiently concealed behind fake information with fluorescence under UV ***,a 3D cubic skeleton is developed with the dual-light-emitting MOF powder dispersed in 3D-printable polymer filaments for 3D dual-pattern *** article outlines a universal principle for developing MOF-based room-temperature multi-light-emitting materials and a strategy for multidimensional information encryption with enhanced capacity and security.

关键词： perovskite light pattern

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON woong KANG MYEONG JIN KIM JOON SEONG park Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Ransomware Classification Framework Using the Behavioral Performance Visualization of Execution Objects

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Computers, Materials & Continua 2022年第8期72卷 3401-3424页

作者： Jun-Seob Kim Ki-woong park Department of Computer and Information Security and Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

A ransomware attack that interrupted the operation of Colonial Pipeline(a large *** pipeline company),showed that security threats by malware have become serious enough to affect industries and social infrastructure rather than individuals *** agents and characteristics of attacks should be identified,and appropriate strategies should be established accordingly in order to respond to such *** this purpose,the first task that must be performed is malware *** creators are well aware of this and apply various concealment and avoidance techniques,making it difficult to classify *** study focuses on new features and classification techniques to overcome these *** propose a behavioral performance visualization method using utilization patterns of system resources,such as the central processing unit,memory,and input/output,that are commonly used in performance analysis or tuning of *** extracted the usage patterns of the system resources for ransomware to performbehavioral performance *** results of the classification performance evaluation using the visualization results indicate an accuracy of at least 98.94%with a 3.69%loss ***,we designed and implemented a framework to perform the entire process—from data extraction to behavioral performance visualization and classification performance measurement—that is expected to contribute to related studies in the future.

关键词： Behavioral performance visualization ransomware malware classification