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Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study

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World Journal of Gastroenterology 2017年第26期23卷 4788-4795页

作者： Trilokesh D Kidambi Gabriela Schmajuk Andrew J Gross James W Ostroff jonathan p Terdiman Jeffrey K Lee Division of Gastroenterology University of California Division of Rheumatology University of California Division of Rheumatology San Francisco Veterans Affairs Medical Center

To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODSA cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a ten year period was performed. Chart review was performed to confirm the diagnosis of dermatomyositis. Findings on endoscopy were collected and statistical analyses stratified by age and presence of symptoms were performed. RESULTSAmong 373 adult patients identified through a code based search strategy, only 163 patients had dermatomyositis confirmed by chart review. Of the 47 patients who underwent upper endoscopy, two cases of Barrett’s esophagus without dysplasia were identified and there were no cases of malignancy. Of the 67 patients who underwent colonoscopy, no cases of malignancy were identified and an adenoma was identified in 15% of cases. No significant differences were identified in the yield of endoscopy when stratified by age or presence of symptoms. CONCLUSIONThe yield of endoscopy is low in patients with dermatomyositis and is likely similar to the general population; we identified no cases of malignancy. A code based search strategy is inaccurate for the diagnosis of dermatomyositis, calling into question the results of prior population-based studies. Larger studies with rigorously validated search strategies are necessary to understand the risk of gastrointestinal malignancy in patients with dermatomyositis.

关键词： Endoscopy Dermatomyositis Colon cancer Screening

Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第9期30卷 1213-1223页

作者： Joseph Edwin Kanu jonathan Soldera post Graduate program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric *** *** is crucial for treating and preventing these *** conventional proton pump inhibitor(ppI)-based triple therapy is effective,there’s growing interest in longer acid suppression *** competitive acid blocker(p-CAB)triple and dual therapy are new regimens for *** *** used in Asian populations,vonoprazan(VpZ)has been recently Food and Drug Administration-approved for *** *** To assess the efficacy of regimens containing p-CABs in eradicating *** *** This study,following pRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"potassium-Competitive Acid Blocker"OR"p-CAB"OR"pCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of p-CABs-based treatment to classical ppIs in eradicating *** were *** criteria included case reports,case series,unpublished trials,or conference *** variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and *** eradication method were gathered by two independent ***-analysis was performed in R software,and forest plots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing p-CAB triple therapy to ppI triple *** intention-to-treat analysis involved 8049 patients,with 4471 in the p-CAB intervention g

关键词： Helicobacter pylori infection potassium competitive acid blockers proton pump inhibitors Vonoprazan Amoxicillin

Jaundice associated pruritis:A review of pathophysiology and treatment

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World Journal of Gastroenterology 2015年第5期21卷 1404-1413页

作者： Ramez Bassari jonathan B Koea Department of Surgery North Shore HospitalTakapunaAuckland 0632New Zealand

To review the underlying pathophysiology and currently available treatments for pruritis associated with *** language literature was reviewed using MEDLINE,pub Med,EMBASE and *** for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with *** advances in the understanding of the peripheral anatomy of itch transmission have defined a histamine stimulated pathway and a cowhage stimulated pathway with sensation conveyed centrally via the contralateral spinothalamic ***,cowhage andhistamine stimulated neurons terminate widely within the thalamus and sensorimotor *** causative factors for itch in jaundice have not been clarified although endogenous opioids,serotonin,steroid and lysophosphatidic acid all play a *** guidelines for the treatment of itching in jaundice recommend initial management with biliary drainage where possible and medical management with ursodeoxycholic acid,followed by cholestyramine,rifampicin,naltrexone and *** than biliary drainage no single treatment has proved universally *** associated with jaundice is a common but poorly understood condition for which biliary drainage is the most effective *** therapy has advanced but remains variably effective.

关键词： Jaundice pruritis Biliary drainage Bile acids Lyso

Intelligent Control for Improvements in pEM Fuel Cell Flow performance

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International Journal of Automation and computing 2008年第2期5卷 145-151页

作者： jonathan G Williams David Rees Faculty of Advanced Technology University of Glamorgan

The performance of fuel cells and the vehicle applications they are embedded into depends on a delicate balance of the correct temperature, humidity, reactant pressure, purity and flow rate. This paper successfully investigates the problem related to flow control with implementation on a single cell membrane electrode assembly （MEA）. This paper presents a systematic approach for performing system identification using recursive least squares identification to account for the non-linear parameters of the fuel cell. Then, it presents a fuzzy controller with a simplified rule base validated against real time results with the existing flow controller which calculates the flow required from the stoichiometry value.

关键词： Fuel cell fuzzy system identification flow control

Components of the human-specific,p53-mediated“kill switch”tumor suppression mechanism are usurped by human tumors,creating the possibility of therapeutic exploitation

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Cancer Drug Resistance 2019年第4期2卷 1207-1214页

作者： jonathan Nyce Clinical Research ACGT BiotechnologyCollegevillePA 19426USA

We recently reported our detection of an anthropoid primate-specific,adrenal androgen-dependent,“kill switch”tumor suppression mechanism that is triggered by the inactivation of the p53 tumor *** mechanism reached its highest expression only in humans as a result of the human-specific harnessing of fire,which resulted in an extraordinary increase in exposure to polycyclic aromatic ***“kill switch”becomes inoperative in modern humans once they exceed the primitive human lifespan of 25-30 years,because lifespan has more than tripled in modern times,but the secretion curve for dehydroepiandrosterone sulfate remains fixed at the level required for the primitive human *** of this“kill switch”are consequently usurped by human tumors,and these are already targets for inhibition in cancer ***,we suggest a different strategy:using the usurped components of the kill switch to activate prodrugs,rather than as targets for *** strategy is in its infancy,but has the potential to enable more tumor-specific cytotoxicity,which the inhibition strategy generally cannot *** of the usurpation of kill switch elements in liquid biopsy analyses enables the collection of information relevant to this new class of tumor biomarkers without the necessity of invasive tissue biopsy.

关键词： p53 Tp53 dehydroepiandrosterone dehydroepiandrosterone sulfate

The Battle over Confucius and Classical Chinese philosophy in European Early Enlightenment Thought （1670-1730）

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Frontiers of philosophy in China 2013年第2期8卷 183-198页

作者： jonathan Israel School of Historical Studies Institute for Advanced Study Princeton NJ 08540 USA

A profound split is evident during the period 1670-1730 in the way European scholars and commentators attempted to understand and describe classical Chinese thought. For some, Confucianism acknowledged divine creation and divine governance of the world, immortality of the soul and other elements of Natural Theology. The Radical Enlightenment thinkers, however, and also some Christian scholars denied that Confucianism was based on Natural Theology or pervaded by belief in divine providence, characterizing it rather as monist, naturalist and Spinozist. The disagreement proved fundamental in several respects and proved divisive for the Church, as well as European thought more generally, producing a series of lively disputes that continued over several decades.

关键词： Radical Enlightenment Confucianism atheism naturalism,Spinozism monism Jesuits creation divine providence Natural Theology

Oxidation behaviors of Co-Al-W-0.1B superalloys in a long-term isothermal exposure at 900~?C

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Journal of Materials Science & Technology 2018年第11期34卷 2212-2217页

作者： Yuzhi Li Florian pyczak jonathan paul Zekun Yao School of Materials Science and Engineering Northwestern Polytechnical UniversityXi'an 710072China Institute of Materials Research Helmholtz-Zentrum Geesthacht21502 GeesthachtGermany

Co-Al-W-0.1B superalloys have been isothermally oxidized at 900℃ for 1000,5000 and 10000 h in order to investigate their oxidation *** oxide layers and morphologies were characterized by X-ray diffraction and scanning electron microscopy combined with energy-dispersive ***1000 h exposure,a Co3W/γ zone,an Al2O3layer,a mixture of Co,Al,W oxides layer and a CoO layer are established on the substrate *** extended oxidation,a discontinuous Al2O3layer in Co-9Al-8W-0.1B and Co-9Al-9W-0.1B alloys leads to an additional mixed oxide layer on the substrate instead of the Co3W/γ *** oxide layers that form on the Co-9Al-8W-0.1B and Co-9Al-9W-0.1B alloys are much thicker than those on the Co-9Al-11W-0.1B alloy,and continuously thicken during *** higher content of W is beneficial to improving the oxidation resistance as it facilitates a faster formation of Co3Was well as Al2O3.

关键词： Isothermal oxidation CoO layer Al2O3 layer Co3W/γ

Lyric, Language, Culture

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山东外语教学 2014年第3期35卷 68-78页

作者： jonathan Culler Departments of English and Comparative Literature Cornell University Cornell University Ithaca NY 14853 -3201

Lyric poetry is not central to literary education these days,nor to language teaching and language *** something important is lost when the reading of poetry is eliminated from foreign language instruction,in the name of communication or social *** fact,some of the most salient characteristics of lyrics,their brevity and memorability as well as their cultural connotations are very relevant to the process of language learning.

关键词：英语学习学习方法阅读知识阅读材料

A Numerical Study of Temporal Mixing Layer with Three-Dimensional Mortar Spectral Element Method

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Chinese physics Letters 2011年第6期28卷 187-189页

作者： ZHANG Xu LIU Jin-Hong jonathan W.N Institute of Fluid physics China Academy of Engineering PhysicsMianyang 621900 Mechanical Department University of WyomingLaramieUSA

We investigate a set of well-posed interface conditions of viscous fluxes of Navier–Stokes equations,extend them to three-dimensional Navier–Stokes equations and successfully study a temporally turbulent mixing *** evolution of a large vortex structure and the non-dimensional statistical quantities in the mixing layer are numerically *** span-wise energy spectrum of the mixing layer exhibits wide band features,which means that the simulation generates the desired amount of small *** results show that too many small scales are present due to insufficient dissipation and the amount of large scales is low,indicating too much dissipation for large-scale structures.

关键词： layer mixing dissipation