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A Record of the Invasive Golden Apple Snail pomacea canaliculata (Lamarck 1819) at Black Dragon Spring,Dianchi Basin

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Zoological Research 2007年第3期28卷 325-328页

作者：杜丽娜 jonathan Davies 陈小勇崔桂华杨君兴中国科学院昆明动物研究所系统动物学研究室

The golden apple snail pomacea canaliculata （Lamarck 1819） was first recorded at Black Dragon Spring, Dianchi Basin, Baiyi Township, Songming County, Kunming City, Yunnan province, China, in October 2004. The water from the spring flows into the Songhuaba Reservoir, the major drinking water resource for Kunming City, and part of the Dianchi Lake basin. This is the first record of this invasive snail in the Dianchi Lake Basin. pomacea canaliculata originates from Central and South America, and in Asia the snail has spread through deliberate and accidental introductions to the philippines, Vietnam, Thailand, Laos, Cambodia, Malaysia, Indonesia, papua New Guinea, Korea, Japan and South China. It has become a major pest in rice-growing areas, resulting in huge damage to crops. Strict prevention and control measures have to be implemented to prevent the spread of the snail in Yunnan, together with public awareness campaigns to inform the public of the dangers of this invasive snail.

关键词： Golden apple snail pomacea canaliculata Dianchi basin Kunming Yunnan China

高时空分辨率研究海盐液滴快速风化过程(英文)

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物理化学学报 2011年第11期27卷 2521-2527页

作者：仝海杰钱正纲 REID jonathan p. 张韫宏北京理工大学物理化学研究所簇科学重点实验室北京100081 School of Chemistry University of Bristol Bristol BS8 1TS UK

以高速摄像仪与显微拉曼光谱联用研究聚四氟(疏水)乙烯基底和石英(亲水)基底上的单个海水液滴的快速风化过程.海水液滴风化的形貌图像达到毫秒时间分辨率和微米空间分辨率.通入干氮气后海水液滴在石英基底上发生快速风化过程,首先析出na... 详细信息

以高速摄像仪与显微拉曼光谱联用研究聚四氟(疏水)乙烯基底和石英(亲水)基底上的单个海水液滴的快速风化过程.海水液滴风化的形貌图像达到毫秒时间分辨率和微米空间分辨率.通入干氮气后海水液滴在石英基底上发生快速风化过程,首先析出na_2Ca_5(SO_4)_6·3H_2O和na_(2x)Ca_(6x)(SO_4)_6·3H_2O(0naCl晶体,最后析出KMgCl_3·6H_2O晶体.我们发现在快速降低湿度的过程中析出钙钠复盐,在缓慢降低湿度的过程中析出CaSO_4·2H_2O,并已经确定各种结晶产物的位置以及na_2Ca_5(SO_4)_6·3H_2O和CaSO_4·2H_2O两种晶体的生长速率,并在聚四氟乙烯基底上观察到中空结构的海盐颗粒.

关键词：海盐高速摄像拉曼光谱风化相对湿度

The consequences of genomic architecture on ecological speciation in postglacial fishes

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Current Zoology 2013年第1期59卷 53-71页

作者： Sean M. ROGERS jonathan A. MEE Ella BOWLES Department of Biological Sciences University of Calgary 2500 University Drive NW Calgary Alberta T2N 1N4 Canada

The quest for the origin of species has entered the genomics era. Despite decades of evidence confirming the role of the environment in ecological speciation, an understanding of the genomics of ecological speciation is still in its infancy. In this review, we explore the role of genomic architecture in ecological speciation in postglacial fishes. Growing evidence for the num- ber, location, effect size, and interactions among the genes underlying population persistence, adaptive trait divergence, and re- productive isolation in these fishes reinforces the importance of considering genomic architecture in studies of ecological speci- ation. Additionally, these populations likely adapt to new freshwater environments by selection on standing genetic variation, as de novo mutations are unlikely under such recent divergence times. We hypothesize that modular genomic architectures in post- glacial fish taxa may be associated with the probability of population persistence. Empirical studies have confirmed the genic na- ture of ecological speciation, implicating surprisingly extensive linkage disequilibrium across the genome. An understanding of these genomic mosaics and how they contribute to reproductive barriers remains unclear, but migration rates and the strength of selection at these loci is predicted to influence the likelihood of population divergence. Altogether, understanding the role of ge- nomic architecture is an important component of speciation research and postglacial fishes continue to provide excellent organ- isms to test these questions, both from the perspective of variation in architectures among taxa, and with respect to the distinct environments they have colonized. However, more empirical tests of ecological speciation predictions are needed [Current Zoo- logy 59 （1）： 53-71, 2013].

关键词： Adaptation Ecological speciation Genomic architecture Modularity postglacial fishes QTL

耦合堆垛与孔径分布的高碱金属煤焦分子建模方法

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西安交通大学学报 2017年第9期51卷 1-10页

作者：王长安 Justin K.WATSON Enette LOUW 车得福 jonathan p.MATHEWS 西安交通大学能源与动力工程学院西安710049 美国宾州州立大学利昂能源与矿物工程系美国宾州16802 美国宾州州立大学应用研究实验室美国宾州16802

针对表征高碱金属煤焦复杂物理化学结构特征的煤焦大分子三维(3D)模型的建模问题,以高分辨率投射电子显微镜(HRTEM)图像数据作为高碱金属煤焦分子模型的基本微观结构信息来源,提出了一种快速耦合堆垛和孔径分布的高碱金属煤焦大分子建... 详细信息

针对表征高碱金属煤焦复杂物理化学结构特征的煤焦大分子三维(3D)模型的建模问题,以高分辨率投射电子显微镜(HRTEM)图像数据作为高碱金属煤焦分子模型的基本微观结构信息来源,提出了一种快速耦合堆垛和孔径分布的高碱金属煤焦大分子建模方法。基于perl语言开发了相应的建模自编程序Fringe3D和Vol3D,实现了构建具有特定孔径分布和多种赋存形态na分布的煤焦大分子模型。提出的煤焦大分子3D建模方法具有建模快速、可控性强和方便耦合复杂结构特征等特点,在高碱金属煤焦分子建模过程中考虑了不同赋存形态na的分布。通过构建的具有特定碱金属分布的煤焦分子3D模型和分子反应动力学模拟,能够深入揭示煤焦热反应过程中na迁移规律与微观反应机理。

关键词：煤焦分子建模孔径分布碱金属钠堆垛分布

Insight into the effects of electrochemical factors on host-guest interaction induced signature events in a biological nanopore

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纳米技术与精密工程（英文） 2020年第1期3卷 2-8页

作者： XiaojunWei Zehui Zhang XiaoqinWang Brian Lenhart Roberto Gambarini jonathan Gray Chang Liu Biomedical Engineering program University of South CarolinaColumbiaSC 29208USA Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

The signature events caused by host-guest interactions in the nanopore system can be used as a novel and characteristic signal in quantitative detection and analysis of various ***,the effect of several electrochemical factors on the host-guest interactions in nanopore still remains ***,we systematically studied host-guest interactions,especially oscillation of Dna-azide adamantane@cucurbit[6]inα-Hemolysin nanopore under varying pH,concentration of electrolytes and counterions(Li+,na+,K+).Our results indicate correlations between the change of pH and the duration of the oscillation *** addition,the asymmetric electrolyte concentration and the charge of the counterions affects the frequency of signature events in oscillation signals,and even the integrity of the protein *** study provides insight into the design of a future biosensing platform based on signature oscillation signals of the host-guest interaction within a nanopore.

关键词： nanopore Host-guest interaction Biosensors Electrochemistry

The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito, Aedes aegypti

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Insect Science 2013年第5期20卷 601-619页

作者： Dawn L. Geiser Guoli Zhou jonathan J. Mayo Joy J. Winzerling Department of Nutritional Sciences College of Agriculture and Life Sciences the University of Arizona Tucson Arizona 85721 USA

Secreted ferritin is the major iron storage and transport protein in insects. Here, we characterize the message and protein expression profiles of yellow fever mosquito （Aedes aegypti） ferritin heavy chain homologue （HCH） and light chain homologue （LCH） subunits in response to iron and bacterial challenge. In vivo experiments demonstrated tissue-specific regulation of HCH and LCH expression over time post-blood meal （pBM）. Transcriptional regulation of HCH and LCH was treatment specific, with differences in regulation for na？ve versus mosquitoes challenged with heat-killed bacteria （HKB）. Translational regulation by iron regulatory protein （IRp） binding activity for the iron-responsive element （IRE） was tissue-specific and time-dependent pBM. However, mosquitoes challenged with HKB showed little change in IRp/IRE binding activity compared to na？ve animals. The changes in ferritin regulation and expression in vivo were confirmed with in vitro studies. We challenged mosquitoes with HKB followed by a blood meal to determine the effects on ferritin expression, and demonstrate a synergistic, time-dependent regulation of expression for HCH and LCH.

关键词： Aedes aegypti bacteria ferritin iron IRp mosquito

Liver decompensation after rapid weight loss from semaglutide in a patient with non-alcoholic steatohepatitis -associated cirrhosis

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World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew peverelle jonathan Ng James peverelle Ryan D.Hirsch Adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLp-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (naSH). remains a paucity of safety data in the vulnerable naSHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with naSHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver Disease-na (MELD-na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELD-na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists Weight loss

Arrhythmogenic mechanisms in ryanodine receptor channelopathies

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Science China(Life Sciences) 2015年第1期58卷 54-58页

作者： ZHAO Yan-Ting VALDIVIA Carmen R. GURROLA Georgina B. HERNNDEZ jonathan J. VALDIVIA Héctor H. Center for Arrhythmia Research Department of Internal MedicineCardiovascular DivisionUniversity of Michigan

Ryanodine receptors(Ry Rs) are the calcium release channels of sarcoplasmic reticulum(SR) that provide the majority of calcium ions(Ca2+) necessary to induce contraction of cardiac and skeletal muscle *** their intracellular environment,Ry R channels are regulated by a variety of cytosolic and luminal factors so that their output signal(Ca2+) induces finely-graded cell contraction without igniting cellular processes that may lead to aberrant electrical activity(ventricular arrhythmias) or cellular *** importance of Ry R dysfunction has been recently highlighted with the demonstration that point mutations in RYR2,the gene encoding for the cardiac isoform of the Ry R(Ry R2),are associated with catecholaminergic polymorphic ventricular tachycardia(CpVT),an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular tachycardia in individuals with an apparently normal *** we summarize the state of the field in regards to the main arrhythmogenic mechanisms triggered by Ry R2 channels harboring mutations linked to *** CpVT mutations characterized to date endow Ry R2 channels with a gain of function,resulting in hyperactive channels that release Ca2+ spontaneously,especially during *** spontaneous Ca2+ release is extruded by the electrogenic na+/Ca2+ exchanger,which depolarizes the external membrane(delayed afterdepolarization or DAD) and may trigger untimely action ***,a rare set of CpVT mutations yield Ry R2 channels that are intrinsically hypo-active and hypo-responsive to stimuli,and it is unclear whether these channels release Ca2+ spontaneously during *** discuss novel cellular mechanisms that appear more suitable to explain ventricular arrhythmias due to Ry R2 loss-of-function mutations.

关键词： ryanodine receptors CpVT sarcoplasmic reticulum cardiac arrhythmias

A retrospective analysis of pain and opioid usage in head and neck free flap reconstruction

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 153-159页

作者： parhom Towfighi Alison Hill Jason R.Crossley Amanda Walsh James A.Leonard jonathan p.Giurintano Matthew L.pierce Michael J.Reilly Georgetown University School of Medicine WashingtonDistrict of ColumbiaUSA Department of Otolaryngology-Head and Neck Surgery Medstar GeorgetownWashingtonDistrict of ColumbiaUSA

Objectives:Investigate opioid usage and postoperative pain in patients undergoing head and neck free flap ***:A retrospective review of 100 consecutive patients undergoing head and neck free flap reconstruction at two academic centers was *** captured included demographics,postoperative inpatient pain,pain at postoperative visits,morphine equivalent doses(MEDs)administration,medication history,and *** were analyzed using regression models,χ2 tests,and student’’***:Seventy-three percent of patients were discharged with opioid medication,with over half(53.4%)continuing to take opioids at their second postoperative visit,and over one-third(34.2%)continuing to take them around 4-month *** out of every five(20.3%)opioid-na?ve patients chronically took opioids *** was a poor association between inpatient postoperative pain scores and daily MEDs administered(R2=0.13,0.17,and 0.22 in postoperative Days 3,5,and 7,respectively).Neither preoperative radiotherapy nor postoperative complications were associated with an increase in opioid ***:For patients undergoing head and neck free flap operations,opioid medications are commonly used for postoperative *** practice may increase the chance an opioid-na?ve patient uses opioids *** found a poor association between MEDs administered and patient-reported pain scores,which suggests that standardized protocols aimed at optimizing analgesia while reducing opioid administration may be *** of Evidence:3(Retrospective cohort study).

关键词： free flap reconstruction head and neck multimodal analgesia opioids postoperative pain