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In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D pancreatic tumor stroma co-cultures via passive particle tracking

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： Dustin p.Jones William Hanna Gwendolyn M.Cramer jonathan p.celli Department of physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including paracrine crosstalk with stromal partners,and biophysical interactions with surrounding cells and *** elucidating the role of physical force and the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3D)tumor *** systems provide the ability to systematically isolate,manipulate,and evaluate impact of stromal components and extracellular mechanics in a platform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires complementary methods for in situ measurements of the local mechanical ***,in 3D tumor/fbroblast co-culture models of pancreatic canocer,a discase characterized by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe dynamic mechanical *** videos of fuorescently labeled polystyrene micro-spheres embedded in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear modulus and *** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dependent on culture geometry with contrast ing behavior for embedded and overlay *** addition to potential application to screening stroma targeted therapeutics,this work also provides insight into how the compoition and plating geometry impact the mechanical propertios of 3D cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3D tumor models matrix remodeling mechanobiology stromal depletion

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Gust response of an elasto-flexible morphing wing using fluid–structure interaction simulations

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Chinese Journal of Aeronautics 2024年第2期37卷 45-57页

作者： jonathan pFLÜGER Christian BREITSAMTER Department of Mechanical Engineering Technical University of MunichGarching 85748Germany

Small and micro unmanned aircraft are the focus of scientific interest due to their wide range of *** often operate in a highly unstable flight environment where the application of new morphing wing technologies offers the opportunity to improve flight *** investigated concept comprises port and starboard adjustable wings,and an adaptive elastoflexible membrane serves as the lifting *** focus is on the benefits of the deforming membrane during the impact of a one-minus-cosine type *** a low Reynolds number of Re=264000,the morphing wing model is investigated numerically by unsteady fluid-structure interaction ***,the numerical results are validated by experimental data from force and moment,flow field,and deformation ***,with the rigid wing as the baseline,the flexible case is investigated,focusing on the advantages of the elastic *** all configurations studied,the maximum amplitude of the lift coefficient under gust load shows good agreement between the experimental and numerical *** the decay of the gust,they differ more the higher the aspect ratio of the *** considering the flow field,the main differences are due to the separation behavior on the upper side of the *** flow reattaches earlier in the experiments than in the simulations,which explains the higher lift values observed in the *** at one intermediate configuration does the lift amplitude of the rigid configuration exceeds that of the flexible by about 12%,with the elastic membrane resulting in a smaller and more uniform peak load,which is also evident in the wing loading and hence in the root bending moment.

关键词： Membrane wing Morphing wing Flexible wing surface Computational fluid dynam-ics Fluid-structure interaction Unsteady inflow condition Gust response

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NLRp3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain

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Neural Regeneration Research 2024年第7期19卷 1425-1426页

作者： Jack jonathan Maran Odunayo Omolola Mugisho Buchanan Ocular Therapeutics Unit Department of OphthalmologyNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Key points:With aging,there is increased nucleotide-binding oligomerization domain-(NOD-)like receptor(NLR) protein-3(NLRp3) activation in neural and ocular *** of the NLRp3 inflammasome appears to be a common denominator in the pathogenesis of age-related diseases of the eye and *** inhibition of the NLRp3 inflammasome may be a potent therapy for preventing the development and progression of age-related eye and brain diseases.

关键词： NLRp3 pathogenesis inflam

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Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第9期30卷 1213-1223页

作者： Joseph Edwin Kanu jonathan Soldera post Graduate program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric *** *** is crucial for treating and preventing these *** conventional proton pump inhibitor(ppI)-based triple therapy is effective,there’s growing interest in longer acid suppression *** competitive acid blocker(p-CAB)triple and dual therapy are new regimens for *** *** used in Asian populations,vonoprazan(VpZ)has been recently Food and Drug Administration-approved for *** *** To assess the efficacy of regimens containing p-CABs in eradicating *** *** This study,following pRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"potassium-Competitive Acid Blocker"OR"p-CAB"OR"pCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of p-CABs-based treatment to classical ppIs in eradicating *** were *** criteria included case reports,case series,unpublished trials,or conference *** variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and *** eradication method were gathered by two independent ***-analysis was performed in R software,and forest plots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing p-CAB triple therapy to ppI triple *** intention-to-treat analysis involved 8049 patients,with 4471 in the p-CAB intervention g

关键词： Helicobacter pylori infection potassium competitive acid blockers proton pump inhibitors Vonoprazan Amoxicillin

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Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： pui Kei KO jonathan E.HALpERT Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(pLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(EL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LEDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

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On the calibration of a shear stress criterion for rock joints to represent the full stress-strain profile

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 379-392页

作者： Akram Deiminiat jonathan D.Aubertin Yannic Ethier Department of Construction Engineering École de Technologie Supérieure(ÉTS)MontréalCanada

Conventional numerical solutions developed to describe the geomechanical behavior of rock interfaces subjected to differential load emphasize peak and residual shear *** detailed analysis of preand post-peak shear stress-displacement behavior is central to various time-dependent and dynamic rock mechanic problems such as rockbursts and structural instabilities in highly stressed *** complete stress-displacement surface(CSDS)model was developed to describe analytically the pre-and post-peak behavior of rock interfaces under differential *** formulations of the CSDS model required extensive curve-fitting iterations which limited its practical applicability and transparent integration into engineering *** present work proposes modifications to the CSDS model aimed at developing a comprehensive and modern calibration protocol to describe the complete shear stressdisplacement behavior of rock interfaces under differential *** proposed update to the CSDS model incorporates the concept of mobilized shear strength to enhance the post-peak ***’s concepts of joint roughness coefficient(JRC)and joint compressive strength(JCS)are incorporated to facilitate empirical estimations for peak shear stress and normal closure ***/uniaxial compression test and direct shear test results are used to validate the updated model and exemplify the proposed calibration *** results illustrate that the revised model successfully predicts the post-peak and complete axial stressestrain and shear stressedisplacement curves for rock joints.

关键词： Full shear profile post-peak shear behavior Rock joint Joint roughness coefficient(JRC) Axial stress-strain curve

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Geochemical elements in suspended particulate matter of Ensenada de La paz Lagoon,Baja California peninsula,Mexico:Sources,distribution,mass balance and ecotoxicological risks

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Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad Morales-García pilar de Acacia pérez-Escamilla Suresh Babu Sujitha pichaimani Godwyn-paulson Andrés Felipe Zuniga-Cabezas Muthuswamy ponniah jonathan Instituto politécnico Nacional(IpN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto politécnico Nacional(IpN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto politécnico Nacional(IpN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,Mg,Mn,Mo,Ni,pb,Sr)in suspended particulate material(SpM)collected from Ensenada de La paz(ELp)lagoon,Baja California Sur,Mexico in two different periods(September and May)to comprehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric SpM levels were found to be 51.7%in September and 40.5%in May,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of SpM,and in this study,Mo had the highest EF of 46.77 probably due to its origin from continental *** the ecotoxicological perspective,the integrated toxic risk index revealed low toxic risk to the benthic ***,the mean-ERM-Quotient calculated using the particulate concentrations of As,Cd,Cr,Cu,Ni,pb indicated 9%probability of toxicity to *** comprehensive geochemical and ecotoxicological assessment of particulate metal concentrations in the ELp lagoon signify low to moderate contamination.

关键词： Suspended particulate material Heavy metals Risk assessment Mass transfer Ensenada de La paz

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Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： jonathan Ruiz Esquius Alec p LaGrow Haiyan Jin Zhipeng Yu Ana Araujo Rita Marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

proton exchange membrane(pEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for pEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

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Insights into skullcap herb-induced liver injury

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World Journal of Hepatology 2024年第2期16卷 120-122页

作者： jonathan Soldera post Graduate program at Acute Medicine and Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

This editorial addresses the growing concern of herb-induced liver injury(HILI),focusing on a unique case of Skullcap-induced HILI *** editorial underscore the significant mortality rate linked to Skullcap-induced HILI,emphasizing the importance of vigilant monitoring and *** herbal supplement usage rises,collaboration among clinicians and researchers is crucial to comprehend and address the complexities of HILI,particularly those involving Skullcap.

关键词： Herb-induced liver injury Drug induced liver injury Dietary supplements Herbal hepatotoxicity Liver transplantation

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Use of machine learning models for the prognostication of liver transplantation: A systematic review

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World Journal of Transplantation 2024年第1期14卷 164-188页

作者： Gidion Chongo jonathan Soldera Department of Gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Liver transplantation(LT)is a life-saving intervention for patients with end-stage liver ***,the equitable allocation of scarce donor organs remains a formidable *** tools are pivotal in identifying the most suitable transplant ***,scoring systems like the model for end-stage liver disease have been instrumental in this ***,the landscape of prognostication is undergoing a transformation with the integration of machine learning(ML)and artificial intelligence *** To assess the utility of ML models in prognostication for LT,comparing their performance and reliability to established traditional scoring *** Following the preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines,we conducted a thorough and standardized literature search using the pubMed/MEDLINE *** search imposed no restrictions on publication year,age,or *** criteria encompassed non-English studies,review articles,case reports,conference papers,studies with missing data,or those exhibiting evident methodological *** Our search yielded a total of 64 articles,with 23 meeting the inclusion *** the selected studies,60.8%originated from the United States and China *** one pediatric study met the ***,91%of the studies were published within the past five *** models consistently demonstrated satisfactory to excellent area under the receiver operating characteristic curve values(ranging from 0.6 to 1)across all studies,surpassing the performance of traditional scoring *** forest exhibited superior predictive capabilities for 90-d mortality following LT,sepsis,and acute kidney injury(AKI).In contrast,gradient boosting excelled in predicting the risk of graft-versus-host disease,pneumonia,and *** This study underscores the potential of ML models in guiding decisions related to allograft allocation and LT,mark

关键词： Liver transplantation Machine learning models prognostication Allograft allocation Artificial intelligence

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