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Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

Signal Transduction and Targeted Therapy 2019年第1期4卷 636-647页

作者： Eliseos J.Mucaki jonathan z.l.zhao Daniel J.lizotte Peter K.Rogan Department of Biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Department of Computer Science Faculty of ScienceWestern UniversityLondonON N6A 2C1Canada Department of Epidemiology&Biostatistics Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Cytognomix Inc.LondonON N5X 3X5Canada Department of Oncology Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada

The selection of effective genes that accurately predict chemotherapy responses might improve cancer *** compare optimized gene signatures for cisplatin,carboplatin,and oxaliplatin responses in the same cell lines and validate each signature using data from patients with *** support vector machine learning is used to derive gene sets whose expression is related to the cell line GI 50 values by backwards feature selection with *** genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI 50 *** of gene signatures at different thresholds are combined to reduce the dependence on specific GI 50 values for predicting drug *** most accurate gene signatures for each platin are:cisplatin:BARD1,BCl2,BCl2l1,CDKN2C,FAAP24,FEN1,MAP3K1,MAPK13,MAPK3,NFKB1,NFKB2,SlC22A5,SlC31A2,TlR4,and TWIST1;carboplatin:AKT1,EIF3K,ERCC1,GNGT1,GSR,MTHFR,NEDD4l,NlRP1,NRAS,RAF1,SGK1,TIGD1,TP53,VEGFB,and VEGFC;and oxaliplatin:BRAF,FCGR2A,IGF1,MSH2,NAGK,NFE2l2,NQO1,PANK3,SlC47A1,SlCO1B1,and *** from The Cancer Genome Atlas(TCGA)patients with bladder,ovarian,and colorectal cancer were used to test the cisplatin,carboplatin,and oxaliplatin signatures,resulting in 71.0%,60.2%,and 54.5%accuracies in predicting disease recurrence and 59%,61%,and 72%accuracies in predicting remission,*** cisplatin signature predicted 100%of recurrence in non-smoking patients with bladder cancer(57%disease-free;N=19),and 79%recurrence in smokers(62%disease-free;N=35).This approach should be adaptable to other studies of chemotherapy responses,regardless of the drug or cancer types.

关键词： bladder chemotherapy signature

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel jonathan Grossberg Daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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PREPARATION AND CORROSION RESISTANCE OF NiP/TiO_2 COMPOSITE FIlM ON CARBON STEEl IN SUlFURIC ACID SOlUTION

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Acta Metallurgica Sinica(English letters) 2006年第2期19卷 117-123页

作者： l.z. Song S.z. Song J. zhao School of Environment ＆ Chemical Engineering Yanshan University Qinhuangdao 066004 China School of Materials Science and Engineering Tianjin University Tianjin 300072 China

A NiP/TiO2 composite film on carbon steel was prepared by electroless plating and sol-gel composite process. An artificial neural network was applied to optimize the prepared condition of the composite film. Corrosion behavior of the NiP/TiO2 composite film was investigated by polarization resistance measurement, anode polarization, ESEM （environmental scanning electron microscopy） and EIS （electrochemical impedance spectroscopy） measurements. Results showed that the NiP/ TiO2 composite film has a good corrosion resistance in 0.5mol/l H2SO4 solution. The element valence of the composite film was characterized by XPS （X-ray photoelectron spectroscopy） spectrum, and an anticorrosion mechanism of the composite film was discussed.

关键词： electroless plating and sol-gel composite process artificial neural network NiP/TiO2 composite film corrosion resistance

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An explicit solution to a three-dimensional wedge problem considering two edges effect

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Friction 2020年第2期8卷 370-383页

作者： l.GUO z.M.zHANG W.WANG Y.zhao P.l.WONG School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China Department of Mechanical Engineering City University of Hong KongHong Kong SARChina

The paper presents an explicit matrix algorithm to solve the problem of an elastic wedge with three loaded *** algorithm makes use of a recently published concept of transformation matrix,by which the original surface loads are converted to equivalent loads in *** three loaded edges are considered *** developed algorithm is used to study the effects of two free edges of a steel block and tapered rollers with different contact *** two load-free edges can substantially increase deformation if the two edges are close in *** results of the tapered roller simulation show that deformation is considerably sensitive to the contact angle of the tapered *** largest deformation appears at the big end of the ***,empirical formulae for correction factors for the calculation of block or quarter-space deformation based on half-space solutions are summarized.

关键词： contact mechanics two edge surfaces finite line contact tapered roller contact

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MODElING OF ISOTHERMAl PRECIPITATION KINETICS IN HSlA STEElS AND ITS APPlICATION

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Acta Metallurgica Sinica(English letters) 2004年第6期17卷 902-906页

作者： X.M.zhao D.Wu l.z.zhang z.Y.liu TheStateKeylab.ofRollingandAutomation NortheastemUniversityShenyang110004China

Microalloying elements in high-strength low-alloy steels, such as Nb, Ti and V, precipitate during hot-rolling processes. On the basis of classical theory of nucleation and growth, quanti- tative modeling of isothermal precipitation was developed, which was tested by the stress rela- xation method, the calculated precipitation-time-temperature curve is in good agreements with the measured results, then the model was applied to predict the precipitation behavior during continuous cooling.

关键词： isothermal precipitation kinetics HSlA steel

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A low-cost and High Efficiency Architecture of AES Crypto-engine

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China Communications 2008年第2期5卷 8-15页

作者： z.F.zhao D.Y.Yu l.li Vinno Technologies Inc

The growing market of WPAN has led to an increasingdemand of security measures and devices forprotecting the user data transmitted over the *** Encryption Standards(AES)isthe basic security approach for *** meet thelow cost,low power feature and high security demandof WPAN,a low cost,high efficient AES coreis proposed in this *** achieve low cost,methods of integration and resource sharing are usedin designing a very low-complexity architecture,especially in(inverse)byte substitution(inv)SubBytes)modules and(inverse)mix column(inv)MixColumn)modules,*** more,AESEncryptor and Decryptor is integrated into a fullfunctional *** very low-cost andhigh efficiency AES core of IEEE 802.15.4-2006 isdesigned and emulated on Xilinx *** show that this kind of design can be used inresource critical applications,such as smart card,PDA and mobile phones.

关键词： AES S-box Sub-Byte WPAN

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Numerical study of the circular opening effect on mechanical behaviour of rock under confinement

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第6期11卷 1201-1210页

作者： Y.l.Gui J.l.Shang J.J.Ma z.Y.zhao school of engineering newcastle universitynewcastle upon tynene17ruunited kingdom school of civil and environmental engineering nanyang technological university639798singapore school of civil engineering sun yat-sen universityguangzhou510275china

Opening holes in rock including their size and distribution can affect the performance of rock-related structures.A good understanding on this will contribute to,for example,rock cavern design,and construction,tunnelling,and mining *** improve the understanding,a comprehensive investigation of the opening hole effect on the rock mechanical behaviour under biaxial loading condition is carried out by virtue of a hybrid continuum-discrete element *** specimens with both single hole and multi-hole of various radii are investigated and compared with the cases subjected to uniaxial *** is demonstrated that the confining pressure can increase both the stiffness and strength due to delaying the crack initiation and *** increase due to the confining pressure is more evident for the compressive *** single hole specimens with 0.75 mm radius hole,the increase ratio of the compressive strength is a linear increasing function with width and the increase ratio ranges from 2.15 for the specimen with 3.5 mm width to 2.45 for 10 mm *** the single hole specimen with 10 mm width,the increase ratio starts at 2.13 for the specimen with 0.75 mm radius hole,ascending to the peak of 2.37 for the specimen with 1 mm radius hole,followed by a decline to 2.2 for the specimen with 1.25 mm radius ***,for the multi-hole specimens,the increase ratio varies from 1.66 to *** addition,to verify the influence of confining pressure magnitude on the performance of the rock specimens,totalling 10 confining pressure levels are applied and *** simulation results show that even though there are opening holes in the specimens,the simulated compressive strength generally follows the generalised Hoek-Brown model.

关键词： Rock with opening Simulation Biaxial loading Strength Stiffness

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Microstructural softening induced adiabatic shear banding in Ti-23Nb-0.7Ta-2zr-O gum metal

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Journal of Materials Science & Technology 2020年第19期54卷 31-39页

作者： Silu liu Y.z.Guo z.l.Pan X.z.liao E.J.lavernia Y.T.zhu Q,M,Wei Yonghao zhao Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of North Carolina at CharlotteNC 28223-0001USA School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneyNSW 2006Australia Department of Materials Science and Engineering University of Californi1IrvineCA 92697USA Department of Materials Science and Engineering North Carolina State UniversityNC 27695USA

Ti-23Nb-0.7Ta-2zr-O gum metal(GM)is an attractive candidate material for applications that require superior mechanical *** our earlier investigation of the GM[1],geometrical softening and the generation of adiabatic shear bands(ASBs)were proposed as primary reasons for the documented anisotropic impact *** the present study,electron backscattered diffraction(EBSD)analysis reveals two different deformed microstructures,i.e.,deformed ultrafine grains(UFGs)and dynamically recrystallized UFGs,formed in the ASBs of GM samples processed by extrusion equal channel angular pressing(ECAP),*** calculation of temperature rise during dynamic compression suggests that the above microstructure differences in the ASBs was originated from their different maximum ASB temperatures(608 K for extruded GM and 1159 K for ECAP-processed GM).Moreover,our calculation on the temperature at the onset of ASBs indicates that microstructural softening is the primary cause for the development of ASBs in both extruded GM(321 K)and ECAP-processed GM(331 K).

关键词： Gum metal Split hopkinson bar Adiabatic shear band Microstructures

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CAlCUlATION OF THE MAGNETIzATION AND MAGNETOCAlORIC EFFECT IN THE MnFeP_(0.45)As_(0.55) COMPOUND

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Acta Metallurgica Sinica(English letters) 2007年第4期20卷 265-269页

作者： G.F. Wang l. Song z.Q. Ou z.R. zhao O. Tegus Key laboratory of Physics and Chemistry of Function Materials Inner Mongolia Normal University Huhhot 010022 China Van der Waals-zeeman Instituut Universiteit van Amsterdam Valckenierstraat 65 1018 XE Amsterdam The Netherlands College of Science and Technology Inner Mongolia University Huhhot 010021 China

A magnetic state equation of the MnFeP0.45As0.55 compound has been obtained by minimizing the Gibbs free energy with respect to the volume and the magnetization based on the Bean-Rodbell model. The isothermal magnetization of the compound has been calculated using this equation. The magnetic entropy change of the compound was determined from the surface area between the two adjacent isothermal magnetization curves divided by the average temperature. A comparison and an error analysis of the calculated magnetic entropy change and the one determined from the experimental data were given.

关键词： bean-rodbell model magnetic state equation magnetocaloric effect

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