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Neural Regenerat.on Research 2024年第7期19卷 1417-1418页

作者： jonathan Wit.on Erica S.Brady Michael t.Craig Depart.ent.of Clinical and Biomedical Sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladst.ne Inst.t.t. for Neurological Disease San FranciscoCAUSA School of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dement.a is a devast.t.ng syndrome charact.rized by memory problems,confusion,and behavior changes t.at.prevent.people from performing everyday *** is t.e leading cause of dependency and disabilit. amongst.older people,result.ng in a global economic cost.of ~$1.3 *** 58 million people are current.y afflict.d by dement.a worldwide,wit. Alzheimer s disease(AD) causing most.60-70%) of t.ese cases.

关键词： Alzheimer everyday performing

Gust.response of an elast.-flexible morphing wing using fluid–st.uct.re int.ract.on simulat.ons

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Chinese Journal of Aeronaut.cs 2024年第2期37卷 45-57页

作者： jonathan PFLÜGER Christ.an BREIt.AMt.R Depart.ent.of Mechanical Engineering Technical University of MunichGarching 85748Germany

Small and micro unmanned aircraft.are t.e focus of scient.fic int.rest.due t. t.eir wide range of *** oft.n operat. in a highly unst.ble flight.environment.where t.e applicat.on of new morphing wing t.chnologies offers t.e opport.nit. t. improve flight.*** invest.gat.d concept.comprises port.and st.rboard adjust.ble wings,and an adapt.ve elast.flexible membrane serves as t.e lift.ng *** focus is on t.e benefit. of t.e deforming membrane during t.e impact.of a one-minus-cosine t.pe *** a low Reynolds number of Re=264000,t.e morphing wing model is invest.gat.d numerically by unst.ady fluid-st.uct.re int.ract.on ***,t.e numerical result. are validat.d by experiment.l dat. from force and moment.flow field,and deformat.on ***,wit. t.e rigid wing as t.e baseline,t.e flexible case is invest.gat.d,focusing on t.e advant.ges of t.e elast.c *** all configurat.ons st.died,t.e maximum amplit.de of t.e lift.coefficient.under gust.load shows good agreement.bet.een t.e experiment.l and numerical *** t.e decay of t.e gust.t.ey differ more t.e higher t.e aspect.rat.o of t.e *** considering t.e flow field,t.e main differences are due t. t.e separat.on behavior on t.e upper side of t.e *** flow reat.aches earlier in t.e experiment. t.an in t.e simulat.ons,which explains t.e higher lift.values observed in t.e *** at.one int.rmediat. configurat.on does t.e lift.amplit.de of t.e rigid configurat.on exceeds t.at.of t.e flexible by about.12%,wit. t.e elast.c membrane result.ng in a smaller and more uniform peak load,which is also evident.in t.e wing loading and hence in t.e root.bending moment.

关键词： Membrane wing Morphing wing Flexible wing surface Comput.t.onal fluid dynam-ics Fluid-st.uct.re int.ract.on Unst.ady inflow condit.on Gust.response

Individual consist.ncy in spat.ot.mporal charact.rist.cs of migrat.ry Whimbrels in t.e East.Asian-Aust.alasian Flyway

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Avian Research 2024年第3期15卷 308-315页

作者： Siwei An Fenliang kuang Wei Wu Chris J.Hassell jonathan t.Coleman Zijing Gao Xuena Sun Yue Yuan Grace Maglio kar-Sin k.Leung Xuesong Feng Zhijun Ma Minist.y of Educat.on key Laborat.ry for Biodiversit. Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River EstuaryInstitute of Biodiversity ScienceSchool of Life SciencesFudan UniversityShanghai200433China School of Chemist.y and Environment Yunnan Minzu UniversityKunming650504China Shanghai Chongming Dongt.n Nat.re Reserve Administ.at.on Cent.r ChongmingShanghai202183China Global Flyway Net.ork PO Box 3089BroomeWA 6725Australia Aust.alasian Wader St.dies Group BroomeWA6725Australia Queensland Wader St.dy Group Shailer ParkQLD4128Australia Hong kong Wat.rbirds Ringing Group Hong Kong999077China

Many migrat.ry birds exhibit.int.rannual consist.ncy in migrat.on schedules,rout.s and st.pover *** t.e int.rannual consist.ncy in spat.ot.mporal charact.rist.cs helps underst.nd t.e maint.nance of migrat.on and enables t.e implement.t.on of t.rget.d conservat.on *** t.acked t.e migrat.on of Whimbrel(Numenius phaeopus)in t.e East.Asian-Aust.alasian Flyway and collect.d spat.ot.mporal dat. from individuals t.at.were t.acked for at.least.t.o *** non-paramet.ic t.st. were used t. compare t.e int.rannual variat.ons in t.e dat.s of depart.re from and arrival at.breeding/nonbreeding sit.s,and t.e int.r-annual variat.on in t.e longit.des when t.e same individual across t.e same *** exhibit.d a high degree of consist.ncy in t.e use of breeding,nonbreeding,and st.pover sit.s bet.een *** variat.on of arrival dat.s at.nonbreeding sit.s was significant.y larger t.an t.at.of t.e depart.re dat.s from nonbreeding and breeding *** used st.pover sit.s by t.e same individuals in mult.ple years were concent.at.d in t.e Yellow Sea coast.during nort.ward migrat.on,but.were more widespread during sout.ward *** st.pover durat.on at.repeat.dly used sit.s was significant.y longer t.an t.at.at.sit.s used only *** flying across t.e Yellow Sea,Whimbrels breeding in Sakha(Yakut.a)exhibit.d t.e highest.consist.ncy in migrat.on rout.s in bot. aut.mn and ***,t.e consist.ncy in migrat.on rout.s of Yakut.a breeding birds was generally higher t.an t.at.of birds breeding in *** result. suggest.t.at.t.e nort.ward migrat.on schedule of t.e Whimbrels is mainly cont.olled by endogenous fact.rs,while t.e sout.ward migrat.on schedule is less affect.d by endogenous *** repeat.d use of st.pover sit.s in t.e Yellow Sea coast.suggest. t.is region is import.nt.for t.e migrat.on of Whimbrel,and t.us has high conservat.on value.

关键词： Consist.ncy Migrat.on rout. Migrat.on t.ming Shorebird

A modular microfluidic plat.orm t. st.dy how fluid shear st.ess alt.rs est.ogen recept.r phenot.pe in ER+breast.cancer cells

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Microsyst.ms & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ort.ga Quesada jonathan Cuccia Rachael Coat.s Blake Nassar Et.an Lit.lefield Elizabet. C.Mart.n Adam t.Melvin Cain Depart.ent.of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricult.ral Engineering Louisiana State UniversityBaton RougeLA 70803USA Depart.ent.Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Met.st.t.c breast.cancer leads t. poor prognoses and worse out.omes in pat.ent. due t. it. invasive behavior and poor response t. *** is st.ll unclear what.biophysical and biochemical fact.rs drive t.is more aggressive phenot.pe in met.st.t.c cancer;however recent.st.dies have suggest.d t.at.exposure t. fluid shear st.ess in t.e vasculat.re could cause *** t.is st.dy a modular microfluidic plat.orm capable of mimicking t.e magnit.de of fluid shear st.ess(FSS)found in human vasculat.re was designed and *** device provides a plat.orm t. evaluat. t.e effect. of FSS on MCF-7 cell line,an est.ogen recept.r posit.ve(ER+)breast.cancer cell line,during circulat.on in t.e *** of t.e effect. of FSS on MCF-7 cells was carried out.ut.lizing t.o approaches:single cell analysis and bulk *** single cell analysis,cells were t.apped in a microarray aft.r exit.ng t.e serpent.ne channel and followed by immunost.ining on t.e device(on-chip).Bulk analysis was performed aft.r cells were collect.d in a microt.be at.t.e out.et.of t.e microfluidic serpent.ne channel for west.rn blot.ing(off-chip).It.was found t.at.cells exposed t. an FSS magnit.de of 10 dyn/cm^(2) wit. a residence t.me of 60 s enhanced expression of t.e proliferat.on marker ki67 in t.e MCF-7 cell line at.a single cell *** underst.nd possible mechanisms for enhanced ki67 expression,on-chip and off-chip analyses were performed for pro-growt. and survival pat.ways ERk,Akt.and JAk/*** demonst.at.d t.at.aft.r shearing t.e cells phosphorylat.on of p-Akt.p-mt.R,and p-St.t. were ***,t.ere was no change in p-ERk1/*** is a mediat.r of ER rapid signaling,analysis of phosphorylat.d ERαwas carried out.and no significant.differences bet.een sheared and non-sheared populat.ons were *** t.get.er t.ese result. demonst.at. t.at.FSS can increase phosphorylat.on of prot.ins associat.d wit. a more aggressive phenot.pe in circulat.ng cancer *** findin

关键词： fluid breast est.ogen

NLRP3 inflammasome plays a vit.l role in t.e pat.ogenesis of age-relat.d diseases in t.e eye and brain

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Neural Regenerat.on Research 2024年第7期19卷 1425-1426页

作者： Jack jonathan Maran Odunayo Omolola Mugisho Buchanan Ocular t.erapeut.cs Unit Department of OphthalmologyNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

key point.:Wit. aging,t.ere is increased nucleot.de-binding oligomerizat.on domain-(NOD-)like recept.r(NLR) prot.in-3(NLRP3) act.vat.on in neural and ocular *** of t.e NLRP3 inflammasome appears t. be a common denominat.r in t.e pat.ogenesis of age-relat.d diseases of t.e eye and *** inhibit.on of t.e NLRP3 inflammasome may be a pot.nt.t.erapy for prevent.ng t.e development.and progression of age-relat.d eye and brain diseases.

关键词： NLRP3 pat.ogenesis inflam

t.eat.ent.of Helicobact.r pylori wit. pot.ssium compet.t.ve acid blockers:A syst.mat.c review and met.-analysis

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World Journal of Gast.oent.rology 2024年第9期30卷 1213-1223页

作者： Joseph Edwin kanu jonathan Soldera Post.Graduat. Program at.Acut. Medicine and Gast.oent.rology University of South WalesCardiff CF371DLUnited Kingdom

BACkGROUND Helicobact.r pylori(***)infect. over half t.e global populat.on,causing gast.oint.st.nal diseases like dyspepsia,gast.it.s,duodenit.s,pept.c ulcers,GMALt.lymphoma,and gast.ic *** *** is crucial for t.eat.ng and prevent.ng t.ese *** convent.onal prot.n pump inhibit.r(PPI)-based t.iple t.erapy is effect.ve,t.ere’s growing int.rest.in longer acid suppression *** compet.t.ve acid blocker(P-CAB)t.iple and dual t.erapy are new regimens for *** *** used in Asian populat.ons,vonoprazan(VPZ)has been recent.y Food and Drug Administ.at.on-approved for *** *** t. assess t.e efficacy of regimens cont.ining P-CABs in eradicat.ng *** *** t.is st.dy,following PRISMA 2020 guidelines,conduct.d a syst.mat.c review and met.-analysis by searching MEDLINE and Scopus libraries for randomized clinical t.ials(RCt.)or observat.onal st.dies wit. t.e following command:[("Helicobact.r pylori"OR"H pylori")AND("t.eat.ent.OR"t.erapy"OR"Eradicat.on")AND("Vonaprazan"OR"Pot.ssium-Compet.t.ve Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"t.goprazan")].St.dies comparing t.e efficacy of P-CABs-based t.eat.ent.t. classical PPIs in eradicat.ng *** were *** crit.ria included case report.,case series,unpublished t.ials,or conference *** variables encompassed age,diagnosis met.od,sample sizes,st.dy durat.on,int.rvent.on and cont.ol,and *** eradicat.on met.od were gat.ered by t.o independent.***-analysis was performed in R soft.are,and forest.plot. were *** A t.t.l of 256 references were init.ally ret.ieved t.rough t.e search ***,fift.en st.dies(7 RCt.,7 ret.ospect.ve observat.onal st.dies,and 1 comparat.ve unique st.dy)were included,comparing P-CAB t.iple t.erapy t. PPI t.iple *** int.nt.on-t.-t.eat.analysis involved 8049 pat.ent.,wit. 4471 in t.e P-CAB int.rvent.on g

关键词： Helicobact.r pylori infect.on Pot.ssium compet.t.ve acid blockers Prot.n pump inhibit.rs Vonoprazan Amoxicillin

Formadinium Cat.on Doping St.bilized Ult.a-deep-blue Lead Halide perovskit. Nanocryst.l Light.emit.ing Diodes

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Chemical Research in Chinese Universit.es 2024年第3期40卷 556-560页

作者： Pui kei kO jonathan E.HALpeRt Depart.ent.of Chemist.y The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

t.e halide migrat.on effect.in mixed-halide lead-based perovskit. is a serious problem hindering t.e development.of it. display *** t.is st.dy,we have successfully addressed t.is issue by report.ng formadinium(FA)doped mixed-halide perovskit. nanocryst.ls(NCs)wit. ult.a-deep-blue emission of 450 nm,narrow bandwidt. of 16 nm,and a high phot.luminescence quant.m yield(PLQY)of 66%.t.e perovskit. nanocryst.l light.emit.ing diodes(NC-LEDs)using t.is nanocryst.l as an act.ve layer achieved a maximum ext.rnal quant.m efficiency(EQE)of 0.32%,30-fold improved compared t. t.at.of prist.ne and st.ble elect.oluminescence(EL)spect.a at.450 nm under a 4.9–8.0 V *** findings demonst.at. t.e pot.nt.al of our approach in developing st.ble and efficient.deep blue perovskit. NC-LEDs.

关键词： Halide perovskit. Light.emit.ing diode Deep-blue

On t.e calibrat.on of a shear st.ess crit.rion for rock joint. t. represent.t.e full st.ess-st.ain profile

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第2期16卷 379-392页

作者： Akram Deiminiat.jonathan D.Aubert.n Yannic Et.ier Depart.ent.of Const.uct.on Engineering École de Technologie Supérieure(ÉTS)MontréalCanada

Convent.onal numerical solut.ons developed t. describe t.e geomechanical behavior of rock int.rfaces subject.d t. different.al load emphasize peak and residual shear *** det.iled analysis of preand post.peak shear st.ess-displacement.behavior is cent.al t. various t.me-dependent.and dynamic rock mechanic problems such as rockburst. and st.uct.ral inst.bilit.es in highly st.essed *** complet. st.ess-displacement.surface(CSDS)model was developed t. describe analyt.cally t.e pre-and post.peak behavior of rock int.rfaces under different.al *** formulat.ons of t.e CSDS model required ext.nsive curve-fit.ing it.rat.ons which limit.d it. pract.cal applicabilit. and t.ansparent.int.grat.on int. engineering *** present.work proposes modificat.ons t. t.e CSDS model aimed at.developing a comprehensive and modern calibrat.on prot.col t. describe t.e complet. shear st.essdisplacement.behavior of rock int.rfaces under different.al *** proposed updat. t. t.e CSDS model incorporat.s t.e concept.of mobilized shear st.engt. t. enhance t.e post.peak ***’s concept. of joint.roughness coefficient.JRC)and joint.compressive st.engt.(JCS)are incorporat.d t. facilit.t. empirical est.mat.ons for peak shear st.ess and normal closure ***/uniaxial compression t.st.and direct.shear t.st.result. are used t. validat. t.e updat.d model and exemplify t.e proposed calibrat.on *** result. illust.at. t.at.t.e revised model successfully predict. t.e post.peak and complet. axial st.essest.ain and shear st.essedisplacement.curves for rock joint..

关键词： Full shear profile Post.peak shear behavior Rock joint Joint.roughness coefficient.JRC) Axial st.ess-st.ain curve

Insight. int. skullcap herb-induced liver injury

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World Journal of Hepat.logy 2024年第2期16卷 120-122页

作者： jonathan Soldera Post.Graduat. Program at.Acut. Medicine and Gast.oent.rology University of South WalesCardiff CF371DLUnited Kingdom

t.is edit.rial addresses t.e growing concern of herb-induced liver injury(HILI),focusing on a unique case of Skullcap-induced HILI *** edit.rial underscore t.e significant.mort.lit. rat. linked t. Skullcap-induced HILI,emphasizing t.e import.nce of vigilant.monit.ring and *** herbal supplement.usage rises,collaborat.on among clinicians and researchers is crucial t. comprehend and address t.e complexit.es of HILI,part.cularly t.ose involving Skullcap.

关键词： Herb-induced liver injury Drug induced liver injury Diet.ry supplement. Herbal hepat.t.xicit. Liver t.ansplant.t.on

Use of machine learning models for t.e prognost.cat.on of liver t.ansplant.t.on: A syst.mat.c review

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World Journal of t.ansplant.t.on 2024年第1期14卷 164-188页

作者： Gidion Chongo jonathan Soldera Depart.ent.of Gast.oent.rology University of South WalesCardiff CF371DLUnited Kingdom

BACkGROUND Liver t.ansplant.t.on(Lt.is a life-saving int.rvent.on for pat.ent. wit. end-st.ge liver ***,t.e equit.ble allocat.on of scarce donor organs remains a formidable *** t.ols are pivot.l in ident.fying t.e most.suit.ble t.ansplant.***,scoring syst.ms like t.e model for end-st.ge liver disease have been inst.ument.l in t.is ***,t.e landscape of prognost.cat.on is undergoing a t.ansformat.on wit. t.e int.grat.on of machine learning(ML)and art.ficial int.lligence *** t. assess t.e ut.lit. of ML models in prognost.cat.on for Lt.comparing t.eir performance and reliabilit. t. est.blished t.adit.onal scoring *** Following t.e Preferred Report.ng It.ms for Syst.mat.c Reviews and Met.-Analysis guidelines,we conduct.d a t.orough and st.ndardized lit.rat.re search using t.e PubMed/MEDLINE *** search imposed no rest.ict.ons on publicat.on year,age,or *** crit.ria encompassed non-English st.dies,review art.cles,case report.,conference papers,st.dies wit. missing dat.,or t.ose exhibit.ng evident.met.odological *** Our search yielded a t.t.l of 64 art.cles,wit. 23 meet.ng t.e inclusion *** t.e select.d st.dies,60.8%originat.d from t.e Unit.d St.t.s and China *** one pediat.ic st.dy met.t.e ***,91%of t.e st.dies were published wit.in t.e past.five *** models consist.nt.y demonst.at.d sat.sfact.ry t. excellent.area under t.e receiver operat.ng charact.rist.c curve values(ranging from 0.6 t. 1)across all st.dies,surpassing t.e performance of t.adit.onal scoring *** forest.exhibit.d superior predict.ve capabilit.es for 90-d mort.lit. following Lt.sepsis,and acut. kidney injury(AkI).In cont.ast.gradient.boost.ng excelled in predict.ng t.e risk of graft.versus-host.disease,pneumonia,and *** t.is st.dy underscores t.e pot.nt.al of ML models in guiding decisions relat.d t. allograft.allocat.on and Lt.mark

关键词： Liver t.ansplant.t.on Machine learning models Prognost.cat.on Allograft.allocat.on Art.ficial int.lligence