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Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways

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Research 2023年第3期2022卷 229-241页

作者： Da Hyun Kim Minju Jeong Jae Hwan Kim Joe Eun Son John JYLee Sang-jun Park Juyeon Lee Minwoo Kim jong-won oh Myeong Soo Park Sanguine Byun Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Program in Developmental and Stem Cell Biology The Hospital for Sick ChildrenTorontoOntarioCanada Research Center BIFIDO Co.Ltd.Hanam 12930Republic of Korea

The composition of commensal bacteria plays a critical role in controlling immune responses in the *** have shown that specific bacterial strains may have the capacity to enhance host immune defense against gastrointestinal viral *** norovirus is known to be the most common cause of gastroenteritis,leading to an estimated 200,000 deaths every year,identification of bacterial strains with protective effects against norovirus infection remains ***,we discovered Lactobacillus salivarius HHuMin-U(HHuMin-U)as a potent antiviral strain against norovirus ***-U significantly suppressed murine norovirus replication and lowered viral RNA titers in *** transcriptome sequencing(RNA sequencing)analysis revealed that HHuMin-U markedly enhanced the expression level of antiviral interferon-stimulated genes compared to mock ***-U treatment dose-dependently induced type I interferons(IFN-αand IFN-β)and tumor necrosis factor-αproduction in mouse and human macrophages,promoting antiviral innate responses against norovirus *** on the molecular mechanism demonstrated that HHuMin-U can activate nuclear factorκB and TANK-binding kinase 1(TBK1)–interferon regulatory factor 3 signaling pathways,leading to the phosphorylation of signal transducer and activator of transcription 1 and signal transducer and activator of transcription 2,the key mediators of interferon-stimulated ***,oral administration of HHuMin-U increased IFN-βlevels in the ileum of mice and altered the gut microbiome *** results suggest the species/strain-specific importance of gut microbial composition for antiviral immune responses and the potential use of HHuMin-U as a probiotic agent.

关键词： TBK1 interferon protective

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim jong-won oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Unlocking Novel Functionality:Pseudocapacitive Sensing in MXene-Based Flexible Supercapacitors

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Nano-Micro Letters 2025年第4期17卷 212-229页

作者： Eunji Kim Seongbeen Kim Hyeong Min Jin Gyungtae Kim Hwi-Heon Ha Yunhui Choi Kyoungha Min Su-Ho Cho Hee Han Chi won Ahn Jaewoo Roh Il-Kwon oh Jinwoo Lee Yonghee Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea National Nano Fab Center(NNFC) 291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Nano&Advanced Materials Science and Engineering Kyungpook National University2559Gyeongsang-DaeroSangju-SiGyeongsangbuk-Do 37224Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea

Extensively explored for their distinctive pseudocapacitance characteristics,MXenes,a distinguished group of 2D materials,have led to remarkable achievements,particularly in the realm of energy storage *** work presents an innovative Pseudocapacitive *** key lies in switching the energy storage kinetics from pseudocapacitor to electrical double layer capacitor by employing the change of local pH(-log[H^(+)])in MXene-based flexible supercapacitors during *** sensing is observed in acidic electrolyte but absent in neutral *** shearing during bending causes liquid-crystalline MXene sheets to increase in their degree of anisotropic *** blocking of H+mobility due to the higher diffusion barrier,local pH *** electrochemical energy storage kinetics transits from Faradaic chemical protonation(intercalation)to non-Faradaic physical *** utilize the phenomenon of capacitance change due to shifting energy storage kinetics for strain sensing *** developed highly sensitive Pseudocapacitive Sensors feature a remarkable gauge factor(GF)of approximately 1200,far surpassing conventional strain sensors(GF:~1 for dielectric-cap sensor).The introduction of the Pseudocapacitive Sensor represents a paradigm shift,expanding the application of pseudocapacitance from being solely confined to energy devices to the realm of multifunctional *** technological leap enriches our understanding of the pseudocapacitance mechanism of MXenes,and will drive innovation in cutting-edge technology areas,including advanced robotics,implantable biomedical devices,and health monitoring systems.

关键词： MXenes Supercapacitors Pseudocapacitive sensing Local pH Operando measurements

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee oh Eileen L Yoon Dae won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Logic-in-memory cell enabling binary and ternary Boolean logics

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Science China(Information Sciences) 2025年第2期68卷 370-379页

作者： Jeongyun oh Juhee JEON Yunwoo SHIN Kyougah CHO Sangsig KIM Department of Electrical Engineering Korea University

In computing systems, processing and memory units have been integrated into logic-in-memory(LiM) to enhance the computational efficiency and performance. LiM has been attempted to perform not only binary but also ternary logic functions, which reduces computing complexity. Herein, we demonstrate a binary and ternary LiM(BT-LiM) cell with eight triple-gated(TG) feedback field-effect transistors(FBFETs) reconfigured into n-or p-channel modes. The TG FBFETs exhibit symmetrical latch-up voltages and an on-current ratio of 1.02 between the n-and p-channel modes, which indicates a high potential for reconfigurable logic applications. The BT-LiM cell can perform YES, NOT, AND, OR, NAND, NOR, XNOR, and XOR logic functions in a single cell because of these reconfigurable characteristics. Further, binary and ternary logic functions are realized in the cell without a programming stage, and the cell maintains the results of the logic functions under zero-bias conditions. This study achieves multifunctional LiM that can operate all binary and ternary Boolean logics.

关键词： logic-in-memory reconfigurable channel modes ternary logic triple-gated feedback field-effect transistors

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae won Hongwei Song Lin Xu jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo jonggeol Na J.Jay Liu Young-Ju Kim Wangyun won Department of Chemical and Biological Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemical Engineering(Integrated process) Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Republic of Korea Department of Chemical Engineering and Materials Science Ewha Womans University52 Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical Engineering Pukyong National University45 Yongso-roNam-guBusan 48513Republic of Korea Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Gut–brain axis and environmental factors in Parkinson's disease:bidirectional link between disease onset and progression

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Neural Regeneration Research 2025年第12期20卷 3416-3429页

作者： Soo Jung Park Kyung won Kim Eun Jeong Lee Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheonSouth Korea

Parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies containingα-synuclein *** recent decades,however,accumulating research has revealed that Parkinson's disease also involves the gut and uncovered an intimate and important bidirectional link between the brain and the gut,called the“gut–brain axis.”Numerous clinical studies demonstrate that gut dysfunction frequently precedes motor symptoms in Parkinson's disease patients,with findings including impaired intestinal permeability,heightened inflammation,and distinct gut microbiome profiles and ***,α-synuclein deposition has been consistently observed in the gut of Parkinson's disease patients,suggesting a potential role in disease ***,individuals with vagotomy have a reduced Parkinson's disease *** these observations,researchers have hypothesized thatα-synuclein accumulation may initiate in the gut and subsequently propagate to the central dopaminergic neurons through the gut–brain axis,leading to Parkinson's *** review comprehensively examines the gut's involvement in Parkinson's disease,focusing on the concept of a gut-origin for the *** also examine the interplay between altered gut-related factors and the accumulation of pathologicalα-synuclein in the gut of Parkinson's disease *** the accessibility of the gut to both dietary and pharmacological interventions,targeting gut-localizedα-synuclein represents a promising avenue for developing effective Parkinson's disease therapies.

关键词： gut inflammation gut microbiome gut-brain axis micro/nano-plastics Parkinson’s disease α-synuclein

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Permeability evaluation for artificial single rock fracture according to geometric aperture variation using electrical resistivity

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 787-797页

作者： Hangbok Lee jong-won Lee Tae-Min oh Deep Subsurface Research Center Korea Institute of Geoscience and Mineral ResourcesDaejeon34132Republic of Korea Department of Civil and Environmental Engineering Pusan National UniversityBusan46241Republic of Korea

A convenient approach was proposed by which to evaluate and monitor the permeability of a rock fracture by verifying the quantitative correlation between the electrical resistivity and permeability at laboratory *** this purpose,an electrical resistivity measurement system was applied to the laboratory experiments using artificial cells with the shape of a single rock *** experiments were conducted using rock fractures according to the geometry,aperture sizes,wavelengths,and roughness *** overall negative relationship between the normalized electrical resistivity values and the aperture sizes directly linked with the permeability,was well fitted by the power-law function with a large determination coefficient(≈0.86).The effects of wavelength and roughness amplitude of the rock fracture on the electrical resistivity were also *** showed that the electrical resistivity was slightly increased with decreasing wavelength and increasing roughness *** empirical model for evaluating the permeability of a rock fracture was proposed based on the experimental *** the field,if the electrical resistivity of pore groundwater could be measured in advance,this empirical model could be applied effectively for simple,quick monitoring of the fracture *** uncertainty may be associated with the permeability estimation due to the limited control parameters considered in this research,this electrical resistivity approach could be helpful to monitor the rock permeability in deep underground facilities such as those used for radioactive waste repositories or forms of energy storage.

关键词： Permeability Rock fracture Electrical resistivity Fracture geometry Long-term monitoring

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