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Recent research progress on magnesium alloys in Korea:A review

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Journal of Magnesium and Alloys 2023年第10期11卷 3545-3584页

作者： Sung Hyuk Park Ye Jin kim hyun Ji kim Sang-Cheol Jin jong Un Lee Alexander Komissarov Kwang Seon Shin School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Laboratory of Hybrid Nanostructured Materials National University of Science and TechnologyMoscow 119049Russia Laboratory of Medical Bioresorption and Bioresistance Moscow State University of Medicine and DentistryMoscow 127473Russia Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National UniversitySeoul 08826Republic of Korea

This review highlights the recent advancements in Mg research in South Korea with a prime focus on high-speed-extrudable Mg–Bi-based alloys for high productivity and strength,innovative techniques utilizing{10–12}twinning for improved mechanical properties,and alloying and processing methods for enhanced corrosion ***-alloyed Mg–Bi-based alloys possess thermally stableα-Mg matrix and secondary phase,which ensures high-speed extrusion of these alloys at elevated temperatures without hot ***,they exhibit outstanding extrudability with a maximum extrusion speed of up to 70 m/***,their high alloying contents offer excellent strength even after high-speed extrusion through strong solid solution hardening and particle hardening effects,making them suitable for high-performance extruded Mg *** pre-twinning process utilizing{10–12}twinning and the combined process of pre-twinning and subsequent annealing have shown promise in controlling microstructure and texture of wrought Mg alloys and thus enhancing their mechanical *** pre-twinning process enhances tensile strength,fatigue properties,and age-hardening rate of Mg ***,the combined processes of pre-twinning and subsequent annealing considerably improve their ductility,stretch formability,bending formability,and damping *** have been made to improve the corrosion resistance of Mg alloys through alloying additions,process treatments,and surface *** elements like Ca,Sc,and Sm alter the microstructural features(such as secondary phases and grain size)that affect the corrosion *** treatments such as multidirectional forging,screw rolling,and pulse electron beam can also improve the corrosion resistance by refining the ***,advanced surface coating technologies can create durable and corrosion-resistant layers for effectively protecting the Mg *** these research activities conducted

关键词： South Korea Mg–Bi alloys {10–12}twinning Corrosion Mechanical properties

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor

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Chinese Journal of Natural Medicines 2018年第6期16卷 428-435页

作者： Huiyoung Kwon Ji Wook Jung Young Choon Lee jong Hoon Ryu Dong hyun kim Department of Medicinal Biotechnology College of Health SciencesDong-A UniversityBusan 49315Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityKyungsan 38610Republic of Korea Institute of Convergence Bio-Health Dong-A UniversityBusan 49315Republic of Korea Department of Life and Nanopharmaeeutical Sciences Kyung Hee UniversityKyung Hee UniversitySeou102447Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute Kyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea

Artemisia capillaris Thunberg is a medicinal plant used as a traditional medicine in many cultures. It is an effective remedy for liver problems including hepatitis. Recent pharmacological reports have indicated that Artemisia species can exert various neurological effects. Previously, we reported a memory-enhancing effect of Artemisia species. However, the mechanisms underlying the neuroprotective effect of A. capillaris(AC) are still unknown. In the present study, we investigated the effect of an ethanol extract of AC on ischemic brain injury in a mouse model of transient forebrain ischemia. The mice were treated with AC for seven days, beginning one day before induction of transient forebrain ischemia. Behavioral deficits were investigated using the Y-maze. Nissl and Fluoro-jade B staining were used to indicate the site of injury. To determine the underlying mechanisms for the drug, we measured acetylcholinesterase activity. AC(200 mg·kg-1) treatment reduced transient forebrain ischemia-induced neuronal cell death in the hippocampal CA1 region. The AC-treated group also showed significant amelioration in the spontaneous alternation of the Y-maze test performance, compared to that in the untreated transient forebrain ischemia group. Moreover, AC treatment showed a concentration-dependent inhibitory effect on acetylcholinesterase activity in vitro. Finally, the effect of AC on forebrain ischemia was blocked by mecamylamine, a nonselective nicotinic acetylcholine receptor antagonist. Our results suggested that in a model of forebrain ischemia, AC protected against neuronal death through the activation of nicotinic acetylcholine receptors.

关键词： Artemisia capillaris Transient forebrain ischemia Acetylcholinesterase Nicotinic acetylcholine receptor

Is forceps more useful than visualization for measurement of colon polyp size?

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World Journal of Gastroenterology 2016年第11期22卷 3220-3226页

作者： Jae hyun kim Seun Ja Park jong Hoon Lee Tae Oh kim hyun Jin kim hyung Wook kim Sang Heon Lee Dong Hoon Baek Department of Gastroenterology Kosin University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Dong-A University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Haeundae Paik Hospital Inje University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Gyeongsang National University Hospital Jinju 660-702 South Korea Department of Gastroenterology Pusan National University Yangsan Hospital Yangsan 626-770 South Korea Department of Gastroenterology Inje University Busan Paik Hospital Inje University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Pusan National University School of Medicine Busan 602-702 South Korea

AIM: To identify whether the forceps estimation is more useful than visual estimation in the measurement of colon polyp ***: We recorded colonoscopy video clips that included scenes visualizing the polyp and scenes using open biopsy forceps in association with the polyp, which were used for an exam. A total of 40 endoscopists from the Busan Ulsan Gyeongnam Intestinal Study Group Society(BIGS) participated in this study. Participants watched 40 pairs of video clips of the scenes for visual estimation and forceps estimation, and wrote down the estimated polyp size on the exam paper. When analyzing the results of the exam, we assessed interobserver differences, diagnostic accuracy, and error range in the measurement of the polyp size.R E S U LT S : The overall intra-class correlation coefficients(ICC) of inter-observer agreement for forceps estimation and visual estimation were 0.804(95%CI: 0.731-0.873, P < 0.001) and 0.743(95%CI: 0.656-0.828, P < 0.001), respectively. The ICCs of each group for forceps estimation were higher than those for visual estimation(Beginner group, 0.761 vs 0.693; Expert group, 0.887 vs 0.840, respectively). The overall diagnostic accuracy for visual estimation was 0.639 and for forceps estimation was 0.754(P < 0.001). In the beginner group and the expert group, the diagnostic accuracy for the forceps estimation was significantly higher than that of the visual estimation(Beginner group, 0.734 vs 0.613, P < 0.001; Expert group, 0.784 vs 0.680, P < 0.001, respectively). The overall error range for visual estimation and forceps estimation were 1.48 ± 1.18 and 1.20 ± 1.10, respectively(P < 0.001). The error ranges of each group for forceps estimation were significantly smaller than those for visual estimation(Beginner group, 1.38 ± 1.08 vs 1.68 ± 1.30, P < 0.001; Expert group, 1.12 ± 1.11 vs 1.42 ± 1.11, P < 0.001, respectively).CONCLUSION: Application of the open biopsy forceps method when measuring colon polyp size could help reduce int

关键词： Colon polyp Colonoscopy Measurement Endoscopy

Knot impingement after arthroscopic rotator cuff repair mimicking infection:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5097-5102页

作者： Du-Han kim jong-Hyuk Jeon Byung-Chan Choi Chul-hyun Cho Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND Knot impingement as a complication after arthroscopic rotator cuff repair(ARCR)has been suggested as a cause of persistent pain with limited *** report on a case involving a patient who developed knot impingement after ARCR who complained of acute onset of pain with limited motion,which was confused with *** SUMMARY A 55-year-old female who complained of severe pain with limited motion of the right shoulder visited our emergency *** range of motion could not be evaluated due to the patient’s severe *** patient had undergone ARCR using a suture-bridge technique at a local clinic four months ago for treatment of a small supraspinatus tear of the right *** erosive change of the undersurface of the acromion was observed on plain radiographs of the right shoulder,and a moderate amount of bursal fluid and synovial thickening with enhancement was observed by magnetic resonance *** of an analysis of the aspirated fluid showed that the WBC count was 3960 with 90% *** arthroscopic view showed healing of the repaired supraspinatus tendon and loose suture threads and knots with severe subacromial bursitis were *** of inflammatory tissues of the glenohumeral joint and subacromial space was performed for the removal of all suture *** patient’s symptoms subsided immediately after the surgical *** Although the incidence of knot impingement is rare,the possibility of knot impingement after ARCR should be a consideration.

关键词： Rotator cuff Knot impingement Shoulder Infection Arthroscopy Case report

Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-,mitogen-activated protein kinase-,and Nrf2-dependent pathway

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World Journal of Gastroenterology 2020年第3期26卷 291-306页

作者： Su Hyuk Ko jong Ik Jeon hyun Ae Woo Jung Mogg kim Department of Microbiology and Department of Biomedical Science Hanyang University College of Medicine and Graduate School of Biomedical Science and EngineeringSeoul 04763South Korea Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760South Korea

BACKGROUND Enterotoxigenic Bacteroides fragilis(ETBF)causes colitis and diarrhea,and is considered a candidate pathogen in inflammatory bowel diseases as well as colorectal *** diseases are dependent on ETBF-secreted toxin(BFT).Dendritic cells(DCs)play an important role in directing the nature of adaptive immune responses to bacterial infection and heme oxygenase-1(HO-1)is involved in the regulation of DC *** To investigate the role of BFT in HO-1 expression in *** Murine DCs were generated from specific pathogen-free C57BL/6 and Nrf2−/−knockout *** were exposed to BFT,after which HO-1 expression and the related signaling factor activation were measured by quantitative RT-PCR,EMSA,fluorescent microscopy,immunoblot,and *** HO-1 expression was upregulated in DCs stimulated with *** BFT activated transcription factors such as NF-κB,AP-1,and Nrf2,activation of NF-κB and AP-1 was not involved in the induction of HO-1 expression in BFT-exposed ***,upregulation of HO-1 expression was dependent on Nrf2 activation in ***,HO-1 expression via Nrf2 in DCs was regulated by mitogenactivated protein kinases such as ERK and ***,BFT enhanced the production of reactive oxygen species(ROS)and inhibition of ROS production resulted in a significant decrease of phospho-ERK,phospho-p38,Nrf2,and HO-1 CONCLUSION These results suggest that signaling pathways involving ROS-mediated ERK and p38 mitogen-activated protein kinases-Nrf2 activation in DCs are required for HO-1 induction during exposure to ETBF-produced BFT.

关键词： Bacteroides fragilis enterotoxin Dendritic cells Heme oxygenase-1 Mitogen-activated protein kinases Nrf2 Signaling

Comparative outcomes of the pathogen in cultured Jones tubes used in lacrimal bypass surgery according to follow up periods

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International Journal of Ophthalmology(English edition) 2023年第10期16卷 1623-1629页

作者： Bo hyun Park Hui Kyung kim Yeon Ji Jo jong Soo Lee Department of Ophthalmology Pusan National University School of Medicine&Medical Research Institute of Pusan National University HospitalPusan 49241Republic of Korea

AIM:To evaluate the pathogens in cultured Jones tubes used in lacrimal bypass surgery according to the postoperative periods and to obtain data for the prevention of infection of functional lacrimal stent ***:Totally 71 patients(81 eyes)who underwent the removal of Jones tubes were enrolled in *** the removed Jones tubes were cultured for bacterial and fungal identification and tested for bacterial antibiotic *** results were analyzed according to the duration of the inserted Jones tube after lacrimal bypass ***:Of the 81 eyes,bacteria were isolated from 69 eyes(85.2%)and fungi from 6 eyes(7.4%).Among 69 eyes,40.6% showed Staphylococcus aureus(***),11.6% were Pseudomonas aeruginosa(***).Gram-positive bacteria were isolated more than Gramnegative bacteria,but Gram-negative bacteria showed a higher incidence in the Jones tube implanted for over 10y(P=0.035).The antibiotic sensitivity test showed that 46.4% of *** were resistant to *** terms of antibiotics commonly used in ocular clinical practice,vancomycin was sensitive to *** and Streptococcus pneumoniae(***),amikacin responded to *** and Proteus mirabilis(***).Trimethoprim/sulfamethoxazole(TMP/SMX)was all sensitive to ***,*** and *** except ***:*** is the most commonly found organism in the Jones tube after lacrimal bypass surgery,and 46.4% of them are methicillin-resistant ***(MRSA),sensitive to ***,*** responded with amikacin is dominantly detected in the Jones tubes implanted for more than 10y.

关键词： Jones tube lacrimal bypass surgery Pseudomonas aeruginosa Proteus mirabilis Staphylococcus aureus

Anti-scarring effects of butaprost on human subconjunctival Tenon's fibroblasts

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1028-1033页

作者： jong Hoon Shin Je hyun Seo Jae Ho Jung Tae Woo kim Department of Ophthalmology Pusan National University Hospital Department of Ophthalmology Pusan National University Yangsan Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang Hospital

AIM： To investigate the toxicity of the E-prostanoid 2（EP2） receptor agonist, butaprost against human subconjunctival（Tenon＇s capsule） fibroblasts, and to determine the underlying mechanism. METHODS： We isolated Tenon＇s fibroblasts from the subconjunctival area of healthy subjects and evaluated the types of EP receptors expressed using quantitative realtime reverse transcription polymerase chain reaction（RTPCR）. The toxicity of butaprost against the fibroblasts was evaluated using methyl thiazolyl tetrazolium and lactic dehydrogenase assays. The inhibition of conjunctival fibroblast proliferation by butaprost was assessed by measuring α-actin levels. The underlying mechanism was assessed by measuring intracellular cyclic adenosine monophosphate（c AMP） levels. Intergroup differences were statistically analyzed using an independent t-test. Densitometry of the Western blot bands was performed using the Image J software. RESULTS： Quantitative real-time RT-PCR revealed that the fibroblast EP2 receptor levels were higher than those of the other EP receptors. Butaprost did not show toxicity against Tenon＇s tissue, but inhibited conjunctival fibroblast proliferation by reducing collagen synthesis. EP2 receptor activation enhanced the c AMP cascade, which might be an important mechanism underlying this ***： Butaprost effectively reduces the subconjunctival scarring response. Given the significanceof wound healing modulation in blebs, butaprost＇s inhibitory effect on subconjunctival Tenon＇s fibroblasts may be beneficial in managing postoperative scarring in glaucoma surgery.

关键词： butaprost Tenon's capsule trabeculectomy fibroblasts

Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy

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World Journal of Gastroenterology 2009年第34期15卷 4298-4304页

作者： hyun Gun kim Young Koog Cheon Young Deok Cho jong Ho Moon Do hyun Park Tae Hoon Lee hyun jong Choi Sang-Heum Park Joon Seong Lee Moon Sung Lee Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medicine

AIM： To compare small sphincterotomy combined with endoscopic papillary large balloon dilation （SES ＋ ELBD） and endoscopic sphincterotomy （EST） for large bile duct stones. METHODS： We compared prospectively SES ＋ ELBD （group A, n = 27） with conventional EST （group B, n = 28） for the treatment of large bile duct stones （≥ 15 mm）. When the stone could not be removed with a normal basket, mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS： No significant differences were observed in the mean largest stone size （A： 20.8 mm, B： 21.3 mm）, bile duct diameter （A： 21.4 turn, B： 20.5 ram）, number of stones （A： 2.2, B： 2.3）, or procedure time （A： 18 min, B： 19 rain） between the two groups. The rates of complete stone removal with one session was 85% in group A and 86% in group B （P = 0.473）. Mechanical lithotripsy was required for stone removal in nine of 27 patients （33%） in group A and nine of 28 patients （32%, P = 0.527） in group ***： SES ＋ ELBD did not show significant benefits compared to conventional EST, especially for the removal of large （≥ 15 mm） bile duct stones.

关键词： Sphincterotomy Endoscopic Balloon dilatation Cholelithiasis Lithotripsy