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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

The Need for Fuzzy AI

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 610-622页

作者： jonathan m.Garibaldi IEEE the School of Computer Science University of Nottingham

Artificial intelligence(AI) is once again a topic of huge interest for computer scientists around the world. Whilst advances in the capability of machines are being made all around the world at an incredible rate, there is also increasing focus on the need for computerised systems to be able to explain their decisions, at least to some degree. It is also clear that data and knowledge in the real world are characterised by *** systems can provide decision support, which both handle uncertainty and have explicit representations of uncertain knowledge and inference processes. However, it is not yet clear how any decision support systems, including those featuring fuzzy methods, should be evaluated as to whether their use is *** paper presents a conceptual framework of indistinguishability as the key component of the evaluation of computerised decision support systems. Case studies are presented in which it has been clearly demonstrated that human expert performance is less than perfect, together with techniques that may enable fuzzy systems to emulate human-level performance including *** conclusion, this paper argues for the need for "fuzzy AI" in two senses:(i) the need for fuzzy methodologies(in the technical sense of Zadeh's fuzzy sets and systems) as knowledge-based systems to represent and reason with uncertainty; and(ii) the need for fuzziness(in the non-technical sense) with an acceptance of imperfect performance in evaluating AI systems.

关键词： Artificial intelligence approximate reasoning fuzzy inference systems fuzzy sets human reasoning

Harnessing migraines for neural regeneration

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Neural Regeneration Research 2018年第4期13卷 609-615页

作者： jonathan m.Borkum Department of Psychology University of Maine Orono ME USA Health Psych maine Waterville MEUSA

The success of naturalistic or therapeutic neuroregeneration likely depends on an internal milieu that facilitates the survival,proliferation,migration,and differentiation of stem cells and their assimilation into neural *** attacks are an integrated sequence of physiological processes that may protect the brain from oxidative stress by releasing growth factors,suppressing apoptosis,stimulating neurogenesis,encouraging mitochondrial biogenesis,reducing the production of oxidants,and upregulating antioxidant ***,the migraine attack may constitute a physiologic environment conducive to stem *** this paper,key components of migraine are reviewed – neurogenic inflammation with release of calcitonin gene-related peptide（CGRP） and substance P,plasma protein extravasation,platelet activation,release of serotonin by platelets and likely by the dorsal raphe nucleus,activation of endothelial nitric oxide synthase（e NOS）,production of brain-derived neurotrophic factor（BDNF） and,in migraine aura,cortical spreading depression – along with their potential neurorestorative *** possibility is considered of using these components to facilitate successful stem cell *** methods for doing so are discussed,including chemical stimulation of the TRPA1 ion channel,conjoint activation of a subset of migraine components,invasive and noninvasive deep brain stimulation of the dorsal raphe nucleus,transcranial focused ultrasound,and stimulation of the Zusanli（ST36） acupuncture point.

关键词： neuroprotection neurorestoration neurogenesis stem cells migraine transient receptor potential ankyrin-1 calcitonin gene-related peptide albumin acupuncture oxidative stress

Sexual dimorphism in cranial shape and size in geomyoid rodents:multivariate and evolutionary perspectives

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Current Zoology 2022年第4期68卷 469-487页

作者： jonathan J m Calede Andrew Brown Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.300 Aronoff LaboratoryColumbusOH 43210USA The Ohio State University at marion 1459 Mount Vernon AvenueMarionOH 43302USA College of Veterinary medicine Texas A&M University660 Raymond Stotzer PkwyCollege StationTX 77843USA

Geomyoid rodents provide a great study system for the analysis of sexual *** are polygynic and many inhabit harsh arid environments thought to promote sexual *** fact,there has been extensive work published on the sexual size dimorphism of individual populations and species within this rodent ***,little work has been undertaken to assess the evolutionary patterns and processes associated with this sexual *** use multivariate analyses of cranial measurements in a phylogenetic framework to determine the distribution of size and shape dimorphism among geomyoids and test for Rensch’s *** results suggest that sexual dimorphism is more common in geomyids than heteromyids,but it is not in fact *** is evidence for variation in sexual dimorphism across ***,in many taxa,geographic variation appears to overwhelm existing sexual *** find support for the repeated independent evolution of shape and size dimorphism across geomyoid taxa,but we do not find support for an association between size and shape *** is no evidence for Rensch’s rule in geomyoids,whether at the superfamily or family ***,our findings suggest that there is no single explanation for the evolution of sexual dimorphism in geomyoids and that,instead,it is the product of numerous evolutionary *** studies incorporating phylogenetic relationships will be necessary to paint a more complete picture of the evolution of sexual dimorphism in geomyoids.

关键词： Geomyidae Heteromyidae phylogenetic comparative methods morphometrics Rensch’s rule

Dangers of scientific bias against herbal drugs for coronavirus disease 2019

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Journal of Integrative medicine 2020年第6期18卷 459-461页

作者： jonathan m.Fields Integrative medicine US TamaracFL 33321USA

On may 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.

关键词： Herbal Coronavirus COVID-19 SARS-CoV-2 medicine,Chinese traditional Complementary therapies

multivariate analyses of skull morphology inform the taxonomy and evolution of geomyoid rodents

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Current Zoology 2023年第4期69卷 456-474页

作者： Lily A.Noftza jonathan J.m.Calede aBiology Program The Ohio State University at Marion1459 Mount Vernon AvenueMarionOH 43302USA Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.ColumbusOH 43210USA.

morphological analyses are critical to quantify phenotypic variation,identify taxa,inform phylogenetic relationships,and shed light on evolutionary *** work is particularly important in groups that display great morphological *** is the case in geomyoid rodents,a group that includes 2 of the most species-rich families of rodents in North America:the Geomyidae(pocket gophers)and the Heteromyidae(kangaroo rats,pocket mice,and their relatives).We assessed variation in skull morphology(including both shape and size)among geomyoids to test the hypothesis that there are statistically significant differences in skull measurements at the family,genus,and species *** sample includes 886 specimens representing all geomyoid genera and 39 *** used the geometric mean to compare size across *** used 14 measurements of the cranium and lower jaw normalized for size to compare shape among and within *** results show that skull measurements enable the distinction of geomyoids at the family,genus,and species *** is a larger amount of size variation within Geomyidae than within *** phylomorphospace analysis shows that the skull shape of the common ancestor of all geomyoids was more similar to the common ancestor of heteromyids than that of *** skulls display negative allometry whereas heteromyid skulls display positive *** heteromyids,dipodomyines,and non-dipodomyines show significantly different allometric *** analyses including fossils will be necessary to test our evolutionary hypotheses.

关键词： canalization convergent evolution Geomyidae Heteromyidae morphometrics phylomorphospace

The heterogeneity of store-operated calcium entry in melanoma

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Science China(Life Sciences) 2016年第8期59卷 764-769页

作者： Robert Hooper m.Raza Zaidi jonathan Soboloff Fels Institute for Cancer Research and molecular Biology Lewis Katz School of Medicine at Temple University Department of medical Genetics & molecular Biochemistry Lewis Katz School of Medicine at Temple University

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIm and Orai mediate store-operated calcium entry(SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIm and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIm, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

关键词： melanoma STIm1 Orail metastasis

Current taxane formulations and emerging cabazitaxel delivery systems

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Nano Research 2018年第10期11卷 5193-5218页

作者： Boyang Sun Robert m. Straubinger jonathan F. Lovell Department of Biomedical Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Chemical and Biological Engineering University at Buffalo State University of New York Buffalo NY 14260 USA Department of Pharmaceutical Sciences University at Buffalo State University of New York Buffalo NY 14214 USA

Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes （i.e. paclitaxel and docetaxel） have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

关键词： cabazitaxel Jevtana taxanes drug delivery systems nanocarriers

Sequential fusion estimation for multisensor systems with non-Gaussian noises

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Science China(Information Sciences) 2020年第12期63卷 153-165页

作者： Liping YAN Chenying DI Q.m.jonathan WU Yuanqing XIA Key Laboratory of Intelligent Control and Decision of Complex Systems School of AutomationBeijing Institute of Technology Department of Electrical and Computer Engineering University of Windsor

The sequential fusion estimation for multisensor systems disturbed by non-Gaussian but heavytailed noises is studied in this paper. Based on multivariate t-distribution and the approximate t-filter,the sequential fusion algorithm is presented. The performance of the proposed algorithm is analyzed and compared with the t-filter-based centralized batch fusion and the Gaussian Kalman filter-based optimal centralized fusion. Theoretical analysis and exhaustive experimental analysis show that the proposed algorithm is effective. As the generalization of the classical Gaussian Kalman filter-based optimal sequential fusion algorithm, the presented algorithm is shown to be superior to the Gaussian Kalman filter-based optimal centralized batch fusion and the optimal sequential fusion in estimation of dynamic systems with non-Gaussian noises.

关键词： state estimation sequential fusion non-Gaussian disturbance heavy-tailed noise multivariate t-distribution