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Early expressions of hypoxia-inducible factor 1alpha and vascular endothelial growth factor increase the neuronal plasticity of activated endogenous neural stem cells after focal cerebral ischemia

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Neural Regeneration Research 2014年第9期9卷 912-918页

作者： Seung Song jong-tae park Joo Young Na Man-Seok park Jeong-Kil Lee Min-Cheol Lee Hyung-Seok Kim Department of Forensic Medicine Chonnam National University Medical School Department of Neurology Chonnam National University Medical School Department of Neurosurgery Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Endogenous neural stem cells become ＂activated＂ after neuronal injury, but the activation sequence and fate of endogenous neural stem cells in focal cerebral ischemia model are little known. We evaluated the relationships between neural stem cells and hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a photothromobotic rat stroke model using immunohistochemistry and western blot analysis. We also evaluated the chronological changes of neural stem cells by 5-bromo-2′-deoxyuridine（BrdU） incorporation. Hypoxia-inducible factor-1α expression was initially increased from 1 hour after ischemic injury, followed by vascular endothelial growth factor expression. Hypoxia-inducible factor-1α immunoreactivity was detected in the ipsilateral cortical neurons of the infarct core and peri-infarct area. Vascular endothelial growth factor immunoreactivity was detected in bilateral cortex, but ipsilateral cortex staining intensity and numbers were greater than the contralateral cortex. Vascular endothelial growth factor immunoreactive cells were easily found along the peri-infarct area 12 hours after focal cerebral ischemia. The expression of nestin increased throughout the microvasculature in the ischemic core and the peri-infarct area in all experimental rats after 24 hours of ischemic injury. Nestin immunoreactivity increased in the subventricular zone during 12 hours to 3 days, and prominently increased in the ipsilateral cortex between 3–7 days. Nestin-labeled cells showed dual differentiation with microvessels near the infarct core and reactive astrocytes in the peri-infarct area. BrdU-labeled cells were increased gradually from day 1 in the ipsilateral subventricular zone and cortex, and numerous BrdU-labeled cells were observed in the peri-infarct area and non-lesioned cortex at 3 days. BrdU-labeled cells rather than neurons, were mainly co-labeled with nestin and GFAP. Early expressions of hypoxia-inducible factor-1α and vascular endothelial gr

关键词： nerve regeneration brain ischemia neural stem cell neural precursor cell hypoxia-inducible factor 1α vascular endothelial growth factor microenvironment photothrombosis neural regeneration

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Energy-Efficieng MAC Protocols for Wireless Body Area Networks: A Survey

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China Communications 2011年第5期8卷 1-10页

作者： Sai Anand Gopalan jong-tae park School of Electronics Engineering Kyungpook National University

In this paper, we provide a comprehensive survey of key energy-efficient Medium Access Control (MAC) protocols for Wireless Body Area Networks (WBANs). At the outset, we outline the crucial attributes of a good MAC protocol for WBAN. Several sources that contribute to the energy inefficiency of WBAN are identified, and features of the various MAC protocols qualitatively compared. Then, we further investigate some representative TDMA-based energy-efficient MAC protocols for WBAN by emphasizing their strengths and weaknesses. Finally, we conclude with a number of open research issues with regard to WBAN MAC layer.

关键词： Medium Access Control (MAC) Wireless Body Area Networks (WBANs) energy-efficiency

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Thermal energy harvesting circuit with maximum power point tracking control for self-powered sensor node applications

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Frontiers of Information Technology & Electronic Engineering 2018年第2期19卷 285-296页

作者： Eun-Jung YOON jong-tae park Chong-Gun YU Department of Electronics Engineering Incheon National University

We present a simple implementation of a thermal energy harvesting circuit with the maximum power point tracking（MPPT） control for self-powered miniature-sized sensor nodes. Complex start-up circuitry and direct current to direct current（DC-DC） boost converters are not required, because the output voltage of targeted thermoelectric generator（TEG） devices is high enough to drive the load applications directly. The circuit operates in the active/asleep mode to overcome the power mismatch between TEG devices and load applications. The proposed circuit was implemented using a 0.35-μm complementary metal-oxide semiconductor（CMOS） process. Experimental results confirmed correct circuit operation and demonstrated the performance of the MPPT scheme. The circuit achieved a peak power efficiency of 95.5% and an MPPT accuracy of higher than 99%.

关键词： Thermoelectric energy Energy harvesting Maximum power point tracking (MPPT) control Self-powered system Sensor node

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Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats

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Neural Regeneration Research 2018年第2期13卷 340-346页

作者： Min Cheol Joo Chul Hwan Jang jong tae park Seung Won Choi Seungil Ro Min Seob Kim Moon Young Lee Department of Rehabilitation Medicine and Institute of Wonkwang Medical Science School of Medicine Wonkwang University Department of Neurosurgery School of Medicine Wonkwang University Department of Anesthesiology and Pain Medicine School of Medicine Wonkwang University Department of Physiology and Cell Biology School of Medicine University of Nevada Department of Physiology and Institute of Wonkwang Medical Science School of Medicine Wonkwang University

Although electrical stimulation is therapeutically applied for neural regeneration in patients, it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal cord injury （SCI）. To identify the signaling pathway involved in electrical stimulation improving the function of injured spinal cord, 21 female Sprague-Dawley rats were randomly assigned to three groups： control （no surgical intervention, n = 6）, SCI （SCI only, n = 5）, and electrical simulation （ES; SCI induction followed by ES treatment, n = 10）. A complete spinal cord transection was performed at the 10^th thoracic level. Electrical stimulation of the injured spinal cord region was applied for 4 hours per day for 7 days. On days 2 and 7 post SCI, the Touch-Test Sensory Evaluators and the Basso-Beattie-Bresnahan locomotor scale were used to evaluate rat sensory and motor function. Somatosensory-evoked potentials of the tibial nerve of a hind paw of the rat were measured to evaluate the electrophysiological function of injured spinal cord. Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Com- pared with the SCI group, in the ES group, the latencies of the somatosensory-evoked potential of the tibial nerve of rats were significantly shortened, the amplitudes were significantly increased, RhoA protein level was significantly decreased, protein gene product 9.5 expression, ERK1/2, p38, and Bcl-2 protein levels in the spinal cord were significantly increased. These data suggest that ES can promote the recovery of electrophysiological function of the injured spinal cord through regulating p38-RhoA and ERK1/2-Bcl-2 pathway-related protein levels in the injured spinal cord.

关键词： Bcl-2 ERKI/2 p38 PGP9.5 RhoA spinal cord injury somatosensory evoked potential muscle contraction electrical impulses neural regeneration

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo park jong-Seong Bae taehyun park Il tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

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用农作物秸秆高效生物合成人造淀粉和单细胞蛋白

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Science Bulletin 2023年第2期68卷 214-223,M0004页

作者：徐欣欣张伟游淳范超纪王莉 jong-tae park Jiyun Kwak 陈红歌张以恒马延和 Key Laboratory of Engineering Biology for Low-Carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin 300308China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Department of Food Science and Technology Chungnam National UniversityDaejeon 34134Republic of Korea College of Life Sciences Henan Agricultural UniversityZhengzhou 450002China

全球人口快速增长和气候变化正在引发可能的粮食危机.本研究开发了一种利用现有且丰富的农业废弃物(秸秆)高效合成人造淀粉和微生物蛋白的新技术.利用没有辅酶的体外多酶分子机器和酿酒酵母进行一锅法生物转化,将预处理玉米秸秆中的纤... 详细信息

全球人口快速增长和气候变化正在引发可能的粮食危机.本研究开发了一种利用现有且丰富的农业废弃物(秸秆)高效合成人造淀粉和微生物蛋白的新技术.利用没有辅酶的体外多酶分子机器和酿酒酵母进行一锅法生物转化,将预处理玉米秸秆中的纤维素进行酶水解合成人造淀粉,同时在有氧条件下发酵生产微生物蛋白.低成本去除β-葡萄糖糖苷酶的商业化纤维素酶以及在酿酒酵母细胞表面展示骨架蛋白用于固定淀粉磷酸化酶和纤维二糖磷酸化酶,构成一个多酶分子机器与酵母的复合体系,从而实现稀酸预处理秸秆的高效纤维素水解;利用纤维素水解中间产物的底物穿梭效应(从纤维素到微生物),快速消除葡萄糖对纤维素酶的产物抑制,比富含商业β-葡萄糖苷酶的纤维素酶混合物表现出更好的纤维素水解速率.动物实验结果显示,人造直链淀粉摄入引起缓慢平缓的血糖水平变化,表明直链淀粉作为预防肥胖和糖尿病的健康食品的应用前景.利用农业废弃物资源高效生物合成人造淀粉和微生物蛋白是解决粮食危机,实现农业可持续发展的重要途径之一.

关键词：直链淀粉微生物蛋白产物抑制纤维素水解淀粉磷酸化酶粮食危机动物实验结果单细胞蛋白

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG park MINSUK KWON MINAE AN JUNG YONG HONG JOON OH park SUNG HEE LIM SEUNG tae KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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无取向电工钢晶粒长大过程中织构的发展

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现代冶金（内蒙古） 2006年第4期 39-45页

作者： jong-tae park[韩国] 张怀军(译) 谌智勇(校)

无取向电工钢应同时具有低铁损和高磁导率。这些磁性大多受晶粒尺寸和织构影响，关于晶粒长大过程中晶粒尺寸优化问题已经被广泛研究。相反很少有人关注晶粒长大过程中织构变化。本文根据试验结果提出无取向电工钢晶粒长大过程中织构发... 详细信息

无取向电工钢应同时具有低铁损和高磁导率。这些磁性大多受晶粒尺寸和织构影响，关于晶粒长大过程中晶粒尺寸优化问题已经被广泛研究。相反很少有人关注晶粒长大过程中织构变化。本文根据试验结果提出无取向电工钢晶粒长大过程中织构发展的机理，对于2％Si的试样，在晶粒长大过程中，作为主要织构组分的高斯组分和{111}〈112）组分减弱；对于1％Si的试样，在晶粒长大过程中，作为主要织构组分的{111}（112）组分和{111}（110）组分增强，并且提出如果具有特别取向的晶粒不仅尺寸超过其它取向，而且发生高角度，高晶界能频率高，这样的织构组分在晶粒长大过程中能连续被增强。

关键词：无取向电工钢晶粒长大织构取向偏差角晶粒尺寸

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Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-Hee park Su-hwan Yun tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

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加热速率对无取向电工钢退火织构发展的影响

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现代冶金（内蒙古） 2007年第4期 52-55页

作者： jong - tae park[加拿大] 张怀军(译) 李德奎(校)

本文研究了具有不同初始晶粒尺寸的无取向电工钢，在最终退火工艺过程中，加热速率对织构发展的影响，同时讨论了织构变化的原因。无论在晶粒粗大试样中，还是在晶粗细小的试样中，平均晶粒尺寸均随加热速率的增加而减小。在晶粒粗大试... 详细信息

本文研究了具有不同初始晶粒尺寸的无取向电工钢，在最终退火工艺过程中，加热速率对织构发展的影响，同时讨论了织构变化的原因。无论在晶粒粗大试样中，还是在晶粗细小的试样中，平均晶粒尺寸均随加热速率的增加而减小。在晶粒粗大试样中，当加热速率增加时，高斯织构显著增强，但是{111}〈112〉织构组分轻微减弱。另一方面，在晶粒细小试样中，当加热速率增加时，{111}〈112〉织构强度大幅度降低，但是高斯强度却有少许增加。当加热速率达到退火温度时，影响形成不同织构的主要原因是冷轧前的不同初始晶粒尺寸，这些差别主要与在冷轧过程中具有不同晶粒尺寸形成的大量剪切带有关。

关键词：无取向电工钢退火织构加热速率平均晶粒尺寸晶粒粗大冷轧过程小试样工艺过程

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