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Asian Journal of Urology 2021年第4期8卷 436-439页

作者： jonathan s.m.teo Han Jie Lee John s.P.Yuen Department of Urology Sengkang General HospitalSingapore Department of Urology Singapore General HospitalSingapore

Childhood priapism is a rare entity and there is currently no consensus regarding its contemporary *** use of perioperative anticoagulation and open distal corporaglandular shunt procedure in the management of childhood priapism has not been reported in the *** present a stuttering case of a 13-year-old boy who presented with idiopathic ischaemic priapism lasting 13 h in duration,which recurred despite corporal aspiration and alpha-adrenergic agonist injections,percutaneous distal shunt surgery,and revision of percutaneous distal shunt *** was eventually successfully managed with perioperative subcutaneous enoxaparin,oral aspirin and clopidogrel in conjunction with an Al-Ghorab shunt,which led to sustained detumescence but with spontaneous morning *** paediatric patients with sustained childhood priaprism failing stepwise treatments,an Al-Ghorab shunt with perioperative anticoagulation is a viable option.

关键词： Paediatric Ischaemic priapism Anticoagulation Percutaneous distal shunt

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John mitrofanis jonathan stone michael R.Hamblin Pierre magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance school of medical science University of SydneySydneyAustralia Faculty of Health sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Wilson's disease in two siblings from Ecuador:Two case reports

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World Journal of Clinical Cases 2025年第3期13卷 50-60页

作者： Enrique Carrera jonathan Alvarado martina Astudillo Galo Pillajo Department of Gastroenterology and Hepatology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador Faculty of medicine Pontificia Universidad Catolica del EcuadorQuito 170143PichinchaEcuador Department of Radiology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador

BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and *** and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are *** diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life *** clinical presentations and outcomes of WD can vary within a single *** sUmmARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having WD during a family *** male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer *** developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication *** condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of *** female patient,diagnosed at age 10,exhibited only biochemical *** treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up *** discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic *** Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.

关键词： Wilson disease Kayser-Fleischer rings Copper chelator D-penicillamine Trientine tetrahydrochloride Case report

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

The Need for Fuzzy AI

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IEEE/CAA Journal of Automatica sinica 2019年第3期6卷 610-622页

作者： jonathan m.Garibaldi IEEE the school of Computer science University of Nottingham

Artificial intelligence(AI) is once again a topic of huge interest for computer scientists around the world. Whilst advances in the capability of machines are being made all around the world at an incredible rate, there is also increasing focus on the need for computerised systems to be able to explain their decisions, at least to some degree. It is also clear that data and knowledge in the real world are characterised by *** systems can provide decision support, which both handle uncertainty and have explicit representations of uncertain knowledge and inference processes. However, it is not yet clear how any decision support systems, including those featuring fuzzy methods, should be evaluated as to whether their use is *** paper presents a conceptual framework of indistinguishability as the key component of the evaluation of computerised decision support systems. Case studies are presented in which it has been clearly demonstrated that human expert performance is less than perfect, together with techniques that may enable fuzzy systems to emulate human-level performance including *** conclusion, this paper argues for the need for "fuzzy AI" in two senses:(i) the need for fuzzy methodologies(in the technical sense of Zadeh's fuzzy sets and systems) as knowledge-based systems to represent and reason with uncertainty; and(ii) the need for fuzziness(in the non-technical sense) with an acceptance of imperfect performance in evaluating AI systems.

关键词： Artificial intelligence approximate reasoning fuzzy inference systems fuzzy sets human reasoning

An update on transurethral surgery for benign prostatic obstruction

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Asian Journal of Urology 2017年第3期4卷 195-198页

作者： jonathan shunming teo Yee mun Lee Henry sun sien Ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Clinical benign prostatic hyperplasia(BPH)is one of the most common cause of lower urinary tract symptoms and transurethral resection of prostate(TURP)has been the gold standard technique for surgical treatment of benign prostate obstruction(BPO)over the last 2 *** monopolar TURP is considered a safe and effective option for surgical management of BPO,there are some disadvantages,namely bleeding,transurethral resection syndrome,incompleteness of *** review aims to highlight these problems,and describe the advances in technology and techniques that have evolved to minimise such *** the advent of lasers and bipolar technology,as well as enucleative techniques to remove the prostatic adenoma/adenomata,the problems of bleeding,transurethral resection syndrome and incomplete treatment are significantly *** TURPwill likely be replaced by such technology and techniques in the near future such that transurethral surgery of the prostate remain a safe and effective option in alleviating the harmful effects of BPO.

关键词： Transurethral resection of prostate Benign prostatic obstruction Bleeding Prostatectomy

Harnessing migraines for neural regeneration

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Neural Regeneration Research 2018年第4期13卷 609-615页

作者： jonathan m.Borkum Department of Psychology University of Maine Orono ME USA Health Psych maine Waterville MEUSA

The success of naturalistic or therapeutic neuroregeneration likely depends on an internal milieu that facilitates the survival,proliferation,migration,and differentiation of stem cells and their assimilation into neural *** attacks are an integrated sequence of physiological processes that may protect the brain from oxidative stress by releasing growth factors,suppressing apoptosis,stimulating neurogenesis,encouraging mitochondrial biogenesis,reducing the production of oxidants,and upregulating antioxidant ***,the migraine attack may constitute a physiologic environment conducive to stem *** this paper,key components of migraine are reviewed – neurogenic inflammation with release of calcitonin gene-related peptide（CGRP） and substance P,plasma protein extravasation,platelet activation,release of serotonin by platelets and likely by the dorsal raphe nucleus,activation of endothelial nitric oxide synthase（e NOs）,production of brain-derived neurotrophic factor（BDNF） and,in migraine aura,cortical spreading depression – along with their potential neurorestorative *** possibility is considered of using these components to facilitate successful stem cell *** methods for doing so are discussed,including chemical stimulation of the TRPA1 ion channel,conjoint activation of a subset of migraine components,invasive and noninvasive deep brain stimulation of the dorsal raphe nucleus,transcranial focused ultrasound,and stimulation of the Zusanli（sT36） acupuncture point.

关键词： neuroprotection neurorestoration neurogenesis stem cells migraine transient receptor potential ankyrin-1 calcitonin gene-related peptide albumin acupuncture oxidative stress

Investigation of a ship resonance through numerical simulation

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Journal of Hydrodynamics 2020年第5期32卷 969-983页

作者： s.s.Kianejad Hossein Enshaei jonathan Duffy Nazanin Ansarifard Australian maritime College University of TasmaniaLauncestonAustralia

Understanding dynamic stability of a ship on a resonance frequency is important because comparatively smaller external forces and moments generate larger *** roll motion is most susceptible because of smaller restoring *** studies related to the failure modes such as parametric roll and dead ship condition,identified by second generation of intact stability criteria(sGIsC)are performed at a resonance ***,the nature of resonance,where the model experiences an incremental roll motion,has not been well *** this study,nonlinear unsteady computational fluid dynamics(CFD)simulations were conducted to investigate the resonance phenomenon using a containership under a sinusoidal roll exciting *** capture the complexity of the phenomenon,simulations were conducted over a range of frequencies to cover the resonance frequency including lower and higher *** addition to the resonance frequency,the phase shift between roll exciting moment and roll angle,as well as the phase difference between acceleration and roll angle,were found to have significant effects on the occurrence of resonance.

关键词： Resonance harmonic excited roll motion natural frequency phase shift phase difference

sexual dimorphism in cranial shape and size in geomyoid rodents:multivariate and evolutionary perspectives

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Current Zoology 2022年第4期68卷 469-487页

作者： jonathan J m Calede Andrew Brown Department of Evolution Ecologyand Organismal BiologyThe Ohio State University318 W.12th Ave.300 Aronoff LaboratoryColumbusOH 43210USA The Ohio state University at marion 1459 Mount Vernon AvenueMarionOH 43302USA College of Veterinary medicine Texas A&M University660 Raymond Stotzer PkwyCollege StationTX 77843USA

Geomyoid rodents provide a great study system for the analysis of sexual *** are polygynic and many inhabit harsh arid environments thought to promote sexual *** fact,there has been extensive work published on the sexual size dimorphism of individual populations and species within this rodent ***,little work has been undertaken to assess the evolutionary patterns and processes associated with this sexual *** use multivariate analyses of cranial measurements in a phylogenetic framework to determine the distribution of size and shape dimorphism among geomyoids and test for Rensch’s *** results suggest that sexual dimorphism is more common in geomyids than heteromyids,but it is not in fact *** is evidence for variation in sexual dimorphism across ***,in many taxa,geographic variation appears to overwhelm existing sexual *** find support for the repeated independent evolution of shape and size dimorphism across geomyoid taxa,but we do not find support for an association between size and shape *** is no evidence for Rensch’s rule in geomyoids,whether at the superfamily or family ***,our findings suggest that there is no single explanation for the evolution of sexual dimorphism in geomyoids and that,instead,it is the product of numerous evolutionary *** studies incorporating phylogenetic relationships will be necessary to paint a more complete picture of the evolution of sexual dimorphism in geomyoids.

关键词： Geomyidae Heteromyidae phylogenetic comparative methods morphometrics Rensch’s rule

Dangers of scientific bias against herbal drugs for coronavirus disease 2019

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Journal of Integrative medicine 2020年第6期18卷 459-461页

作者： jonathan m.Fields Integrative medicine Us TamaracFL 33321USA

On may 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.

关键词： Herbal Coronavirus COVID-19 sARs-CoV-2 medicine,Chinese traditional Complementary therapies